Gene Symbol:	NFE2L3 ( NRF3 )
Gene Full Name:	nuclear factor (erythroid-derived 2)-like 3
Band:	7p15.2
Quick Links	Entrez ID:9603; OMIM: 604135; Uniprot ID:NF2L3_HUMAN; ENSEMBL ID: ENSG00000050344; HGNC ID: 7783
Relate to Another Database:	SFARIGene; denovo-db

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of NFE2L3 mRNA	decreases expression	20106945
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of NFE2L3 mRNA	increases expression	20382639
D016572	Cyclosporine	Cyclosporine results in increased expression of NFE2L3 mRNA	increases expression	20106945
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of NFE2L3 mRNA	decreases expression	20024957
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of NFE2L3 mRNA	decreases expression	18175754

Disease ID	Disease Name	Inference Chemical Name	Inference Score	Publication
MESH:D000230	Adenocarcinoma	Benzo(a)pyrene	2.05	20127859 20464547
MESH:D000236	Adenoma	Benzo(a)pyrene	2.84	6695378
MESH:D017544	Aortic Aneurysm, Abdominal	Benzo(a)pyrene	4.56	19183758
MESH:D001943	Breast Neoplasms	Benzo(a)pyrene	2.00	20146248 17474063
MESH:D002294	Carcinoma, Squamous Cell	Benzo(a)pyrene	2.13	20419170
MESH:D002471	Cell Transformation, Neoplastic	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	12.69	20889678
MESH:D002471	Cell Transformation, Neoplastic	Cyclosporine	12.69	12371664
MESH:D002471	Cell Transformation, Neoplastic	monomethylarsonous acid	12.69	19716837
MESH:D002779	Cholestasis	Cyclosporine	3.17	19486331
MESH:D019457	Chromosome Breakage	Sodium Selenite	5.24	15894690
MESH:D003920	Diabetes Mellitus	Sodium Selenite	4.10	16285004
MESH:D056486	Drug-Induced Liver Injury	Sodium Selenite	2.36	15131321
MESH:D004938	Esophageal Neoplasms	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	4.59	20426865
MESH:D004938	Esophageal Neoplasms	Benzo(a)pyrene	4.59	16530937
MESH:D005234	Fatty Liver	Cyclosporine	3.23	19224547
MESH:D005355	Fibrosis	Cyclosporine	3.62	12639820 12168785
MESH:D005885	Gingival Hyperplasia	Cyclosporine	4.76	8708960
MESH:D006330	Heart Defects, Congenital	Benzo(a)pyrene	2.82	20471113
MESH:D006457	Hemoglobinuria, Paroxysmal	Cyclosporine	4.96	15720958
MESH:D006973	Hypertension	Cyclosporine	2.20	10903974
MESH:D007333	Insulin Resistance	Sodium Selenite	3.49	14714311
MESH:D007638	Keratoconjunctivitis Sicca	Cyclosporine	5.05	15604871
MESH:D007674	Kidney Diseases	Cyclosporine	2.52	8314463 18776723 10903974
MESH:D007680	Kidney Neoplasms	Cyclosporine	3.04	12371664
MESH:D008113	Liver Neoplasms	Benzo(a)pyrene	2.14	21137059 20195826
MESH:D008175	Lung Neoplasms	Benzo(a)pyrene	1.57	17053015 18569708 18816296 20464547 20135361 18520028 20869020 20064080 6695378
MESH:D016393	Lymphoma, B-Cell	Sodium Selenite	4.46	14737004
MESH:D008664	Metal Metabolism, Inborn Errors	Cyclosporine	5.40	16801185
MESH:D009062	Mouth Neoplasms	Benzo(a)pyrene	3.46	16381670
MESH:D009369	Neoplasms	Benzo(a)pyrene	2.31	11141357
MESH:D009402	Nephrosis, Lipoid	Cyclosporine	5.05	17954296
MESH:D009404	Nephrotic Syndrome	Cyclosporine	3.61	19348381 18481113
MESH:D011230	Precancerous Conditions	Cyclosporine	3.55	12371664
MESH:D011471	Prostatic Neoplasms	Benzo(a)pyrene	3.15	17292933
MESH:D011471	Prostatic Neoplasms	Sodium Selenite	3.15	18760546
MESH:D011565	Psoriasis	Cyclosporine	2.32	16882103
MESH:D012871	Skin Diseases	monomethylarsonous acid	3.45	17431481
MESH:D012878	Skin Neoplasms	Benzo(a)pyrene	2.51	10029692 19755658
MESH:D013274	Stomach Neoplasms	Benzo(a)pyrene	1.56	20155912 2093021
MESH:D001749	Urinary Bladder Neoplasms	Benzo(a)pyrene	5.78	17053015
MESH:D001749	Urinary Bladder Neoplasms	monomethylarsonous acid	5.78	20375083
MESH:D014605	Uveitis	Cyclosporine	4.59	1336536
MESH:D014985	Xerophthalmia	Cyclosporine	5.05	17120751

AutismKB 2.0

Annotation Detail for NFE2L3

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics