AutismKB 2.0

Annotation Detail for CLOCK


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Basic Information Top
Gene Symbol:CLOCK ( KAT13D,KIAA0334,bHLHe8 )
Gene Full Name: clock homolog (mouse)
Band: 4q12
Quick LinksEntrez ID:9575; OMIM: 601851; Uniprot ID:CLOCK_HUMAN; ENSEMBL ID: ENSG00000134852; HGNC ID: 2082
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04710Circadian rhythm - mammal
No data
Pathway IDPathway Name
200068Circadian rhythm pathway
Pathway IDPathway Name
P00015Circadian clock system
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1856Obesity
1901Endometriosis
1904Diabetes mellitus
1907Depression
1914Cerebrovascular disorder
2006Anorexia nervosa
2045Bipolar disorder
2078Narcolepsy
2221Behavior disease
Desease Name
bipolar disorder
anorexia nervosa bulimia
personality dimensions
PSYCH
insomnia
PHARMACOGENOMIC
depression sleep disorders
schizophrenia
diurnal preference
sleep disorders
Desease Name
Personality dimensions
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of CLOCK mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CLOCK mRNAaffects expression 16483693
D019324 beta-Naphthoflavone beta-Naphthoflavone inhibits the reaction [CLOCK protein binds to ARNTL protein]affects binding|decreases reaction 20106950
D019324 beta-Naphthoflavone beta-Naphthoflavone inhibits the reaction [CLOCK protein binds to PER1 promoter]affects binding|decreases reaction 20106950
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CLOCK mRNAincreases expression 17879257
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CLOCK mRNAincreases expression 20127859
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CLOCK mRNAaffects cotreatment|decreases expression 20360939
D003024 Clozapine CLOCK gene SNP affects the susceptibility to Clozapineaffects response to substance 15331141
D004052 Diethylnitrosamine CLOCK protein promotes the reaction [Diethylnitrosamine results in increased activity of CASP3 protein]increases activity|increases reaction 21167249
D004052 Diethylnitrosamine CLOCK protein promotes the reaction [Diethylnitrosamine results in increased activity of CASP7 protein]increases activity|increases reaction 21167249
D004052 Diethylnitrosamine CLOCK protein promotes the reaction [Diethylnitrosamine results in increased expression of and results in increased phosphorylation of TRP53 protein]increases expression|increases phosphorylation|increases reaction 21167249
D004052 Diethylnitrosamine CLOCK protein results in increased susceptibility to Diethylnitrosamineincreases response to substance 21167249
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of CLOCK mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of CLOCK mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CLOCK mRNAaffects cotreatment|decreases expression 20360939
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CLOCK mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CLOCK mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CLOCK mRNAaffects cotreatment|increases expression 17942748
D010634 Phenobarbital Phenobarbital results in decreased expression of CLOCK mRNAdecreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CLOCK mRNAaffects binding|increases activity|increases expression 19710929
D013629 Tamoxifen Tamoxifen affects the expression of CLOCK mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CLOCK mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CLOCK mRNAdecreases expression 18295293
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CLOCK mRNAincreases expression 17942748
D014212 Tretinoin RARA protein inhibits the reaction [Tretinoin results in increased activity of [CLOCK protein binds to ARNTL protein]]affects binding|decreases reaction|increases activity 17069763
D014212 Tretinoin Tretinoin results in increased activity of [CLOCK protein binds to ARNTL protein]affects binding|increases activity 17069763
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6814745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.696195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.6915322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2420127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2414692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 16.363712494
MESH:D000236 Adenoma Benzo(a)pyrene 16.366695378
MESH:D000236 Adenoma beta-Naphthoflavone 16.3619389873
MESH:D000236 Adenoma Diethylnitrosamine 16.366695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 25.9118056438 19061943 17620307 19052882 17162532 16434500
MESH:D018248 Adenoma, Liver Cell Phenobarbital 25.9117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 25.9116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 25.9116835633
MESH:D000380 Agranulocytosis Clozapine 5.1612649775 14617031 16160616
MESH:D000505 Alopecia Tretinoin 3.6815955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.3715885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.3716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2816292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D001471 Barrett Esophagus Tretinoin 4.5016935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.151440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.7619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.7612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.7616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3420146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3417474063
MESH:D001943 Breast Neoplasms Tamoxifen 2.3417261762 19142967 17440819 20544844 19487384 16202921 19189210 18629630 19288272 19155303 19059307 15668708 18997820 19084267 19200415 15565566 20390343 18855134 19011961 19115204 20859285 19103187 16273361 20005174 19244106 18984771 16873071 19289846 17893378 18425577 21152245 18351453 19410462 20135344 16818667 11161223 17049068 19189212 21138602 18815881 17242785 19221464 20065188 18821012 19066611
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3420435547
MESH:D001943 Breast Neoplasms Tretinoin 2.3416166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7116813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6119066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2916168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.017296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.0119919837 18691550 19171122 18056438 10672840 16807293 16540662 19519916 16935385 11831363 19539802 16779866 17978847 19394651 16288022 18971187 19208518 10737359 20727157 18665156 17055752 19822196 16502159 20512989 16569478 19418558 20214788 17428255 16328049 20524982 18788625 20101231 19701751 17162532 18978308 19383236 20514400 19107877 18506893 20935162 17173139 20084675 16698587 18785209 16878318 18494052 16830150 20432363 17138121 16681979 3084413 18393292 19052882 19335982 17761372 21159647 3581430 18210153 20007298
