AutismKB 2.0

Annotation Detail for NCOR2


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Basic Information Top
Gene Symbol:NCOR2 ( CTG26,FLJ25011,N-CoR2,SMAP270,SMRT,SMRTE,SMRTE-tau,TNRC14,TRAC,TRAC-1,TRAC1 )
Gene Full Name: nuclear receptor corepressor 2
Band: 12q24.31
Quick LinksEntrez ID:9612; OMIM: 600848; Uniprot ID:NCOR2_HUMAN; ENSEMBL ID: ENSG00000196498; HGNC ID: 7673
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04330Notch signaling pathway
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
Pathway IDPathway Name
200070Signaling events mediated by HDAC Class I
200019Signaling events mediated by HDAC Class II
200142Retinoic acid receptors-mediated signaling
200112RXR and RAR heterodimerization with other nuclear receptor
Pathway IDPathway Name
P00029Huntington disease
P00045Notch signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1944Breast cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NCOR2 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of NCOR2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of NCOR2 mRNAaffects expression 17562736
D013196 Dihydrotestosterone Dihydrotestosterone inhibits the reaction [NCOR2 protein binds to KLK3 promoter]affects binding|decreases reaction 16648561
D013196 Dihydrotestosterone methylselenic acid inhibits the reaction [Dihydrotestosterone inhibits the reaction [NCOR2 protein binds to KLK3 promoter]]affects binding|decreases reaction 16648561
D013196 Dihydrotestosterone NCOR2 protein inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]affects binding|decreases reaction|increases activity 17804755
C061133 Am 80 Am 80 results in increased expression of NCOR2 mRNAincreases expression 17229644
D015761 4-Aminopyridine [Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 proteinaffects cotreatment|affects localization 15773917
D015761 4-Aminopyridine KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]affects cotreatment|affects localization|decreases reaction 15773917
D015761 4-Aminopyridine PD 98059 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]affects cotreatment|affects localization|decreases reaction 15773917
D015761 4-Aminopyridine STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]affects cotreatment|affects localization|decreases reaction 15773917
C015001 arsenite arsenite results in increased expression of NCOR2 mRNAincreases expression 18191166
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased stability of and results in increased expression of NCOR2 proteinincreases expression|increases stability 15857753
C053541 bicalutamide bicalutamide promotes the reaction [AR protein binds to NCOR2 protein]affects binding|increases reaction 11981028
D001640 Bicuculline [Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 proteinaffects cotreatment|affects localization 15773917
D001640 Bicuculline KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]affects cotreatment|affects localization|decreases reaction 15773917
D001640 Bicuculline PD 98059 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]affects cotreatment|affects localization|decreases reaction 15773917
D001640 Bicuculline STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]affects cotreatment|affects localization|decreases reaction 15773917
C006780 bisphenol A bisphenol A results in increased expression of NCOR2 proteinincreases expression 18653720
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of NCOR2 mRNAincreases expression 15336504
D004958 Estradiol Estradiol promotes the reaction [NCOR2 protein binds to TFF1 promoter]affects binding|increases reaction 19698761
D004958 Estradiol Estradiol results in decreased expression of NCOR2 mRNAdecreases expression 19432593
D004958 Estradiol Estradiol results in increased expression of NCOR2 mRNAincreases expression 20406620
D004958 Estradiol Tamoxifen inhibits the reaction [Estradiol results in increased expression of NCOR2 mRNA]decreases reaction|increases expression 20406620
D004958 Estradiol U 0126 promotes the reaction [Tamoxifen inhibits the reaction [Estradiol results in increased expression of NCOR2 mRNA]]decreases reaction|increases expression|increases reaction 20406620
D004958 Estradiol Estradiol affects the expression of NCOR2 mRNAaffects expression 15598610
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of NCOR2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of NCOR2 mRNAaffects expression 17351261
C063302 KN 62 KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]affects cotreatment|affects localization|decreases reaction 15773917
C008493 methylselenic acid methylselenic acid inhibits the reaction [Dihydrotestosterone inhibits the reaction [NCOR2 protein binds to KLK3 promoter]]affects binding|decreases reaction 16648561
C044361 M-VAC protocol NCOR2 protein results in decreased susceptibility to M-VAC protocoldecreases response to substance 15814643
D019319 Okadaic Acid Okadaic Acid affects the localization of NCOR2 proteinaffects localization 15773917
C093973 PD 98059 PD 98059 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]affects cotreatment|affects localization|decreases reaction 15773917
D020849 Raloxifene Raloxifene inhibits the reaction [NCOR2 protein binds to IGF1 promoter]affects binding|decreases reaction 17872375
D020849 Raloxifene Raloxifene inhibits the reaction [NCOR2 protein binds to PTGS2 promoter]affects binding|decreases reaction 17872375
D020849 Raloxifene Raloxifene results in decreased expression of NCOR2 mRNAdecreases expression 19432593
