AutismKB 2.0

Annotation Detail for FEZ1


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Basic Information Top
Gene Symbol:FEZ1 ( - )
Gene Full Name: fasciculation and elongation protein zeta 1 (zygin I)
Band: 11q24.2
Quick LinksEntrez ID:9638; OMIM: 604825; Uniprot ID:FEZ1_HUMAN; ENSEMBL ID: ENSG00000149557; HGNC ID: 3659
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2051Leukemia
2069Schizophrenia
Desease Name
PSYCH
schizophrenia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FEZ1 mRNAaffects expression 16483693
D001151 Arsenic FEZ1 mRNA results in increased susceptibility to Arsenicincreases response to substance 17976673
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of FEZ1 mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of FEZ1 mRNA]decreases reaction|increases expression 17854601
D005419 Flavonoids Flavonoids results in decreased expression of FEZ1 mRNAdecreases expression 18035473
C008493 methylselenic acid methylselenic acid results in increased expression of FEZ1 mRNAincreases expression 18548127
D018038 Sodium Selenite Sodium Selenite results in increased expression of FEZ1 mRNAincreases expression 18175754
C004648 testosterone enanthate testosterone enanthate affects the expression of FEZ1 mRNAaffects expression 17440010
D014635 Valproic Acid Valproic Acid results in increased expression of FEZ1 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.828875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1719490988
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000236 Adenoma Diethylnitrosamine 2.9810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.2417162532 17620307 16434500 19052882 18056438 19061943
MESH:D018246 Adrenocortical Adenoma Arsenic 5.5917306315
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.7617497229
MESH:D020261 Arsenic Poisoning Arsenic 2.9216835338 12569548 18414634 16251483
MESH:D050197 Atherosclerosis Arsenic 3.3819371607 12928151
MESH:D001321 Autistic Disorder Valproic Acid 1.9920603192 18396377 18985861 19460635 15238991 18775368 18558336 18940202 17507914 16609825 18316065 19232924 18177632 17157402 17688650
MESH:D001714 Bipolar Disorder Valproic Acid 3.1817594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.548888407
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2017474063
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7117687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.2816507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.2820514400 18978308 19418558 11831363 16569478 16681979 20512989 16698587 19171122 17162532 16502159 20524982 17761372 18056438 18971187 18691550 16288022 17428255 17173139 18494052 17055752 16830150 17138121 20432363 19052882 16540662 19539802 19107877 18393292 18785209 18210153 20935162 17978847 16807293 19208518 10737359 19919837 19519916 3084413 19383236 20214788 20084675 10672840 18665156 16935385 20101231 16328049 19394651 18788625 19701751 16878318 19335982 20727157 21159647 18506893 19822196 3581430 20007298 16779866
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7415504454 17687452 18922899
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3018640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.6115738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.5218022660 16973168
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.0117174075 2727394 7505956 21159647
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0615894690
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.908888407 16575769 17688650
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9916285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.6619107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.6615131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.661733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.311851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.4617275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.293922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0420417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.806426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.403659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D005234 Fatty Liver Diethylnitrosamine 8.7021071580 20387270
MESH:D005234 Fatty Liver Valproic Acid 8.7019224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.418888407 18558336
MESH:D005534 Foot Diseases Arsenic 5.946392382
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.1217440010
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6817050553
MESH:D006973 Hypertension Arsenic 2.949931084 11953799 16076760
MESH:D006987 Hypesthesia Arsenic 5.9416093927
MESH:D007249 Inflammation Diethylnitrosamine 5.5618785209
MESH:D007249 Inflammation Flavonoids 5.5617296493
MESH:D007333 Insulin Resistance Sodium Selenite 3.4214714311
MESH:D007642 Keratosis Arsenic 5.3316930632 12749816
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1816294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7017339181
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9418665156 18407596 18522880 19638242 20032147
MESH:D008107 Liver Diseases Arsenic 4.4111134558
MESH:D008107 Liver Diseases Diethylnitrosamine 4.4117034775
MESH:D008113 Liver Neoplasms Arsenic 5.0116368122
MESH:D008113 Liver Neoplasms Diethylnitrosamine 5.0118644402 2862719 2422723 20583210 19090486 15885732 18648771 20501860 20137499 9163691 20452335 19996281 19294768 19255062 19812893 19833225 19551842 19850985 18754104 19256749 12112319 19642983 18977376 21071580 19690152 20405173 20434301 20492335 15175105 10737359 20101389 21167192 19254457 20118626 12771043 18978307 19427195 19073162 16942905 19638242 21047994 21278145 19426721 19499222
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.779362446 19126423 18093689 3124819 18282651 18079962 19519916 18775883 17854601 2563599 18164116 19539802 18253720 16267830 18308698 18544905 21159647 19009564 17942915 17174075 19004024 16842330
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.6417228818
MESH:D008175 Lung Neoplasms Arsenic 2.6717306315 17976673 19168569
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.676695378 20970405 20512841 21163286
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3214737004
MESH:D008881 Migraine Disorders Valproic Acid 3.3618803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2817596541
MESH:D017202 Myocardial Ischemia Arsenic 4.1815371236
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.659029167 3581430
MESH:D009436 Neural Tube Defects Arsenic 7.9516620997
MESH:D009436 Neural Tube Defects Valproic Acid 7.9516359493 8888407
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5420387270
MESH:D020078 Neurogenic Inflammation Arsenic 4.6417056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D010051 Ovarian Neoplasms Arsenic 2.8017306315
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4916540662
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.4616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.3315371236 6392382 16905509
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.772563599
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.1720603192
MESH:D011471 Prostatic Neoplasms Arsenic 2.6916140617
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.6916205645
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6918760546
MESH:D011507 Proteinuria Arsenic 4.2621343184
MESH:D019310 Pseudolymphoma Valproic Acid 4.9211422049 12752131
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4419155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8911738929 3137016 17978042 14763951 15475178 11044598 16876388 1511512
MESH:D012871 Skin Diseases Arsenic 2.8016759981 19834688 16702368 18709164 17938729 15952646 6392382 17453740 17548696 16353154 17050553
MESH:D012878 Skin Neoplasms Arsenic 3.1016251483 15504454 17029826 17050553 17976673 19538983
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.167505956
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.8911144890 17306315 19322015 15987713 17976673 18640142 19429237
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D014652 Vascular Diseases Arsenic 5.0717056641
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28100
    • No data
    Releated disease ID Related disease Name
    PA445062Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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