AutismKB 2.0

Annotation Detail for TTLL4


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Basic Information Top
Gene Symbol:TTLL4 ( KIAA0173 )
Gene Full Name: tubulin tyrosine ligase-like family, member 4
Band: 2q35
Quick LinksEntrez ID:9654; OMIM: NA; Uniprot ID:TTLL4_HUMAN; ENSEMBL ID: ENSG00000135912; HGNC ID: 28976
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016572 Cyclosporine Cyclosporine results in increased expression of TTLL4 mRNAincreases expression 20106945
C013038 hydroxyhydroquinone hydroxyhydroquinone results in increased expression of TTLL4 mRNAincreases expression 17572062
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TTLL4 mRNAaffects binding|increases activity|increases expression 19710929
C017947 sodium arsenite sodium arsenite affects the expression of TTLL4 mRNAaffects expression 19590694
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.1116434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.4215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.6317306315 16712894
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5719483382
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 2.0116507464 17306315 15276417
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4618572023
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.5412371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.5420056578 19524636
MESH:D002779 Cholestasis Cyclosporine 8.7419486331
MESH:D002779 Cholestasis pirinixic acid 8.7419176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D004487 Edema pirinixic acid 2.9012083418
MESH:D005234 Fatty Liver Cyclosporine 9.0119224547
MESH:D005234 Fatty Liver pirinixic acid 9.0120131406 19236843
MESH:D005355 Fibrosis Cyclosporine 3.7012639820 12168785
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.3116452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.858708960
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.0515720958
MESH:D006529 Hepatomegaly pirinixic acid 3.5519176532 19772884 18467677 16221962
MESH:D006689 Hodgkin Disease sodium arsenite 3.5212676792
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D006973 Hypertension Cyclosporine 2.2110903974
MESH:D007248 Infertility, Male sodium arsenite 3.2415346721 12646999
MESH:D007333 Insulin Resistance pirinixic acid 2.8716306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.1615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.708314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 6.7020008137
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0812371664
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms pirinixic acid 4.8920007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 4.8916712894 15276417
MESH:D008171 Lung Diseases sodium arsenite 3.4219095001
MESH:D008175 Lung Neoplasms sodium arsenite 1.9015276417 16712894 17077188 17306315 19931552
MESH:D008545 Melanoma sodium arsenite 2.0716487513 19082730
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.5116801185
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2516411023
MESH:D009369 Neoplasms pirinixic acid 5.5117405874
MESH:D009369 Neoplasms sodium arsenite 5.5111559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.2220056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6518481113 19348381
MESH:D009436 Neural Tube Defects sodium arsenite 3.3812854658
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5315276417 17306315
MESH:D011230 Precancerous Conditions Cyclosporine 3.5912371664
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2416039940
MESH:D011565 Psoriasis Cyclosporine 2.3316882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D012878 Skin Neoplasms sodium arsenite 2.8519524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 4.1012854658
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.6311723127 16452187 16712894 17306315
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.1611813266
MESH:D014605 Uveitis Cyclosporine 4.711336536
MESH:D014652 Vascular Diseases sodium arsenite 5.0617056641
MESH:D014985 Xerophthalmia Cyclosporine 5.1617120751
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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