AutismKB 2.0

Annotation Detail for APOBEC3B


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Basic Information Top
Gene Symbol:APOBEC3B ( APOBEC1L,ARCD3,ARP4,DJ742C19.2,FLJ21201,PHRBNL,bK150C2.2 )
Gene Full Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
Band: 22q13.1
Quick LinksEntrez ID:9582; OMIM: 607110; Uniprot ID:ABC3B_HUMAN; ENSEMBL ID: ENSG00000179750; HGNC ID: 17352
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of APOBEC3B mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of APOBEC3B mRNAdecreases expression 20382639
C006780 bisphenol A bisphenol A results in increased expression of APOBEC3B mRNAincreases expression 16474171
D016572 Cyclosporine Cyclosporine results in decreased expression of APOBEC3B mRNAdecreases expression 20106945
D003561 Cytarabine Cytarabine results in increased expression of APOBEC3B mRNAincreases expression 19194470
C014347 decitabine pyrimidin-2-one beta-ribofuranoside inhibits the reaction [APOBEC3B protein results in decreased amination of decitabine]decreases amination|decreases reaction 18398609
C014347 decitabine [pyrimidin-2-one beta-ribofuranoside results in decreased activity of APOBEC3B protein] which results in increased susceptibility to decitabinedecreases activity|increases response to substance 18398609
D004958 Estradiol Estradiol results in increased expression of APOBEC3B mRNAincreases expression 16474171
19139166
20106945
D004958 Estradiol [Progesterone co-treated with Estradiol] affects the expression of APOBEC3B mRNAaffects cotreatment|affects expression 17404688
D019833 Genistein Genistein results in increased expression of APOBEC3B mRNAincreases expression 16474171
D007529 Isoflavones Isoflavones results in decreased expression of APOBEC3B mRNAdecreases expression 17374662
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of APOBEC3B mRNAincreases expression 16474171
D011374 Progesterone [Progesterone co-treated with Estradiol] affects the expression of APOBEC3B mRNAaffects cotreatment|affects expression 17404688
C009131 pyrimidin-2-one beta-ribofuranoside pyrimidin-2-one beta-ribofuranoside inhibits the reaction [APOBEC3B protein results in decreased amination of decitabine]decreases amination|decreases reaction 18398609
C009131 pyrimidin-2-one beta-ribofuranoside [pyrimidin-2-one beta-ribofuranoside results in decreased activity of APOBEC3B protein] which results in increased susceptibility to decitabinedecreases activity|increases response to substance 18398609
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.2420127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.2411473722
MESH:D000230 Adenocarcinoma Genistein 7.2411473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D000505 Alopecia Isoflavones 4.8117569567
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001862 Bone Resorption bisphenol A 3.9711985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.5117868700
MESH:D001930 Brain Injuries Progesterone 4.4015665606 15380490 15845082
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.0117474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 3.0117123778
MESH:D001943 Breast Neoplasms decitabine 3.0118320071 19208741
MESH:D001943 Breast Neoplasms Estradiol 3.0117261762 17289903 19861407 12948864 16675129 17018787 14630087 18497071
MESH:D001943 Breast Neoplasms Genistein 3.0116541309 16873071 17200150
MESH:D001943 Breast Neoplasms Progesterone 3.0117614352 15562024 16175315
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1516924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 3.1516924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.1417123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7720419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.7719215824
MESH:D002318 Cardiovascular Diseases Genistein 8.0116332659
MESH:D002318 Cardiovascular Diseases Isoflavones 8.0117689850
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.7120889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.7112371664
MESH:D002471 Cell Transformation, Neoplastic Cytarabine 16.718243401
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.7118566989
MESH:D002779 Cholestasis Cyclosporine 3.0019486331
MESH:D003110 Colonic Neoplasms decitabine 3.9517616700
MESH:D003110 Colonic Neoplasms Genistein 3.9517182828
MESH:D015179 Colorectal Neoplasms decitabine 3.7618981723
MESH:D015179 Colorectal Neoplasms Isoflavones 3.7617116718
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 3.7615531428
MESH:D003704 Dementia Polychlorinated Biphenyls 4.8116140633
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5116647724
MESH:D003928 Diabetic Nephropathies Estradiol 3.5119279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.6317187935
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.9117692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2919294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.7416402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.7411473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 7.7411473722
MESH:D004715 Endometriosis Progesterone 3.8716134523
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4320426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4316530937
MESH:D005234 Fatty Liver Cyclosporine 2.9619224547
MESH:D005355 Fibrosis Cyclosporine 3.2812639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D005909 Glioblastoma Genistein 3.3316598420
