AutismKB 2.0

Annotation Detail for BCAR1


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Basic Information Top
Gene Symbol:BCAR1 ( CAS,CAS1,CASS1,CRKAS,FLJ12176,FLJ45059,P130Cas )
Gene Full Name: breast cancer anti-estrogen resistance 1
Band: 16q23.1
Quick LinksEntrez ID:9564; OMIM: 602941; Uniprot ID:BCAR1_HUMAN; ENSEMBL ID: ENSG00000050820; HGNC ID: 971
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa05100Bacterial invasion of epithelial cells
hsa04810Regulation of actin cytoskeleton
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
Pathway IDPathway Name
Hemostasis
Signaling by PDGF
Integrin cell surface interactions
Pathway IDPathway Name
200033Signaling events mediated by PTP1B
200185EPHA2 forward signaling
200032Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
200178Paxillin-independent events mediated by a4b1 and a4b7
200004Endothelins
200006Signaling events mediated by PRL
200127PDGFR-beta signaling pathway
200083CXCR4-mediated signaling events
200084IGF1 pathway
200074Netrin-mediated signaling
200011LPA receptor mediated events
200117Paxillin-dependent events mediated by a4b1
200042Osteopontin-mediated events
200109Integrins in angiogenesis
200029Plasma membrane estrogen receptor signaling
200192Signaling events mediated by focal adhesion kinase
200190RAC1 signaling pathway
200057CDC42 signaling events
200058Signaling events regulated by Ret tyrosine kinase
Pathway IDPathway Name
P00034Integrin signalling pathway
Pathway IDPathway Name
500007p130Cas linkage to MAPK signaling for integrins
500509Down-stream signal transduction
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2177Wiskott-Aldrich syndrome
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of BCAR1 mRNAdecreases expression 18648102
C016601 4-hydroxytamoxifen BCAR1 protein results in decreased susceptibility to 4-hydroxytamoxifendecreases response to substance 18351453
D000082 Acetaminophen Acetaminophen affects the expression of BCAR1 mRNAaffects expression 17562736
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of BCAR1 mRNAincreases expression 17023530
D000643 Ammonium Chloride Ammonium Chloride affects the expression of BCAR1 mRNAaffects expression 16483693
D005419 Flavonoids Flavonoids results in decreased expression of BCAR1 mRNAdecreases expression 18035473
C053629 fluoroaluminum fluoroaluminum results in increased phosphorylation of BCAR1 proteinincreases phosphorylation 11792571
C032881 lysophosphatidic acid lysophosphatidic acid results in increased phosphorylation of BCAR1 proteinincreases phosphorylation 11792571
D010126 Ozone Ozone results in increased expression of BCAR1 mRNAincreases expression 16330353
C500434 phenyl caffeate phenyl caffeate results in decreased phosphorylation of BCAR1 proteindecreases phosphorylation 10741720
D010656 Phenylephrine ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]affects binding|affects reaction|increases reaction 17615370
D010656 Phenylephrine ABL1 protein affects the reaction [Phenylephrine results in increased phosphorylation of BCAR1 protein]affects reaction|increases phosphorylation 17615370
D010656 Phenylephrine Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]affects binding|increases reaction 17615370
D010656 Phenylephrine Phenylephrine results in increased phosphorylation of BCAR1 proteinincreases phosphorylation 17615370
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of BCAR1 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of BCAR1 mRNAaffects binding|increases activity|increases expression 19710929
D011189 Potassium Chloride ABL1 protein affects the reaction [Potassium Chloride results in increased phosphorylation of BCAR1 protein]affects reaction|increases phosphorylation 17615370
D011189 Potassium Chloride Potassium Chloride results in increased phosphorylation of BCAR1 proteinincreases phosphorylation 17615370
C009166 retinol acetate retinol acetate results in increased expression of BCAR1 mRNAincreases expression 16772331
C025462 sulindac sulfide sulindac sulfide results in decreased phosphorylation of BCAR1 proteindecreases phosphorylation 10741720
D013629 Tamoxifen BCAR1 protein results in decreased susceptibility to Tamoxifendecreases response to substance 19330798
D013629 Tamoxifen Tamoxifen promotes the reaction [BCAR1 protein mutant form results in decreased expression of BCL2 protein]decreases expression|increases reaction 19330798
D014212 Tretinoin Tretinoin results in increased expression of BCAR1 mRNAincreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5514745880
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1018653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.743712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.4716434500
MESH:D000505 Alopecia Tretinoin 3.6015955085
MESH:D000544 Alzheimer Disease Ozone 4.5615513908
MESH:D000544 Alzheimer Disease sulindac sulfide 4.5618759972
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.0917460149
MESH:D001169 Arthritis, Experimental Tretinoin 3.0616412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.6515570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.6516292516
MESH:D001249 Asthma Ozone 4.9317854713 16373670
