AutismKB 2.0

Annotation Detail for USP6NL


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Basic Information Top
Gene Symbol:USP6NL ( KIAA0019,RNTRE,TRE2NL )
Gene Full Name: USP6 N-terminal like
Band: 10p14
Quick LinksEntrez ID:9712; OMIM: 605405; Uniprot ID:US6NL_HUMAN; ENSEMBL ID: ENSG00000148429; HGNC ID: 16858
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200113ErbB1 downstream signaling
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of USP6NL mRNAaffects expression 17562736
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of USP6NL mRNA]affects reaction|increases expression 18700144
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of USP6NL mRNAaffects expression 17484886
D002117 Calcitriol Calcitriol results in increased expression of USP6NL mRNAincreases expression 16002434
D010634 Phenobarbital Phenobarbital results in decreased expression of USP6NL mRNAdecreases expression 19270015
C017947 sodium arsenite sodium arsenite results in increased expression of USP6NL mRNAincreases expression 16014739
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of USP6NL mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.886195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.8814514962 15322242 11752688
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.6717620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.6716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.2215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.4217306315 16712894
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Calcitriol 2.0811237771
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0820435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2018705752 16227642 16097048 10355542 16050911 15700767 16011737 15721981 16124888 15673190 3786805 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.903084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.9018788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.901701930 17173139 6705139 20007298 20935162
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.9017306315 16507464 15276417
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 5.0611237771
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 5.0618572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5216120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.1920056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.674080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.218697196 16354765 15340226 15668235 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5816393943 12540782 11739529 14725611 16081117 19739265 10663392 12705907 19164858 16781746 10774834 17906064 12594235 14550746 17562736 11287661 19420014 11529661 17522070 10915739 16227642 14986274 11461765 18713872 19370779 12153990 11421492 16485898 11743745 2444490 19923254 12392966 15968718 12958197 16109766 15619225 16177239 11834606 19416960 19085960 18071297
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.587120509 10915739 15968718 2869522 16227642 21278145 16177239 7179309 3732212 6623471 19085960 11566570 3786805 15998439 19336974 15027814 9327722 10092053 4309450 7440962 17522070 6884620
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004421 Dystonia Phenobarbital 4.361851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4215322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.3115138306
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3310568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.533659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.3911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.836401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.677750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.483659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.4915959796 12631006 16239168 12795759 17595544 16045604 61145 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 10.0218705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.0220067830
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.1416452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4710048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9719900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 9.8716109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.8715340226 12621046 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 3.4312676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.578697196 15340226 16959395 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9916899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5015338365
MESH:D007248 Infertility, Male sodium arsenite 3.1912646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007674 Kidney Diseases Acetaminophen 6.5115629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 6.5120008137
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.1511903743 17174718 17157831 16221502 17334410 11408273 16239168 16943688 21278145
MESH:D008103 Liver Cirrhosis Phenobarbital 7.1521047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3618187930 14716833 17766677 12649538 18418968 14512876 17631135 18166357 18156304 12609069 18395914 15876570 18429990 16136751 17714472 12445421 12958196 16097048 16192424 18277467 17525996 15673190 10355542 11481614 18339082 17761835 16027843 14748882 15362042 15925388 15123356 15370692 12741479 18705752 18376398 14724832 18205269 17944888 18412020 15893842 17721639 17481882 18251166 17557913 12586293 18472094 13678700 17565644 18279442 16015684 15818738 17869086 12632512 18472332 15996030 16116963 12667390 12389079 12445418 12546737 17823541 18210741 15052691 18054572 15730626 15931870 16248980 14620537 18395095 18481824 18263696 18317297 14716496 20821823 15338365 12666154 17640975 15959796 17900296 15057751 18420326 17805973 16638106 18006644 16011737 17698563 17708605 12898905 12632514 15650968 17922224 17976157 16033810
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3612878042
MESH:D008107 Liver Diseases Acetaminophen 6.8819460945 12587719 19014921 16610002 19784758 11587558 12969438 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.8816246199 15720792 17285989 15830285 16964402
MESH:D008107 Liver Diseases Phenobarbital 6.8819363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.4416871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.4414706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.5419294768
MESH:D008113 Liver Neoplasms Phenobarbital 11.5421047994 19073162 8742319 15975961 19482888 19812893
MESH:D008113 Liver Neoplasms sodium arsenite 11.5416712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.5416984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.8915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.8918308698 17172636 6150874 1399818 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.8912151625
MESH:D008171 Lung Diseases sodium arsenite 3.3719095001
MESH:D008175 Lung Neoplasms sodium arsenite 2.3817306315 17077188 19931552 15276417 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3819555203 11884234
MESH:D008545 Melanoma sodium arsenite 2.0619082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.9417484760
MESH:D009369 Neoplasms sodium arsenite 2.6311559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.0820056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.3312854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D010018 Osteomalacia Phenobarbital 4.8317016548
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5115276417 17306315
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5816965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.912563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511222880 11118676 11399792 11896295
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.2415572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.3312479363 15754350 16289102 18247401 16644109
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3316039940
MESH:D019310 Pseudolymphoma Phenobarbital 5.0212752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012640 Seizures Phenobarbital 2.893137016 4039156 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.286407741
MESH:D012878 Skin Neoplasms sodium arsenite 6.0218572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0216192470
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0412854658
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.291399818
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.6016452187 16712894 11723127 17306315
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.0711813266
MESH:D014652 Vascular Diseases sodium arsenite 4.8917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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