AutismKB 2.0

Annotation Detail for ISG15


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Basic Information Top
Gene Symbol:ISG15 ( G1P2,IFI15,IP17,UCRP,hUCRP )
Gene Full Name: ISG15 ubiquitin-like modifier
Band: 1p36.33
Quick LinksEntrez ID:9636; OMIM: 147571; Uniprot ID:ISG15_HUMAN; ENSEMBL ID: ENSG00000187608; HGNC ID: 4053
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04622RIG-I-like receptor signaling pathway
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1770Melanoma
1781Rheumatoid arthritis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ISG15 proteinaffects expression 20106945
C006632 arsenic trioxide arsenic trioxide results in decreased expression of ISG15 proteindecreases expression 19364129
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ISG15 mRNAincreases expression 19152381
D001564 Benzo(a)pyrene chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of ISG15 mRNA]decreases reaction|increases expression 19152381
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ISG15 mRNAincreases expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of ISG15 mRNAincreases expression 14729362
15003993
C007020 chlorophyllin chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of ISG15 mRNA]decreases reaction|increases expression 19152381
D016572 Cyclosporine Cyclosporine results in decreased expression of ISG15 mRNAdecreases expression 20106945
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of ISG15 mRNAincreases expression 15289156
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ISG15 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of ISG15 mRNAincreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of ISG15 mRNAincreases expression 15289156
D004958 Estradiol Estradiol results in decreased expression of ISG15 mRNAdecreases expression 20068009
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ISG15 mRNAincreases expression 17557909
D005472 Fluorouracil Fluorouracil results in increased expression of ISG15 mRNAincreases expression 16557594
16101138
D019833 Genistein Genistein results in increased expression of ISG15 mRNAincreases expression 15289156
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of ISG15 mRNAincreases expression 15860229
D008942 Mitoxantrone ISG15 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
C406082 monomethylarsonous acid [monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of ISG15 promoteraffects acetylation|affects methylation 18448484
D010081 Oxazolone Oxazolone results in decreased expression of ISG15 mRNAdecreases expression 11379042
D017239 Paclitaxel ISG15 protein affects the susceptibility to Paclitaxelaffects response to substance 16217747
D010656 Phenylephrine Phenylephrine results in decreased expression of ISG15 mRNAdecreases expression 18158353
D028321 Plant Preparations Plant Preparations affects the expression of ISG15 mRNAaffects expression 16046712
C017947 sodium arsenite [sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of ISG15 promoteraffects acetylation|affects methylation 18448484
C017947 sodium arsenite sodium arsenite results in decreased expression of ISG15 mRNAdecreases expression 12377979
C004648 testosterone enanthate testosterone enanthate affects the expression of ISG15 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ISG15 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ISG15 mRNAdecreases expression 19619570
12377990
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ISG15 mRNAincreases expression 16704738
D013750 Tetrachloroethylene Tetrachloroethylene results in decreased expression of ISG15 mRNAdecreases expression 16010555
D014051 Toluene 2,4-Diisocyanate Toluene 2,4-Diisocyanate results in decreased expression of ISG15 mRNAdecreases expression 11379042
D019772 Topotecan ISG15 protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014212 Tretinoin Tretinoin results in increased expression of ISG15 mRNAincreases expression 17218384
D014212 Tretinoin Tretinoin results in increased expression of ISG15 proteinincreases expression 16647867
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of ISG15 mRNAincreases expression 17982090
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of ISG15 mRNAaffects cotreatment|increases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6114514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6917505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.589612607
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.8111850527 18653653
MESH:D000230 Adenocarcinoma arsenic trioxide 16.2811798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 16.2820127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 16.2811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 16.2814692618
MESH:D000230 Adenocarcinoma Fluorouracil 16.2817638652
MESH:D000230 Adenocarcinoma Genistein 16.2811473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.516695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1316835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6517306315 16712894
MESH:D000505 Alopecia Tretinoin 3.4215955085
MESH:D000686 Amyloidosis Diethylstilbestrol 4.2415469931
MESH:D000740 Anemia Fluorouracil 7.9716511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.9711748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8319183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.9017460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7115885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2116292516
MESH:D001249 Asthma Toluene 2,4-Diisocyanate 5.0110934080 12762349 18394133 15855793 17015710 11467998 19187332 12585506 3040596 10797510 170078 12684321 15590891 16792590 7684630 6091945 15590890 6091946 11077013 16210060 20032816 8156442 11742282
MESH:D001249 Asthma Tretinoin 5.0116456186
MESH:D001471 Barrett Esophagus Tretinoin 4.1716935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.0616206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.0612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.0616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D001859 Bone Neoplasms Paclitaxel 4.3415867366
