AutismKB 2.0

Annotation Detail for SDC3


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Basic Information Top
Gene Symbol:SDC3 ( SDCN,SYND3 )
Gene Full Name: syndecan 3
Band: 1p35.2
Quick LinksEntrez ID:9672; OMIM: 186357; Uniprot ID:SDC3_HUMAN; ENSEMBL ID: ENSG00000162512; HGNC ID: 10660
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05144Malaria
hsa04514Cell adhesion molecules (CAMs)
hsa04512ECM-receptor interaction
No data
Pathway IDPathway Name
200170Syndecan-3-mediated signaling events
200111Proteogylcan syndecan-mediated signaling events
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1734Muscular dystrophy
1781Rheumatoid arthritis
1856Obesity
Desease Name
METABOLIC
obesity
No data
Desease Name
Obesity, association with
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D013196 Dihydrotestosterone Dihydrotestosterone results in decreased expression of SDC3 mRNAdecreases expression 17023530
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SDC3 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SDC3 mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of SDC3 mRNAdecreases expression 16239168
D005688 Galactosamine Galactosamine results in increased expression of SDC3 mRNAincreases expression 12057922
D012643 Selenium Selenium results in increased expression of SDC3 mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of SDC3 mRNAaffects expression 15977195
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of SDC3 mRNAaffects cotreatment|affects expression 15977195
D014501 Uranium Uranium affects the expression of SDC3 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of SDC3 mRNAaffects expression 15672453
D014810 Vitamin E Vitamin E results in increased expression of SDC3 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1314514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.8116192424 10355542 18705752 16227642 16011737 15721981 16124888 15673190 16097048 15700767 3786805 16050911
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.8116050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8518788625
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic Galactosamine 4.997505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1815340226 12621046 8697196 15668235 16354765
MESH:D003092 Colitis Selenium 4.0417936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5315322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5319769572
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.5221278145 4309450 6623471 19085960 11566570 2869522 15998439 7440962 3786805 15968718 15027814 16177239 10915739 16227642 7179309 19336974 7120509 17522070 10092053 9327722 6884620 3732212
MESH:D056486 Drug-Induced Liver Injury Galactosamine 9.5215968718
MESH:D056486 Drug-Induced Liver Injury Selenium 9.5215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.5220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2215322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.3715959796 12795759 16239168 61145 17595544 12631006 16045604 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Carbon Tetrachloride 9.4718705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.4720067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9010048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.9016080930
MESH:D006333 Heart Failure Selenium 3.1917162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8319900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1512621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3616959395 8697196 16354765 18606429 15340226
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512878042 12200463
MESH:D007251 Influenza, Human Selenium 12.0416624496
MESH:D007251 Influenza, Human Vitamin E 12.0416624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Vitamin E 2.9112488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0916518626
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9117157831 17174718 17334410 11408273 16943688 11903743 16221502 16239168 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5715893842 12389079 12586293 17900296 18317297 17698563 18481824 18472094 12898905 15338365 17766677 18420326 17557913 18054572 18156304 14716833 18279442 14724832 12958196 15931870 15057751 18210741 17721639 17805973 17525996 12649538 15650968 18277467 12667390 17976157 17640975 16248980 16027843 16136751 12632512 17869086 18429990 18395095 15362042 15959796 15996030 17922224 18395914 18472332 16116963 12609069 18187930 18251166 18705752 18263696 10355542 12445418 17944888 18376398 12546737 15673190 17565644 12666154 18205269 17823541 15876570 14748882 17631135 14512876 13678700 15370692 12445421 16097048 18418968 14716496 18166357 16015684 16192424 11481614 15123356 15730626 15818738 17761835 12741479 15925388 18339082 14620537 18412020 17481882 17714472 12632514 20821823 18006644 16033810 17708605 16638106 15052691 16011737
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5712878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5716169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1216246199 15720792 16964402 17285989 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 12.8415123358
MESH:D017093 Liver Failure Galactosamine 12.8411023982
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8816899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.6219294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6216984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.1615583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1612151625
MESH:D008171 Lung Diseases Vitamin E 3.3116863852
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3519555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 2.3511062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8815318939
MESH:D008654 Mesothelioma Selenium 2.8615107826
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009765 Obesity marker/mechanism
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010954 Plasmacytoma Selenium 5.2115087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811399792 11896295 11222880 11118676
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2715084515
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
KEGG:04514 Cell adhesion molecules (CAMs)
KEGG:04512 ECM-receptor interaction
KEGG:05144 Malaria
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35590
    • No data
    No data
    Releated drug ID Related drug Name
    PA449177cytarabine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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