AutismKB 2.0

Annotation Detail for PDIA4


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Basic Information Top
Gene Symbol:PDIA4 ( ERP70,ERP72,ERp-72 )
Gene Full Name: protein disulfide isomerase family A, member 4
Band: 7q36.1
Quick LinksEntrez ID:9601; OMIM: NA; Uniprot ID:PDIA4_HUMAN; ENSEMBL ID: ENSG00000155660; HGNC ID: 30167
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
hsa05110Vibrio cholerae infection
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PDIA4 mRNAaffects expression 21346803
C016392 3,3'-diindolylmethane 3,3'-diindolylmethane results in increased expression of PDIA4 mRNAincreases expression 16192472
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PDIA4 mRNAincreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of PDIA4 mRNAaffects expression 21346803
C105260 4-tert-octylphenol 4-tert-octylphenol results in increased expression of PDIA4 mRNAincreases expression 17011747
D000082 Acetaminophen Acetaminophen affects the expression of PDIA4 mRNAaffects expression 17562736
D013196 Dihydrotestosterone Dihydrotestosterone results in decreased expression of PDIA4 mRNAdecreases expression 17023530
D006710 Homocysteine Homocysteine results in increased expression of PDIA4 mRNAincreases expression 17326132
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PDIA4 mRNAaffects expression 16483693
D000965 Antimony Antimony results in decreased expression of PDIA4 mRNAdecreases expression 17547211
D000966 Antimony Potassium Tartrate Antimony Potassium Tartrate results in decreased expression of PDIA4 mRNAdecreases expression 17547211
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PDIA4 mRNAdecreases expression 15003993
D002509 Cephaloridine Cephaloridine results in increased expression of PDIA4 mRNAincreases expression 18172885
D002713 Chlorine Chlorine results in increased expression of PDIA4 mRNAincreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of PDIA4 mRNAaffects cotreatment|decreases expression 18636392
D002857 Chromium Chromium results in decreased expression of PDIA4 mRNAdecreases expression 17547211
C030123 coumarin coumarin results in increased expression of PDIA4 mRNAincreases expression 18480146
C057862 cyanoginosin LR cyanoginosin LR results in decreased expression of PDIA4 mRNAdecreases expression 17383702
D003520 Cyclophosphamide Cyclophosphamide results in increased expression of PDIA4 mRNAincreases expression 11599041
D016572 Cyclosporine Cyclosporine results in increased expression of PDIA4 mRNAincreases expression 20106945
D016190 Carboplatin Carboplatin results in decreased expression of PDIA4 mRNAdecreases expression 18172885
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of PDIA4 mRNAincreases expression 17011747
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of PDIA4 mRNAdecreases expression 17547211
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PDIA4 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PDIA4 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDIA4 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil Fluorouracil results in decreased expression of PDIA4 mRNAdecreases expression 16709241
D005839 Gentamicins Gentamicins results in increased expression of PDIA4 mRNAincreases expression 18172885
C016517 indole-3-carbinol indole-3-carbinol results in increased expression of PDIA4 mRNAincreases expression 16192472
D008628 Mercury Mercury results in decreased expression of PDIA4 mRNAdecreases expression 17547211
C022838 nickel chloride nickel chloride results in decreased expression of PDIA4 mRNAdecreases expression 17547211
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of PDIA4 mRNAaffects cotreatment|decreases expression 18636392
D010269 Paraquat Paraquat results in increased expression of PDIA4 mRNAincreases expression 17935786
D011192 Potassium Dichromate Potassium Dichromate results in decreased expression of PDIA4 mRNAdecreases expression 17547211
C035988 procymidone procymidone results in decreased expression of PDIA4 mRNAdecreases expression 15686871
D011374 Progesterone Progesterone affects the expression of PDIA4 mRNAaffects expression 17251523
C031280 pyrazole pyrazole results in increased expression of PDIA4 mRNAincreases expression 17945193
D013629 Tamoxifen Tamoxifen affects the expression of PDIA4 mRNAaffects expression 17555576
C534735 tetraarsenic tetrasulfide tetraarsenic tetrasulfide results in increased expression of PDIA4 mRNAincreases expression 19208803
C534735 tetraarsenic tetrasulfide tetraarsenic tetrasulfide results in increased expression of PDIA4 proteinincreases expression 19208803
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDIA4 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PDIA4 mRNAincreases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PDIA4 proteindecreases expression 16548065
D014415 Tunicamycin Tunicamycin results in increased expression of PDIA4 mRNAincreases expression 17127020
C025643 vinclozolin vinclozolin results in decreased expression of PDIA4 mRNAdecreases expression 15686871
