AutismKB 2.0

Annotation Detail for CD69


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CD69 ( CLEC2C )
Gene Full Name: CD69 molecule
Band: 12p13.31
Quick LinksEntrez ID:969; OMIM: 107273; Uniprot ID:CD69_HUMAN; ENSEMBL ID: ENSG00000110848; HGNC ID: 1694
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
type 1 diabetes
IMMUNE
Desease Name
Type 1 diabetes
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen [Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of CD69 mRNAaffects cotreatment|decreases expression 17093179
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CD69 mRNAaffects expression 16483693
D001151 Arsenic Arsenic affects the expression of CD69 mRNAaffects expression 18414638
D047071 beta-Glucans beta-Glucans results in increased expression of CD69 proteinincreases expression 17572156
D003606 Dacarbazine Dacarbazine affects the reaction [IFNA2 protein results in increased expression of CD69 protein]affects reaction|increases expression 17973783
D003606 Dacarbazine [Dacarbazine co-treated with IFNA2 protein] results in increased expression of CD69 proteinaffects cotreatment|increases expression 14669796
D003606 Dacarbazine [Dacarbazine co-treated with Isotretinoin] affects the reaction [IFNA2 protein results in increased expression of CD69 protein]affects cotreatment|affects reaction|increases expression 17973783
C014347 decitabine decitabine affects the expression of CD69 mRNAaffects expression 17145863
D003907 Dexamethasone Dexamethasone results in increased expression of CD69 mRNAincreases expression 12782123
D004040 Dietary Carbohydrates [Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of CD69 mRNAaffects cotreatment|decreases expression 17093179
D015735 Mifepristone Mifepristone results in increased expression of CD69 mRNAincreases expression 17584828
C016599 mono-(2-ethylhexyl)phthalate mono-(2-ethylhexyl)phthalate results in increased expression of CD69 mRNAincreases expression 16809437
C029938 nickel sulfate nickel sulfate results in increased expression of CD69 mRNAincreases expression 16780908
C059514 resveratrol resveratrol results in increased expression of CD69 proteinincreases expression 17088997
D015474 Isotretinoin [Dacarbazine co-treated with Isotretinoin] affects the reaction [IFNA2 protein results in increased expression of CD69 protein]affects cotreatment|affects reaction|increases expression 17973783
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of CD69 proteinincreases expression 12749906
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 4.6218769834
MESH:D000015 Abnormalities, Multiple Isotretinoin 5.0318769834
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D017486 Acneiform Eruptions Isotretinoin 6.3816232082
MESH:D000152 Acne Vulgaris Isotretinoin 5.5816185265 18769834
MESH:D058186 Acute Kidney Injury resveratrol 3.9016538975
MESH:D055371 Acute Lung Injury nickel sulfate 4.3712718980 11954676 19131640 16100012
MESH:D000236 Adenoma resveratrol 3.3515688382
MESH:D018246 Adrenocortical Adenoma Arsenic 5.3117306315
MESH:D000544 Alzheimer Disease resveratrol 2.5816162502 16183991
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001005 Anus Neoplasms Dacarbazine 6.3612170190
MESH:D020261 Arsenic Poisoning Arsenic 2.8816835338 12569548 16251483 18414634
MESH:D001168 Arthritis therapeutic 12882836
MESH:D001169 Arthritis, Experimental marker/mechanism 12882836
MESH:D001169 Arthritis, Experimental Dexamethasone 7.7917659584
MESH:D001169 Arthritis, Experimental resveratrol 7.7917115116
MESH:D050197 Atherosclerosis Arsenic 7.0012928151 19371607
MESH:D050197 Atherosclerosis resveratrol 7.0016873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D002545 Brain Ischemia resveratrol 4.3717600658
MESH:D001943 Breast Neoplasms Dacarbazine 2.2417983394
MESH:D001943 Breast Neoplasms decitabine 2.2418320071 19208741
MESH:D001943 Breast Neoplasms resveratrol 2.2416393696 17534123 17651959
MESH:D002276 Carcinoid Tumor Dacarbazine 6.2516051944
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6215504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.703084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.7017306315 16507464
MESH:D006528 Carcinoma, Hepatocellular resveratrol 4.7016227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.6716675471
MESH:D002292 Carcinoma, Renal Cell Dacarbazine 4.5216201981
MESH:D002294 Carcinoma, Squamous Cell Arsenic 14.5518922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell decitabine 14.5519215824
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 14.5511237771
MESH:D002294 Carcinoma, Squamous Cell resveratrol 14.5516227395
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 14.5518922899
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.1318640142
MESH:D002318 Cardiovascular Diseases Arsenic 7.6915738583 19152805 17938729
MESH:D002318 Cardiovascular Diseases resveratrol 7.6915458977
MESH:D002340 Carotid Artery Diseases Arsenic 4.3616973168 18022660
