AutismKB 2.0

Annotation Detail for GREB1


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Basic Information Top
Gene Symbol:GREB1 ( KIAA0575 )
Gene Full Name: growth regulation by estrogen in breast cancer 1
Band: 2p25.1
Quick LinksEntrez ID:9687; OMIM: 611736; Uniprot ID:GREB1_HUMAN; ENSEMBL ID: ENSG00000196208; HGNC ID: 24885
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1944Breast cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of GREB1 mRNAincreases expression 16496412
C447119 bazedoxifene acetate bazedoxifene acetate results in decreased expression of GREB1 mRNAdecreases expression 19914376
C053541 bicalutamide bicalutamide inhibits the reaction [Testosterone results in increased expression of GREB1 mRNA]decreases reaction|increases expression 16496412
C006780 bisphenol A bisphenol A results in increased expression of GREB1 mRNAincreases expression 16474171
D017373 Cyproterone Acetate Cyproterone Acetate inhibits the reaction [Testosterone results in increased expression of GREB1 mRNA]decreases reaction|increases expression 16496412
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of GREB1 mRNAincreases expression 19371625
D004958 Estradiol Estradiol affects the expression of GREB1 mRNAaffects expression 14699072
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GREB1 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol promotes the reaction [ESR1 protein binds to GREB1 enhancer]affects binding|increases reaction 20068169
D004958 Estradiol Estradiol results in increased expression of GREB1 mRNAincreases expression 16474171
19619570
20068169
15986123
15849065
17283378
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of GREB1 mRNAaffects cotreatment|increases expression 17404688
D004958 Estradiol sodium arsenite inhibits the reaction [Estradiol results in increased expression of GREB1 mRNA]decreases reaction|increases expression 17283378
D004958 Estradiol TBX21 protein inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to GREB1 enhancer]]affects binding|decreases reaction|increases reaction 20068169
D004958 Estradiol TBX21 protein inhibits the reaction [Estradiol results in increased expression of GREB1 mRNA]decreases reaction|increases expression 20068169
D015025 Zearalenone Zearalenone results in increased expression of GREB1 mRNAincreases expression 19371625
D005485 Flutamide Flutamide inhibits the reaction [Testosterone results in increased expression of GREB1 mRNA]decreases reaction|increases expression 16496412
D019833 Genistein Genistein results in increased expression of GREB1 mRNAincreases expression 16474171
19371625
C533894 LG 100815 LG 100815 results in decreased expression of GREB1 mRNAdecreases expression 16951191
D015741 Metribolone Metribolone results in increased expression of GREB1 mRNAincreases expression 16496412
C021277 nilutamide nilutamide inhibits the reaction [Testosterone results in increased expression of GREB1 mRNA]decreases reaction|increases expression 16496412
C062198 octa-2,4,6-trienoic acid octa-2,4,6-trienoic acid results in decreased expression of GREB1 mRNAdecreases expression 16951191
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of GREB1 mRNAincreases expression 16474171
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of GREB1 mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of GREB1 mRNAincreases expression 17404688
C017947 sodium arsenite sodium arsenite inhibits the reaction [Estradiol results in increased expression of GREB1 mRNA]decreases reaction|increases expression 17283378
C017947 sodium arsenite sodium arsenite results in decreased expression of GREB1 mRNAdecreases expression 17283378
D013739 Testosterone bicalutamide inhibits the reaction [Testosterone results in increased expression of GREB1 mRNA]decreases reaction|increases expression 16496412
D013739 Testosterone Cyproterone Acetate inhibits the reaction [Testosterone results in increased expression of GREB1 mRNA]decreases reaction|increases expression 16496412
D013739 Testosterone Flutamide inhibits the reaction [Testosterone results in increased expression of GREB1 mRNA]decreases reaction|increases expression 16496412
D013739 Testosterone nilutamide inhibits the reaction [Testosterone results in increased expression of GREB1 mRNA]decreases reaction|increases expression 16496412
D013739 Testosterone Testosterone results in increased expression of GREB1 mRNAincreases expression 16496412
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GREB1 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GREB1 mRNAdecreases expression 19619570
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7914514962 15322242 11752688
MESH:D000230 Adenocarcinoma Estradiol 4.4111473722
MESH:D000230 Adenocarcinoma Genistein 4.4111473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8516712894 17306315
MESH:D000686 Amyloidosis Diethylstilbestrol 4.4215469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D000987 Antisocial Personality Disorder Testosterone 5.807506515
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7215746008
MESH:D001862 Bone Resorption bisphenol A 3.8011985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2817868700
MESH:D001930 Brain Injuries Progesterone 4.1915665606 15845082 15380490
MESH:D001943 Breast Neoplasms bisphenol A 3.7317123778
MESH:D001943 Breast Neoplasms Diethylstilbestrol 3.7315324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 3.7318497071 12948864 17261762 17289903 19861407 16675129 17018787 14630087
MESH:D001943 Breast Neoplasms Genistein 3.7317200150 16541309 16873071
MESH:D001943 Breast Neoplasms Progesterone 3.7316175315 17614352 15562024
MESH:D001943 Breast Neoplasms Testosterone 3.7317261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.7320435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7416835633
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 6.5315948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.5316924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.5316924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.5316507464 17306315 15276417
MESH:D002278 Carcinoma in Situ bisphenol A 4.9317123778
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.3618572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3318670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Genistein 3.2616332659
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.5918566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.5919524636 20056578
MESH:D002659 Child Development Disorders, Pervasive Testosterone 3.6520678186
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1016835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0815668235 15340226 8697196 16354765 12621046
MESH:D003110 Colonic Neoplasms Genistein 2.2817182828
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.7315531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0014669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.4912952375 16002989
MESH:D003704 Dementia Polychlorinated Biphenyls 4.6416140633
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.2716647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2717107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3519279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.4317187935
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7111462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8516714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.7217692515
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 11.6916402032
MESH:D004714 Endometrial Hyperplasia Genistein 11.6916402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 12.2715700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 12.2719148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 12.2711473722