MESH:D001919 Bradycardia Phenylephrine 4.3015306635
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 8.0220146248 17474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 8.0217129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 8.0217289903 18497071 12948864 14630087 17018787 16675129 17261762 19861407
MESH:D001943 Breast Neoplasms Fluorouracil 8.0215136595 16595493 19217205 16110121 16557594 18357371 18608205
MESH:D001943 Breast Neoplasms Genistein 8.0216873071 17200150 16541309
MESH:D001943 Breast Neoplasms Paclitaxel 8.0218234424 16244791 18223236 18323546 16115903 16273361 11325840 15136595
MESH:D001943 Breast Neoplasms Plant Preparations 8.0217398067
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 8.0220435547
MESH:D001943 Breast Neoplasms Tetrachloroethylene 8.0215986119
MESH:D001943 Breast Neoplasms Toluene 2,4-Diisocyanate 8.0211921183
MESH:D001943 Breast Neoplasms Tretinoin 8.0216166294 16443354 16873071
MESH:D016535 Bronchial Hyperreactivity Toluene 2,4-Diisocyanate 4.358156442 15590891 12507178
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3416813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1011589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2216111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4216051944
MESH:D002277 Carcinoma Fluorouracil 7.5517121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.5516835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9116168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 19.0821507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 19.0814691202 16217749 11135700 15073043 15553829
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 19.0815948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 19.0816924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 19.0816332177 18930000 17045692 17971768 17088986 16799960
MESH:D006528 Carcinoma, Hepatocellular Genistein 19.0816924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 19.0816313753
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 19.0817306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 19.081917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6319014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9018695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9012490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 13.5620419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 13.5616280240 18986760 16757204 17066447
MESH:D002294 Carcinoma, Squamous Cell Plant Preparations 13.5617418620
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 13.5618572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 13.5616051514 16096774
MESH:D006332 Cardiomegaly Phenylephrine 6.4315728586 11754973 17124262 11179087 17287366 16170337
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.4318850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 7.2916332659
MESH:D002318 Cardiovascular Diseases Plant Preparations 7.2916862667
MESH:D016893 Carotid Stenosis Plant Preparations 5.8915158307
MESH:D002386 Cataract Tretinoin 2.9517460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 19.3320889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 19.3312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 19.3318566989
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 19.3319716837
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 19.3319524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3416129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D002779 Cholestasis Cyclosporine 7.1819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.1817681005 17333356 16919318 11677210 15861022 16105132 17110522
MESH:D002822 Choriocarcinoma Tretinoin 4.9116461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4212621046 15340226 15668235 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 5.429407595
MESH:D003092 Colitis Tretinoin 8.9717035595
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 8.9717936198 16804969 17991707 16474422 16867261 18200517 18023891 11698051 16782535
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.3617276891
MESH:D003110 Colonic Neoplasms Fluorouracil 3.6917018589 16510598 17172411 15001691 17287894 17725105 17169374 18772588 16340194 17016597
MESH:D003110 Colonic Neoplasms Genistein 3.6917182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.3920501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.3916282729 14970324 18802399 15289873 17695437 17255274 16524972 17594712 20501625 16391804 16331619 18949393 17401013 17094418 18509181 18288408 17454858 18448328 18383874 17016601 16303861 15148649
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.3918802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8514669216 17141729
MESH:D003324 Coronary Artery Disease Plant Preparations 3.9015158307
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.6010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6010048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.6014991402 10589399 9664655 16925845 9224671 17551590 9142499 8800419 9211117 9125849
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3212952375 16002989
MESH:D007644 Darier Disease Fluorouracil 4.5416733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8715213294
MESH:D017449 Dermatitis, Allergic Contact Toluene 2,4-Diisocyanate 3.8718759878 15491423 12956900
MESH:D003877 Dermatitis, Contact Oxazolone 9.4315944321 12811023
MESH:D003877 Dermatitis, Contact Toluene 2,4-Diisocyanate 9.4317010967
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.1216647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1217107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2119279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.4720420201
MESH:D004362 Drug Toxicity Plant Preparations 12.8911033412
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 12.8911462148
MESH:D004362 Drug Toxicity Zidovudine 12.8915040536