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1314745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 7.147525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.1411752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.1518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5317505938
MESH:D058186 Acute Kidney Injury Gentamicins 4.1811274264
MESH:D055371 Acute Lung Injury Chlorine 3.9520601635
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 6.4816033868
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.4814692618
MESH:D000230 Adenocarcinoma Fluorouracil 6.4817638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.123712494
MESH:D000236 Adenoma Dimethylnitrosamine 6.1219555203
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 2.9716835633
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.3711874814
MESH:D000544 Alzheimer Disease Ozone 2.3515513908
MESH:D000686 Amyloidosis Diethylstilbestrol 4.0915469931
MESH:D000740 Anemia Fluorouracil 7.5116511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.5111748828
MESH:D000799 Angioedema Acetaminophen 3.4310982225
MESH:D001008 Anxiety Disorders vinclozolin 3.3219015723
MESH:D001161 Arteriosclerosis Cyclophosphamide 8.8515014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.8511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4115885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4615570426
MESH:D001249 Asthma Ozone 2.5116373670 17854713
MESH:D001321 Autistic Disorder Acetaminophen 2.2718445737
MESH:D001321 Autistic Disorder Homocysteine 2.2716297937 20468076
MESH:D001321 Autistic Disorder Mercury 2.2717497416
MESH:D001327 Autoimmune Diseases Mercury 4.4816634805
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.6011289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.6812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5015746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9217868700
MESH:D001930 Brain Injuries Progesterone 3.8615845082 15665606 15380490
MESH:D001943 Breast Neoplasms Chromium 4.3515986119
MESH:D001943 Breast Neoplasms Cyclophosphamide 4.3511325840 16978400 15093573 17388661 12006526 18234424 15136595 18323546 17020986
MESH:D001943 Breast Neoplasms Diethylstilbestrol 4.3515324884 17129689
MESH:D001943 Breast Neoplasms Fluorouracil 4.3518357371 19217205 16110121 15136595 16595493 16557594 18608205
MESH:D001943 Breast Neoplasms indole-3-carbinol 4.3516082211
MESH:D001943 Breast Neoplasms Progesterone 4.3515562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tamoxifen 4.3520135344 19115204 20065188 15668708 19410462 19189212 19103187 20859285 17261762 19142967 21152245 17440819 19200415 16202921 21138602 17893378 16818667 18351453 18629630 18815881 16273361 16873071 19059307 19011961 11161223 20544844 18984771 15565566 20005174 19221464 20390343 18855134 18997820 19084267 19288272 19189210 17049068 19244106 19155303 19066611 18425577 19289846 17242785 18821012 19487384
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.3520435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3618315731 16777450 15516495 19059883 14754758 17626835 18417511
MESH:D001991 Bronchitis Antimony 5.728768112
MESH:D002100 Cachexia Ozone 4.3316183385
MESH:D002276 Carcinoid Tumor Fluorouracil 4.2516051944
MESH:D002277 Carcinoma Dimethylnitrosamine 12.1419555203
MESH:D002277 Carcinoma Fluorouracil 12.1417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 12.1416835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1119066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 12.8816705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 12.887296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 12.883084413
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 12.8819701751
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 12.8816924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 12.8817088986 18930000 17971768 17045692 16799960 16332177
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 12.8816924424
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.4816152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung Carboplatin 3.8316685392
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 9.677296757
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 9.6716201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 9.6718695887
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 4.5316033868
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.5316757204 17066447 18986760 16280240
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.2617572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1418850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Antimony 6.0310334427
MESH:D002311 Cardiomyopathy, Dilated Mercury 6.0310334427
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 6.6114694615
MESH:D002386 Cataract Acetaminophen 6.6110977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 5.647505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 5.6412371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 11.649022650 19486331
MESH:D002779 Cholestasis Cyclosporine 11.6419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 11.6416919318 11677210 16105132 15861022 17681005 17333356 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.938697196 15668235 16354765 12621046 15340226
