Annotation Detail for RAPGEF2
Basic Information
Top
| Gene Symbol: | RAPGEF2 ( CNrasGEF,NRAPGEP,PDZ-GEF1,PDZGEF1,RA-GEF,Rap-GEP,nRap GEP ) |
|---|
| Gene Full Name: | Rap guanine nucleotide exchange factor (GEF) 2 |
|---|
| Band: | 4q32.1 |
|---|
| Quick Links | Entrez ID:9693; OMIM: 609530; Uniprot ID:RPGF2_HUMAN; ENSEMBL ID: ENSG00000109756; HGNC ID: 16854 |
|---|
| Relate to Another Database: |
SFARIGene;
denovo-db |
| Pathway ID | Pathway Name |
|---|
| hsa04010 | MAPK signaling pathway |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D000082 |
Acetaminophen |
Acetaminophen affects the expression of RAPGEF2 mRNA | affects expression | 17562736
|
| D016718 |
Arachidonic Acid |
Arachidonic Acid results in increased expression of RAPGEF2 mRNA | increases expression | 16704987
|
| D015123 |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RAPGEF2 mRNA | decreases expression | 19150397
|
| D020122 |
tert-Butylhydroperoxide |
tert-Butylhydroperoxide results in increased expression of RAPGEF2 mRNA | increases expression | 15336504
|
| D009151 |
Mustard Gas |
Mustard Gas affects the expression of RAPGEF2 mRNA | affects expression | 15651846
|
| D013654 |
Taurine |
Taurine results in decreased expression of RAPGEF2 mRNA | decreases expression | 16579726
|
| C004648 |
testosterone enanthate |
testosterone enanthate affects the expression of RAPGEF2 mRNA | affects expression | 17440010
|
| C034613 |
triacsin C |
triacsin C results in increased expression of RAPGEF2 mRNA | increases expression | 16704987
|
| D014810 |
Vitamin E |
Vitamin E results in decreased expression of RAPGEF2 mRNA | decreases expression | 19244175
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000799 |
Angioedema |
|
Acetaminophen |
4.16 | 10982225 |
| MESH:D001249 |
Asthma |
|
Mustard Gas |
2.76 | 10378619 |
| MESH:D001321 |
Autistic Disorder |
|
Acetaminophen |
2.23 | 18445737 |
| MESH:D001321 |
Autistic Disorder |
|
Arachidonic Acid |
2.23 | 18582451 |
| MESH:D001768 |
Blister |
|
Mustard Gas |
5.44 | 19167455 |
| MESH:D001989 |
Bronchiolitis Obliterans |
|
Mustard Gas |
5.44 | 15286001 |
| MESH:D029481 |
Bronchitis, Chronic |
|
Mustard Gas |
5.29 | 17687719 10378619 |
| MESH:D002252 |
Carbon Tetrachloride Poisoning |
|
Vitamin E |
4.19 | 16050911 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Acetaminophen |
1.39 | 3084413 |
| MESH:D002386 |
Cataract |
|
Acetaminophen |
2.69 | 10977129 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
2.86 | 20889678 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
Vitamin E |
1.92 | 19769572 |
| MESH:D058065 |
Diabetic Cardiomyopathies |
|
Taurine |
6.34 | 16025228 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Acetaminophen |
4.47 | 16485898 16781746 10663392 14986274 15619225 19739265 10774834 14725611 19085960 17906064 17522070 11529661 15968718 12705907 16109766 11739529 17562736 19416960 19923254 14550746 2444490 11834606 16393943 12540782 19370779 12958197 18713872 18071297 19420014 11743745 12392966 10915739 11421492 16227642 16081117 11461765 19164858 11287661 16177239 12153990 12594235 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Taurine |
4.47 | 9328219 |
| MESH:D056487 |
