AutismKB 2.0

Annotation Detail for NCOR1


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Basic Information Top
Gene Symbol:NCOR1 ( KIAA1047,MGC104216,N-CoR,N-CoR1,TRAC1,hN-CoR )
Gene Full Name: nuclear receptor corepressor 1
Band: 17p12-p11.2
Quick LinksEntrez ID:9611; OMIM: 600849; Uniprot ID:NCOR1_HUMAN; ENSEMBL ID: ENSG00000141027; HGNC ID: 7672
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
Pathway IDPathway Name
200070Signaling events mediated by HDAC Class I
200002Regulation of nuclear SMAD2/3 signaling
200009ErbB4 signaling events
200130C-MYB transcription factor network
Pathway IDPathway Name
P00029Huntington disease
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1944Breast cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of NCOR1 mRNAdecreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NCOR1 mRNAaffects expression 21346803
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen promotes the reaction [NCOR1 protein binds to TFF1 promoter]affects binding|increases reaction 19858209
D000082 Acetaminophen Acetaminophen affects the expression of NCOR1 mRNAaffects expression 17562736
D013196 Dihydrotestosterone Dihydrotestosterone inhibits the reaction [NCOR1 protein binds to KLK3 promoter]affects binding|decreases reaction 16648561
D013196 Dihydrotestosterone methylselenic acid inhibits the reaction [Dihydrotestosterone inhibits the reaction [NCOR1 protein binds to KLK3 promoter]]affects binding|decreases reaction 16648561
D013196 Dihydrotestosterone NCOR1 protein inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]affects binding|decreases reaction|increases activity 17804755
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NCOR1 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NCOR1 mRNAdecreases expression 19150397
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased stability of and results in increased expression of NCOR1 proteinincreases expression|increases stability 15857753
C006780 bisphenol A bisphenol A affects the expression of NCOR1 mRNAaffects expression 19696011
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of NCOR1 mRNAaffects expression 12734012
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of NCOR1 mRNAdecreases expression 16644059
D017373 Cyproterone Acetate [Cyproterone Acetate binds to AR protein] promotes the reaction [NCOR1 protein binds to KLK3 promoter]affects binding|increases reaction 15308689
D004958 Estradiol Estradiol inhibits the reaction [NCOR1 protein binds to IGF1 promoter]affects binding|decreases reaction 17872375
D004958 Estradiol Estradiol inhibits the reaction [NCOR1 protein binds to PTGS2 promoter]affects binding|decreases reaction 17872375
D004958 Estradiol Estradiol promotes the reaction [NCOR1 protein binds to CDKN1A promoter]affects binding|increases reaction 20696891
D004958 Estradiol Estradiol promotes the reaction [NCOR1 protein binds to TFF1 promoter]affects binding|increases reaction 19858209
19698761
D004958 Estradiol [Estradiol co-treated with ormeloxifene] promotes the reaction [NCOR1 protein binds to ESR1 protein]affects binding|affects cotreatment|increases reaction 19460436
D005472 Fluorouracil NCOR1 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]affects cotreatment|affects response to substance 18927307
C070081 fulvestrant fulvestrant promotes the reaction [NCOR1 protein binds to TFF2 promoter]affects binding|increases reaction 20696891
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of NCOR1 mRNAaffects cotreatment|increases expression 17183730
C051890 irinotecan irinotecan analog results in decreased expression of NCOR1 mRNAdecreases expression 18927307
C051890 irinotecan NCOR1 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]affects cotreatment|affects response to substance 18927307
C008493 methylselenic acid methylselenic acid inhibits the reaction [Dihydrotestosterone inhibits the reaction [NCOR1 protein binds to KLK3 promoter]]affects binding|decreases reaction 16648561
D015735 Mifepristone [Mifepristone binds to AR protein] promotes the reaction [NCOR1 protein binds to KLK3 promoter]affects binding|increases reaction 15308689
D009151 Mustard Gas Mustard Gas affects the expression of NCOR1 mRNAaffects expression 15651846
D019319 Okadaic Acid Okadaic Acid results in decreased activity of NCOR1 proteindecreases activity 17312396
D019319 Okadaic Acid [Tretinoin co-treated with Okadaic Acid] results in decreased activity of NCOR1 proteinaffects cotreatment|decreases activity 17312396
C508548 ormeloxifene [Estradiol co-treated with ormeloxifene] promotes the reaction [NCOR1 protein binds to ESR1 protein]affects binding|affects cotreatment|increases reaction 19460436
C508548 ormeloxifene ormeloxifene promotes the reaction [NCOR1 protein binds to ESR1 protein]affects binding|increases reaction 19460436
C084656 paricalcitol [Phosphorus co-treated with paricalcitol] affects the localization of NCOR1 proteinaffects cotreatment|affects localization 17715259
C084656 paricalcitol [Phosphorus co-treated with paricalcitol] results in decreased expression of NCOR1 proteinaffects cotreatment|decreases expression 17715259
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of NCOR1 mRNAdecreases expression 17616710
C119222 phorbol-12-myristate phorbol-12-myristate promotes the reaction [NR1I2 protein binds to NCOR1 protein]affects binding|increases reaction 15710363