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D003092 Colitis resveratrol 4.2016474422
MESH:D003110 Colonic Neoplasms decitabine 6.0017616700
MESH:D003110 Colonic Neoplasms Dexamethasone 6.0015824018
MESH:D003110 Colonic Neoplasms resveratrol 6.0016338953
MESH:D015179 Colorectal Neoplasms Dacarbazine 3.7515273666
MESH:D015179 Colorectal Neoplasms decitabine 3.7518981723
MESH:D015179 Colorectal Neoplasms resveratrol 3.7516550006
MESH:D003327 Coronary Disease resveratrol 3.7816507316
MESH:D019465 Craniofacial Abnormalities Dexamethasone 3.2517728286
MESH:D019465 Craniofacial Abnormalities Isotretinoin 3.2518769834 9879862
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 7.6012438553
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 7.6016780908 16823706 11298694
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.8116873680
MESH:D003922 Diabetes Mellitus, Type 1 marker/mechanism 19430480
MESH:D003928 Diabetic Nephropathies resveratrol 4.0116286809
MESH:D003967 Diarrhea Dexamethasone 3.767237001
MESH:D004342 Drug Hypersensitivity Dacarbazine 4.9916508601
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6019370779 19739265 10774834 14986274 14550746 11421492 12540782 16109766 12153990 16081117 18713872 12958197 16393943 2444490 12392966 11287661 10663392 16227642 16485898 19164858 17562736 15619225 18071297 17906064 11529661 19085960 11743745 15968718 16781746 10915739 11739529 19923254 11461765 12594235 14725611 19420014 19416960 16177239 12705907 17522070 11834606
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004485 Eczema Dexamethasone 4.5212438553
MESH:D004487 Edema Dexamethasone 12.0519703484
MESH:D004487 Edema resveratrol 12.058985016
MESH:D004487 Edema Tetradecanoylphorbol Acetate 12.058273558 9599246 16716910 15177302 11698051 8113982 7812673
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.0917872969
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2119294695
MESH:D004715 Endometriosis Mifepristone 4.4216134523
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.9217923197
MESH:D018222 Fibromatosis, Aggressive Dacarbazine 6.0119069698
MESH:D005534 Foot Diseases Arsenic 5.666392382
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005909 Glioblastoma Dacarbazine 4.7212853885 12592361
MESH:D006258 Head and Neck Neoplasms decitabine 3.5219215824
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.097520565
MESH:D006561 Herpes Simplex resveratrol 4.2616876885
MESH:D006689 Hodgkin Disease Dacarbazine 4.7918501091 16170182
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006937 Hypercholesterolemia resveratrol 4.0617188708
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5117050553
MESH:D006949 Hyperlipidemias resveratrol 4.0916873680
MESH:D006973 Hypertension Arsenic 5.6711953799 16076760 9931084
MESH:D006973 Hypertension Dexamethasone 5.6717042910
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.3517488730
MESH:D006987 Hypesthesia Arsenic 5.6616093927
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.7217600658
MESH:D007248 Infertility, Male decitabine 3.2417581917
MESH:D007249 Inflammation Dexamethasone 8.7311099482 8960868
MESH:D007249 Inflammation resveratrol 8.7316366677
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 8.738273558 15177302 11698051 7562506 7812673
MESH:D007251 Influenza, Human resveratrol 4.6416624496
MESH:D007642 Keratosis Arsenic 5.0712749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 2.2315629191 12587719
MESH:D007938 Leukemia decitabine 3.1018980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 4.0617236224 19117987 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3917679729 19010910 18460780 18704418 19387464 18206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.5618055864
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 8.0317339181
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 8.0316087638
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 2.2616718785
MESH:D008107 Liver Diseases Acetaminophen 4.1112587719 19784758 16611625 12969438 16610002 19014921 11587558 19460945
MESH:D008107 Liver Diseases Arsenic 4.1111134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2916871587 17185352
MESH:D008113 Liver Neoplasms Arsenic 4.9916368122
MESH:D008113 Liver Neoplasms resveratrol 4.9919812893 19073162 19321006 20405173
MESH:D008175 Lung Neoplasms Arsenic 5.0417306315 17976673 19168569
MESH:D008175 Lung Neoplasms Dexamethasone 5.0415824018 11195469
MESH:D008175 Lung Neoplasms Isotretinoin 5.0415899809
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 5.0411807781
MESH:D008223 Lymphoma decitabine 3.4619470736
MESH:D016393 Lymphoma, B-Cell resveratrol 4.3617088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.9114749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.3315688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 6.5511606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 6.558985016
