AutismKB 2.0

Annotation Detail for GTPBP1


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Basic Information Top
Gene Symbol:GTPBP1 ( GP-1,GP1,HSPC018,MGC20069 )
Gene Full Name: GTP binding protein 1
Band: 22q13.1
Quick LinksEntrez ID:9567; OMIM: 602245; Uniprot ID:GTPB1_HUMAN; ENSEMBL ID: ENSG00000100226; HGNC ID: 4669
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of GTPBP1 mRNAaffects expression 21346803
D003561 Cytarabine Cytarabine results in increased expression of GTPBP1 mRNAincreases expression 19194470
C014347 decitabine decitabine results in increased expression of GTPBP1 mRNAincreases expression 19194470
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of GTPBP1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GTPBP1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GTPBP1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GTPBP1 mRNAincreases expression 17108234
C006253 pirinixic acid pirinixic acid results in decreased expression of GTPBP1 mRNAdecreases expression 20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of GTPBP1 mRNA]decreases expression|increases reaction 20059764
D013629 Tamoxifen Tamoxifen affects the expression of GTPBP1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GTPBP1 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2415322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.2616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.7319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms decitabine 1.8719208741 18320071
MESH:D001943 Breast Neoplasms Tamoxifen 1.8719059307 20544844 19244106 19011961 16273361 20135344 19066611 19115204 20065188 11161223 16818667 17893378 20859285 19155303 17242785 15565566 19487384 19221464 18984771 15668708 20390343 18629630 20005174 19084267 19103187 18351453 17440819 16202921 21152245 18855134 17261762 16873071 19289846 19142967 17049068 19189212 19200415 19189210 19410462 18815881 19288272 18821012 18997820 18425577 21138602
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.0916705839
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.0916924424
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6519215824
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic Cytarabine 4.448243401
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.4217110522 16919318 15861022 17681005 11677210 16105132 17333356
MESH:D002779 Cholestasis pirinixic acid 8.4219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2015668235 8697196 12621046 16354765 15340226
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3718551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7219279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.9218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema pirinixic acid 7.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0619031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.5619294695
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2119155303 17893378 20544844 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.7415345470
MESH:D005234 Fatty Liver pirinixic acid 14.7420131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 14.7419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.6619215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4611294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly pirinixic acid 9.4816221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.4815340226 16120746 12621046
MESH:D006689 Hodgkin Disease Cytarabine 4.6716200630
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4918606429 16959395 15340226 16354765 8697196
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male decitabine 7.3117581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.3117937319
MESH:D007249 Inflammation Tamoxifen 5.3219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3212200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.1716705839
MESH:D007680 Kidney Neoplasms Tamoxifen 8.1718625569
MESH:D007938 Leukemia decitabine 3.1918980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 4.2817236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4118206229 17679729 19387464 19010910 18704418 18460780
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.9118055864
MESH:D008064 Lipidoses Tamoxifen 3.3515342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5315474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5312878042
MESH:D008113 Liver Neoplasms pirinixic acid 7.8615890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 7.8616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8616984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2612151625
MESH:D008175 Lung Neoplasms Tamoxifen 2.3118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3119555203 11884234
MESH:D008223 Lymphoma decitabine 3.6119470736
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7914580682 16827153 11731420 19196722 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008545 Melanoma decitabine 3.5216505122 17785578
MESH:D008545 Melanoma Tamoxifen 3.5219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D009101 Multiple Myeloma decitabine 3.5418172295
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5219157545 18608210 19010910 16882708
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2518551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms decitabine 5.4217925555 19116145 19470736
MESH:D009369 Neoplasms pirinixic acid 5.4217405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419189210 19200415 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6912819281 16049721
MESH:D010051 Ovarian Neoplasms decitabine 2.7219331143 19259094
MESH:D010190 Pancreatic Neoplasms decitabine 2.8419294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cytarabine 4.5821297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911222880 11896295 11118676 11399792
MESH:D055728 Primary Myelofibrosis decitabine 5.0917616702
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1015067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7115861022 16919318
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.7119155313
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7118551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 13.0916709447
MESH:D013088 Spermatocele Tamoxifen 13.0916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms decitabine 3.5417967635
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.8916049721
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.8919087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.898653321 16712894 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7110091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D014604 Uveal Neoplasms decitabine 5.3617785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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