AutismKB 2.0

Annotation Detail for CD47


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Basic Information Top
Gene Symbol:CD47 ( IAP,MER6,OA3 )
Gene Full Name: CD47 molecule
Band: 3q13.12
Quick LinksEntrez ID:961; OMIM: 601028; Uniprot ID:CD47_HUMAN; ENSEMBL ID: ENSG00000196776; HGNC ID: 1682
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04512ECM-receptor interaction
Pathway IDPathway Name
Interactions of the immunoglobulin superfamily (IgSF) member proteins
Hemostasis
Cell junction organization
Pathway IDPathway Name
200109Integrins in angiogenesis
No data
Pathway IDPathway Name
500305Cell surface interactions at the vascular wall
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of CD47 mRNAdecreases expression 19933214
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of CD47 mRNAdecreases expression 16788091
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of CD47 mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of CD47 mRNAaffects expression 17562736
D001554 Benzene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of CD47 mRNAaffects cotreatment|increases expression 17905399
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CD47 mRNAaffects cotreatment|decreases expression 18164116
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of CD47 mRNAdecreases expression 12419474
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of CD47 mRNAdecreases expression 17484886
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CD47 mRNAaffects cotreatment|affects expression 17602206
D003474 Curcumin Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CD47 mRNA]decreases reaction|increases expression 18200517
D003513 Cycloheximide Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CD47 mRNA]decreases expression|decreases reaction 11007951
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CD47 mRNAaffects cotreatment|decreases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CD47 mRNAaffects cotreatment|affects expression 17602206
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CD47 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CD47 mRNAincreases expression 17557909
C020326 ferric nitrilotriacetate ferric nitrilotriacetate results in increased expression of CD47 mRNAincreases expression 9119739
D005419 Flavonoids Flavonoids results in decreased expression of CD47 mRNAdecreases expression 18035473
C051890 irinotecan irinotecan analog results in increased expression of CD47 mRNAincreases expression 18927307
D001556 Lindane Lindane results in decreased expression of CD47 mRNAdecreases expression 17785943
C030957 methylmercury II [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of CD47 mRNAaffects cotreatment|increases expression 17905399
D009151 Mustard Gas Mustard Gas results in increased expression of CD47 mRNAincreases expression 18955075
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of CD47 mRNAdecreases expression 17616710
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of CD47 mRNAincreases expression 17616710
D010126 Ozone Ozone results in decreased expression of CD47 mRNAdecreases expression 12763052
D010126 Ozone Ozone results in increased expression of CD47 mRNAincreases expression 16330353
D017239 Paclitaxel CD47 mRNA results in decreased susceptibility to Paclitaxeldecreases response to substance 16322897
C008776 pelargonic acid pelargonic acid results in increased expression of CD47 mRNAincreases expression 11379042
D018038 Sodium Selenite Sodium Selenite results in increased expression of CD47 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CD47 mRNA]decreases expression|decreases reaction 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CD47 mRNAdecreases expression 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CD47 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CD47 mRNAdecreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CD47 mRNAincreases expression 16054898
D014051 Toluene 2,4-Diisocyanate Toluene 2,4-Diisocyanate results in decreased expression of CD47 mRNAdecreases expression 11379042
D014241 Trichloroethylene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of CD47 mRNAaffects cotreatment|increases expression 17905399
D014302 Trinitrobenzenesulfonic Acid Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CD47 mRNA]decreases reaction|increases expression 18200517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of CD47 mRNAincreases expression 18200517
D014635 Valproic Acid Valproic Acid results in increased expression of CD47 mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of CD47 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.3811752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.388875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6819490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7414692618