MESH:D004715 Endometriosis Progesterone 8.7316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.7310568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9611564622
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.6116534752 16611131 15751030 16513791 16002989
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.8920067830
MESH:D005391 Firesetting Behavior Testosterone 5.807506515
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 12.6116452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 12.6116452187
MESH:D005909 Glioblastoma Genistein 7.4516598420
MESH:D005909 Glioblastoma Testosterone 7.4517162496
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3011294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8316120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.9815709030
MESH:D006628 Hirsutism Testosterone 5.6017019078
MESH:D006689 Hodgkin Disease sodium arsenite 3.1012676792
MESH:D019584 Hot Flashes Estradiol 3.7017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9915340226 18606429 8697196 16354765 16959395
MESH:D017588 Hyperandrogenism Flutamide 12.0415356085
MESH:D017588 Hyperandrogenism Testosterone 12.0417019078
MESH:D006965 Hyperplasia Diethylstilbestrol 4.3714722030 12960047
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8818670907 18850075
MESH:D007006 Hypogonadism Testosterone 4.5412002444
MESH:D007018 Hypopituitarism Testosterone 6.1517426086
MESH:D007021 Hypospadias Diethylstilbestrol 4.5216002989
MESH:D007174 Impulse Control Disorders Testosterone 5.807506515
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3415869954
MESH:D007246 Infertility Diethylstilbestrol 4.2915036965
MESH:D007248 Infertility, Male sodium arsenite 2.9415346721 12646999
MESH:D007249 Inflammation Progesterone 4.8615869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8612878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 7.2916393666
MESH:D007333 Insulin Resistance Estradiol 7.2916393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2716580747
MESH:D007674 Kidney Diseases Estradiol 5.9815618244
MESH:D007674 Kidney Diseases sodium arsenite 5.9820008137
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 7.3614681315 15003126 16762066
MESH:D007680 Kidney Neoplasms Estradiol 7.3615610895
MESH:D007859 Learning Disorders Diethylstilbestrol 4.0017184923
MESH:D007938 Leukemia Genistein 2.9918980019 17468513
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.4317823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4312878042
MESH:D008113 Liver Neoplasms Diethylstilbestrol 7.3216712894 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 7.3215276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.3216984957
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 5.981423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9812151625
MESH:D008171 Lung Diseases sodium arsenite 3.1319095001
MESH:D008175 Lung Neoplasms sodium arsenite 2.2816712894 15276417 17306315 17077188 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2811884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.0915166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.4215700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.4616002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.7617203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 9.7614578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.7617203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.4319453300
MESH:D008545 Melanoma sodium arsenite 2.0216487513 19082730
MESH:D009203 Myocardial Infarction Genistein 2.8317141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.3416810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.3417141266
MESH:D009369 Neoplasms Diethylstilbestrol 5.1315313581
MESH:D009369 Neoplasms sodium arsenite 5.1311559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6020056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6717289903
MESH:D009421 Nervous System Malformations bisphenol A 30.0816427766 11399458
MESH:D009421 Nervous System Malformations Diethylstilbestrol 30.0811399458
MESH:D009421 Nervous System Malformations Estradiol 30.0811399458 16427766
MESH:D009421 Nervous System Malformations Genistein 30.0816427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 30.0814600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.1012854658
MESH:D010024 Osteoporosis Genistein 3.2119401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.0216169203
MESH:D010049 Ovarian Diseases bisphenol A 4.9311985600
MESH:D010051 Ovarian Neoplasms Estradiol 11.1419401270
MESH:D010051 Ovarian Neoplasms Genistein 11.1419005980
MESH:D010051 Ovarian Neoplasms Progesterone 11.1416525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 11.1417306315 15276417
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.3716702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.1114722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.6115687265 16977796
MESH:D011085 Polycystic Ovary Syndrome Flutamide 4.9415356085
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 15.9310548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 15.9317184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.9311222880 11896295 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 17.7020887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 17.7020887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 17.7020887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 16496412
MESH:D011471 Prostatic Neoplasms bicalutamide 2.4615638997 17914592 19011039 19240160 18487222
MESH:D011471 Prostatic Neoplasms bisphenol A 2.4616740699
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.4617136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.4616740699
MESH:D011471 Prostatic Neoplasms Flutamide 2.463169114
MESH:D011471 Prostatic Neoplasms Genistein 2.4615256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.4615721890
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.4616039940
MESH:D011629 Puberty, Precocious bisphenol A 4.7210548101
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8318045962
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 6.1516631401
MESH:D012878 Skin Neoplasms sodium arsenite 5.4918572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4916192470
MESH:D013088 Spermatocele Diethylstilbestrol 4.6616002989 16709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.2215862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7412854658
MESH:D019966 Substance-Related Disorders bisphenol A 3.9216684133 16045194
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013978 Tibial Fractures Estradiol 4.6319048282
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.1916452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.1917306315 16452187 16712894 11723127
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 9.3416175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.3411813266
MESH:D014591 Uterine Diseases bisphenol A 13.6314652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 13.6314652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.0015809267 16690809
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.3716002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 4.3617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA164747489
    • No data
    No data
    Releated drug ID Related drug Name
    PA164768822chlorotrianisene
    PA164754789conjugated estrogens
    PA164745534dienestrol
    PA449307diethylstilbestrol
    PA449503estradiol
    PA449509estrogens
    PA449512estrone
    PA449527ethinyl estradiol
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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