C458525 STO 609 STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]affects cotreatment|affects localization|decreases reaction 15773917
D013629 Tamoxifen BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOR2 protein]]affects binding|affects reaction|increases reaction 18997820
D013629 Tamoxifen BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [NCOR2 protein binds to CCND1 promoter]]affects binding|affects reaction|increases reaction 18997820
D013629 Tamoxifen NCOR2 protein inhibits the reaction [Tamoxifen results in increased activity of ESR1 protein]decreases reaction|increases activity 20406620
D013629 Tamoxifen Tamoxifen inhibits the reaction [Estradiol results in increased expression of NCOR2 mRNA]decreases reaction|increases expression 20406620
D013629 Tamoxifen Tamoxifen promotes the reaction [ESR1 protein binds to NCOR2 protein]affects binding|increases reaction 18997820
D013629 Tamoxifen Tamoxifen promotes the reaction [NCOR2 protein binds to CCND1 promoter]affects binding|increases reaction 18997820
D013629 Tamoxifen Tamoxifen promotes the reaction [NCOR2 protein binds to PGR promoter]affects binding|increases reaction 20406620
D013629 Tamoxifen Tamoxifen promotes the reaction [NCOR2 protein binds to TFF1 promoter]affects binding|increases reaction 20406620
D013629 Tamoxifen Tamoxifen results in decreased expression of NCOR2 mRNAdecreases expression 19432593
D013629 Tamoxifen U 0126 promotes the reaction [Tamoxifen inhibits the reaction [Estradiol results in increased expression of NCOR2 mRNA]]decreases reaction|increases expression|increases reaction 20406620
D013629 Tamoxifen U 0126 promotes the reaction [Tamoxifen promotes the reaction [NCOR2 protein binds to PGR promoter]]affects binding|increases reaction 20406620
D013629 Tamoxifen U 0126 promotes the reaction [Tamoxifen promotes the reaction [NCOR2 protein binds to TFF1 promoter]]affects binding|increases reaction 20406620
D013749 Tetrachlorodibenzodioxin NCOR2 protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]decreases reaction|increases expression 12139968
D013749 Tetrachlorodibenzodioxin NCOR2 protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein results in increased expression of CYP1A1 mRNA]]increases expression|increases reaction 12139968
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NCOR2 protein]affects binding|increases reaction 12139968
C012589 trichostatin A trichostatin A affects the localization of NCOR2 proteinaffects localization 15773917
C113580 U 0126 U 0126 promotes the reaction [NCOR2 protein binds to ESR1 protein]affects binding|increases reaction 20406620
C113580 U 0126 [U 0126 promotes the reaction [NCOR2 protein binds to ESR1 protein]] which results in decreased activity of ESR1 proteinaffects binding|decreases activity|increases reaction 20406620
C113580 U 0126 U 0126 promotes the reaction [Tamoxifen inhibits the reaction [Estradiol results in increased expression of NCOR2 mRNA]]decreases reaction|increases expression|increases reaction 20406620
C113580 U 0126 U 0126 promotes the reaction [Tamoxifen promotes the reaction [NCOR2 protein binds to PGR promoter]]affects binding|increases reaction 20406620
C113580 U 0126 U 0126 promotes the reaction [Tamoxifen promotes the reaction [NCOR2 protein binds to TFF1 promoter]]affects binding|increases reaction 20406620
C113580 U 0126 U 0126 results in decreased expression of NCOR2 mRNAdecreases expression 20406620
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3514745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 7.847525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.8414514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7517505938
MESH:D000168 Acrocephalosyndactylia U 0126 5.2817694057
MESH:D000230 Adenocarcinoma Estradiol 4.0511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.0514692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1916835633
MESH:D000419 Albuminuria Raloxifene 4.4117451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5015800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7811748828
MESH:D000799 Angioedema Acetaminophen 3.6510982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5515885639
MESH:D001172 Arthritis, Rheumatoid Am 80 3.7116819260
MESH:D050197 Atherosclerosis Am 80 4.2316484594
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.8712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D001862 Bone Resorption bisphenol A 3.6911985600
MESH:D001930 Brain Injuries Raloxifene 4.2916580743
MESH:D001943 Breast Neoplasms bisphenol A 2.2717123778
MESH:D001943 Breast Neoplasms Estradiol 2.2716675129 17289903 14630087 12948864 17018787 17261762 18497071 19861407
MESH:D001943 Breast Neoplasms Raloxifene 2.2715572757 17261762 17893378 17595753 16912660 15758505 17049068 17952589 17242785 17440819 15775269 16837676
MESH:D001943 Breast Neoplasms Tamoxifen 2.2716273361 20859285 20065188 11161223 16818667 16202921 19288272 19221464 17261762 19189212 19289846 21152245 18821012 19142967 18997820 15668708 20005174 15565566 18425577 18815881 19487384 19189210 17440819 19084267 17049068 16873071 19066611 20135344 18351453 20544844 19244106 19155303 21138602 19011961 20390343 19115204 18855134 18629630 17242785 17893378 19103187 19200415 19410462 18984771 19059307