MESH:D001249 Asthma Tretinoin 4.9316456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001471 Barrett Esophagus Tretinoin 4.3916935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.0211289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.9119483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.9116206674 16197459
MESH:D001919 Bradycardia Phenylephrine 4.5415306635
MESH:D001943 Breast Neoplasms Tamoxifen 2.1717242785 19410462 18984771 19084267 19066611 19487384 18821012 18815881 19155303 18351453 18997820 21138602 20005174 16873071 19142967 19189210 16818667 15668708 20065188 15565566 11161223 19189212 20135344 18855134 18629630 17440819 16273361 16202921 19289846 19011961 19288272 17049068 20859285 19221464 18425577 19115204 19059307 20544844 19244106 17893378 20390343 19200415 19103187 17261762 21152245
MESH:D001943 Breast Neoplasms Tretinoin 2.1716873071 16443354 16166294
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6618417511 17626835 15516495 16777450 14754758 18315731 19059883
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5816813970
MESH:D002100 Cachexia Ozone 4.7316183385
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4919066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1616168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.537296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.533084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.5316924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.531917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.4412391285
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.667296757
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.2816096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6017572228
MESH:D006332 Cardiomegaly Phenylephrine 3.5211754973 15728586 16170337 17287366 17124262 11179087
MESH:D002386 Cataract Acetaminophen 7.1810977129
MESH:D002386 Cataract Tretinoin 7.1817460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.747505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5816129372
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.7919486331 9022650
MESH:D002779 Cholestasis pirinixic acid 7.7919176532
MESH:D002822 Choriocarcinoma Tretinoin 5.1616461808
MESH:D002972 Cleft Palate Tretinoin 2.669407595
MESH:D003092 Colitis Tretinoin 3.6917035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.829211117 16925845 9224671 17551590 14991402 10589399 9664655 8800419 9125849 9142499
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3519031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7914531868 11298694 11906362 18759878 12868966 8156756 2524372 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.473621924 2952479
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.4619279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.696482804 9653073 11289319 1440618 8291058 16192314 9022650 7440962 18648102 6679447 18692083 9328219 18289764
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.6915968718 19164858 11461765 10774834 19739265 14550746 18713872 19923254 12705907 12594235 16177239 12153990 11739529 2444490 14725611 12540782 17906064 16393943 11743745 11529661 10915739 17562736 16781746 19370779 18071297 16485898 11287661 10663392 19085960 19420014 19416960 12392966 16081117 16227642 11421492 16109766 11834606 14986274 17522070 15619225 12958197
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004487 Edema pirinixic acid 2.4612083418
MESH:D004489 Edema, Cardiac Tretinoin 4.4718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.5219031437
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 12.5019148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.5016202921 19155303 17893378 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 12.5016569247
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.103581430
MESH:D005124 Eye Abnormalities Tretinoin 3.569664655 16938888
MESH:D005234 Fatty Liver pirinixic acid 7.6119236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 7.6119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2216709447
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.026705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1719069698
MESH:D005355 Fibrosis Tretinoin 3.5017994277
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D005909 Glioblastoma Tretinoin 2.9917312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.027505956
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1616084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.8814991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.5220558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.506705139
MESH:D006529 Hepatomegaly pirinixic acid 2.9818467677 19176532 16221962 19772884
MESH:D006930 Hyperalgesia Acetaminophen 7.5716870215
MESH:D006930 Hyperalgesia Tretinoin 7.5716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5516778211
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9215034207
MESH:D006973 Hypertension Phenylephrine 3.068949925 12717712
MESH:D006984 Hypertrophy Phenylephrine 4.5312791704 18502941
MESH:D007249 Inflammation Flavonoids 5.1417296493
MESH:D007249 Inflammation Tamoxifen 5.1419457130
MESH:D007333 Insulin Resistance pirinixic acid 2.6216306350
MESH:D007410 Intestinal Diseases Tretinoin 3.7517994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.029022650 8074119