D010758 Phosphorus [Phosphorus co-treated with paricalcitol] affects the localization of NCOR1 proteinaffects cotreatment|affects localization 17715259
D010758 Phosphorus [Phosphorus co-treated with paricalcitol] results in decreased expression of NCOR1 proteinaffects cotreatment|decreases expression 17715259
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of NCOR1 mRNAaffects binding|increases activity|increases expression 19710929
C013649 plastochromanol 8 plastochromanol 8 inhibits the reaction [NR1I2 protein binds to NCOR1 protein]affects binding|decreases reaction 15269186
C017947 sodium arsenite sodium arsenite results in increased expression of NCOR1 mRNAincreases expression 16322246
D013629 Tamoxifen Tamoxifen promotes the reaction [NCOR1 protein binds to TFF1 promoter]affects binding|increases reaction 19858209
D013629 Tamoxifen Tamoxifen promotes the reaction [NCOR1 protein binds to TFF2 promoter]affects binding|increases reaction 20696891
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NCOR1 mRNAincreases expression 19465110
C082032 tocotrienol, alpha tocotrienol, alpha inhibits the reaction [NR1I2 protein binds to NCOR1 protein]affects binding|decreases reaction 15269186
C082089 tocotrienol, beta tocotrienol, beta inhibits the reaction [NR1I2 protein binds to NCOR1 protein]affects binding|decreases reaction 15269186
C082097 tocotrienol, delta tocotrienol, delta inhibits the reaction [NR1I2 protein binds to NCOR1 protein]affects binding|decreases reaction 15269186
D014212 Tretinoin [Tretinoin co-treated with Okadaic Acid] results in decreased activity of NCOR1 proteinaffects cotreatment|decreases activity 17312396
D014212 Tretinoin Tretinoin results in decreased activity of NCOR1 proteindecreases activity 17312396
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of NCOR1 mRNAaffects cotreatment|increases expression 17183730
C025643 vinclozolin vinclozolin affects the expression of NCOR1 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in decreased expression of NCOR1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1614745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.0511752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.058875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.5919490988
MESH:D000138 Acidosis Ammonium Chloride 3.1818287403
MESH:D055371 Acute Lung Injury pirinixic acid 2.7718653653
MESH:D000230 Adenocarcinoma Estradiol 4.0911473722
MESH:D000230 Adenocarcinoma Fluorouracil 4.0917638652
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.6316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.6316835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5117306315 16712894
MESH:D000505 Alopecia Tretinoin 3.3215955085
MESH:D000550 Amblyopia Valproic Acid 4.8417688650
MESH:D000740 Anemia Fluorouracil 7.5917963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.5911748828
MESH:D000799 Angioedema Acetaminophen 3.4610982225
MESH:D001008 Anxiety Disorders Valproic Acid 7.8617497229
MESH:D001008 Anxiety Disorders vinclozolin 7.8619015723
MESH:D001169 Arthritis, Experimental Tretinoin 2.8416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1716292516
MESH:D001249 Asthma Mustard Gas 4.5510378619
MESH:D001249 Asthma Tretinoin 4.5516456186
MESH:D001284 Atrophy fulvestrant 4.4911514358
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518316065 18940202 17507914 18177632 20603192 18985861 15238991 17157402 17688650 18775368 18396377 16609825 19460635 19232924 18558336
MESH:D001471 Barrett Esophagus Tretinoin 4.0416935849
MESH:D001714 Bipolar Disorder Valproic Acid 2.8817594078 20046352
MESH:D001768 Blister Mustard Gas 4.7819167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.3019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.3012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.3016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.2015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.208888407
MESH:D001862 Bone Resorption bisphenol A 3.5211985600
MESH:D001943 Breast Neoplasms marker/mechanism 19781322
MESH:D001943 Breast Neoplasms bisphenol A 3.4917123778
MESH:D001943 Breast Neoplasms Estradiol 3.4916675129 17289903 17261762 17018787 14630087 12948864 18497071 19861407
MESH:D001943 Breast Neoplasms Fluorouracil 3.4916557594 19217205 16595493 18357371 18608205 16110121 15136595
MESH:D001943 Breast Neoplasms fulvestrant 3.4918984771
MESH:D001943 Breast Neoplasms Tamoxifen 3.4918855134 16873071 19189210 21152245 18629630 20390343 19142967 17049068 19059307 18425577 11161223 19066611 16202921 18821012 20135344 20005174 19084267 17440819 19155303 19103187 17893378 19288272 18815881 16818667 17242785 19200415 19221464 19244106 15565566 20065188 18351453 15668708 20544844 17261762 19189212 18997820 19115204 18984771 16273361 21138602 19289846 19487384 20859285 19410462 19011961
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.4920435547
MESH:D001943 Breast Neoplasms Tretinoin 3.4916873071 16443354 16166294
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.7815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.5917687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2116813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 8.703786805 15700767 16050911 18705752 16011737 15721981 10355542 16227642 16124888 15673190 16192424 16097048