MESH:D003110 Colonic Neoplasms Fluorouracil 2.1618772588 17169374 17172411 17725105 16340194 16510598 17018589 15001691 17287894 17016597
MESH:D015179 Colorectal Neoplasms Fluorouracil 1.9918949393 18383874 18288408 16331619 16391804 18509181 17016601 16524972 17695437 20501625 16282729 16303861 18448328 17454858 17594712 17094418 17255274 14970324 15289873 17401013 18802399 15148649
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 8.0515095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.0514669216 17141729
MESH:D003324 Coronary Artery Disease Homocysteine 3.6016379339
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2410048152 15322242 20055451
MESH:D003456 Cryptorchidism Diethylstilbestrol 10.0916002989 12952375
MESH:D003456 Cryptorchidism vinclozolin 10.0914966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.6218551238
MESH:D003556 Cystitis Cyclophosphamide 4.5718483878 10498854 15643279 16614059 11948286 16413132 10700343 18433785 17010015 18372110 12161096 12913760 17979934 12388444 16989017 15276878 18295254 18093676 16651033 18710439
MESH:D007644 Darier Disease Fluorouracil 4.3816733453
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9619031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 9.5514531868 8156756 11906362 12868966 11298694 18759878 8970840 2524372
MESH:D017449 Dermatitis, Allergic Contact Mercury 9.5516823706
MESH:D017449 Dermatitis, Allergic Contact Potassium Dichromate 9.5516823706
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.123621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.7410990075 15331540 11751995
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.0918772604
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 4.2119647726
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2117107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.1419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.0917187935
MESH:D004283 Dog Diseases Antimony 5.2512019027
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 19.8321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 19.8318289764 16192314 18692083 9653073 7440962 6679447 6482804 11289319 8291058 9022650 18648102 9328219 1440618
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 19.8321346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 19.8311743745 11834606 16485898 14986274 16227642 11461765 10663392 19416960 19370779 19739265 11421492 14725611 17562736 19085960 16393943 16109766 19164858 12153990 12540782 16781746 17522070 12705907 12594235 10915739 11529661 17906064 11739529 11287661 19923254 15968718 14550746 18071297 2444490 16081117 19420014 18713872 15619225 16177239 10774834 12392966 12958197
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 19.8317654400
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 19.838172417
MESH:D056486 Drug-Induced Liver Injury pyrazole 19.8312499123
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 19.8320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6819426721
MESH:D004362 Drug Toxicity Gentamicins 7.3915033597 11033412
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.3911462148
MESH:D004417 Dyspnea Chlorine 4.2120016425
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.0311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.4918230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.0912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 13.0917692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 13.0919031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.2916402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 6.6716804899 15700306
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.6717893378 16202921 20544844 19155303
MESH:D004715 Endometriosis Progesterone 7.7616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.7610568697 9294722
MESH:D004802 Eosinophilia Cyclophosphamide 3.8211006010
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.653581430
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 6.6517016578
MESH:D004938 Esophageal Neoplasms Fluorouracil 6.6516481741 17638652 16337965 16785472 15173087
MESH:D017889 Exfoliation Syndrome Homocysteine 5.2916504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7111564622
MESH:D005234 Fatty Liver Cyclosporine 10.9619224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 10.9615345470
MESH:D005234 Fatty Liver Tamoxifen 10.9614986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.3716002989 16513791 16611131 15751030 16534752
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.3716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0611858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.606705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.7819069698
MESH:D005355 Fibrosis Cyclosporine 7.1712639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.1720067830
MESH:D005739 Gas Poisoning Chlorine 4.6020016425
MESH:D005756 Gastritis Acetaminophen 3.2616983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5316973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.8916417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.5416452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.818708960
