AutismKB 2.0

Annotation Detail for CARTPT


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Basic Information Top
Gene Symbol:CARTPT ( CART )
Gene Full Name: CART prepropeptide
Band: 5q13.2
Quick LinksEntrez ID:9607; OMIM: 602606; Uniprot ID:CART_HUMAN; ENSEMBL ID: ENSG00000164326; HGNC ID: 24323
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1856Obesity
1870Drug abuse
Desease Name
bipolar disorder
CARDIOVASCULAR
blood pressure
PSYCH
alcoholism
hypertension
schizophrenia
METABOLIC
obesity
No data
Desease Name
Obesity, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000521 alpha-MSH alpha-MSH binds to and results in increased activity of CARTPT proteinaffects binding|increases activity 15659233
D015081 2-Naphthylamine 2-Naphthylamine results in increased expression of CARTPT mRNAincreases expression 18247414
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CARTPT mRNAaffects expression 16483693
D000661 Amphetamine Amphetamine results in increased expression of CARTPT mRNAincreases expression 16896163
C120841 astressin B astressin B inhibits the reaction [CARTPT protein results in increased abundance of Corticosterone]decreases reaction|increases abundance 15271883
C120841 astressin B astressin B inhibits the reaction [CARTPT protein results in increased secretion of POMC protein alternative form]decreases reaction|increases secretion 15271883
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CARTPT mRNAincreases expression 18247414
C070515 bisindolylmaleimide I bisindolylmaleimide I inhibits the reaction [CARTPT protein results in increased phosphorylation of GRIN1 protein]decreases reaction|increases phosphorylation 19632277
D002713 Chlorine Chlorine results in decreased expression of CARTPT mRNAdecreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of CARTPT mRNAaffects cotreatment|affects expression 18636392
D003024 Clozapine Clozapine results in decreased expression of CARTPT mRNAdecreases expression 14696011
D003345 Corticosterone astressin B inhibits the reaction [CARTPT protein results in increased abundance of Corticosterone]decreases reaction|increases abundance 15271883
D003345 Corticosterone CARTPT protein results in increased abundance of Corticosteroneincreases abundance 15271883
D015102 3,4-Dihydroxyphenylacetic Acid CARTPT protein results in increased abundance of 3,4-Dihydroxyphenylacetic Acidincreases abundance 15659233
D004958 Estradiol Estradiol results in increased expression of CARTPT mRNAincreases expression 20068009
C056599 icariin icariin results in increased expression of CARTPT mRNAincreases expression 19858766
C056599 icariin icariin results in increased expression of CARTPT proteinincreases expression 19858766
C057416 KT 5720 KT 5720 inhibits the reaction [CARTPT protein results in increased phosphorylation of GRIN1 protein]decreases reaction|increases phosphorylation 19632277
D008070 Lipopolysaccharides Lipopolysaccharides affects the localization of CARTPT proteinaffects localization 12559087
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of CARTPT proteinincreases expression 12559087
D009020 Morphine Morphine results in increased expression of CARTPT mRNAincreases expression 20144693
D009538 Nicotine Nicotine results in decreased expression of CARTPT mRNAdecreases expression 18247414
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of CARTPT mRNAaffects cotreatment|affects expression 18636392
D012402 Rotenone Rotenone results in decreased expression of CARTPT mRNAdecreases expression 19013527
D013311 Streptozocin GHRL protein promotes the reaction [Streptozocin results in decreased expression of CARTPT mRNA]decreases expression|increases reaction 20219977
D013311 Streptozocin Streptozocin results in decreased expression of CARTPT mRNAdecreases expression 20219977
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of CARTPT mRNAaffects cotreatment|affects expression 15977195
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CARTPT mRNAincreases expression 15093705
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7415322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.4518287403
MESH:D055371 Acute Lung Injury Chlorine 9.1420601635
MESH:D055371 Acute Lung Injury Lipopolysaccharides 9.1411850527 18653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.1920127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.1911473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.596695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2716835633
MESH:D000380 Agranulocytosis Clozapine 4.9512649775 14617031 16160616
MESH:D000505 Alopecia astressin B 5.8021359208
MESH:D000544 Alzheimer Disease icariin 6.8419858766 19782061
MESH:D000544 Alzheimer Disease Nicotine 6.8416627626
MESH:D000544 Alzheimer Disease Ozone 6.8415513908
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.9518475255 15010207 16459022 16916582