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 9.011701930 20007298 6705139 17173139 20935162
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 9.0116924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 9.011917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.717296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6420419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.6416051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4116120746 18850075 18670907
MESH:D002386 Cataract Tretinoin 3.1417460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.877505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.8721159647 17174075 7505956 2727394
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.364080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7116129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.5719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.5716835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.739022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.7317333356 16919318 17110522 17681005 15861022 11677210 16105132
MESH:D002779 Cholestasis pirinixic acid 13.7319176532
MESH:D002822 Choriocarcinoma Tretinoin 5.2916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8715668235 15340226 16354765 8697196 12621046
MESH:D002972 Cleft Palate Tretinoin 5.879407595
MESH:D003072 Cognition Disorders Clozapine 5.0717123785
MESH:D003092 Colitis Tretinoin 3.8117035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4715322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.479224671 10589399 9664655 17551590 14991402 16925845 9125849 9142499 8800419 9211117
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4719031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.908156756 2524372 11906362 14531868 12868966 8970840 11298694 18759878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.583621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 7.2816402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.2820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.2817107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5519279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.6915331141
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.3118692083 18289764 9328219 6482804 6679447 11289319 8291058 9653073 7440962 9022650 18648102 16192314 1440618
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.3119107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D050171 Dyslipidemias Clozapine 4.2416402076
MESH:D004421 Dystonia Phenobarbital 4.091851702
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.4016714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 12.4018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.2612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.2619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.6119155303 17893378 20544844 16202921
MESH:D016889 Endometrial Neoplasms Tretinoin 7.6116569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.213659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.003922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.616401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.367750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.143659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.433581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.0411564622
MESH:D005124 Eye Abnormalities Tretinoin 9.0416938888 9664655
MESH:D005234 Fatty Liver Diethylnitrosamine 19.4520387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.4515345470
MESH:D005234 Fatty Liver pirinixic acid 19.4519236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 19.4514986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.156705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3019069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9720067830
MESH:D005355 Fibrosis Tretinoin 8.9717994277
MESH:D005909 Glioblastoma Tretinoin 3.0517312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.127505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2916084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.3320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.3310048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 11.3314991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.616705139
MESH:D006529 Hepatomegaly Phenobarbital 15.0116109766
MESH:D006529 Hepatomegaly pirinixic acid 15.0119772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.0115340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.188697196 15340226 16959395 16354765 18606429
MESH:D006930 Hyperalgesia Tretinoin 3.2816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6716778211
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006948 Hyperkinesis Clozapine 5.0316046005
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0415034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Diethylnitrosamine 8.5018785209
MESH:D007249 Inflammation Tamoxifen 8.5019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5012200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007410 Intestinal Diseases Tretinoin 3.8717994277
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.6610783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.158074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.2116580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.2115992940 17551590
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 3.5915369732
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.616582329
MESH:D007680 Kidney Neoplasms Tamoxifen 7.6118625569
MESH:D007938 Leukemia Tretinoin 2.8117143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7819285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0917596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 8.0916766008
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.0916788101 9834237 16766008 17217047 17301526 16140955 19225113 19035177 17368321 19642359 17506722 19075265 19029980 17294898 15748426 16823087 16331271 17107899 16935935 17361223 12679006 17712046 16891316 17339181 17649720
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.369224671
MESH:D008064 Lipidoses Clozapine 8.2717567588
MESH:D008064 Lipidoses Tamoxifen 8.2717567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.7820032147 19638242 18665156 18522880 18407596
MESH:D008103 Liver Cirrhosis Phenobarbital 6.7821047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.249327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9915474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.9918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.9918397230 16248980
MESH:D008107 Liver Diseases Diethylnitrosamine 4.1717034775
MESH:D008107 Liver Diseases Phenobarbital 4.1719363144