MESH:D005901 Glaucoma Homocysteine 4.9116504073
MESH:D005910 Glioma Fluorouracil 2.7016145905
MESH:D018316 Gliosarcoma Cyclophosphamide 5.1111389073
MESH:D005911 Gliosis Paraquat 4.7511124998
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.667505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1810696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.6415172196 11014644 16376943
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.1115162350 15102660 18337622
MESH:D034381 Hearing Loss Gentamicins 4.5419130971 15968427 17868369 18024279
MESH:D006330 Heart Defects, Congenital Homocysteine 6.2019638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2011294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0115720958
MESH:D006467 Hemophilia A Cyclophosphamide 4.8911918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9711000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.1214986274
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.136705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5012621046 16120746 15340226
MESH:D006689 Hodgkin Disease Cyclophosphamide 3.4617606976 16135485
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.638697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.3816870215
MESH:D053565 Hypercalciuria Gentamicins 5.3017652376
MESH:D020138 Hyperhomocysteinemia Homocysteine 4.3617369066 18234410 17292331
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 9.5115034207
MESH:D006965 Hyperplasia Diethylstilbestrol 9.5112960047 14722030
MESH:D006973 Hypertension Cyclosporine 4.3910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.3918670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 9.9216002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.9216569931 16945680
MESH:D007154 Immune System Diseases Cyclophosphamide 4.9216076520
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0015869954
MESH:D007246 Infertility Diethylstilbestrol 3.9715036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0912013081
MESH:D007248 Infertility, Male Cyclophosphamide 13.837193160 16517039
MESH:D007248 Infertility, Male Ethinyl Estradiol 13.8317937319
MESH:D007248 Infertility, Male Paraquat 13.834850670
MESH:D007248 Infertility, Male vinclozolin 13.8316467254
MESH:D007249 Inflammation Progesterone 7.0215869954
MESH:D007249 Inflammation Tamoxifen 7.0219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.0212200463 12878042
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.608074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.9716580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0315604871
MESH:D007673 Kidney Cortex Necrosis Gentamicins 5.3118842672
MESH:D007674 Kidney Diseases Acetaminophen 20.7612587719 15629191
MESH:D007674 Kidney Diseases Chromium 20.7617934191
MESH:D007674 Kidney Diseases Cyclosporine 20.7610903974 18776723 8314463
MESH:D007674 Kidney Diseases Gentamicins 20.7619349640 17934191 18289764
MESH:D007674 Kidney Diseases Mercury 20.7617934191
MESH:D007674 Kidney Diseases Potassium Dichromate 20.7619665454
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 24.8316705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 24.836582329
MESH:D007680 Kidney Neoplasms Cyclosporine 24.8312371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 24.8315003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Fluorouracil 24.8316985049
MESH:D007680 Kidney Neoplasms Tamoxifen 24.8318625569
MESH:D007683 Kidney Tubular Necrosis, Acute Gentamicins 4.9711231351
MESH:D007859 Learning Disorders Diethylstilbestrol 3.6717184923
MESH:D007896 Leishmaniasis Antimony 4.4721182181 15220340 10953559 21063981 12019027
MESH:D016773 Leishmaniasis, Cutaneous Antimony 8.068889330 11475954 19141829
MESH:D016773 Leishmaniasis, Cutaneous Gentamicins 8.0610219319
MESH:D007897 Leishmaniasis, Mucocutaneous Antimony 5.0811370249 10651420 7854095 10881086 9643325
MESH:D007898 Leishmaniasis, Visceral Antimony 7.7120495762 7554475 1899875 8142506 7875148 11105143 7854095
MESH:D007898 Leishmaniasis, Visceral Antimony Potassium Tartrate 7.7112707265
MESH:D007938 Leukemia Cyclophosphamide 3.2810602166
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.3217658394 18172266 17802794 18587576 17296974 17008537
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 8.2110373061
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive tetraarsenic tetrasulfide 8.2119208803
MESH:D015473 Leukemia, Promyelocytic, Acute Antimony Potassium Tartrate 4.259834237
MESH:D007970 Leukopenia Cyclophosphamide 4.5610052129 11830472
MESH:D007984 Leydig Cell Tumor vinclozolin 4.3216417039
MESH:D008064 Lipidoses Tamoxifen 2.8715342952 17567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.949327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 3.2315733078 17036385 14659978 18629640 16270385 15744066 12925901 15591649 17465448 16570917 15842777 15504291 18637143 18239293 12918455 16042886 15798949 15942678 17881167 15723089 17348192 15492853 15086199 15763062 15479170 15067225 14709902 15081153 15099470 14643895 17719030 16009107 16544323 16603200 18237412 18364076 15298665 17201889 15161499 15793283 15339415 17198567 18210741 17666798 18371158 14726149 17196135 16627068 18672772 14568256 17534399 15383259 17640959 15577212 15864749 17724770 15138612 15571005 15366600 15369754 18095165 17203207 16169303 17432682 18567088