MESH:D000236 Adenoma beta-Naphthoflavone 6.3419389873
MESH:D000236 Adenoma Diethylnitrosamine 6.346695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.1218056438 19061943 17162532 19052882 16434500 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.1216835633
MESH:D000382 Agricultural Workers' Diseases Lindane 4.1012661182
MESH:D019973 Alcohol-Related Disorders Curcumin 4.8017887948
MESH:D000544 Alzheimer Disease Curcumin 4.1715590663
MESH:D000544 Alzheimer Disease Ozone 4.1715513908
MESH:D000550 Amblyopia Valproic Acid 4.9517688650
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.9310965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7111748828
MESH:D000741 Anemia, Aplastic Benzene 4.1611369114 17661222 14761424
MESH:D000799 Angioedema Acetaminophen 3.5610982225
MESH:D001008 Anxiety Disorders Valproic Acid 8.1317497229
MESH:D001008 Anxiety Disorders vinclozolin 8.1319015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4915885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.6116807698
MESH:D001172 Arthritis, Rheumatoid Ozone 4.6115570426
MESH:D001249 Asthma Mustard Gas 7.5910378619
MESH:D001249 Asthma Ozone 7.5917854713 16373670
MESH:D001249 Asthma Toluene 2,4-Diisocyanate 7.597684630 16210060 15590891 12762349 12684321 12585506 10797510 11467998 6091946 20032816 18394133 16792590 19187332 6091945 3040596 8156442 10934080 15855793 17015710 11077013 15590890 11742282 170078
MESH:D050197 Atherosclerosis Curcumin 3.1618704882
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8515238991 17157402 18316065 18177632 17507914 18940202 20603192 18985861 17688650 18396377 19232924 19460635 18775368 16609825 18558336
MESH:D001327 Autoimmune Diseases Curcumin 4.2219761891
MESH:D001714 Bipolar Disorder Valproic Acid 2.9417594078 20046352
MESH:D001768 Blister Mustard Gas 4.8819167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.8012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.4315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.438888407
MESH:D001855 Bone Marrow Diseases Benzene 4.9516183116
MESH:D001859 Bone Neoplasms Paclitaxel 4.3115867366
MESH:D002545 Brain Ischemia Curcumin 4.0516770732
MESH:D001932 Brain Neoplasms Curcumin 3.7017596214
MESH:D001943 Breast Neoplasms Benzene 4.5011921183 17162533
MESH:D001943 Breast Neoplasms Curcumin 4.5019250217 18462866 18593918 16243823
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.5017474063
MESH:D001943 Breast Neoplasms Lindane 4.5014688026
MESH:D001943 Breast Neoplasms Paclitaxel 4.5018323546 15136595 18234424 16244791 18223236 16273361 16115903 11325840
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.5020435547
MESH:D001943 Breast Neoplasms Toluene 2,4-Diisocyanate 4.5011921183
MESH:D001943 Breast Neoplasms Trichloroethylene 4.5015986119
MESH:D016535 Bronchial Hyperreactivity Ozone 8.1916777450 18315731 19059883 17626835 15516495 18417511 14754758
MESH:D016535 Bronchial Hyperreactivity Toluene 2,4-Diisocyanate 8.1915590891 8156442 12507178
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.8815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.6917687719 10378619
MESH:D002100 Cachexia Ozone 4.4616183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5115721981 3786805 15700767 16192424 15673190 16124888 16227642 10355542 18705752 16050911 16011737 16097048
MESH:D002277 Carcinoma Curcumin 7.5618593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.5616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.193084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.1918788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.1917138121 20727157 16779866 19052882 19822196 19107877 20007298 18056438 17173139 19383236 17978847 18665156 3084413 16935385 19539802 17761372 16288022 20512989 18506893 18494052 19171122 18393292 19701751 17055752 21159647 20514400 19394651 16681979 19335982 20101231 11831363 20432363 19519916 18788625 18978308 19208518 16807293 17162532 20935162 20214788 18785209 16569478 17428255 16328049 20524982 19418558 16830150 18210153 16540662 16878318 20084675 19919837 18971187 10672840 16698587 10737359 3581430 16502159 18691550
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 6.1916313753
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.8818414057
MESH:D002292 Carcinoma, Renal Cell ferric nitrilotriacetate 4.248340253
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.6818462866
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2116120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.4210977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.6717174075 7505956 21159647 2727394