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2720435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2716111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3219066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.2916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.293084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.2916924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.2916924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.8017123778
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.9417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.9417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2618850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.3115775269
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.0514694615
MESH:D002386 Cataract Acetaminophen 7.0510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.236135515
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.2318566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0016835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.7316919318 17333356 17681005 11677210 16105132 15861022 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0316354765 15668235 15340226 12621046 8697196
MESH:D003072 Cognition Disorders Raloxifene 4.4315800139
MESH:D003110 Colonic Neoplasms arsenite 2.5615037631
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 8.6515095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.6514669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8318551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1719031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.0017474826
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6217107852
MESH:D003928 Diabetic Nephropathies Estradiol 14.0919279558
MESH:D003928 Diabetic Nephropathies Raloxifene 14.0915920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.0919279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.4918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 8.4921346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.4919085960 19416960 14550746 18071297 11743745 16227642 19164858 17522070 12392966 14725611 16177239 16109766 12594235 16081117 10774834 11461765 11739529 12153990 16393943 12705907 16485898 16781746 18713872 11834606 11529661 10915739 17562736 19739265 19370779 11421492 15968718 10663392 19923254 12958197 12540782 11287661 2444490 17906064 19420014 14986274 15619225
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.4920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6211462148
MESH:D004487 Edema Raloxifene 6.2915860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.2912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7118230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Am 80 20.4816819260
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 20.4812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 20.4815845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 20.4819031437
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 5.4519294695
MESH:D016889 Endometrial Neoplasms Estradiol 6.9811473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.9816202921 19155303 17893378 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.869294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8711564622
MESH:D005234 Fatty Liver arsenite 17.4018296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 17.4015345470
MESH:D005234 Fatty Liver Raloxifene 17.4017473493
MESH:D005234 Fatty Liver Tamoxifen 17.4019224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9919069698
MESH:D005355 Fibrosis arsenite 8.1918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.1920067830
MESH:D005756 Gastritis Acetaminophen 3.4816983495
MESH:D005909 Glioblastoma Okadaic Acid 7.6117312396
MESH:D005909 Glioblastoma trichostatin A 7.6118801729
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2310048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.4011110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7112621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.8415709030
MESH:D019584 Hot Flashes Estradiol 3.5617088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.858697196 15340226 18606429 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.5516870215
MESH:D006973 Hypertension Raloxifene 4.9915787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9918850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3617937319
MESH:D007249 Inflammation Tamoxifen 4.5619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.5612878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 7.0316393666
MESH:D007333 Insulin Resistance Estradiol 7.0316393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1616580747
MESH:D007674 Kidney Diseases Acetaminophen 5.5212587719 15629191
MESH:D007674 Kidney Diseases Estradiol 5.5215618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.5116705839
MESH:D007680 Kidney Neoplasms Estradiol 11.5115610895
MESH:D007680 Kidney Neoplasms Tamoxifen 11.5118625569
MESH:D007889 Leiomyoma Raloxifene 4.3216973256
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 11.4516972261
MESH:D007948 Leukemia, Monocytic, Acute U 0126 11.4516972261
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 2.8718206229
MESH:D015473 Leukemia, Promyelocytic, Acute Am 80 4.5216531727 16819260
MESH:D008064 Lipidoses Tamoxifen 3.0215342952 17567588
MESH:D008103 Liver Cirrhosis arsenite 3.3218296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.3014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.3018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3012878042
MESH:D008107 Liver Diseases Acetaminophen 1.5912969438 16611625 19014921 16610002 19784758 11587558 19460945 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0716871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 6.967678174