Drug-Induced Liver Injury, Chronic |
|
Acetaminophen |
4.42 | 19426721 |
| MESH:C538011 |
Eales disease |
|
Vitamin E |
5.02 | 9068938 |
| MESH:D004487 |
Edema |
|
Arachidonic Acid |
8.14 | 11698051 9599246 9831321 7990266 16716910 15177302 |
| MESH:D004487 |
Edema |
|
Mustard Gas |
8.14 | 9260866 11428647 11428631 11402378 |
| MESH:D004890 |
Erythema |
|
Mustard Gas |
5.44 | 9357497 |
| MESH:D004938 |
Esophageal Neoplasms |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
2.11 | 20426865 |
| MESH:D005334 |
Fever |
|
Arachidonic Acid |
4.85 | 11852909 |
| MESH:D005756 |
Gastritis |
|
Acetaminophen |
3.99 | 16983495 |
| MESH:D006330 |
Heart Defects, Congenital |
|
Vitamin E |
3.08 | 16080930 |
| MESH:D006548 |
Hernia, Diaphragmatic |
|
Vitamin E |
2.76 | 16490937 16863852 |
| MESH:D019247 |
HIV Wasting Syndrome |
|
testosterone enanthate |
6.06 | 17440010 |
| MESH:D019584 |
Hot Flashes |
|
Vitamin E |
4.29 | 14716179 |
| MESH:D006930 |
Hyperalgesia |
|
Acetaminophen |
2.86 | 16870215 |
| MESH:D007249 |
Inflammation |
|
Arachidonic Acid |
5.98 | 17371808 9831321 15177302 |
| MESH:D007249 |
Inflammation |
|
Mustard Gas |
5.98 | 11428647 17524151 9357497 11428620 16001271 9260866 11402378 11428631 8975870 |
| MESH:D007251 |
Influenza, Human |
|
Vitamin E |
4.53 | 16624496 |
| MESH:D007674 |
Kidney Diseases |
|
Acetaminophen |
6.33 | 15629191 12587719 |
| MESH:D007674 |
Kidney Diseases |
|
Vitamin E |
6.33 | 12488133 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Taurine |
3.14 | 15931870 15893842 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Vitamin E |
3.14 | 16169303 |
| MESH:D008107 |
Liver Diseases |
|
Acetaminophen |
1.67 | 19460945 11587558 19014921 16611625 19784758 16610002 12969438 12587719 |
| MESH:D017114 |
Liver Failure, Acute |
|
Acetaminophen |
3.43 | 17185352 16871587 |
| MESH:D008171 |
Lung Diseases |
|
Mustard Gas |
7.99 | 18702808 18161513 |
| MESH:D008171 |
Lung Diseases |
|
Vitamin E |
7.99 | 16863852 |
| MESH:D008175 |
Lung Neoplasms |
|
Mustard Gas |
2.70 | 8781369 3148597 |
| MESH:D008175 |
Lung Neoplasms |
|
Vitamin E |
2.70 | 11062179 |
| MESH:D008546 |
Melanoma, Experimental |
|
Acetaminophen |
3.83 | 19513568 |
| MESH:D019636 |
Neurodegenerative Diseases |
|
Acetaminophen |
3.04 | 18514411 |
| MESH:D009503 |
Neutropenia |
|
Mustard Gas |
4.19 | 16761898 7688884 |
| MESH:D010146 |
Pain |
|
Acetaminophen |
2.56 | 16870215 |
| MESH:D011041 |
Poisoning |
|
Mustard Gas |
4.02 | 15727166 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Vitamin E |
3.27 | 15084515 |
| MESH:D011537 |
Pruritus |
|
Mustard Gas |
4.38 | 18058305 |
| MESH:D011658 |
Pulmonary Fibrosis |
|
Mustard Gas |
2.99 | 17266442 17620002 10334151 17720292 17894541 |
| MESH:D012871 |
Skin Diseases |
|
Mustard Gas |
5.18 | 16961503 12880345 15451306 |
| MESH:D012871 |
Skin Diseases |
|
Vitamin E |
5.18 | 18709164 |
| MESH:D012878 |
Skin Neoplasms |
|
tert-Butylhydroperoxide |
2.77 | 8532709 |
| MESH:D020521 |
Stroke |
|
Vitamin E |
3.68 | 16517955 |
| MESH:D014581 |
Urticaria |
|
Acetaminophen |
3.20 | 10982225 |
| Pathway ID |
Pathway Name |
|---|
| KEGG:04010 |
MAPK signaling pathway |
Related Diseases/Disorders