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8511748828
MESH:D000855 Anorexia Amphetamine 4.9112005258 16084549 12183048 16101753
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9619183758
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5315570426
MESH:D001249 Asthma Ozone 2.6016373670 17854713
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001847 Bone Diseases icariin 6.3018295595
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6915746008
MESH:D002545 Brain Ischemia icariin 10.7019303870
MESH:D002545 Brain Ischemia Morphine 10.7019211983
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.7917474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 1.7917261762 12948864 16675129 19861407 14630087 18497071 17289903 17018787
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7920435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5918417511 16777450 18315731 17626835 15516495 19059883 14754758
MESH:D002100 Cachexia Ozone 4.6316183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3516111702
MESH:D002276 Carcinoid Tumor Streptozocin 5.5016051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7116835633
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7516924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0220419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3118850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.7018566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0716835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0615668235 8697196 16354765 12621046 15340226
MESH:D003072 Cognition Disorders Clozapine 4.8517123785
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 15322242 10048152
MESH:D003920 Diabetes Mellitus Streptozocin 4.6316285004
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 4.3919496084 16286809 11055810 7637645 2177838 16684804 18603373 15298345 12446591 17442507 15862027 18715473 8740154 12093613 11260395 12083368 12644472 17874149 15831366 1374869 19960420 19298542 19586609 6379147
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.6018603373
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 7.1716402076
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 7.1719647726 19586609
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.1717107852
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.6216025228
MESH:D003928 Diabetic Nephropathies Estradiol 8.9619279558
MESH:D003928 Diabetic Nephropathies Streptozocin 8.9619682444 19960420
MESH:D003930 Diabetic Retinopathy Streptozocin 5.3217662242
MESH:D003967 Diarrhea Morphine 4.412540324
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.4515331141
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6811462148
MESH:D050171 Dyslipidemias Clozapine 4.1016402076
MESH:D004417 Dyspnea Chlorine 4.5220016425
MESH:D020821 Dystonic Disorders Nicotine 5.8217881519
MESH:D004487 Edema bisindolylmaleimide I 6.918273558
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8016714409 15322242 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 2.9118566989 19148513 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9210568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.2915328337 17637181 15821434
MESH:D007172 Erectile Dysfunction icariin 5.3216281085 15329286
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9816530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9311564622
MESH:D005221 Fatigue Amphetamine 5.4919890266
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D005334 Fever Lipopolysaccharides 3.9111852909 9205823
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.8420067830
MESH:D005739 Gas Poisoning Chlorine 4.9020016425
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.2620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2611294989 10048152
MESH:D006331 Heart Diseases Streptozocin 4.2012093613
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.2816366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7816120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.9315709030
MESH:D019584 Hot Flashes Estradiol 3.6517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9416354765 18606429 8697196 15340226 16959395
MESH:D006948 Hyperkinesis Amphetamine 11.441977408 14960337
MESH:D006948 Hyperkinesis Clozapine 11.4416046005
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8718850075 18670907
MESH:D006980 Hyperthyroidism marker/mechanism 12395121
MESH:D007249 Inflammation bisindolylmaleimide I 8.218273558
MESH:D007249 Inflammation Lipopolysaccharides 8.219205823 17237260 12878042 17255318 17963957
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.2112878042 12200463
MESH:D007333 Insulin Resistance Estradiol 2.8916627594 16393666
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.5317255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2316580747
MESH:D007674 Kidney Diseases Estradiol 6.2815618244
MESH:D007674 Kidney Diseases Streptozocin 6.2812093613