MESH:D006258 Head and Neck Neoplasms decitabine 3.5619215824
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7120471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D006689 Hodgkin Disease Cytarabine 4.5216200630
MESH:D019584 Hot Flashes Estradiol 11.0117088409
MESH:D019584 Hot Flashes Isoflavones 11.0117290160 14716179
MESH:D006973 Hypertension Cyclosporine 2.1310903974
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5415869954
MESH:D007248 Infertility, Male decitabine 3.2717581917
MESH:D007249 Inflammation Progesterone 2.6515869954
MESH:D007333 Insulin Resistance bisphenol A 7.6716393666
MESH:D007333 Insulin Resistance Estradiol 7.6716627594 16393666
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Cyclosporine 6.1418776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 6.1415618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5812371664
MESH:D007680 Kidney Neoplasms Estradiol 7.5815610895
MESH:D007938 Leukemia decitabine 6.6919235587 18980019
MESH:D007938 Leukemia Genistein 6.6917468513 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.1118454857 17236224 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3918460780 18704418 17679729 19387464 19010910 18206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6418055864
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.5917823541
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.0820195826 21137059
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 3.661423854
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5620135361 20464547 18816296 18520028 6695378 17053015 18569708 20869020 20064080
MESH:D008223 Lymphoma decitabine 3.4919470736
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.4211807958 11408345 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 10.4212929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.4217203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008545 Melanoma decitabine 4.1416505122 17785578
MESH:D008545 Melanoma pyrimidin-2-one beta-ribofuranoside 4.1416505122
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009101 Multiple Myeloma decitabine 3.4218172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4418608210 16882708 19010910 19157545
MESH:D009203 Myocardial Infarction Genistein 2.9017141266
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.8016810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.8017141266
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2711141357
MESH:D009369 Neoplasms decitabine 5.2719116145 17925555 19470736
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 17.2411399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 17.2411399458 16427766
MESH:D009421 Nervous System Malformations Genistein 17.2416427766
MESH:D010024 Osteoporosis Genistein 7.8119401787
MESH:D010024 Osteoporosis Isoflavones 7.8116562857
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.2016169203
MESH:D010049 Ovarian Diseases bisphenol A 5.1411985600
MESH:D010051 Ovarian Neoplasms decitabine 11.5819331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 11.5819401270
MESH:D010051 Ovarian Neoplasms Genistein 11.5819005980
MESH:D010051 Ovarian Neoplasms Progesterone 11.5817393432 16525653
MESH:D010190 Pancreatic Neoplasms decitabine 2.8019294695
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.4316702228
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cytarabine 4.5021297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.1010548101
MESH:D055728 Primary Myelofibrosis decitabine 4.8717616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.9220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.9220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9017292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.9016740699
MESH:D011471 Prostatic Neoplasms Estradiol 1.9016740699
MESH:D011471 Prostatic Neoplasms Genistein 1.9015378649 16925846 15256057
MESH:D011471 Prostatic Neoplasms Isoflavones 1.9017374662 17571952 16365062 17219775
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 1.9015721890
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D011629 Puberty, Precocious bisphenol A 4.9410548101
MESH:D012208 Rhabdomyosarcoma decitabine 4.5219155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8918045962
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4119755658 10029692
MESH:D013119 Spinal Cord Injuries Progesterone 4.4316503802 15862959
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.482093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 2.4819037991
MESH:D019966 Substance-Related Disorders bisphenol A 4.1416684133 16045194
MESH:D013964 Thyroid Neoplasms decitabine 3.4117967635
MESH:D013978 Tibial Fractures Estradiol 4.8619048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2617053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.2617616700 19087683
MESH:D014591 Uterine Diseases bisphenol A 5.1814652134
MESH:D014604 Uveal Neoplasms decitabine 5.0917785578
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24892
    • No data
    Releated disease ID Related disease Name
    PA443685Uterine Cervical Neoplasms
    PA447189Papillomavirus Infections
    PA446061Warts
    No data
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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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