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 8.7016050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.2816051944
MESH:D002277 Carcinoma Fluorouracil 7.1917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.1916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1319066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7716168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 15.6616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 15.663084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 15.6618788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 15.6616924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 15.6617971768 16332177 17045692 16799960 17088986 18930000
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 15.6617306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 15.6616924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 15.661917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.6117123778
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8318695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 6.8516280240 16757204 18986760 17066447
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 6.8518572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 6.8516051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.2917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1518670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 6.4710977129
MESH:D002386 Cataract Tretinoin 6.4717460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.6720889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.6718566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 9.6720056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2116129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5620734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D002779 Cholestasis pirinixic acid 2.5519176532
MESH:D002822 Choriocarcinoma Tretinoin 4.7716461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.2015668235 15340226 16354765 8697196 12621046
MESH:D002972 Cleft Palate Tretinoin 5.209407595
MESH:D003092 Colitis Tretinoin 3.3317035595
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.5120423518
MESH:D003110 Colonic Neoplasms Fluorouracil 3.7017172411 16510598 17287894 15001691 17016597 17725105 17169374 18772588 16340194 17018589
MESH:D003110 Colonic Neoplasms irinotecan 3.7017725105 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6317255274 18802399 17094418 20501625 18949393 16331619 18448328 16303861 14970324 16282729 16391804 18383874 15289873 17401013 15148649 17695437 18288408 16524972 17016601 17454858 17594712 18509181
MESH:D015179 Colorectal Neoplasms irinotecan 2.6315273666 17159606 18509181 18259882 16303861 16391804 17454858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.9915322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.999142499 17551590 9664655 10589399 8800419 9125849 14991402 16925845 9224671 9211117
MESH:D019465 Craniofacial Abnormalities Valproic Acid 4.998888407 17688650 16575769
MESH:D019465 Craniofacial Abnormalities Vitamin E 4.9919769572
MESH:D003456 Cryptorchidism vinclozolin 3.9814966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.6418551238
MESH:D007644 Darier Disease Fluorouracil 4.4116733453
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9919031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5717107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.7819279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 7.7819279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 10.6621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 10.6610774834 11834606 14550746 16109766 19420014 2444490 18713872 15619225 11743745 16081117 16485898 10915739 12540782 11421492 11529661 17522070 11461765 11287661 12153990 19739265 19370779 18071297 11739529 19085960 17562736 15968718 10663392 12958197 12392966 14986274 16781746 12705907 16393943 17906064 19164858 16177239 12594235 19923254 19416960 16227642 14725611
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 10.6616177239 15027814 2869522 3732212 16227642 15968718 10915739 19336974 21278145 3786805 10092053 7120509 6884620 17522070 7440962 11566570 19085960 6623471 9327722 15998439 4309450 7179309
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 10.6620420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 10.6619641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4811462148
MESH:D004421 Dystonia Valproic Acid 3.701851702
MESH:C538011 Eales disease Vitamin E 4.329068938
MESH:D004487 Edema Mustard Gas 9.4811428647 11402378 9260866 11428631
MESH:D004487 Edema pirinixic acid 9.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.6516714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.6518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.1819031437
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 15.7519148513
MESH:D016889 Endometrial Neoplasms Estradiol 15.7511473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 15.7519155303 20544844 16202921 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 15.7516569247
MESH:D004715 Endometriosis Mifepristone 8.0616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.069294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.783659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.5316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.7420417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.277562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.927750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.683659116