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6120734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.5519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.5516835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.6717681005 15861022 17333356 16919318 11677210 16105132 17110522
MESH:D019457 Chromosome Breakage Sodium Selenite 4.4815894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9912621046 15340226 16354765 8697196 15668235
MESH:D003092 Colitis Curcumin 9.0416782535 16804969 18200517
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 9.0418023891 18200517 16474422 17936198 16804969 17991707 16782535 16867261 11698051
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.3517276891
MESH:D003103 Coloboma Curcumin 4.3018809619
MESH:D003110 Colonic Neoplasms Curcumin 3.8819359593 16340194
MESH:D003110 Colonic Neoplasms irinotecan 3.8817287894 17725105
MESH:D015179 Colorectal Neoplasms irinotecan 2.8217159606 15273666 18259882 17454858 16391804 16303861 18509181
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.8218802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8314669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.6218497527
MESH:D019465 Craniofacial Abnormalities Benzene 3.6615643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6620055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.6617688650 8888407 16575769
MESH:D003456 Cryptorchidism vinclozolin 4.0714966744
MESH:D003872 Dermatitis Benzene 4.4915902427
MESH:D017449 Dermatitis, Allergic Contact Toluene 2,4-Diisocyanate 3.8418759878 15491423 12956900
MESH:D003877 Dermatitis, Contact Toluene 2,4-Diisocyanate 4.5317010967
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.5416285004
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 6.7018403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.7020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7017107852
MESH:D003928 Diabetic Nephropathies Curcumin 3.7818204486
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 17.3416485898 10915739 11739529 11287661 12392966 16081117 12705907 19739265 14550746 17522070 18713872 16109766 11529661 11421492 17562736 17906064 19370779 15968718 10774834 15619225 19416960 16177239 10663392 14986274 16781746 19420014 12153990 19164858 14725611 12958197 11461765 11834606 11743745 16227642 16393943 19085960 18071297 2444490 12540782 19923254 12594235
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 17.3415968718 10915739 16177239 6884620 6623471 7179309 11566570 10092053 15998439 15027814 3732212 16227642 7120509 9327722 7440962 21278145 19336974 2869522 3786805 4309450 19085960 17522070
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 17.3419107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 17.3415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 17.3420420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 17.347120509
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 17.3419641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5611462148
MESH:D004381 Duodenal Ulcer Curcumin 3.7817351913
MESH:D004421 Dystonia Valproic Acid 3.791851702
MESH:D004487 Edema Mustard Gas 6.0311402378 11428647 11428631 9260866
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6215322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.789294722 10568697
MESH:D004802 Eosinophilia Toluene 2,4-Diisocyanate 4.388156442
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.883659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.6316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.7918234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.367562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.027750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.793659116
MESH:D004890 Erythema Mustard Gas 4.889357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8316302075
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.6815547733 16704527 15150132 15547721 16805852 16510608 15623463 15264214 15878914
MESH:D004938 Esophageal Neoplasms Paclitaxel 4.6816481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8111564622
MESH:D005128 Eye Diseases Toluene 2,4-Diisocyanate 5.4718447907
MESH:D005234 Fatty Liver Carbon Tetrachloride 22.0017595544 19224547 15959796 61145 16239168 12631006 16045604 12795759
MESH:D005234 Fatty Liver Curcumin 22.0019297423
MESH:D005234 Fatty Liver Diethylnitrosamine 22.0020387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.0015345470
MESH:D005234 Fatty Liver Valproic Acid 22.0014986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1811858732
MESH:D005315 Fetal Diseases Valproic Acid 4.6016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.868888407 18558336
MESH:D005355 Fibrosis Carbon Tetrachloride 18.9618705752
MESH:D005355 Fibrosis Curcumin 18.9618705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.9620067830
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 18.9617994277