MESH:D007569 Jaw Abnormalities Tretinoin 3.8815992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 2.1912587719 15629191
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.326582329
MESH:D007680 Kidney Neoplasms Tamoxifen 7.3218625569
MESH:D007938 Leukemia Tretinoin 2.7617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6816482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0719850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1419225113 17368321 19035177 12679006 16788101 17506722 17649720 16140955 19029980 16766008 17301526 15748426 16823087 16331271 19075265 17217047 19642359 17107899 17339181 17712046 17361223 9834237 17294898 16891316 16935935
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.299224671
MESH:D008064 Lipidoses Tamoxifen 3.1417567588 15342952
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4515474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4518564211
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.4516248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6216611625 12969438 12587719 16610002 19014921 11587558 19460945 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2217185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 4.4115890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 4.4116684651
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.521399818 6587162 3712494 598648
MESH:D008171 Lung Diseases Ozone 3.368266340 19066396
MESH:D055370 Lung Injury Ozone 3.8320417186
MESH:D008175 Lung Neoplasms Ozone 2.567614698 8597069
MESH:D008175 Lung Neoplasms Tamoxifen 2.5618625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6119196723 19196722 16827153 14580682 11731420
MESH:D020149 Manganese Poisoning Tamoxifen 4.5519453300
MESH:D008527 Medulloblastoma Tretinoin 2.7817453147
MESH:D008545 Melanoma Tamoxifen 3.2712393984 19393235
MESH:D008545 Melanoma Tretinoin 3.2716752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D008591 Meningomyelocele Tretinoin 4.4116940565
MESH:D008679 Metaplasia Ozone 5.1110496685
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0717596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1319151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9316411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.673581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.6719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5119410462
MESH:D009369 Neoplasms pirinixic acid 4.8717405874
MESH:D009369 Neoplasms Tretinoin 4.8716594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0019196722 19189210 19200415
MESH:D009421 Nervous System Malformations Tretinoin 3.769125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.186679447
MESH:D009436 Neural Tube Defects Tretinoin 7.189142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8518514411
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.404026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.023988306
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3416936753
MESH:D010146 Pain Acetaminophen 6.5316870215
MESH:D010146 Pain Tretinoin 6.5316870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4515976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.477296757
MESH:D010538 Peritonitis Ozone 4.1216369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.476228378
MESH:D011014 Pneumonia Ozone 4.3918007984 18929643 18381685
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1615067354
MESH:D011507 Proteinuria Tretinoin 3.5916636307
MESH:D011625 Pterygium Tretinoin 4.7816723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.363692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0816116481 16283617
MESH:D012852 Sinusitis Phenylephrine 4.697327846
MESH:D012878 Skin Neoplasms Tretinoin 2.6016467112
MESH:D013088 Spermatocele Tamoxifen 4.2916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0319457130
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.086587162 1399818 7505956 3712494 6582329
MESH:D013964 Thyroid Neoplasms Tretinoin 7.0817045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.7716051514
MESH:D014376 Tuberculosis Tretinoin 3.2116040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.018074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.0117572228 16712894 8653321
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6616129372
MESH:D014594 Uterine Neoplasms sulindac sulfide 4.6418645019
MESH:D014604 Uveal Neoplasms Tretinoin 4.6116752155
MESH:D014820 Vitiligo Tretinoin 4.0416761959
MESH:D009396 Wilms Tumor Tretinoin 3.9516287080
MESH:D014947 Wounds and Injuries lysophosphatidic acid 5.2815541073
Pathway ID Pathway Name
KEGG:05100 Bacterial invasion of epithelial cells
KEGG:04062 Chemokine signaling pathway
KEGG:04510 Focal adhesion
REACT:604 Hemostasis
REACT:13552 Integrin cell surface interactions
KEGG:04670 Leukocyte transendothelial migration
KEGG:04810 Regulation of actin cytoskeleton
REACT:16888 Signaling by PDGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25281
    • No data
    Releated disease ID Related disease Name
    PA443756Colonic Neoplasms
    Releated drug ID Related drug Name
    PA448948chloroquine
    PA164747225l-citrulline
    PA448871celecoxib
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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