MESH:D004890 Erythema Mustard Gas 4.789357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.1520426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.1516785472 16337965 16481741 17638652 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.9011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.9016938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 15.9912795759 15959796 61145 19224547 12631006 16239168 17595544 16045604
MESH:D005234 Fatty Liver pirinixic acid 15.9920131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 15.9914986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 15.9919224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0811858732
MESH:D005315 Fetal Diseases Valproic Acid 4.5016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.778888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8019069698
MESH:D005355 Fibrosis Carbon Tetrachloride 12.6118705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.6120067830
MESH:D005355 Fibrosis Tretinoin 12.6117994277
MESH:D005756 Gastritis Acetaminophen 3.2916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5516973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9116417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3016452187
MESH:D005909 Glioblastoma marker/mechanism 17312396
MESH:D005909 Glioblastoma Okadaic Acid 6.8817312396
MESH:D005909 Glioblastoma Tretinoin 6.8817312396
MESH:D005910 Glioma Fluorouracil 2.7116145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2110696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 6.9318337622 15102660 15162350
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.9316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7716084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.9311294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 9.9314991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 9.9316080930
MESH:D006333 Heart Failure pirinixic acid 2.3020558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0011000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.2419110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 7.0319176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.0315340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5616490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.6415709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.8412676792
MESH:D019584 Hot Flashes Estradiol 8.7617088409
MESH:D019584 Hot Flashes Vitamin E 8.7614716179
MESH:D006849 Hydrocephalus Valproic Acid 4.4817688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6615340226 16354765 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 6.6316870215
MESH:D006930 Hyperalgesia Tretinoin 6.6316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1516899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2016778211
MESH:D006943 Hyperglycemia pirinixic acid 2.8520558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7618850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7215338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.2516612254
MESH:D007248 Infertility, Male fulvestrant 9.8911514358
MESH:D007248 Infertility, Male sodium arsenite 9.8912646999 15346721
MESH:D007248 Infertility, Male vinclozolin 9.8916467254
MESH:D007249 Inflammation Mustard Gas 7.1311402378 8975870 11428647 9357497 16001271 17524151 11428620 9260866 11428631
MESH:D007249 Inflammation Tamoxifen 7.1319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.1312878042 12200463
MESH:D007251 Influenza, Human Vitamin E 3.8316624496
MESH:D007333 Insulin Resistance bisphenol A 10.8616393666
MESH:D007333 Insulin Resistance Estradiol 10.8616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 10.8616306350
MESH:D007410 Intestinal Diseases Tretinoin 3.4017994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.8016580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.8017551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 12.5912587719 15629191
MESH:D007674 Kidney Diseases Estradiol 12.5915618244
MESH:D007674 Kidney Diseases sodium arsenite 12.5920008137
MESH:D007674 Kidney Diseases Vitamin E 12.5912488133
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 15.2516705839
MESH:D007680 Kidney Neoplasms Estradiol 15.2515610895
MESH:D007680 Kidney Neoplasms Fluorouracil 15.2516985049
MESH:D007680 Kidney Neoplasms Tamoxifen 15.2518625569
MESH:D007938 Leukemia Tretinoin 2.5817143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.3616482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.6217596541 16294345 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.6217596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9016935935 17107899 17361223 9834237 16140955 16788101 15748426 17339181 16766008 19075265 12679006 17294898 16331271 17712046 19225113 16823087 19029980 19642359 17301526 19035177 16891316 17649720 17506722 17368321 17217047
MESH:D007984 Leydig Cell Tumor vinclozolin 4.3516417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.049224671