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.1712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.1115322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.1118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9512538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 11.0716402032
MESH:D004714 Endometrial Hyperplasia Genistein 11.0716402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 16.4915700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 16.4918566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 16.4911473722
MESH:D016889 Endometrial Neoplasms Tretinoin 16.4916569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8110568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.1515328337 17637181 15821434
MESH:D004802 Eosinophilia Toluene 2,4-Diisocyanate 4.418156442
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.6120426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 16.6112903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 16.6116530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 16.6115173087 16481741 16337965 17638652 16785472
MESH:D004938 Esophageal Neoplasms Paclitaxel 16.6116481741
MESH:D004938 Esophageal Neoplasms Plant Preparations 16.6116510608
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.2411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.249664655 16938888
MESH:D005128 Eye Diseases Toluene 2,4-Diisocyanate 5.5018447907
MESH:D005234 Fatty Liver arsenic trioxide 16.9815073043
MESH:D005234 Fatty Liver Cyclosporine 16.9819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.9815345470
MESH:D005234 Fatty Liver Zidovudine 16.9818299183
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5115751030 16611131 16002989 16513791 16534752
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D005334 Fever Lipopolysaccharides 3.809205823 11852909
MESH:D005355 Fibrosis Cyclosporine 19.1812168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.1820067830
MESH:D005355 Fibrosis Tretinoin 19.1817994277
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 19.1817994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0316904648
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 11.9916452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 11.9916452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.978708960
MESH:D005909 Glioblastoma Genistein 6.6816598420
MESH:D005909 Glioblastoma Tretinoin 6.6817312396
MESH:D005910 Glioma Fluorouracil 2.7716145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.2515102660 15162350 18337622
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.2516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9116084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.3420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.3411294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.349664655 14991402
MESH:D006331 Heart Diseases Mitoxantrone 3.9816019553
MESH:D006402 Hematologic Diseases Zidovudine 4.4812579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1715720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1716366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6515340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.7815709030
MESH:D015658 HIV Infections Zidovudine 3.3617358032 11363243 11141242 11698656 20032539
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.5017440010
MESH:D006689 Hodgkin Disease sodium arsenite 2.9512676792
MESH:D019584 Hot Flashes Estradiol 3.5017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.808697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.0216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3316778211
MESH:D006965 Hyperplasia Diethylstilbestrol 4.1912960047 14722030
MESH:D006967 Hypersensitivity Toluene 2,4-Diisocyanate 4.3911019492 10880147
MESH:D006973 Hypertension Cyclosporine 8.0610903974
MESH:D006973 Hypertension Phenylephrine 8.068949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.0618670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.3312791704 18502941
MESH:D007021 Hypospadias Diethylstilbestrol 10.4416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.4416945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 4.1215036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.1017937319
MESH:D007248 Infertility, Male sodium arsenite 6.1012646999 15346721
MESH:D007249 Inflammation Lipopolysaccharides 4.6612878042 9205823 17237260 17963957 17255318
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.6612878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.4818200517
MESH:D007333 Insulin Resistance Estradiol 2.8116627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 9.1817994277
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 9.1817994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4017255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.2015992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1915604871
MESH:D007674 Kidney Diseases Cyclosporine 9.248314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 9.2415618244
MESH:D007674 Kidney Diseases sodium arsenite 9.2420008137
MESH:D007680 Kidney Neoplasms Cyclosporine 21.2512371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 21.2515003126 16762066 14681315
MESH:D007680 Kidney Neoplasms Estradiol 21.2515610895
MESH:D007680 Kidney Neoplasms Fluorouracil 21.2516985049
MESH:D007680 Kidney Neoplasms Zidovudine 21.2512579204
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8217184923
MESH:D007938 Leukemia arsenic trioxide 9.7915070760
MESH:D007938 Leukemia Genistein 9.7917468513 18980019
MESH:D007938 Leukemia Tretinoin 9.7917143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.6818172266
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 9.1117077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 9.1120370541
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.7419077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.7416932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.7216467208 16968895 17050201 19850784 20471514
