AutismKB 2.0

Annotation Detail for PDE4DIP


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Basic Information Top
Gene Symbol:PDE4DIP ( CMYA2,DKFZp781J054,MGC75440,MMGL )
Gene Full Name: phosphodiesterase 4D interacting protein
Band: 1q21.2
Quick LinksEntrez ID:9659; OMIM: 608117; Uniprot ID:MYOME_HUMAN; ENSEMBL ID: ENSG00000178104; HGNC ID: 15580
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1993Esophagus cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PDE4DIP mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of PDE4DIP mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PDE4DIP mRNAaffects expression 16483693
D016718 Arachidonic Acid Arachidonic Acid results in decreased expression of PDE4DIP mRNAdecreases expression 16704987
C006632 arsenic trioxide arsenic trioxide results in increased expression of PDE4DIP mRNAincreases expression 15761015
C006780 bisphenol A bisphenol A results in increased expression of PDE4DIP mRNAincreases expression 20678512
C006780 bisphenol A bisphenol A results in increased expression of PDE4DIP mRNAincreases expression 18180321
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of PDE4DIP mRNAincreases expression 15336504
D016572 Cyclosporine Cyclosporine results in decreased expression of PDE4DIP mRNAdecreases expression 20106945
C014347 decitabine decitabine affects the expression of PDE4DIP mRNAaffects expression 17145863
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDE4DIP mRNAaffects cotreatment|increases expression 17942748
D008628 Mercury Mercury results in increased expression of PDE4DIP mRNAincreases expression 16823088
C025299 polyphenols polyphenols results in decreased expression of PDE4DIP mRNAdecreases expression 16293270
C004648 testosterone enanthate testosterone enanthate affects the expression of PDE4DIP mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDE4DIP mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PDE4DIP mRNAincreases expression 19465110
C034613 triacsin C triacsin C results in decreased expression of PDE4DIP mRNAdecreases expression 16704987
C034028 vanadyl sulfate vanadyl sulfate results in increased expression of PDE4DIP mRNAincreases expression 16330358
C025643 vinclozolin vinclozolin affects the expression of PDE4DIP mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 8.457525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.4515322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9417505938
MESH:D000230 Adenocarcinoma arsenic trioxide 4.2719825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2714692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D001008 Anxiety Disorders vinclozolin 3.6219015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6515885639
MESH:D001321 Autistic Disorder Arachidonic Acid 2.7318582451
MESH:D001321 Autistic Disorder Mercury 2.7317497416
MESH:D001327 Autoimmune Diseases Mercury 4.8616634805
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.9016206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.9012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001862 Bone Resorption bisphenol A 3.8411985600
MESH:D001943 Breast Neoplasms bisphenol A 1.9017123778
MESH:D001943 Breast Neoplasms decitabine 1.9018320071 19208741
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9020435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3111589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.0216705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.0216217749 15073043 14691202 11135700 15553829
MESH:D002278 Carcinoma in Situ bisphenol A 4.9817123778
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8719014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1012490120
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.5919215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.4410334427
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.6214694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.526135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.5212371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1416835633
MESH:D002779 Cholestasis Cyclosporine 7.7219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.7216105132 15861022 17681005 17110522 16919318 17333356 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0915668235 8697196 12621046 15340226 16354765
MESH:D003110 Colonic Neoplasms decitabine 4.0217616700
MESH:D003110 Colonic Neoplasms polyphenols 4.0216293270
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5820501625
MESH:D015179 Colorectal Neoplasms decitabine 2.5818981723
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.1315095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.1314669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.4610525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4620055451 10048152 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.3214966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0018551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0815213294
MESH:D017449 Dermatitis, Allergic Contact Mercury 3.7816823706
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 4.3516684804
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.9818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 8.9821346803
MESH:D056486 Drug-Induced Liver Injury polyphenols 8.9819370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.9820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D004487 Edema Arachidonic Acid 7.0515177302 9599246 16716910 7990266 11698051 9831321
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9018230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1712538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.1219294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.009294722 10568697
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3012903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver arsenic trioxide 12.9715073043
MESH:D005234 Fatty Liver Cyclosporine 12.9719224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.9715345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005334 Fever Arachidonic Acid 4.6411852909
MESH:D005355 Fibrosis Cyclosporine 8.4412639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.4420067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2416904648
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3016417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.218708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.4719215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3211294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8815340226 12621046 16120746
