AutismKB 2.0

Annotation Detail for PREPL


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Basic Information Top
Gene Symbol:PREPL ( FLJ16627,KIAA0436 )
Gene Full Name: prolyl endopeptidase-like
Band: 2p21
Quick LinksEntrez ID:9581; OMIM: 609557; Uniprot ID:PPCEL_HUMAN; ENSEMBL ID: ENSG00000138078; HGNC ID: 30228
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P04395Vasopressin synthesis
No data
Related Diseases/Disorders Top
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Desease IDDesease Name
2032Kidney disease
2125Bladder cancer
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001194 Asbestos Asbestos affects the expression of PREPL mRNAaffects expression 17297452
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PREPL mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of PREPL mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of PREPL mRNAincreases expression 18042831
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of PREPL mRNA]affects reaction|decreases expression 15016801
D019833 Genistein Genistein results in increased expression of PREPL mRNAincreases expression 17341692
C041786 palm oil palm oil results in increased expression of PREPL mRNAincreases expression 18042831
C010327 salinomycin salinomycin results in decreased expression of PREPL mRNAdecreases expression 19682730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Fluorouracil 4.7517638652
MESH:D000230 Adenocarcinoma Genistein 4.7511473722
MESH:D000740 Anemia Fluorouracil 3.9416511603 15504547 17963324
MESH:D001161 Arteriosclerosis Dietary Fats 4.1915238619
MESH:D050197 Atherosclerosis Asbestos 4.3518795166
MESH:D001943 Breast Neoplasms Dietary Fats 2.0720435547
MESH:D001943 Breast Neoplasms Fluorouracil 2.0719217205 16595493 16557594 18357371 16110121 18608205 15136595
MESH:D001943 Breast Neoplasms Genistein 2.0716541309 17200150 16873071
MESH:D001943 Breast Neoplasms salinomycin 2.0719682730
MESH:D002276 Carcinoid Tumor Fluorouracil 5.0416051944
MESH:D002277 Carcinoma Fluorouracil 3.7617121937
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.3116332177 18930000 17088986 16799960 17045692 17971768
MESH:D006528 Carcinoma, Hepatocellular Genistein 3.3116924424
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1118695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5518986760 16757204 17066447 16280240
MESH:D002318 Cardiovascular Diseases Genistein 3.4616332659
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6812371664
MESH:D002779 Cholestasis Cyclosporine 3.0919486331
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9716510598 17287894 18772588 17169374 15001691 17018589 17725105 16340194 17016597 17172411
MESH:D003110 Colonic Neoplasms Genistein 3.9717182828
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018448328 16303861 16282729 18509181 20501625 15289873 17695437 18383874 16391804 14970324 18802399 17094418 16331619 17255274 16524972 17016601 15148649 17454858 17401013 17594712 18949393 18288408
MESH:D007644 Darier Disease Fluorouracil 5.1316733453
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5316647724
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004714 Endometrial Hyperplasia Genistein 4.9316402032
MESH:D016889 Endometrial Neoplasms Genistein 3.5111473722
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5017638652 15173087 16481741 16337965 16785472
MESH:D005234 Fatty Liver Cyclosporine 8.5519224547
MESH:D005234 Fatty Liver Dietary Fats 8.5517967931 18296743 19004024 19551842
MESH:D005355 Fibrosis Cyclosporine 9.7312639820 12168785
MESH:D005355 Fibrosis Dietary Fats 9.7318296743
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D005909 Glioblastoma Genistein 3.4016598420
MESH:D005910 Glioma Fluorouracil 2.9516145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5415102660 15162350 18337622
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D006973 Hypertension Cyclosporine 2.1710903974
OMIM:606407 HYPOTONIA-CYSTINURIA SYNDROME marker/mechanism
MESH:D007249 Inflammation Dietary Fats 2.5420412841
MESH:D007333 Insulin Resistance Dietary Fats 3.2511836018 18457598
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4618776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 8.0712371664
MESH:D007680 Kidney Neoplasms Fluorouracil 8.0716985049
MESH:D007938 Leukemia Genistein 3.1317468513 18980019
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9918296743
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.0617823541
MESH:D008113 Liver Neoplasms Fluorouracil 2.5518383874 17045692 16603448 15113037
MESH:D008175 Lung Neoplasms Asbestos 3.1112111688
MESH:D008175 Lung Neoplasms Fluorouracil 3.1115246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.1315086387
MESH:D008325 Mammary Neoplasms, Experimental Genistein 7.0212929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 7.0219682730
MESH:D008654 Mesothelioma Asbestos 4.1616919927 16564556 18310086 16319530 18709470
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8118986760 16757204
MESH:D009203 Myocardial Infarction Genistein 2.9417141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.8417141266
MESH:D009369 Neoplasms Fluorouracil 2.7118239605 16928823 18600527
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009421 Nervous System Malformations Genistein 4.3116427766
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5916436463
MESH:D009765 Obesity Dietary Fats 2.3320518802 19632207 17217161 11836018 18457598 18674790 16723640 21332399 20132043
MESH:D010024 Osteoporosis Genistein 3.3919401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3516169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6619005980
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7316929163 19003803 15113037 16500647
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3618626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 3.3615378649 15256057 16925846
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.2316160472 15538739 18722050 18286688
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.798532709
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0017172411 16424979 17498489 18396642 17522103 16951190 19084572 19015929 18567086 15786421
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2216280240
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1116803524
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
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Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA142671134
    • No data
    Releated disease ID Related disease Name
    PA145007197Hypotonia-Cystinuria Syndrome(HCS)
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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