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.2318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.2312878042
MESH:D008107 Liver Diseases Acetaminophen 1.5311587558 16611625 19014921 12969438 12587719 19460945 19784758 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 8.5016871587 17185352
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 8.5017457977
MESH:D008113 Liver Neoplasms Diethylstilbestrol 12.4716712894 15890375
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 12.4715890375 3113478
MESH:D008113 Liver Neoplasms Fluorouracil 12.4718383874 17045692 15113037 16603448
MESH:D008113 Liver Neoplasms Tamoxifen 12.4716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 12.4716984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 8.386587162 1399818 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 8.381848544 6150874 15603536
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.3812151625
MESH:D008171 Lung Diseases Ozone 3.108266340 19066396
MESH:D055370 Lung Injury Ozone 3.4620417186
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 5.9716061637 11884234 19555203
MESH:D008175 Lung Neoplasms Fluorouracil 5.9715246190
MESH:D008175 Lung Neoplasms Ozone 5.977614698 8597069
MESH:D008175 Lung Neoplasms Tamoxifen 5.9718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.9711884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.3815086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.7415166399
MESH:D008223 Lymphoma Cyclophosphamide 6.9212854902
MESH:D008223 Lymphoma Diethylstilbestrol 6.9215700306
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.2216675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 3.8411911406
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.1016002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.3619428831
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 5.2111408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.2114580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.1319453300
MESH:D008545 Melanoma Carboplatin 3.5716342250 11712820 16225601 12040289
MESH:D008545 Melanoma Tamoxifen 3.5719393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.7815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 9.5119513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 9.5116388313
MESH:D008591 Meningomyelocele Homocysteine 5.1416602021
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3716801185
MESH:D008679 Metaplasia Ozone 4.6910496685
MESH:D009062 Mouth Neoplasms Fluorouracil 3.3216757204 18986760
MESH:D009137 Muscular Dystrophy, Animal Gentamicins 5.8618694830
MESH:D009203 Myocardial Infarction Homocysteine 3.5417412321
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7012213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.4518551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.113581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.1119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3719410462
MESH:D009369 Neoplasms Carboplatin 10.2618854779 17925555
MESH:D009369 Neoplasms Cyclophosphamide 10.2618854779
MESH:D009369 Neoplasms Diethylstilbestrol 10.2615313581
MESH:D009369 Neoplasms Fluorouracil 10.2618239605 18600527 16928823
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.5919189210 19200415 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9419348381 18481113
MESH:D009410 Nerve Degeneration Paraquat 3.4116893418
MESH:D009421 Nervous System Malformations Diethylstilbestrol 8.3611399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.3614600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.656679447
MESH:D009447 Neuroblastoma Cyclophosphamide 3.428761367 15176712 16115947
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.5418514411
MESH:D017599 Neuroectodermal Tumors Carboplatin 10.5212837982
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 10.528761367 12837982
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1616436463
MESH:D009503 Neutropenia Cyclophosphamide 3.958291058
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 13.1212819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 13.124026338 6482804
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 13.1214694615
MESH:D009845 Oligospermia Cyclophosphamide 4.3116517039
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.603988306
MESH:D010051 Ovarian Neoplasms Progesterone 2.3917393432 16525653
MESH:D010146 Pain Acetaminophen 5.7816870215
MESH:D010146 Pain Cyclophosphamide 5.7812161096 18093676
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 5.0811332152
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.0816500647 16929163 15113037 19003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3111578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.097296757
MESH:D010300 Parkinson Disease Homocysteine 5.2516275827
MESH:D010300 Parkinson Disease Paraquat 5.2511181820 15824117 11445065 11124998 12911755 16510128 15451049 16140633
