AutismKB 2.0

Annotation Detail for IQCB1


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Basic Information Top
Gene Symbol:IQCB1 ( NPHP5,PIQ,SLSN5 )
Gene Full Name: IQ motif containing B1
Band: 3q13.33
Quick LinksEntrez ID:9657; OMIM: 609237; Uniprot ID:IQCB1_HUMAN; ENSEMBL ID: ENSG00000173226; HGNC ID: 28949
Relate to Another Database: SFARIGene; denovo-db
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Desease Name
Senior-Loken syndrome 5
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of IQCB1 mRNAaffects expression 17562736
C006780 bisphenol A bisphenol A results in decreased expression of IQCB1 mRNAdecreases expression 20678512
D016572 Cyclosporine Cyclosporine results in increased expression of IQCB1 mRNAincreases expression 20106945
D002117 Calcitriol Calcitriol results in increased expression of IQCB1 mRNAincreases expression 16002434
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of IQCB1 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of IQCB1 mRNAdecreases expression 19244175
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of IQCB1 mRNAaffects cotreatment|decreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001862 Bone Resorption bisphenol A 4.1911985600
MESH:D001943 Breast Neoplasms bisphenol A 2.3617123778
MESH:D001943 Breast Neoplasms Calcitriol 2.3611237771
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.3516050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002278 Carcinoma in Situ bisphenol A 5.4517123778
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6911237771
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7312371664
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D003092 Colitis Selenium 4.2017936198
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0414986274 18713872 11421492 19164858 14725611 19923254 16781746 17562736 16109766 18071297 19416960 15619225 16227642 16393943 10915739 12392966 11834606 14550746 11287661 12594235 19739265 2444490 17522070 11739529 11461765 12153990 15968718 19420014 19085960 11743745 16081117 12540782 16177239 19370779 12958197 10774834 17906064 11529661 12705907 16485898 10663392
MESH:D056486 Drug-Induced Liver Injury Selenium 4.0415131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:C538011 Eales disease Vitamin E 5.229068938
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.3115138306
MESH:D005234 Fatty Liver Cyclosporine 3.1819224547
MESH:D005355 Fibrosis Cyclosporine 3.5612639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1316080930
MESH:D006333 Heart Failure Selenium 3.2517162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7916490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.4914716179
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D007251 Influenza, Human Selenium 12.7616624496
MESH:D007251 Influenza, Human Vitamin E 12.7616624496
MESH:D007333 Insulin Resistance bisphenol A 3.4816393666
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Acetaminophen 10.9715629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.9718776723 10903974 8314463
MESH:D007674 Kidney Diseases Vitamin E 10.9712488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.2116518626
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0012371664
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008107 Liver Diseases Acetaminophen 1.6912969438 16611625 19014921 12587719 19460945 11587558 19784758 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D008171 Lung Diseases Vitamin E 3.3716863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9515318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008654 Mesothelioma Selenium 2.8915107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5719348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 4.3516427766 11399458
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D010049 Ovarian Diseases bisphenol A 5.4511985600
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010954 Plasmacytoma Selenium 5.4115087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.4110548101
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.2415572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.5320887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.5916740699
MESH:D011471 Prostatic Neoplasms Calcitriol 2.5916289102 16644109 15754350 12479363 18247401
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5915084515
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D011629 Puberty, Precocious bisphenol A 5.2510548101
OMIM:609254 SENIOR-LOKEN SYNDROME 5 marker/mechanism
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D020521 Stroke Vitamin E 3.7716517955
MESH:D019966 Substance-Related Disorders bisphenol A 4.4516684133 16045194
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014591 Uterine Diseases bisphenol A 5.5314652134
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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