MESH:D007680 Kidney Neoplasms Estradiol 2.8915610895
MESH:D007859 Learning Disorders icariin 5.2119782061
MESH:D007970 Leukopenia Lipopolysaccharides 4.5915821434
MESH:D008064 Lipidoses Clozapine 3.8817567588
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.4312878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4312878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.1921137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.1916984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.0412151625
MESH:D008171 Lung Diseases Ozone 3.3019066396 8266340
MESH:D055370 Lung Injury Lipopolysaccharides 8.8821114838
MESH:D055370 Lung Injury Ozone 8.8820417186
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.3220464547 20064080 18520028 18816296 17053015 20135361 18569708 20869020 6695378
MESH:D008175 Lung Neoplasms Ozone 3.328597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3219555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 6.1012807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.1011408345 11807958 17203775 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.3819453300
MESH:D008569 Memory Disorders icariin 5.1919782061
MESH:D001523 Mental Disorders Clozapine 3.8416856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.3219142101
MESH:D008679 Metaplasia Ozone 5.0010496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1016381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1916810080
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2311141357
MESH:D009369 Neoplasms Nicotine 5.2316365874
MESH:D009389 Neovascularization, Pathologic Estradiol 10.0017289903
MESH:D009389 Neovascularization, Pathologic Nicotine 10.0016365874
MESH:D009410 Nerve Degeneration Rotenone 3.7917356569 15790535 18619942
MESH:D009421 Nervous System Malformations Estradiol 9.1111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.1114600291
MESH:D019636 Neurodegenerative Diseases Amphetamine 4.5515183010
MESH:D009765 Obesity marker/mechanism
MESH:D009765 Obesity Clozapine 2.9919142110 18515891
MESH:D010024 Osteoporosis icariin 4.5519747809 18236786
MESH:D010051 Ovarian Neoplasms Estradiol 2.1919401270
MESH:D010146 Pain Morphine 4.106776300 20225289 18699797 16273134 15215642 15275824
MESH:D010300 Parkinson Disease Rotenone 2.9416412576 11535288 19232380 11445065 18619942 15451049 16140633 18191903 19114014
MESH:D020734 Parkinsonian Disorders Rotenone 3.9818197244 15927086 15574749 15795934
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D010538 Peritonitis Ozone 4.0216369182
MESH:D011014 Pneumonia Lipopolysaccharides 10.7412224865 11605937
MESH:D011014 Pneumonia Ozone 10.7418007984 18381685 18929643
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0811896295 11118676 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7820887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1417292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.1416740699
MESH:D011618 Psychotic Disorders Clozapine 4.1015331141
MESH:D011629 Puberty, Precocious astressin B 6.7520002962
MESH:D015427 Reperfusion Injury Morphine 4.0819211983
MESH:D012120 Respiration Disorders Chlorine 5.1118579056
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6610835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012559 Schizophrenia Clozapine 2.7211763009 20452607 20521326 17667964 20580759 17123785 20168265 20521320 18855531 19369910 20107430 18806925 16141801 11151749 17726453
MESH:D012640 Seizures Nicotine 3.7217873105
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.3010029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3016192470
MESH:D019956 Stereotypic Movement Disorder Amphetamine 6.321977408
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.552093021 20155912
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.0715821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8012697716
MESH:D013978 Tibial Fractures Estradiol 4.5819048282
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.6516785264 11259349 16720336
MESH:D014029 Tobacco Use Disorder Nicotine 5.3415735609 18305452 17979512 18041664
MESH:D001749 Urinary Bladder Neoplasms 2-Naphthylamine 5.3611144890
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3617053015
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
MESH:D015430 Weight Gain Clozapine 4.3720107430 17502770 20564506 20521320 16402076 16141801
MESH:D015431 Weight Loss Clozapine 4.9717933447
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA130691815
    • No data
    Releated disease ID Related disease Name
    PA445131Obesity
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00182 agonist Adderall XR 5mg Adrenergic Agents;Dopamine Agents;Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants;Amphetamines;Sympathomimetics
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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