MESH:D005756 Gastritis Acetaminophen 3.3916983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.4218462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0216417039
MESH:D005909 Glioblastoma Curcumin 3.3017596214
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3110696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.4718462866 18829502
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1811294989 10048152
MESH:D006402 Hematologic Diseases Benzene 4.4016183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0911000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3319900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6212621046 15340226 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.7717701891
MESH:D006849 Hydrocephalus Valproic Acid 4.5917688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7615340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.4816870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2516899240
MESH:D006937 Hypercholesterolemia Curcumin 3.8018704882
MESH:D006967 Hypersensitivity Toluene 2,4-Diisocyanate 4.3611019492 10880147
MESH:D006973 Hypertension Benzene 4.9517940673
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9518670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8115338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5416945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.0517937319
MESH:D007248 Infertility, Male vinclozolin 6.0516467254
MESH:D007249 Inflammation Curcumin 14.3216956363 18403477 17151092
MESH:D007249 Inflammation Diethylnitrosamine 14.3218785209
MESH:D007249 Inflammation Flavonoids 14.3217296493
MESH:D007249 Inflammation Mustard Gas 14.3211428647 9357497 16001271 17524151 11402378 8975870 9260866 11428620 11428631
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.3212200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 6.3118200517 18596194
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 6.3118200517
MESH:D007333 Insulin Resistance Sodium Selenite 3.1014714311
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.3317994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.9810783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0916580747
MESH:D007674 Kidney Diseases Acetaminophen 5.9712587719 15629191
MESH:D007674 Kidney Diseases ferric nitrilotriacetate 5.9718617210 15834431
MESH:D007680 Kidney Neoplasms ferric nitrilotriacetate 4.449667754 18055543
MESH:D007889 Leiomyoma Curcumin 4.3118555241
MESH:D007938 Leukemia Benzene 6.2518335105 15935818 17119257 14694614
MESH:D007938 Leukemia Curcumin 6.2518462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.9616106398
MESH:D007951 Leukemia, Myeloid Benzene 4.0717506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 3.9319478238
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9316294345 17596541
MESH:D015458 Leukemia, T-Cell Curcumin 4.5016106398
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4516417039
MESH:D008080 Liposarcoma Paclitaxel 4.5617353645
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.1011408273 16239168 16943688 17157831 11903743 17334410 21278145 17174718 16221502
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.1018407596 19638242 18522880 18665156 20032147
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.3216033810 17976157 18472094 18317297 16015684 17944888 12609069 15052691 16136751 16011737 18472332 16116963 15931870 15057751 16097048 18705752 17900296 16192424 11481614 12632512 14748882 17631135 12445418 15362042 17481882 18339082 20821823 18187930 18277467 15123356 14724832 15959796 17922224 18156304 14716833 18429990 12649538 17766677 18420326 18481824 16638106 18166357 18395095 12741479 17869086 12586293 15673190 15650968 17698563 15893842 10355542 18263696 12898905 15996030 17708605 17565644 17761835 12958196 17805973 18205269 15818738 15925388 16248980 17640975 17714472 18006644 18376398 15730626 18210741 12667390 13678700 14620537 15370692 18395914 14716496 14512876 12666154 12445421 18054572 18412020 15876570 18418968 17525996 12632514 17557913 12546737 16027843 12389079 17823541 18279442 15338365 18251166 17721639
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 3.3218006644 17355460 18705752
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3212878042
MESH:D008107 Liver Diseases Acetaminophen 11.7216610002 12969438 12587719 16611625 11587558 19014921 19460945 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 11.7215720792 16964402 16246199 17285989 15830285
MESH:D008107 Liver Diseases Curcumin 11.7216956363
MESH:D008107 Liver Diseases Diethylnitrosamine 11.7217034775
MESH:D008107 Liver Diseases Lindane 11.721715830
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.6116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.6116899240 14706259