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 22.3821137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 22.3821295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 22.3815885732 18648771 2422723 2862719 19073162 20137499 19090486 19426721 19850985 19642983 10737359 12112319 20434301 19996281 20492335 19294768 19551842 19499222 9163691 20583210 20501860 12771043 20405173 21071580 20118626 19255062 19256749 20101389 18978307 19690152 19833225 15175105 19427195 21278145 18754104 21167192 18644402 19254457 20452335 19638242 21047994 18977376 19812893 16942905
MESH:D008113 Liver Neoplasms Phenobarbital 22.3819812893 19073162 15975961 21047994 8742319 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 22.3816377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 22.3816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 22.3816984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 19.19598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 19.1918164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 19.1919519916 3124819 18308698 18544905 16267830 18079962 19009564 18775883 18282651 18093689 19539802 19126423 9362446 17854601 17942915 2563599 18164116 16842330 18253720 17174075 21159647 19004024
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 19.196150874 17172636 2563599 1399818 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.1912151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.8920869020 18569708 20064080 18816296 17053015 20464547 20135361 6695378 18520028
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.8920970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Tamoxifen 4.8918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8911884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8819428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6714580682 19196722 16827153 11731420 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.6819453300
MESH:D008527 Medulloblastoma Tretinoin 2.8117453147
MESH:D008545 Melanoma Tamoxifen 3.3312393984 19393235
MESH:D008545 Melanoma Tretinoin 3.3316752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3015990972
MESH:D008591 Meningomyelocele Tretinoin 4.5316940565
MESH:D001523 Mental Disorders Clozapine 4.0616856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.4819142101
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1217596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5917484760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.643581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.643581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5419410462
MESH:D009369 Neoplasms Benzo(a)pyrene 8.4211141357
MESH:D009369 Neoplasms pirinixic acid 8.4217405874
MESH:D009369 Neoplasms Tretinoin 8.4216594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1319200415 19196722 19189210
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.8314600291
MESH:D009421 Nervous System Malformations Tretinoin 9.839125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.406679447
MESH:D009436 Neural Tube Defects Tretinoin 7.409142499
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D009765 Obesity Clozapine 4.7618515891 19142110
MESH:D009765 Obesity pirinixic acid 4.7620558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.504026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.153988306
MESH:D010018 Osteomalacia Phenobarbital 4.4817016548
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3716936753
MESH:D010146 Pain Tretinoin 2.9716870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.7716540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.7716965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.7715976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.597296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.606228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.332563599
MESH:D011230 Precancerous Conditions Phenobarbital 9.332563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111399792 11896295 11222880 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1117292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1115067354
MESH:D011507 Proteinuria Tretinoin 3.6916636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.6312752131
MESH:D011618 Psychotic Disorders Clozapine 4.2415331141
MESH:D011625 Pterygium Tretinoin 4.9116723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.433692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1916116481 16283617
MESH:D012559 Schizophrenia Clozapine 2.7420580759 17123785 17726453 19369910 20107430 11151749 20521326 11763009 20452607 20521320 17667964 18806925 18855531 20168265 16141801
MESH:D012640 Seizures Phenobarbital 2.7411442880 3137016 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.946407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.6019755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.6016192470
MESH:D012878 Skin Neoplasms Tretinoin 9.6016467112
MESH:D013088 Spermatocele Ethinyl Estradiol 12.0116709447
MESH:D013088 Spermatocele Tamoxifen 12.0116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1519457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.372093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3718456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.3717261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 17.636582329 7505956 1399818 3712494 6587162
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 17.637505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 17.631399818
MESH:D013964 Thyroid Neoplasms Tretinoin 17.6316026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.8616051514
MESH:D014376 Tuberculosis Tretinoin 3.2716040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.458074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.4517053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.4516712894 8653321 17572228
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7516129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.7416752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.1516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D015430 Weight Gain Clozapine 4.5416141801 20107430 16402076 17502770 20564506 20521320
MESH:D015431 Weight Loss Clozapine 5.1917933447
MESH:D009396 Wilms Tumor Tretinoin 4.0416287080
Pathway ID Pathway Name
REACT:24941 Circadian Clock
REACT:24972 Circadian Clock (mouse)
KEGG:04710 Circadian rhythm - mammal
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26609
    • No data
    Releated disease ID Related disease Name
    PA447278Depression
    PA444552Hypertension
    PA162370415metabolic syndrome
    PA445131Obesity
    Releated drug ID Related drug Name
    PA452229antidepressants
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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