AutismKB 2.0

Annotation Detail for RIMS2


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Basic Information Top
Gene Symbol:RIMS2 ( DKFZp781A0653,KIAA0751,OBOE,RAB3IP3,RIM2 )
Gene Full Name: regulating synaptic membrane exocytosis 2
Band: 8q22.3
Quick LinksEntrez ID:9699; OMIM: 606630; Uniprot ID:RIMS2_HUMAN; ENSEMBL ID: ENSG00000176406; HGNC ID: 17283
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P05734Synaptic vesicle trafficking
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Related Diseases/Disorders Top
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Desease Name
CHEMDEPENDENCY
smoking cessation
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of RIMS2 mRNAdecreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RIMS2 mRNAaffects expression 16483693
D003474 Curcumin Curcumin results in decreased expression of RIMS2 mRNAdecreases expression 17999991
C065180 fluvastatin [zoledronic acid co-treated with fluvastatin] results in increased expression of RIMS2 mRNAaffects cotreatment|increases expression 16996129
C011890 kojic acid kojic acid results in decreased expression of RIMS2 mRNAdecreases expression 16595896
C006253 pirinixic acid pirinixic acid results in increased expression of RIMS2 mRNAincreases expression 18301758
C025643 vinclozolin vinclozolin affects the expression of RIMS2 mRNAaffects expression 19015723
C088658 zoledronic acid [zoledronic acid co-treated with fluvastatin] results in increased expression of RIMS2 mRNAaffects cotreatment|increases expression 16996129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D058186 Acute Kidney Injury zoledronic acid 4.7019715164
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.8220200999
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D019973 Alcohol-Related Disorders Curcumin 5.4617887948
MESH:D000544 Alzheimer Disease Curcumin 2.6615590663
MESH:D001008 Anxiety Disorders vinclozolin 3.8319015723
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7816807698
MESH:D050197 Atherosclerosis Curcumin 3.4518704882
MESH:D001327 Autoimmune Diseases Curcumin 4.8019761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4011289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001859 Bone Neoplasms zoledronic acid 5.2217312309 19442620 16778634 11697798 16121404 15867366
MESH:D001862 Bone Resorption zoledronic acid 4.9418404659 8053405 11869084 16769263 15845617 18496637
MESH:D002545 Brain Ischemia Curcumin 4.6716770732
MESH:D001932 Brain Neoplasms Curcumin 4.1617596214
MESH:D001943 Breast Neoplasms Curcumin 2.7218462866 19250217 16243823 18593918
MESH:D001943 Breast Neoplasms zoledronic acid 2.7218695136 16096432
MESH:D002277 Carcinoma Curcumin 4.0318593918
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.773581430 7296757
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 6.2018414057
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 6.2019233551
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 7.137296757
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 7.1318507039
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8218462866
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.917505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.4319486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.4319176532
MESH:D003092 Colitis Curcumin 4.4816804969 16782535 18200517
MESH:D003103 Coloboma Curcumin 4.7918809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5319359593 16340194
MESH:D016510 Corneal Neovascularization Curcumin 5.2018497527
MESH:D003327 Coronary Disease fluvastatin 4.9516142594
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.102524372 8156756 14531868 8970840 11906362 11298694 18759878 12868966
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.752952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7518403477
MESH:D003928 Diabetic Nephropathies Curcumin 4.2218204486
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.0118289764 16192314 8291058 7440962 18648102 9653073 18692083 6679447 11289319 9328219 9022650 6482804 1440618
MESH:D004381 Duodenal Ulcer Curcumin 4.3317351913
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005234 Fatty Liver Curcumin 8.6919297423
MESH:D005234 Fatty Liver pirinixic acid 8.6919236843 20131406
MESH:D005264 Femoral Fractures zoledronic acid 6.1716234978
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005355 Fibrosis Curcumin 4.2918705752
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.0018462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D005909 Glioblastoma Curcumin 3.6217596214
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006258 Head and Neck Neoplasms Curcumin 3.8118829502 18462866
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006529 Hepatomegaly pirinixic acid 3.3016221962 19176532 19772884 18467677
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.3517701891
MESH:D006930 Hyperalgesia zoledronic acid 4.4416769263
MESH:D006934 Hypercalcemia zoledronic acid 5.2919622757 18089816
MESH:D006937 Hypercholesterolemia Curcumin 4.2918704882
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D006996 Hypocalcemia zoledronic acid 6.5712669777
MESH:D007248 Infertility, Male vinclozolin 3.1916467254
MESH:D007249 Inflammation Curcumin 3.0017151092 16956363 18403477
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2918200517 18596194
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007414 Intestinal Neoplasms Curcumin 4.4510783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.408074119 9022650
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.176582329
MESH:D007889 Leiomyoma Curcumin 4.8318555241
MESH:D007938 Leukemia Curcumin 3.3418462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 10.9416106398
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 10.9418089816
MESH:D015458 Leukemia, T-Cell Curcumin 5.0416106398
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.5818705752 18006644 17355460
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5815474484
MESH:D008107 Liver Diseases Curcumin 2.6616956363
MESH:D008113 Liver Neoplasms pirinixic acid 1.8920007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.656587162 1399818 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental kojic acid 6.6518544905
MESH:D008175 Lung Neoplasms Curcumin 2.2816243823 19359593 18462866
MESH:D008223 Lymphoma Curcumin 3.7518462866
MESH:D016399 Lymphoma, T-Cell Curcumin 5.0016173963
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 3.8617312309
MESH:D008545 Melanoma Curcumin 2.4417885582 18462866
MESH:D008569 Memory Disorders Curcumin 4.4317263510
MESH:D008654 Mesothelioma zoledronic acid 3.8316675582
MESH:D009101 Multiple Myeloma Curcumin 13.4719372569
MESH:D009101 Multiple Myeloma fluvastatin 13.4716996129
MESH:D009101 Multiple Myeloma zoledronic acid 13.4716996129 18089719 19621390
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.2617962980
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009361 Neoplasm Invasiveness Curcumin 4.6518495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.373581430
MESH:D009362 Neoplasm Metastasis zoledronic acid 6.3717312309 15867366 19139120
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.9112497104
MESH:D009423 Nervous System Neoplasms Curcumin 6.0118462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D009765 Obesity Curcumin 4.7719297423
MESH:D009765 Obesity pirinixic acid 4.7720558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.656482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010014 Osteolysis zoledronic acid 5.7115867366
MESH:D010024 Osteoporosis Curcumin 8.1118719352
MESH:D010024 Osteoporosis zoledronic acid 8.1117882678
MESH:D010051 Ovarian Neoplasms Curcumin 2.8819020741 18462866
MESH:D010146 Pain zoledronic acid 4.1316475674
MESH:D010190 Pancreatic Neoplasms Curcumin 3.0019401701 17440100 19196508
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.2318042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D011471 Prostatic Neoplasms Curcumin 3.7418769126 12497104 15129424 11398177 10851300 18156803 18226269
MESH:D011471 Prostatic Neoplasms zoledronic acid 3.7419103299 12438248
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D011656 Pulmonary Emphysema Curcumin 4.7619168576
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.2818379247 10666014
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012509 Sarcoma Curcumin 4.3418462866
MESH:D012512 Sarcoma, Ewing's zoledronic acid 5.2116121404
MESH:D018805 Sepsis Curcumin 4.2818389075
MESH:D013276 Stomach Ulcer Curcumin 3.7316631530 19188055
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.061399818 6587162 7505956 6582329 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.508074119
MESH:D001749 Urinary Bladder Neoplasms Curcumin 5.5018593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.6018462866
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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