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.0316190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8312520081
MESH:D010409 Penile Diseases Antimony 5.349643325
MESH:D010493 Pericarditis Antimony 5.7120465667
MESH:D010538 Peritonitis Ozone 3.7416369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.066228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.7514722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.2715687265 16977796
MESH:D011014 Pneumonia Ozone 9.7118007984 18929643 18381685
MESH:D011014 Pneumonia Paraquat 9.7112504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1718163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.8812371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.5721297632
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 13.9217184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.9211222880 11118676 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 13.9219015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.5318220299
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.2217136230
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.2215846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.2219082440 18626508
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.2215067354
MESH:D011472 Prostatitis vinclozolin 4.5318629315
MESH:D011507 Proteinuria Gentamicins 4.3515033597
MESH:D011537 Pruritus Ethinyl Estradiol 2.9116919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.0816882103
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 5.4416636934
MESH:D011658 Pulmonary Fibrosis Paraquat 5.4416324872 17997886
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6718722050 16160472 18286688 15538739
MESH:D051437 Renal Insufficiency Gentamicins 4.6017132701 15728788
MESH:D012120 Respiration Disorders Chlorine 4.8018579056
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.5311700416
MESH:D012135 Respiratory Sounds Paraquat 3.6611874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4518990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 7.903692021
MESH:D012162 Retinal Degeneration Paraquat 7.9016458197
MESH:D012173 Retinitis Gentamicins 5.8618644591
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7018045962
MESH:D012559 Schizophrenia Homocysteine 3.0516641680
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.4516636934
MESH:D012640 Seizures 2,4-dinitrotoluene 2.2718551238
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 4.928532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 4.9216192470
MESH:D013088 Spermatocele Diethylstilbestrol 17.7316709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 17.7316709447
MESH:D013088 Spermatocele Tamoxifen 17.7316709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.1116517039
MESH:D013119 Spinal Cord Injuries Progesterone 9.5216503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.5219457130
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.8512587719
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 2.6416033868
MESH:D013274 Stomach Neoplasms Fluorouracil 2.6417522103 19084572 17498489 16951190 16424979 15786421 18396642 18567086 17172411 19015929
MESH:D015173 Supratentorial Neoplasms Carboplatin 11.1212837982
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 11.1212837982
MESH:D013733 Testicular Diseases pyrazole 4.416499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4912697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.581399818 6587162 3712494 6582329 7505956
MESH:D014062 Tongue Neoplasms Fluorouracil 3.6416280240
MESH:D014352 Trypanosomiasis Antimony 5.5215220340
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 13.9816049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 13.988074119
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 13.9814692829
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 13.9816712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 13.9816712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.9110091137
MESH:D014581 Urticaria Acetaminophen 2.6110982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 14.0416175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 14.0416803524
MESH:D002583 Uterine Cervical Neoplasms indole-3-carbinol 14.0416082211
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.7514652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.1915809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.1914692618
MESH:D014605 Uveitis Cyclosporine 3.571336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.0416513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1812125929
MESH:D014689 Venous Insufficiency coumarin 5.3612708602
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1815869587 14671159
MESH:D015837 Vestibular Diseases Gentamicins 5.1318776599
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8315886252
MESH:D014985 Xerophthalmia Cyclosporine 4.0317120751
Pathway ID Pathway Name
KEGG:04141 Protein processing in endoplasmic reticulum
KEGG:05110 Vibrio cholerae infection
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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