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7217596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.1115336539 16891316 17217047 19035177 16966277 17649720 12679006 11468182 16331271 17712046 15748426 16112521 11161223 12712474 12018890 15213294 15622746 19075265 17869043 19642359 19225113 17107899 9834237 16823087 16330433
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.1116766008 17361223 17506722 17294898 12679006 19035177 15748426 17339181 17301526 17107899 19029980 9834237 16935935 17712046 16331271 16788101 19225113 19642359 17217047 16823087 17368321 19075265 16140955 16891316 17649720
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1216882451
MESH:D007970 Leukopenia Lipopolysaccharides 4.4515821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.139224671
MESH:D008080 Liposarcoma Paclitaxel 4.5917353645
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.3314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.3317823541
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 8.3312878042
MESH:D008106 Liver Cirrhosis, Experimental Plant Preparations 8.3317724770
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.3312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.3318397230 16248980
MESH:D008107 Liver Diseases Tetrachloroethylene 3.6617267091
MESH:D008113 Liver Neoplasms Aflatoxin B1 20.452125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms arsenic trioxide 20.4514682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.4521137059 20195826
MESH:D008113 Liver Neoplasms Diethylstilbestrol 20.4516712894 15890375
MESH:D008113 Liver Neoplasms Fluorouracil 20.4516603448 17045692 18383874 15113037
MESH:D008113 Liver Neoplasms sodium arsenite 20.4516712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.4516984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 12.948603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 12.9420377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.9412151625
MESH:D008114 Liver Neoplasms, Experimental Tetrachloroethylene 12.947955063
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1715213294
MESH:D008171 Lung Diseases sodium arsenite 3.0119095001
MESH:D055370 Lung Injury Lipopolysaccharides 3.7721114838
MESH:D008175 Lung Neoplasms Aflatoxin B1 10.2114755239
MESH:D008175 Lung Neoplasms arsenic trioxide 10.2111798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.216695378 20464547 20064080 18816296 20135361 18569708 18520028 20869020 17053015
MESH:D008175 Lung Neoplasms Fluorouracil 10.2115246190
MESH:D008175 Lung Neoplasms sodium arsenite 10.2117306315 17077188 16712894 15276417 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.2119555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 10.2118800350
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5415086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9015166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.3015700306
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.8914749477
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2716002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.5717203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 5.5714578162 12929590
MESH:D020149 Manganese Poisoning Estradiol 4.2319453300
MESH:D008527 Medulloblastoma Tretinoin 2.6917453147
MESH:D008545 Melanoma Paclitaxel 4.9212025231 16342250 12040289
MESH:D008545 Melanoma sodium arsenite 4.9216487513 19082730
MESH:D008545 Melanoma Tretinoin 4.9216752155
MESH:D008591 Meningomyelocele Tretinoin 4.1816940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5416801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.5917358032
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 13.4516381670
MESH:D009062 Mouth Neoplasms Fluorouracil 13.4516757204 18986760
MESH:D009062 Mouth Neoplasms Plant Preparations 13.4517418620
MESH:D009101 Multiple Myeloma arsenic trioxide 6.9311468182 19417148 15949261 19549372 14977855
MESH:D009101 Multiple Myeloma Paclitaxel 6.9314749477
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.9316882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.9317596541
MESH:D009203 Myocardial Infarction Genistein 2.7617141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.8916810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.8917141266
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7316624393
MESH:D009362 Neoplasm Metastasis Paclitaxel 3.1615867366
MESH:D009369 Neoplasms Benzo(a)pyrene 22.1911141357
MESH:D009369 Neoplasms Diethylstilbestrol 22.1915313581
MESH:D009369 Neoplasms Fluorouracil 22.1918239605 18600527 16928823
MESH:D009369 Neoplasms Mitoxantrone 22.1916640825
MESH:D009369 Neoplasms sodium arsenite 22.1911559025
MESH:D009369 Neoplasms Tetrachloroethylene 22.1911911487
MESH:D009369 Neoplasms Tretinoin 22.1916594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.6920056578
MESH:D009374 Neoplasms, Experimental Toluene 2,4-Diisocyanate 8.691670384
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0819348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 28.2311399458
MESH:D009421 Nervous System Malformations Estradiol 28.2316427766 11399458
MESH:D009421 Nervous System Malformations Genistein 28.2316427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 28.2314600291
MESH:D009421 Nervous System Malformations Tretinoin 28.239125849
MESH:D009436 Neural Tube Defects arsenic trioxide 11.2410525206
MESH:D009436 Neural Tube Defects sodium arsenite 11.2412854658
MESH:D009436 Neural Tube Defects Tretinoin 11.249142499
MESH:D009447 Neuroblastoma Topotecan 3.7215176712
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2716436463
MESH:D009784 Occupational Diseases Toluene 2,4-Diisocyanate 4.5018394133 11077013 3040596 12585506 6091946 6091945 8156442
MESH:D010014 Osteolysis Paclitaxel 4.7315867366
MESH:D010024 Osteoporosis Genistein 3.1019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.8616169203
MESH:D010051 Ovarian Neoplasms arsenic trioxide 17.8419769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Estradiol 17.8419401270