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 13.0919389873 21295105
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.0919294768
MESH:D008113 Liver Neoplasms Clofibric Acid 13.0917602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.0920434301 19426721 20501860 12771043 18978307 20137499 18644402 19833225 19812893 19499222 15175105 12112319 18648771 19638242 19254457 19427195 20118626 16942905 19294768 19690152 20452335 19073162 19850985 21278145 20101389 20583210 18754104 2422723 19551842 20405173 18977376 2862719 15885732 10737359 20492335 19090486 19642983 21071580 21167192 19256749 21047994 9163691 19996281 19255062
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.0916984957
MESH:D008114 Liver Neoplasms, Experimental Benzene 21.1312562636
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 21.1318164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 21.1312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 21.1318093689 17854601 19126423 19004024 18282651 19539802 17942915 18775883 16842330 19009564 9362446 2563599 18164116 16267830 18253720 21159647 18308698 18544905 3124819 18079962 19519916 17174075
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 21.1312151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 21.137955063
MESH:D008171 Lung Diseases Mustard Gas 7.0018702808 18161513
MESH:D008171 Lung Diseases Ozone 7.008266340 19066396
MESH:D017563 Lung Diseases, Interstitial Benzene 10.4414698565
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 10.4417228818
MESH:D055370 Lung Injury Ozone 3.5820417186
MESH:D008175 Lung Neoplasms Benzene 8.0812562636
MESH:D008175 Lung Neoplasms Curcumin 8.0819359593 16243823 18462866
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.086695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Mustard Gas 8.088781369 3148597
MESH:D008175 Lung Neoplasms Ozone 8.087614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.0819555203 11884234
MESH:D008223 Lymphoma Benzene 7.2317584886 17119257
MESH:D008223 Lymphoma Curcumin 7.2318462866
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.8014737004
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.8714749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.4216173963
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.1612562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 3.1411921183
MESH:D008545 Melanoma Curcumin 3.5518462866 17885582
MESH:D008545 Melanoma Paclitaxel 3.5512040289 12025231 16342250
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2919513568
MESH:D008569 Memory Disorders Curcumin 3.8917263510
MESH:D008679 Metaplasia Ozone 4.8210496685
MESH:D008881 Migraine Disorders Valproic Acid 2.9918803445 18765137
MESH:D052016 Mucositis irinotecan 4.7317159606
MESH:D009101 Multiple Myeloma Benzene 11.1717119195
MESH:D009101 Multiple Myeloma Curcumin 11.1719372569
MESH:D009101 Multiple Myeloma Paclitaxel 11.1714749477
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.6417962980
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.788888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.0017596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8012213967
MESH:D009361 Neoplasm Invasiveness Curcumin 4.1018495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.999029167 3581430
MESH:D009362 Neoplasm Metastasis irinotecan 8.9918259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 8.9915867366
MESH:D009369 Neoplasms Lindane 5.3912807735 16818664
MESH:D009369 Neoplasms Trichloroethylene 5.3911911487
MESH:D009374 Neoplasms, Experimental Toluene 2,4-Diisocyanate 4.461670384
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.2512497104
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.9514600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.3518462866
MESH:D009436 Neural Tube Defects Benzene 6.9315643154
MESH:D009436 Neural Tube Defects Valproic Acid 6.938888407 16359493
MESH:D009447 Neuroblastoma irinotecan 3.348761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.4318514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.4320387270
MESH:D017599 Neuroectodermal Tumors irinotecan 4.458761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8320387270
MESH:D009503 Neutropenia Mustard Gas 3.717688884 16761898
MESH:D009765 Obesity Curcumin 2.6819297423
MESH:D009784 Occupational Diseases Benzene 8.8317479406 15612468 15576619 15727169 17178637 15935809 17119257 16737584 15913788
MESH:D009784 Occupational Diseases Toluene 2,4-Diisocyanate 8.838156442 11077013 6091945 3040596 12585506 6091946 18394133
MESH:D010014 Osteolysis Paclitaxel 4.7015867366
MESH:D010024 Osteoporosis Curcumin 3.3018719352
MESH:D010051 Ovarian Neoplasms Benzene 7.5812562636
MESH:D010051 Ovarian Neoplasms Curcumin 7.5818462866 19020741
