AutismKB 2.0

Annotation Detail for CD74


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Basic Information Top
Gene Symbol:CD74 ( DHLAG,HLADG,II,Ia-GAMMA )
Gene Full Name: CD74 molecule, major histocompatibility complex, class II invariant chain
Band: 5q33.1
Quick LinksEntrez ID:972; OMIM: 142790; Uniprot ID:HG2A_HUMAN; ENSEMBL ID: ENSG00000019582; HGNC ID: 1697
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04612Antigen processing and presentation
No data
No data
Pathway IDPathway Name
P00053T cell activation
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C019499 2-nitrofluorene 2-nitrofluorene results in increased expression of CD74 mRNAincreases expression 14600272
D000082 Acetaminophen Acetaminophen affects the expression of CD74 mRNAaffects expression 17562736
15606129
C061133 Am 80 Am 80 results in increased expression of CD74 mRNAincreases expression 17229644
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CD74 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of CD74 mRNAincreases expression 20458559
D001554 Benzene Benzene results in decreased expression of CD74 mRNAdecreases expression 17905399
C068337 bergamottin bergamottin results in decreased expression of CD74 mRNAdecreases expression 18818744
C095105 bexarotene bexarotene results in increased expression of CD74 mRNAincreases expression 16648578
D002251 Carbon Tetrachloride PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CD74 mRNA]affects reaction|increases expression 18038451
D003520 Cyclophosphamide Cyclophosphamide results in decreased expression of CD74 mRNAdecreases expression 15331540
D004041 Dietary Fats Dietary Fats results in decreased expression of CD74 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of CD74 mRNAincreases expression 19638242
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of CD74 mRNAincreases expression 14600272
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CD74 mRNAdecreases expression 17606305
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CD74 mRNAdecreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CD74 mRNAaffects cotreatment|decreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CD74 mRNAincreases expression 12655037
17351261
C043055 gallium arsenide gallium arsenide results in increased cleavage of CD74 proteinincreases cleavage 12583989
D006581 Hexachlorobenzene Hexachlorobenzene results in decreased expression of CD74 mRNAdecreases expression 15159207
C505097 IMMU-110 IMMU-110 binds to CD74 proteinaffects binding 16033844
D007501 Iron Iron deficiency results in decreased expression of CD74 mRNAdecreases expression 20368581
D047311 Luteolin Luteolin results in decreased expression of CD74 mRNAdecreases expression 18818744
C083079 N-(3-nitratopivaloyl)cysteine ethyl ester N-(3-nitratopivaloyl)cysteine ethyl ester results in decreased expression of CD74 proteindecreases expression 11046123
C008661 nobiletin nobiletin results in decreased expression of CD74 mRNAdecreases expression 18818744
C041786 palm oil palm oil results in decreased expression of CD74 mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CD74 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of CD74 mRNAdecreases expression 15375163
17426115
C006253 pirinixic acid pirinixic acid results in decreased expression of CD74 mRNAdecreases expression 12832660
D011435 Propyl Gallate Propyl Gallate affects the expression of CD74 mRNAaffects expression 18539377
D011794 Quercetin Quercetin results in decreased expression of CD74 mRNAdecreases expression 18818744
D011794 Quercetin Quercetin results in increased expression of CD74 mRNAincreases expression 16455785
D020849 Raloxifene Raloxifene affects the expression of CD74 mRNAaffects expression 16079270
D012643 Selenium Selenium results in increased expression of CD74 mRNAincreases expression 19244175
C017947 sodium arsenite sodium arsenite results in decreased expression of CD74 mRNAdecreases expression 12634122
C017947 sodium arsenite sodium arsenite results in increased expression of CD74 mRNAincreases expression 16322246
C115703 SP 5186 SP 5186 results in decreased expression of CD74 proteindecreases expression 11046123
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CD74 mRNAaffects cotreatment|decreases expression 17942748
D014241 Trichloroethylene Trichloroethylene results in decreased expression of CD74 mRNAdecreases expression 17905399
C025643 vinclozolin vinclozolin affects the expression of CD74 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5414514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.2518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6317505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8318653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.6511798837 19825857
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 6.6516033868
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.6514692618
MESH:D000236 Adenoma Diethylnitrosamine 6.3610737359 6695378
MESH:D000236 Adenoma Dimethylnitrosamine 6.3619555203
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 15.4719052882 19061943 16434500 17620307 18056438 17162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.4716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.4716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3815276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5916712894 17306315