MESH:D010051 Ovarian Neoplasms Genistein 17.8419005980
MESH:D010051 Ovarian Neoplasms Paclitaxel 17.8411161223
MESH:D010051 Ovarian Neoplasms sodium arsenite 17.8415276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 17.8416936753
MESH:D010146 Pain Tretinoin 2.7116870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.1215580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.1216929163 15113037 16500647 19003803
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.1215976015
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 3.9817698068
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4611578682
MESH:D010235 Paraganglioma arsenic trioxide 3.9319927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9214722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4315687265 16977796
MESH:D011014 Pneumonia Lipopolysaccharides 4.3112224865 11605937
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0212371664
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.7517184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.7511896295 11399792 11118676 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6620887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.4019131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4017292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.4017136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 2.4016740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.4018626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 2.4015378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.4017172428 16729912 16356831 17136230
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.4016039940
MESH:D011507 Proteinuria Tretinoin 3.3816636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0716919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011625 Pterygium Tretinoin 4.5516723453
MESH:D011657 Pulmonary Eosinophilia Toluene 2,4-Diisocyanate 5.3714606601
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8016160472 18722050 15538739 18286688
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 8.0910835634
MESH:D012130 Respiratory Hypersensitivity Toluene 2,4-Diisocyanate 8.097692837 16940033 20219652
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012140 Respiratory Tract Diseases Toluene 2,4-Diisocyanate 4.8718447907
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8716116481 16283617
MESH:D012220 Rhinitis Toluene 2,4-Diisocyanate 4.3719050374
MESH:D012221 Rhinitis, Allergic, Perennial Toluene 2,4-Diisocyanate 5.0312617775 15015336
MESH:D006255 Rhinitis, Allergic, Seasonal Toluene 2,4-Diisocyanate 5.2619075512
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7316646077
MESH:D012852 Sinusitis Phenylephrine 4.467327846
MESH:D012871 Skin Diseases monomethylarsonous acid 3.3117431481
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 16.6819755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 16.6818572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 16.688532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.6816192470
MESH:D012878 Skin Neoplasms Tretinoin 16.6816467112
MESH:D012912 Sneezing Toluene 2,4-Diisocyanate 5.2619075512 19050374
MESH:D013088 Spermatocele Diethylstilbestrol 10.8816709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 10.8816709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6112854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 7.9617007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 7.962093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 7.9618396642 16951190 16424979 18567086 17522103 19015929 15786421 17498489 17172411 19084572
MESH:D013274 Stomach Neoplasms Paclitaxel 7.9618396642 18506536
MESH:D013274 Stomach Neoplasms Tretinoin 7.9617261132
MESH:D013274 Stomach Neoplasms Zidovudine 7.9617696246
MESH:D024801 Tauopathies Paclitaxel 4.5716930453
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9515821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6512697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.6019014326
MESH:D013964 Thyroid Neoplasms Tretinoin 6.6017045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.4419048282
MESH:D014062 Tongue Neoplasms Fluorouracil 9.1216280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.1216051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7215213294
MESH:D014376 Tuberculosis Tretinoin 3.0816040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 18.6320435036 11780464 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 18.6317053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 18.6316452187 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 18.6320375083
MESH:D001749 Urinary Bladder Neoplasms Plant Preparations 18.6311251952
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 18.6311723127 17306315 16452187 16712894
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 20.8716175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 20.8716803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 20.8711813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 20.8716129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.9214652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.6916690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.6914692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3616752155
MESH:D014605 Uveitis Cyclosporine 3.731336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 10.3316513791 16002989
MESH:D014625 Vaginal Neoplasms Zidovudine 10.3312579204
MESH:D014652 Vascular Diseases sodium arsenite 4.1817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3214671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.8216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
MESH:D009396 Wilms Tumor Tretinoin 3.7616287080
MESH:D014985 Xerophthalmia Cyclosporine 4.1917120751
Pathway ID Pathway Name
KEGG:04622 RIG-I-like receptor signaling pathway
REACT:6900 Signaling in Immune system
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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