MESH:D010051 Ovarian Neoplasms Paclitaxel 7.5811161223
MESH:D010146 Pain Acetaminophen 2.1716870215
MESH:D010190 Pancreatic Neoplasms Curcumin 5.0819196508 17440100 19401701
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.0816540662
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 3.9517698068
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4311578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9612520081
MESH:D010538 Peritonitis Ozone 3.8616369182
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.2211550810
MESH:D011014 Pneumonia Ozone 4.1218381685 18929643 18007984
MESH:D011041 Poisoning Mustard Gas 3.5415727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.322563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.6111118676 11896295 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 14.6120603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 14.6118220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.6518220299
MESH:D011471 Prostatic Neoplasms Curcumin 2.2312497104 18769126 18226269 10851300 15129424 11398177 18156803
MESH:D011471 Prostatic Neoplasms Lindane 2.2314688026 12661182
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.2317172428 17136230 16356831 16729912
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.2318760546
MESH:D011472 Prostatitis vinclozolin 4.6518629315
MESH:D011537 Pruritus Ethinyl Estradiol 8.5915861022 16919318
MESH:D011537 Pruritus Mustard Gas 8.5918058305
MESH:D019310 Pseudolymphoma Valproic Acid 4.2611422049 12752131
MESH:D011656 Pulmonary Emphysema Curcumin 4.2819168576
MESH:D011657 Pulmonary Eosinophilia Toluene 2,4-Diisocyanate 5.3414606601
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8217894541 17720292 17266442 17620002 10334151
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.7710666014 18379247
MESH:D012130 Respiratory Hypersensitivity Toluene 2,4-Diisocyanate 4.2516940033 20219652 7692837
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5718990726
MESH:D012140 Respiratory Tract Diseases Toluene 2,4-Diisocyanate 4.8418447907
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.9219155313
MESH:D012220 Rhinitis Toluene 2,4-Diisocyanate 4.3419050374
MESH:D012221 Rhinitis, Allergic, Perennial Toluene 2,4-Diisocyanate 4.9912617775 15015336
MESH:D006255 Rhinitis, Allergic, Seasonal Toluene 2,4-Diisocyanate 5.2319075512
MESH:D012509 Sarcoma Curcumin 3.8818462866
MESH:D012559 Schizophrenia Valproic Acid 2.0319110320 15737665
MESH:D012640 Seizures Lindane 5.7212842176 7539098 15475178
MESH:D012640 Seizures Valproic Acid 5.7214763951 11738929 17978042 16876388 11044598 1511512 3137016 15475178
MESH:D018805 Sepsis Curcumin 3.8518389075
MESH:D012871 Skin Diseases Mustard Gas 2.6415451306 16961503 12880345
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.158532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.1516192470
MESH:D012912 Sneezing Toluene 2,4-Diisocyanate 5.2319075512 19050374
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6616709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.5719490988
MESH:D013226 Status Epilepticus Valproic Acid 4.2612833885
MESH:D013274 Stomach Neoplasms Benzene 6.1012562636
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 6.1018456281
MESH:D013274 Stomach Neoplasms irinotecan 6.1015723263
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 6.1017575124 12958204
MESH:D013274 Stomach Neoplasms Paclitaxel 6.1018396642 18506536
MESH:D013276 Stomach Ulcer Curcumin 3.2619188055 16631530
MESH:D024801 Tauopathies Paclitaxel 4.5316930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9215669648
MESH:D013953 Thymus Neoplasms Benzene 4.6810850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6212697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.787505956
MESH:D014178 Translocation, Genetic Valproic Acid 4.9517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.243119515
MESH:D001749 Urinary Bladder Neoplasms Curcumin 2.7818593936
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.378888407
MESH:D014565 Urogenital Neoplasms Curcumin 4.9818462866
MESH:D014581 Urticaria Acetaminophen 2.7210982225
MESH:D014594 Uterine Neoplasms Benzene 8.6912562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.6914692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2914671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9615886252
Pathway ID Pathway Name
REACT:20676 Cell junction organization
KEGG:04512 ECM-receptor interaction
REACT:604 Hemostasis
REACT:23853 Interactions of the immunoglobulin superfamily (IgSF) member proteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26222
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450952phospholipids
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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