AutismKB 2.0

Annotation Detail for CEP57


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Basic Information Top
Gene Symbol:CEP57 ( KIAA0092,PIG8,TSP57 )
Gene Full Name: centrosomal protein 57kDa
Band: 11q21
Quick LinksEntrez ID:9702; OMIM: 607951; Uniprot ID:CEP57_HUMAN; ENSEMBL ID: ENSG00000166037; HGNC ID: 30794
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Cell Cycle, Mitotic
No data
No data
Pathway IDPathway Name
500383Loss of proteins required for interphase microtubule organization from the centrosome
500384Loss of Nlp from mitotic centrosomes
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CEP57 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of CEP57 mRNAincreases expression 20406850
C006632 arsenic trioxide arsenic trioxide results in increased expression of CEP57 mRNAincreases expression 14703492
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CEP57 mRNAdecreases expression 20018196
19150397
C006780 bisphenol A bisphenol A results in decreased expression of CEP57 mRNAdecreases expression 20678512
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of CEP57 mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of CEP57 mRNAincreases expression 20106945
C014347 decitabine decitabine results in decreased expression of CEP57 mRNAdecreases expression 19363521
C014347 decitabine TP53 protein affects the reaction [decitabine results in decreased expression of CEP57 mRNA]affects reaction|decreases expression 19363521
D008727 Methotrexate CEP57 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D016685 Mitomycin CEP57 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D011374 Progesterone Progesterone results in increased expression of CEP57 mRNAincreases expression 18070364
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of CEP57 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of CEP57 mRNAdecreases expression 19244175
C004648 testosterone enanthate testosterone enanthate affects the expression of CEP57 mRNAaffects expression 17440010
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of CEP57 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of CEP57 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 4.3312039119
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3019825857 11798837
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1117286800
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.7216206674
MESH:D001862 Bone Resorption bisphenol A 3.9211985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4317868700
MESH:D001930 Brain Injuries Progesterone 4.3315665606 15380490 15845082
MESH:D001943 Breast Neoplasms bisphenol A 2.0517123778
MESH:D001943 Breast Neoplasms decitabine 2.0518320071 19208741
MESH:D001943 Breast Neoplasms Methotrexate 2.0516978400
MESH:D001943 Breast Neoplasms Progesterone 2.0517614352 15562024 16175315
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3911589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0016050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6316705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.6314691202 15073043 16217749 11135700 15553829
MESH:D002278 Carcinoma in Situ bisphenol A 5.0717123778
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9719014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1712490120
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6119215824
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.356135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.3520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.3512371664
MESH:D002779 Cholestasis Cyclosporine 2.9519486331
MESH:D003092 Colitis Selenium 3.8517936198
MESH:D003110 Colonic Neoplasms decitabine 2.3417616700
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5920501625
MESH:D015179 Colorectal Neoplasms decitabine 2.5918981723
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.9910525206
MESH:D019465 Craniofacial Abnormalities Methotrexate 3.9912039119 9562676
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.9919769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.1418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.1418551238
MESH:D003550 Cystic Fibrosis Methotrexate 4.2919747007
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1515213294
MESH:D003882 Dermatomyositis Methotrexate 5.1920191521
MESH:D003929 Diabetic Neuropathies Progesterone 4.5617187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.3421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.3421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Selenium 6.3415131321
MESH:C538011 Eales disease Vitamin E 4.809068938
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.8417692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2119294695
MESH:D004715 Endometriosis Progesterone 3.8216134523
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5020426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5012903497
MESH:D005234 Fatty Liver arsenic trioxide 7.9315073043
MESH:D005234 Fatty Liver Cyclosporine 7.9319224547
MESH:D005355 Fibrosis Cyclosporine 3.2112168785 12639820
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3316904648
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D006086 Graft vs Host Disease Methotrexate 5.2216518429
MESH:D006258 Head and Neck Neoplasms decitabine 3.5219215824
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0116080930
MESH:D006333 Heart Failure Selenium 3.1117162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7216490937 16863852
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8417440010
MESH:D019584 Hot Flashes Vitamin E 4.0714716179
MESH:D006973 Hypertension Cyclosporine 2.1210903974
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4715869954
MESH:D007248 Infertility, Male decitabine 3.2417581917
MESH:D007249 Inflammation Progesterone 2.6215869954
MESH:D007251 Influenza, Human Selenium 11.2916624496
MESH:D007251 Influenza, Human Vitamin E 11.2916624496
MESH:D007333 Insulin Resistance bisphenol A 3.3216393666