MESH:D000419 Albuminuria Raloxifene 4.3017451421 17308373
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.3416640825
MESH:D000544 Alzheimer Disease Iron 4.3216563566 16640825
MESH:D000544 Alzheimer Disease Raloxifene 4.3215800139
MESH:D000740 Anemia Iron 8.0316434484 16566752
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.0311748828
MESH:D000741 Anemia, Aplastic Benzene 4.1314761424 17661222 11369114
MESH:D000743 Anemia, Hemolytic Quercetin 3.9617084956
MESH:D018798 Anemia, Iron-Deficiency Iron 4.3817162259 17163184 16569441 17147795 17375513
MESH:D000756 Anemia, Sideroblastic Iron 4.5316910769
MESH:D000799 Angioedema Acetaminophen 3.5310982225
MESH:D001008 Anxiety Disorders vinclozolin 3.4019015723
MESH:D001145 Arrhythmias, Cardiac Iron 4.1016604332
MESH:D001161 Arteriosclerosis Cyclophosphamide 15.3115014928
MESH:D001161 Arteriosclerosis Dietary Fats 15.3115238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 15.3111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4715885639
MESH:D001172 Arthritis, Rheumatoid Am 80 3.6816819260
MESH:D001260 Ataxia Telangiectasia Iron 12.0715336622
MESH:D001260 Ataxia Telangiectasia Quercetin 12.0715336622
MESH:D050197 Atherosclerosis Am 80 6.8416484594
MESH:D050197 Atherosclerosis Iron 6.8416632123 16640825
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Iron 2.1417352947
MESH:D001327 Autoimmune Diseases Quercetin 4.1019761891
MESH:D001424 Bacterial Infections Iron 4.8816640825
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 13.6716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.6719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.6712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5715746008
MESH:D001855 Bone Marrow Diseases Benzene 4.9116183116
MESH:D001930 Brain Injuries Raloxifene 4.1716580743
MESH:D001943 Breast Neoplasms Benzene 6.6517162533 11921183
MESH:D001943 Breast Neoplasms bexarotene 6.6516344269 16818667
MESH:D001943 Breast Neoplasms Cyclophosphamide 6.6516978400 11325840 17020986 17388661 15136595 18323546 15093573 12006526 18234424
MESH:D001943 Breast Neoplasms Dietary Fats 6.6520435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 6.6517474063
MESH:D001943 Breast Neoplasms Hexachlorobenzene 6.6512709520 15061365
MESH:D001943 Breast Neoplasms Quercetin 6.6518628248
MESH:D001943 Breast Neoplasms Raloxifene 6.6517595753 15572757 17952589 16912660 15775269 15758505 17261762 17242785 17049068 17893378 16837676 17440819
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.6520435547
MESH:D001943 Breast Neoplasms Trichloroethylene 6.6515986119
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0411589617
MESH:D002105 Cadmium Poisoning Quercetin 5.2316962696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4815673190 16227642 15721981 16097048 16050911 16124888 3786805 18705752 15700767 16011737 16192424 10355542
MESH:D002277 Carcinoma Dimethylnitrosamine 7.5519555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.5516835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.233084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.2315553829 11135700 16217749 15073043 14691202
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.2318788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 13.2319701751
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.2318506893 18785209 16779866 20512989 17978847 20935162 17761372 16540662 16502159 18494052 18210153 17428255 3084413 20101231 19822196 16698587 17138121 18978308 18393292 20524982 11831363 19107877 16935385 19383236 19539802 19335982 17173139 19394651 21159647 3581430 16288022 20084675 16569478 19519916 20727157 16807293 19701751 17162532 20007298 16830150 19171122 18691550 19208518 18056438 20214788 16878318 16328049 18788625 19052882 18665156 10737359 19418558 16681979 10672840 19919837 18971187 20514400 20432363 17055752
MESH:D006528 Carcinoma, Hepatocellular Quercetin 13.2312508355 19519916
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.2317306315 16507464 15276417
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.5816152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.1216247446
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.6517234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5619014326
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.3916201981
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8512490120
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 4.6116033868
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.6118572023
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.8017572228
MESH:D006332 Cardiomegaly Quercetin 6.2319794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.2318670907 18850075 16120746
MESH:D009202 Cardiomyopathies Iron 3.8416640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.3516604332
MESH:D002318 Cardiovascular Diseases Raloxifene 3.2315775269
MESH:D002386 Cataract Acetaminophen 2.4010977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.0721159647 7505956 17174075 2727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.0719524636 20056578
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.4619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.4616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 6.9917110522 16919318 17333356 11677210 15861022 17681005 16105132
