AutismKB 2.0

Annotation Detail for MICAL2


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Basic Information Top
Gene Symbol:MICAL2 ( DKFZp686H03148,DKFZp686H2469,KIAA0750,MICAL2PV1,MICAL2PV2 )
Gene Full Name: microtubule associated monoxygenase, calponin and LIM domain containing 2
Band: 11p15.3
Quick LinksEntrez ID:9645; OMIM: 608881; Uniprot ID:MICA2_HUMAN; ENSEMBL ID: ENSG00000133816; HGNC ID: 24693
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of MICAL2 mRNAdecreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of MICAL2 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MICAL2 mRNAdecreases expression 19150397
D004317 Doxorubicin MICAL2 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MICAL2 mRNAaffects binding|decreases expression|increases activity 19710929
D011374 Progesterone Progesterone results in decreased expression of MICAL2 mRNAdecreases expression 18070364
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MICAL2 mRNAdecreases expression 19933214
C025643 vinclozolin vinclozolin affects the expression of MICAL2 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1815322242 11752688 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Doxorubicin 2.6117418594
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.0516835633
MESH:D000419 Albuminuria Doxorubicin 4.8321441931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001008 Anxiety Disorders vinclozolin 3.8319015723
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.0814601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.7117868700
MESH:D001930 Brain Injuries Progesterone 4.5615845082 15665606 15380490
MESH:D001932 Brain Neoplasms Doxorubicin 4.0417150277
MESH:D001943 Breast Neoplasms Doxorubicin 1.9115567936 15993339 16096432 15634643 19526202 17369602 15939500 18382427 17426702 16595493 15136595 16826403 16264153 16115903 18695136 15668708 16935488 17983394 18234424 16322301 15692762 15994142 11325840 18628466
MESH:D001943 Breast Neoplasms Progesterone 1.9116175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9120435547
MESH:D002276 Carcinoid Tumor Doxorubicin 5.1916051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.083084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 3.0817876044 18059187 16023760 16234567
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.261485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.696189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 16120746 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.6817329180 15792986 16269455 16612575 18627295 16952015 17351982 17974986 17308081 15811867 16731534 17519947 15476868 16455267 16651473 16278810 17928571 17924179 15505089 17382496 16109756 17007740 17131338 16242529 16364871
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0117334414 16243910
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8820889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915668235 15340226 16354765 8697196 12621046
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.8017187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5310915739 11739529 11287661 12153990 14725611 15619225 16781746 17562736 19739265 16177239 11529661 14550746 12705907 12594235 17906064 16109766 15968718 12392966 12958197 10663392 18071297 16485898 11461765 16393943 17522070 19923254 19416960 19085960 11421492 11743745 11834606 10774834 14986274 16081117 16227642 18713872 19164858 19420014 2444490 19370779 12540782
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.5317416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Doxorubicin 8.7018602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.7011462148
MESH:D004487 Edema pirinixic acid 7.3512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.0617692515
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.6017359293
MESH:D004715 Endometriosis Progesterone 9.7016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.709294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.5318037988
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1220426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver pirinixic acid 3.0120131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.9319069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2520067830
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D005909 Glioblastoma Doxorubicin 3.4917150277
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.6815692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.6416707910 16495754 17888722 18006777 18674790 16879835 16330681 17875725 16144979 16244372 16244371 14766674 12587719
MESH:D006333 Heart Failure Doxorubicin 7.5117481944
MESH:D006333 Heart Failure pirinixic acid 7.5120558911
MESH:D006394 Hemangiosarcoma Doxorubicin 4.1415692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly pirinixic acid 9.3019772884 18467677 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.3015340226 12621046 16120746
MESH:D006689 Hodgkin Disease Doxorubicin 3.6217606976 18501091 15147373
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4216354765 18606429 8697196 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818670907 18850075
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.7115869954
MESH:D007248 Infertility, Male vinclozolin 3.1916467254
MESH:D007249 Inflammation Progesterone 5.3515869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3512200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases Acetaminophen 6.4812587719 15629191
MESH:D007674 Kidney Diseases Doxorubicin 6.4816775033 15699352 15369732
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4016707910
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.5316085563
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.5716595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5712878042
MESH:D008107 Liver Diseases Acetaminophen 1.6719460945 16610002 19014921 16611625 19784758 12587719 12969438 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 4.5115890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5116984957
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.3817085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3812151625
MESH:D008175 Lung Neoplasms Doxorubicin 2.456189445 17418594
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4519555203 11884234
MESH:D008223 Lymphoma Doxorubicin 3.6316098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.9917654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.8715621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.7215458769
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.7217203775 11408345
MESH:D008545 Melanoma Doxorubicin 2.3116827129
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008654 Mesothelioma Doxorubicin 3.1417638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.7415792986
MESH:D052016 Mucositis Doxorubicin 5.1317415656
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction Doxorubicin 6.0015857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 6.0019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0318259882
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009401 Nephrosis Doxorubicin 5.0816899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.2116889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009447 Neuroblastoma Doxorubicin 3.3715555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D012516 Osteosarcoma Doxorubicin 4.3115930896
MESH:D010051 Ovarian Neoplasms Progesterone 2.5817393432 16525653
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.5317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.5317638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.6411896295 11399792 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.6419015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.5116729912 15749863 16888761 16868541 15897917 18437689
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D051437 Renal Insufficiency Doxorubicin 4.5317922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9218045962
MESH:D012509 Sarcoma Doxorubicin 4.2215625365 18313854 16767912 17710206 15675481 17203757
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.5214601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.1317846226
MESH:D012878 Skin Neoplasms Doxorubicin 6.0215692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0216192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.8716767912 17203757 15625365
MESH:D013119 Spinal Cord Injuries Progesterone 4.6215862959 16503802
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.5516010429 17909728
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 2.8417653716
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.5317638931 17678736 16364871 17334414
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA142671453
    • No data
    No data
    Releated drug ID Related drug Name
    PA450626nicotine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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