AutismKB 2.0

Annotation Detail for MTRF1


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Basic Information Top
Gene Symbol:MTRF1 ( MGC47721,MRF1,MTTRF1,RF1 )
Gene Full Name: mitochondrial translational release factor 1
Band: 13q14.11
Quick LinksEntrez ID:9617; OMIM: 604601; Uniprot ID:RF1M_HUMAN; ENSEMBL ID: ENSG00000120662; HGNC ID: 7469
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C018855 2-tert-butylhydroquinone 2-tert-butylhydroquinone results in increased expression of MTRF1 mRNAincreases expression 16014739
D000082 Acetaminophen Acetaminophen affects the expression of MTRF1 mRNAaffects expression 17562736
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MTRF1 mRNAaffects cotreatment|increases expression 17942748
C017947 sodium arsenite sodium arsenite results in increased expression of MTRF1 mRNAincreases expression 16014739
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MTRF1 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3815322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.9216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.3115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.5116712894 17306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.033084413
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.0317306315 15276417 16507464
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4618572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5416120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.2219524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1317110522 17681005 17333356 16105132 11677210 16919318 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2215340226 15668235 12621046 16354765 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2720055451 10048152 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8316227642 19923254 11834606 2444490 15968718 12594235 16177239 10915739 14986274 14550746 19739265 16393943 19085960 12705907 12958197 11287661 10774834 17906064 16781746 19164858 16109766 16485898 14725611 11739529 11421492 19420014 19416960 17562736 16081117 10663392 17522070 19370779 18071297 12540782 11461765 12153990 11743745 11529661 18713872 12392966 15619225
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5116714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.6312538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.379294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.1815345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.4320067830
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.2216452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4910048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3715340226 16120746 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 3.4712676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6618606429 8697196 16959395 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0118670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.4017937319
MESH:D007248 Infertility, Male sodium arsenite 7.4012646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007674 Kidney Diseases Acetaminophen 6.5815629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 6.5820008137
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Acetaminophen 1.6919014921 16610002 19460945 11587558 12969438 12587719 16611625 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D008113 Liver Neoplasms sodium arsenite 4.8215276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.8216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3112151625
MESH:D008171 Lung Diseases sodium arsenite 3.4019095001
MESH:D008175 Lung Neoplasms sodium arsenite 2.3816712894 19931552 17306315 17077188 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3811884234 19555203
MESH:D008545 Melanoma sodium arsenite 2.0716487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D009369 Neoplasms sodium arsenite 2.6411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.1520056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.3612854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5217306315 15276417
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2416039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.8516919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012878 Skin Neoplasms sodium arsenite 6.0719524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.5516709447
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0712854658
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.6211723127 17306315 16452187 16712894
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.1111813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D014652 Vascular Diseases sodium arsenite 4.9617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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