MESH:D008064 Lipidoses Tamoxifen 2.8817567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.6011408273 11903743 16943688 17157831 21278145 16221502 16239168 17174718 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.0618317297 12632514 16027843 18472332 15931870 14512876 17900296 17869086 16097048 13678700 15052691 17481882 17766677 12958196 15057751 12546737 18205269 12666154 17944888 14620537 18481824 18277467 15123356 17557913 18166357 12898905 10355542 15925388 17565644 18054572 15959796 17761835 16011737 12389079 16116963 12667390 14716833 15876570 17631135 18210741 16192424 16136751 12632512 18156304 18429990 12649538 17721639 18472094 18279442 15673190 15996030 16015684 18420326 16248980 12609069 17823541 12741479 17698563 18705752 18412020 17976157 15730626 18263696 18395914 14724832 17525996 15650968 17805973 15893842 12445421 16638106 18418968 18395095 18251166 12586293 15370692 15362042 17714472 20821823 18376398 18187930 15818738 16033810 12445418 18339082 17708605 17922224 14716496 11481614 17640975 18006644 14748882 15338365
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.0614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.0615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 10.0618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.0612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 10.0616248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 10.0616169303
MESH:D008107 Liver Diseases Acetaminophen 3.5419784758 16610002 12969438 19460945 11587558 19014921 12587719 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.5416964402 15830285 17285989 15720792 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.3116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.3114706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 15.9519294768
MESH:D008113 Liver Neoplasms Fluorouracil 15.9516603448 18383874 15113037 17045692
MESH:D008113 Liver Neoplasms pirinixic acid 15.9516377806 20007298 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 15.9516712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 15.9516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.9516984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 4.9712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 4.9712151625
MESH:D008171 Lung Diseases Mustard Gas 10.8818702808 18161513
MESH:D008171 Lung Diseases sodium arsenite 10.8819095001
MESH:D008171 Lung Diseases Vitamin E 10.8816863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.8717228818
MESH:D008175 Lung Neoplasms Fluorouracil 7.8415246190
MESH:D008175 Lung Neoplasms Mustard Gas 7.843148597 8781369
MESH:D008175 Lung Neoplasms sodium arsenite 7.8415276417 17306315 19931552 16712894 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 7.8418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.8419555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 7.8411062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4115086387
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.3819428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.1517203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.1519196723 19196722 16827153 14580682 11731420
MESH:D020149 Manganese Poisoning Estradiol 11.3519453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.3519453300
MESH:D008527 Medulloblastoma Tretinoin 2.6317453147
MESH:D008545 Melanoma sodium arsenite 4.6416487513 19082730
MESH:D008545 Melanoma Tamoxifen 4.6412393984 19393235
MESH:D008545 Melanoma Tretinoin 4.6416752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2019513568
MESH:D008591 Meningomyelocele Tretinoin 4.0516940565
MESH:D008881 Migraine Disorders Valproic Acid 2.9218803445 18765137
MESH:D009062 Mouth Neoplasms Fluorouracil 3.3418986760 16757204
MESH:D052016 Mucositis irinotecan 4.6317159606
MESH:D009135 Muscular Diseases pirinixic acid 3.1416239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.698888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.6517596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 6.6517596541
MESH:D009203 Myocardial Infarction pirinixic acid 1.9819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.2816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.2816411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.4818551238
MESH:D009362 Neoplasm Metastasis irinotecan 5.4118259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.4119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3919410462
MESH:D009369 Neoplasms Fluorouracil 10.2418239605 16928823 18600527
MESH:D009369 Neoplasms pirinixic acid 10.2417405874
MESH:D009369 Neoplasms sodium arsenite 10.2411559025
MESH:D009369 Neoplasms Tretinoin 10.2416594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3020056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6119196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3517289903
MESH:D009421 Nervous System Malformations bisphenol A 20.4611399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 20.4616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 20.4614600291
MESH:D009421 Nervous System Malformations Tretinoin 20.469125849
MESH:D009436 Neural Tube Defects sodium arsenite 10.7012854658
MESH:D009436 Neural Tube Defects Tretinoin 10.709142499
MESH:D009436 Neural Tube Defects Valproic Acid 10.7016359493 8888407
MESH:D009447 Neuroblastoma irinotecan 3.288761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.5618514411
MESH:D017599 Neuroectodermal Tumors irinotecan 4.358761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1816436463
MESH:D009503 Neutropenia Mustard Gas 3.6216761898 7688884