MESH:D008113 Liver Neoplasms Tamoxifen 6.9616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 6.9616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.342876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.3412151625
MESH:D008175 Lung Neoplasms arsenite 3.3216809336
MESH:D008175 Lung Neoplasms Tamoxifen 3.3218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3219555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5719428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.5717203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.5711731420 19196723 14580682 16827153 19196722
MESH:D020149 Manganese Poisoning Estradiol 12.0019453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.0019453300
MESH:D008545 Melanoma Tamoxifen 3.4812393984 19393235
MESH:D008545 Melanoma trichostatin A 3.4816505122
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3819513568
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3615863610
MESH:D009101 Multiple Myeloma Am 80 11.6617229644
MESH:D009101 Multiple Myeloma Raloxifene 11.6616497877
MESH:D009101 Multiple Myeloma trichostatin A 11.6618172295
MESH:D009103 Multiple Sclerosis 4-Aminopyridine 5.4319915712
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1316810080
MESH:D009232 Myxoma Raloxifene 5.3616343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.677678174 18551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8119196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic arsenite 9.5115738583
MESH:D009389 Neovascularization, Pathologic Estradiol 9.5117289903
MESH:D009421 Nervous System Malformations bisphenol A 15.2911399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 15.2911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.2914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7218514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.5816049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 8.5814694615
MESH:D010024 Osteoporosis Raloxifene 3.2819059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.0517823083 15579764 15758505 17893378
MESH:D010049 Ovarian Diseases bisphenol A 4.8011985600
MESH:D010051 Ovarian Neoplasms Estradiol 7.7619401270
MESH:D010051 Ovarian Neoplasms trichostatin A 7.7619331143
MESH:D010051 Ovarian Neoplasms U 0126 7.7616211241
MESH:D010146 Pain Acetaminophen 2.2416870215
MESH:D010190 Pancreatic Neoplasms trichostatin A 3.2219294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5111578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.8710548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.8711118676 11896295 11399792 11222880
MESH:D055728 Primary Myelofibrosis trichostatin A 5.0617616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.9820887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.9820887781
MESH:D011471 Prostatic Neoplasms Am 80 2.4216289102
MESH:D011471 Prostatic Neoplasms bicalutamide 2.4219240160 19011039 17914592 15638997 18487222
MESH:D011471 Prostatic Neoplasms bisphenol A 2.4216740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.4216740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.4216205645
MESH:D011471 Prostatic Neoplasms Raloxifene 2.4216536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.4215067354
MESH:D011471 Prostatic Neoplasms trichostatin A 2.4218798265 19789329
MESH:D011537 Pruritus Ethinyl Estradiol 3.1216919318 15861022
MESH:D011565 Psoriasis Am 80 4.0216819260
MESH:D011629 Puberty, Precocious bisphenol A 4.5910548101
MESH:D011693 Purpura Raloxifene 5.3615770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.4118551238
MESH:D012878 Skin Neoplasms Okadaic Acid 9.1312628509
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.138532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.1316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.9216709447
MESH:D013088 Spermatocele Tamoxifen 10.9216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8519457130
MESH:D020521 Stroke Raloxifene 3.6716837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.7916045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013978 Tibial Fractures Estradiol 13.0719048282
MESH:D013978 Tibial Fractures Raloxifene 13.0719048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 7.9216049721
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 7.9217572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.9217572228 16712894 8653321
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.0010091137
MESH:D014571 Urologic Neoplasms M-VAC protocol 12.0017933135
MESH:D014581 Urticaria Acetaminophen 2.8010982225
MESH:D014591 Uterine Diseases bisphenol A 4.8214652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1214692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.0216837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3714671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3616343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:04330 Notch signaling pathway
REACT:27166 Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31478
    • Releated gene ID Related gene Name
    PA378NR1I2
    Releated disease ID Related disease Name
    PA443450Asthma
    Releated drug ID Related drug Name
    PA451746tretinoin
    PA448068salbutamol
    PA134687887selective beta-2-adrenoreceptor agonists
    PA164713253Selective beta-2-adrenoreceptor agonists
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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