MESH:D008545 Melanoma Dacarbazine 7.5511135225 16939954 12535206 15577323 17023156 18176117 12883367 17334785 11254118 15917704 16966688 16098027 16248763 15020614 12202904 12556972 16760174 18505091 16273263 16034308 16508601 12417787 17761969 15176220 17623835 16809738 16225601 12025231 17562445 18089842 11712820 10623706 18332650 15522559 18281670 17973783 17508024 17119449 11746506 12439608 17576460 17239242 18445842 17709802 15577320 12640292 12393984 16928243
MESH:D008545 Melanoma decitabine 7.5517785578 16505122
MESH:D008545 Melanoma Isotretinoin 7.5517237267
MESH:D008545 Melanoma resveratrol 7.5517992120
MESH:D018328 Melanoma, Amelanotic Dacarbazine 6.0115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008659 Metabolic Diseases resveratrol 4.4317112576
MESH:D009101 Multiple Myeloma decitabine 12.4618172295
MESH:D009101 Multiple Myeloma Dexamethasone 12.4616118317 15867202 15744524
MESH:D009101 Multiple Myeloma resveratrol 12.4616267019 17049120 14749477 17164350 17935668 16490592
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.9517962980
MESH:D009190 Myelodysplastic Syndromes decitabine 7.7516882708 19010910 19157545 18608210
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 7.759809623
MESH:D009203 Myocardial Infarction resveratrol 3.0517188708 16317513 16525036 16456233 17125593 17015251
MESH:D017202 Myocardial Ischemia Arsenic 9.5115371236
MESH:D017202 Myocardial Ischemia resveratrol 9.5117125593 17015251
MESH:D009205 Myocarditis resveratrol 4.8417322642
MESH:D009369 Neoplasms decitabine 2.7319470736 17925555 19116145
MESH:D009374 Neoplasms, Experimental resveratrol 4.078985016
MESH:D009436 Neural Tube Defects Arsenic 3.4916620997
MESH:D009447 Neuroblastoma Isotretinoin 4.0717368321
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.5018514411
MESH:D019636 Neurodegenerative Diseases resveratrol 8.5017652729
MESH:D020078 Neurogenic Inflammation Arsenic 10.9017056641
MESH:D020078 Neurogenic Inflammation resveratrol 10.9017929310
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.3117513867
MESH:D010051 Ovarian Neoplasms Arsenic 8.1717306315
MESH:D010051 Ovarian Neoplasms decitabine 8.1719259094 19331143
MESH:D010051 Ovarian Neoplasms Mifepristone 8.1716525653
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010190 Pancreatic Neoplasms Dacarbazine 9.0811583197
MESH:D010190 Pancreatic Neoplasms decitabine 9.0819294695
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 9.0815976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.3612065085 18922899 8330346 18404319
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.2416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.0715371236 16905509 6392382
MESH:D003557 Phyllodes Tumor Dacarbazine 6.5917983394
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.5721297632
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 10.4918769834
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 10.4916679765
MESH:D055728 Primary Myelofibrosis decitabine 4.8017616702
MESH:D011471 Prostatic Neoplasms Arsenic 3.5316140617
MESH:D011471 Prostatic Neoplasms resveratrol 3.5317675339 15767336 17636462 17718901 17804756 16731767
MESH:D011507 Proteinuria Arsenic 4.0621343184
MESH:D011596 Psychomotor Disorders Isotretinoin 6.0018769834
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.6816325855
MESH:D015427 Reperfusion Injury resveratrol 3.3017520802 16314181 16317513 17058453 15827377
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.0711700416 18379247
MESH:D012208 Rhabdomyosarcoma decitabine 4.4619155313
MESH:D012509 Sarcoma Dacarbazine 5.3817898927 18313854
MESH:D012871 Skin Diseases Arsenic 2.7619834688 17938729 18709164 15952646 16353154 17050553 6392382 17548696 16759981 17453740 16702368
MESH:D012878 Skin Neoplasms Arsenic 9.8416251483 19538983 17050553 15504454 17029826 17976673
MESH:D012878 Skin Neoplasms resveratrol 9.848985016 15837718
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 9.8411807781 8330346 12065085 8985016 18404319
MESH:D013272 Stomach Diseases Dexamethasone 4.4015472012
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013276 Stomach Ulcer Dexamethasone 3.5415138204
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.5316321402
MESH:D013964 Thyroid Neoplasms Dacarbazine 8.0515634649 11815960
MESH:D013964 Thyroid Neoplasms decitabine 8.0517967635
MESH:D014062 Tongue Neoplasms resveratrol 4.2616227395
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.4315987713 11144890 17976673 19322015 19429237 18640142 17306315
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.4319087683 17616700
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.1517473185
MESH:D014594 Uterine Neoplasms resveratrol 4.2017044934
MESH:D014604 Uveal Neoplasms decitabine 5.0117785578
MESH:D014605 Uveitis Dexamethasone 4.911336536
MESH:D014625 Vaginal Neoplasms Dacarbazine 5.8315577323
MESH:D014652 Vascular Diseases Arsenic 4.8217056641
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.3717488730
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved