AutismKB 2.0

Annotation Detail for ENTPD3


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Basic Information Top
Gene Symbol:ENTPD3 ( CD39L3,FLJ93839,HB6,NTPDase-3 )
Gene Full Name: ectonucleoside triphosphate diphosphohydrolase 3
Band: 3p22.1
Quick LinksEntrez ID:956; OMIM: 603161; Uniprot ID:ENTP3_HUMAN; ENSEMBL ID: ENSG00000168032; HGNC ID: 3365
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00240Pyrimidine metabolism
hsa00230Purine metabolism
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of ENTPD3 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ENTPD3 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ENTPD3 mRNAaffects expression 16483693
D002117 Calcitriol Calcitriol results in increased expression of ENTPD3 mRNAincreases expression 16002434
D009151 Mustard Gas Mustard Gas results in increased expression of ENTPD3 mRNAincreases expression 15674844
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.933712494
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001249 Asthma Mustard Gas 2.7910378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.631440618 11289319
MESH:D001768 Blister Mustard Gas 5.7019167455
MESH:D001943 Breast Neoplasms Calcitriol 2.5711237771
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.7015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.5917687719 10378619
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.943581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.943084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.817296757
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.7011237771
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.997505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.419022650 19486331
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2811298694 18759878 2524372 8156756 14531868 12868966 11906362 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.892952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.9911289319 18289764 9022650 18692083 6482804 7440962 9653073 8291058 6679447 18648102 9328219 16192314 1440618
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9911529661 10915739 19420014 19085960 17562736 15968718 18071297 16781746 12392966 14725611 11461765 17522070 11739529 11421492 16485898 17906064 16393943 12705907 18713872 16177239 19370779 11287661 19416960 19739265 12153990 19923254 12594235 11834606 10663392 15619225 14550746 16081117 19164858 2444490 11743745 16109766 12540782 12958197 10774834 16227642 14986274
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004487 Edema Mustard Gas 3.6711428647 11428631 9260866 11402378
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.3715138306
MESH:D004890 Erythema Mustard Gas 5.709357497
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.636705139
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.447505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.956705139
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.4215034207
MESH:D007249 Inflammation Mustard Gas 2.9416001271 9260866 11428647 17524151 11402378 8975870 9357497 11428631 11428620
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.638074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.3815629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.276582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.409327722 15034207
MESH:D008107 Liver Diseases Acetaminophen 1.6916611625 19784758 12969438 19460945 11587558 12587719 16610002 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.733712494 6587162 598648 1399818
MESH:D008171 Lung Diseases Mustard Gas 3.6718161513 18702808
MESH:D008175 Lung Neoplasms Mustard Gas 2.173148597 8781369
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.583581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.136679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009503 Neutropenia Mustard Gas 4.377688884 16761898
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.774026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.633988306
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.977296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.086228378
MESH:D011041 Poisoning Mustard Gas 4.2015727166
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.3215572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.4918247401 16289102 15754350 12479363 16644109
MESH:D011537 Pruritus Mustard Gas 4.6318058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0310334151 17894541 17620002 17720292 17266442
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.643692021
MESH:D012871 Skin Diseases Mustard Gas 2.7812880345 16961503 15451306
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.156587162 1399818 7505956 6582329 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.398074119
MESH:D014581 Urticaria Acetaminophen 3.3810982225
Pathway ID Pathway Name
KEGG:00230 Purine metabolism
KEGG:00240 Pyrimidine metabolism
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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