Annotation Detail for TCL1B Basic Information
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Desease Name Leukemia/lymphoma, T-cell
Chemical ID
Chemical Name
Interaction
Interaction Action
Publication D000638 Amiodarone
Amiodarone results in increased expression of TCL1B mRNA increases expression 19774075 D004958 Estradiol
Estradiol results in increased expression of TCL1B mRNA increases expression 20228224 D004958 Estradiol
TCL1B protein promotes the reaction [Estradiol results in increased phosphorylation of and results in increased activity of and results in increased localization of AKT1 protein] increases activity|increases localization|increases phosphorylation|increases reaction 20228224
Disease ID
Disease Name
Direct Evidence
Inference Chemical Name
Inference Score
Publication MESH:D000230
Adenocarcinoma
Estradiol
2.18 11473722 MESH:D001145
Arrhythmias, Cardiac
Amiodarone
4.31 18057881 18218290 20041841 MESH:D001281
Atrial Fibrillation
Amiodarone
4.27 19698954 18651412 MESH:D001778
Blood Coagulation Disorders
Amiodarone
4.45 19483382 MESH:D001943
Breast Neoplasms
marker/mechanism
20228224 MESH:D001943
Breast Neoplasms
Estradiol
2.10 14630087 12948864 18497071 16675129 17261762 17289903 19861407 17018787 MESH:D002181
Candidiasis, Vulvovaginal
Estradiol
5.35 16111702 MESH:D006528
Carcinoma, Hepatocellular
Estradiol
1.80 16924424 MESH:D002311
Cardiomyopathy, Dilated
Amiodarone
3.02 15710769 19225199 MESH:D002341
Carotid Artery Thrombosis
Amiodarone
5.97 18974383 MESH:D002471
Cell Transformation, Neoplastic
Estradiol
3.09 18566989 MESH:D003928
Diabetic Nephropathies
Estradiol
3.88 19279558 MESH:D056486
Drug-Induced Liver Injury
Amiodarone
2.49 15265979 18218290 MESH:D016889
Endometrial Neoplasms
Estradiol
3.28 18566989 19148513 11473722 MESH:D005234
Fatty Liver
Amiodarone
4.07 14986274 MESH:D006529
Hepatomegaly
Amiodarone
4.51 15265979 MESH:D006558
Herpes Genitalis
Estradiol
6.10 15709030 MESH:D019584
Hot Flashes
Estradiol
4.82 17088409 MESH:D006937
Hypercholesterolemia
Amiodarone
4.42 9751232 8137927 MESH:D007037
Hypothyroidism
Amiodarone
5.28 18020914 17991464 MESH:D007333
Insulin Resistance
Estradiol
3.26 16393666 16627594 MESH:D007674
Kidney Diseases
Estradiol
2.83 15618244 MESH:D007680
Kidney Neoplasms
Estradiol
3.41 15610895 MESH:D008064
Lipidoses
Amiodarone
3.85 17567588 15342952 MESH:D008106
Liver Cirrhosis, Experimental
Estradiol
1.69 14716833 14659978 MESH:D008133
Long QT Syndrome
Amiodarone
3.96 17391786 15350150 11989578 MESH:D008171
Lung Diseases
Amiodarone
3.68 12587719 MESH:D017563
Lung Diseases, Interstitial
Amiodarone
5.55 18516814 MESH:D008325
Mammary Neoplasms, Experimental
Estradiol
2.85 11408345 16891317 17203775 11807958 MESH:D020149
Manganese Poisoning
Estradiol
5.55 19453300 MESH:D009181
Mycoses
Amiodarone
5.97 12754197 17974566 MESH:D015428
Myocardial Reperfusion Injury
Estradiol
3.66 16810080 MESH:D009362
Neoplasm Metastasis
marker/mechanism
20228224 MESH:D009389
Neovascularization, Pathologic
Estradiol
4.62 17289903 MESH:D009421
Nervous System Malformations
Estradiol
4.32 11399458 16427766 MESH:D010051
Ovarian Neoplasms
Estradiol
2.33 19401270 MESH:D019048
Prostatic Intraepithelial Neoplasia
Estradiol
4.44 20887781 MESH:D011471
Prostatic Neoplasms
Estradiol
3.01 16740699 MESH:D011658
Pulmonary Fibrosis
Amiodarone
2.99 12490602 12832656 11597910 OMIM:609620
SHORT QT SYNDROME 1
Amiodarone
5.97 18724381 MESH:D013276
Stomach Ulcer
Amiodarone
3.86 18087811 MESH:D013610
Tachycardia
Amiodarone
4.96 11238279 MESH:D017180
Tachycardia, Ventricular
Amiodarone
4.86 19225199 MESH:D013959
Thyroid Diseases
Amiodarone
5.83 19731979 MESH:D013971
Thyrotoxicosis
Amiodarone
5.62 18020914 19584973 MESH:D013978
Tibial Fractures
Estradiol
5.76 19048282 MESH:D016171
Torsades de Pointes
Amiodarone
5.08 17467628 11989578
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