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Cyclosporine 6.128314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 6.1212488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9416518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.6316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.6316705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.6312371664
MESH:D007805 Language Development Disorders Methotrexate 5.169562676
MESH:D007938 Leukemia arsenic trioxide 6.5415070760
MESH:D007938 Leukemia decitabine 6.5418980019 19235587
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8517077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4714633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.7719077051
MESH:D007951 Leukemia, Myeloid decitabine 9.7718454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0220471514 19850784 17050201 16467208 16968895
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.0219010910 17679729 18206229 18460780 19387464 18704418
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.5618055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2515622746 15748426 19075265 15336539 17217047 11161223 9834237 16966277 19035177 12679006 19642359 16330433 16891316 19225113 16823087 17869043 17712046 16331271 15213294 11468182 17649720 16112521 17107899 12018890 12712474
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4216882451
MESH:D008103 Liver Cirrhosis Methotrexate 3.7314986274
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.727678174
MESH:D008113 Liver Neoplasms arsenic trioxide 7.7214682389
MESH:D008113 Liver Neoplasms Mitomycin 7.7215113037
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.072876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.0720377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3915213294
MESH:D008171 Lung Diseases Vitamin E 3.2116863852
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.1218516814
MESH:D008175 Lung Neoplasms arsenic trioxide 2.5519825857 11798837
MESH:D008175 Lung Neoplasms Vitamin E 2.5511062179
MESH:D008223 Lymphoma decitabine 8.0319470736
MESH:D008223 Lymphoma Methotrexate 8.0317352296
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.2411408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.2415318939
MESH:D008545 Melanoma decitabine 2.2517785578 16505122
MESH:D008654 Mesothelioma Selenium 2.8115107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:C536987 Mosaic variegated aneuploidy syndrome marker/mechanism 21552266
MESH:D052016 Mucositis Methotrexate 5.3617488658
MESH:D009101 Multiple Myeloma arsenic trioxide 7.5014977855 19417148 15949261 19549372 11468182
MESH:D009101 Multiple Myeloma decitabine 7.5018172295
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.6016105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 7.6019157545 16882708 19010910 18608210
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.6318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.6318551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0216624393
MESH:D009369 Neoplasms decitabine 2.7319116145 17925555 19470736
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3319348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 4.0411399458 16427766
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1510525206
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.0612819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.0616049721
MESH:D010049 Ovarian Diseases bisphenol A 5.0711985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.0519769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms decitabine 8.0519331143 19259094
MESH:D010051 Ovarian Neoplasms Progesterone 8.0517393432 16525653
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.9015580305
MESH:D010190 Pancreatic Neoplasms decitabine 8.9019294695
MESH:D010190 Pancreatic Neoplasms Mitomycin 8.9015113037
MESH:D010235 Paraganglioma arsenic trioxide 4.2219927285
MESH:D010954 Plasmacytoma Selenium 4.9915087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.0310548101
MESH:D055728 Primary Myelofibrosis decitabine 4.8017616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.2620887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6019131511
MESH:D011471 Prostatic Neoplasms bisphenol A 2.6016740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6015084515
MESH:D011565 Psoriasis Cyclosporine 5.9716882103
MESH:D011565 Psoriasis Methotrexate 5.9717410198
MESH:D011629 Puberty, Precocious bisphenol A 4.8710548101
MESH:D051437 Renal Insufficiency Methotrexate 4.7817352296
MESH:D012208 Rhabdomyosarcoma decitabine 4.4619155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8718045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0216646077
MESH:D012640 Seizures 2,4-dinitrotoluene 5.9918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.9918551238
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.718532709
MESH:D013119 Spinal Cord Injuries Progesterone 4.3616503802 15862959
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.5817007042
MESH:D013274 Stomach Neoplasms decitabine 2.5819037991
MESH:D020521 Stroke Vitamin E 3.5616517955
MESH:D019966 Substance-Related Disorders bisphenol A 4.0716684133 16045194
MESH:D013576 Syndactyly Methotrexate 5.109562676
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.4619014326
MESH:D013964 Thyroid Neoplasms decitabine 7.4617967635
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0415213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.1116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.1116049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.1112845720 20435036 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms decitabine 12.1117616700 19087683
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.2710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.2710091137
MESH:D014591 Uterine Diseases bisphenol A 5.1114652134
MESH:D014604 Uveal Neoplasms decitabine 5.0117785578
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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