MESH:D009765 Obesity pirinixic acid 1.7220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.1012819281 16049721
MESH:D010024 Osteoporosis ormeloxifene 5.1315261309
MESH:D010049 Ovarian Diseases bisphenol A 4.6111985600
MESH:D010051 Ovarian Neoplasms Estradiol 10.2319401270
MESH:D010051 Ovarian Neoplasms Mifepristone 10.2316525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.2317306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 10.2316936753
MESH:D010146 Pain Acetaminophen 5.5816870215
MESH:D010146 Pain Tretinoin 5.5816870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 4.8516500647 16929163 19003803 15113037
MESH:D010190 Pancreatic Neoplasms Tretinoin 4.8515976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8612520081
MESH:D011041 Poisoning Mustard Gas 3.4515727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2018163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 20.1010548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 20.1011896295 11118676 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 20.1020603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 20.1018220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.5518220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.4220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.4220887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0316740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.0316740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0318626508 19082440
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.0316205645
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0316039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0315067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0315084515
MESH:D011472 Prostatitis vinclozolin 4.5518629315
MESH:D011507 Proteinuria Tretinoin 3.2616636307
MESH:D011537 Pruritus Mustard Gas 3.7118058305
MESH:D019310 Pseudolymphoma Valproic Acid 4.1512752131 11422049
MESH:D011625 Pterygium Tretinoin 4.4116723453
MESH:D011629 Puberty, Precocious bisphenol A 4.4010548101
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.7817266442 17894541 17620002 17720292 10334151
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6915538739 18286688 16160472 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.2019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4718990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.7016116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 9.7019155313
MESH:D012559 Schizophrenia Valproic Acid 2.0215737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 5.0918551238
MESH:D012640 Seizures Valproic Acid 5.091511512 11738929 14763951 16876388 3137016 15475178 11044598 17978042
MESH:D012871 Skin Diseases Mustard Gas 4.6612880345 16961503 15451306
MESH:D012871 Skin Diseases Vitamin E 4.6618709164
MESH:D012878 Skin Neoplasms Okadaic Acid 12.0912628509
MESH:D012878 Skin Neoplasms sodium arsenite 12.0919524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.0916192470
MESH:D012878 Skin Neoplasms Tretinoin 12.0916467112
MESH:D013088 Spermatocele Tamoxifen 3.9016709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.6619457130
MESH:D016135 Spinal Dysraphism sodium arsenite 8.5712854658
MESH:D016135 Spinal Dysraphism Valproic Acid 8.5719490988
MESH:D013226 Status Epilepticus Valproic Acid 4.1512833885
MESH:D013274 Stomach Neoplasms Fluorouracil 3.2318396642 15786421 18567086 17172411 17522103 17498489 19015929 19084572 16951190 16424979
MESH:D013274 Stomach Neoplasms irinotecan 3.2315723263
MESH:D013274 Stomach Neoplasms Tretinoin 3.2317261132
MESH:D020521 Stroke Vitamin E 3.2216517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.6016684133 16045194
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 4.5615864552
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5112697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.7416026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.3019048282
MESH:D014062 Tongue Neoplasms Fluorouracil 8.7316280240
MESH:D014062 Tongue Neoplasms Tretinoin 8.7316051514
MESH:D014178 Translocation, Genetic Valproic Acid 4.8417262798
MESH:D014376 Tuberculosis Tretinoin 2.9916040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.143119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.3916049721
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.3911723127 16712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.3917572228 8653321 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.278888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.9310091137
MESH:D014581 Urticaria Acetaminophen 2.6310982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 13.9516803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 13.9511813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 13.9516129372
MESH:D014591 Uterine Diseases bisphenol A 4.6214652134
MESH:D014604 Uveal Neoplasms Tretinoin 4.2216752155
MESH:D014652 Vascular Diseases sodium arsenite 4.0417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2112125929
MESH:D014820 Vitiligo Tretinoin 3.6916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8615886252
MESH:D009396 Wilms Tumor Tretinoin 3.6516287080
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
REACT:22258 Metabolism of lipids and lipoproteins
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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