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.7517440010
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0518606429 16959395 15340226 16354765 8697196
MESH:D006973 Hypertension Cyclosporine 4.9210903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9218670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8016945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4412013081
MESH:D007248 Infertility, Male decitabine 11.1617581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.1617937319
MESH:D007248 Infertility, Male vinclozolin 11.1616467254
MESH:D007249 Inflammation Arachidonic Acid 8.4517371808 15177302 9831321
MESH:D007249 Inflammation polyphenols 8.4516366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.4512878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 3.2716393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4415604871
MESH:D007674 Kidney Diseases Cyclosporine 6.268314463 10903974 18776723
MESH:D007674 Kidney Diseases Mercury 6.2617934191
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.2116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.2112371664
MESH:D007938 Leukemia arsenic trioxide 6.4215070760
MESH:D007938 Leukemia decitabine 6.4219235587 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.5219077051
MESH:D007951 Leukemia, Myeloid decitabine 9.5217236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9817050201 16467208 19850784 20471514 16968895
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.9819010910 18206229 18460780 18704418 17679729 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4618055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2016112521 15213294 11468182 16823087 16331271 17712046 19642359 12712474 15748426 17869043 12018890 16891316 19225113 11161223 16966277 17649720 17217047 9834237 16330433 17107899 15622746 19075265 19035177 12679006 15336539
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3416882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7216417039
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases polyphenols 2.7816698588
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.357678174
MESH:D008113 Liver Neoplasms arsenic trioxide 7.3514682389
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.3516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.722876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 9.7220377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.7212151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3315213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.2911798837 19825857
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2911884234 19555203
MESH:D008223 Lymphoma decitabine 3.4019470736
MESH:D008545 Melanoma decitabine 2.2416505122 17785578
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7916801185
MESH:D009101 Multiple Myeloma arsenic trioxide 7.3319417148 11468182 19549372 15949261 14977855
MESH:D009101 Multiple Myeloma decitabine 7.3318172295
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.4616105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 7.4619010910 19157545 18608210 16882708
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.8518551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9416624393
MESH:D009369 Neoplasms decitabine 2.7019116145 17925555 19470736
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2718481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 9.5316427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.5314600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1010525206
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.0716049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 9.0714694615
MESH:D010049 Ovarian Diseases bisphenol A 4.9811985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.9612452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms decitabine 4.9619331143 19259094
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.3715580305
MESH:D010190 Pancreatic Neoplasms decitabine 5.3719294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6711578682
MESH:D010235 Paraganglioma arsenic trioxide 4.1419927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2012371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 16.2210548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 16.2211118676 11399792 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 16.2218042343 19015723 18220299
MESH:D055728 Primary Myelofibrosis decitabine 4.7117616702
MESH:D011469 Prostatic Diseases vinclozolin 4.9318220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.1920887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.3519131511
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3516740699
MESH:D011472 Prostatitis vinclozolin 4.9318629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.3016919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2216882103
MESH:D011629 Puberty, Precocious bisphenol A 4.7810548101
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.3819155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9416646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5218551238
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.568532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5616192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9416709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.5617007042
MESH:D013274 Stomach Neoplasms decitabine 2.5619037991
MESH:D019966 Substance-Related Disorders bisphenol A 3.9716684133 16045194
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.2517997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.2619014326
MESH:D013964 Thyroid Neoplasms decitabine 7.2617967635
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9515213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.3216049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.3212845720 12973940 20435036 11780464
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.3217616700 19087683
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3110091137
MESH:D014591 Uterine Diseases bisphenol A 5.0114652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2814692618
MESH:D014604 Uveal Neoplasms decitabine 4.9117785578
MESH:D014605 Uveitis Cyclosporine 3.981336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4417120751
Pathway ID Pathway Name
KEGG:04810 Regulation of actin cytoskeleton
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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