MESH:D002779 Cholestasis pirinixic acid 6.9919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.978697196 15668235 16354765 12621046 15340226
MESH:D003072 Cognition Disorders Raloxifene 4.3115800139
MESH:D003092 Colitis Selenium 3.4817936198
MESH:D003110 Colonic Neoplasms Iron 3.9316640825
MESH:D003110 Colonic Neoplasms Quercetin 3.9315741050 11134977 17148506 16640504 17191121 19056647 19440933
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5320501625
MESH:D015179 Colorectal Neoplasms Quercetin 2.5318095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8017141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.6310525206
MESH:D019465 Craniofacial Abnormalities Benzene 3.6315643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6310048152 15322242 20055451
MESH:D003456 Cryptorchidism vinclozolin 4.0514966744
MESH:D003556 Cystitis Cyclophosphamide 4.6718295254 18433785 10700343 12913760 18710439 18093676 18483878 16614059 17979934 16413132 16651033 15276878 12161096 18372110 17010015 11948286 15643279 10498854 12388444 16989017
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8115213294
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9017474826
MESH:D003872 Dermatitis Benzene 4.4615902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2818249437
MESH:D003920 Diabetes Mellitus Iron 4.1916640825 16604332
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 7.8310990075 15331540 11751995
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 7.8319496084
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 5.6418772604
MESH:D003922 Diabetes Mellitus, Type 1 Iron 5.6416506275
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.7020387270
MESH:D003924 Diabetes Mellitus, Type 2 Iron 6.7016506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7017107852
MESH:D003928 Diabetic Nephropathies Raloxifene 3.6815920148 17308373 17451421
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 17.1619739265 17906064 11743745 16109766 11739529 18071297 11461765 12705907 18713872 11421492 16781746 15968718 19416960 19085960 14725611 16177239 12153990 10915739 15619225 11287661 10774834 16081117 2444490 17522070 14550746 10663392 19420014 16393943 14986274 19164858 12540782 11834606 12594235 11529661 19370779 12392966 16227642 17562736 12958197 16485898 19923254
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 17.167440962 7120509 2869522 7179309 4309450 6884620 19085960 10915739 17522070 10092053 16227642 3786805 16177239 6623471 15968718 15027814 19336974 21278145 9327722 15998439 3732212 11566570
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 17.1619107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 17.168172417
MESH:D056486 Drug-Induced Liver Injury Selenium 17.1615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 17.1620420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 17.167120509
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7819426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2318367378
MESH:D004487 Edema pirinixic acid 9.8412083418
MESH:D004487 Edema Raloxifene 9.8415860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.8412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5915322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Am 80 13.8516819260
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.8512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 13.8515845917
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7610568697 9294722
MESH:D004802 Eosinophilia Cyclophosphamide 3.9211006010
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8016302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.4812903497
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 4.4817016578
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7811564622
MESH:D005234 Fatty Liver arsenic trioxide 38.4915073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 38.4919224547 16239168 17595544 15959796 16045604 12631006 61145 12795759
MESH:D005234 Fatty Liver Dietary Fats 38.4919004024 17967931 19551842 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 38.4921071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 38.4915345470
MESH:D005234 Fatty Liver Iron 38.4916640825
MESH:D005234 Fatty Liver pirinixic acid 38.4920131406 19236843
MESH:D005234 Fatty Liver Raloxifene 38.4917473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1511858732
MESH:D005355 Fibrosis Carbon Tetrachloride 18.6718705752
MESH:D005355 Fibrosis Dietary Fats 18.6718296743
MESH:D005355 Fibrosis Quercetin 18.6719474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.6720067830
MESH:D005621 Friedreich Ataxia Iron 5.1216640825 16604332
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9716904648
MESH:D005756 Gastritis Acetaminophen 3.3616983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6216973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9816417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3716452187
MESH:D005909 Glioblastoma Quercetin 3.1919804834
MESH:D005910 Glioma Quercetin 2.9317643826
MESH:D018316 Gliosarcoma Cyclophosphamide 5.2011389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2810696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.7311014644 16376943 15172196
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1711294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.3211110106
MESH:D006333 Heart Failure pirinixic acid 6.3220558911
MESH:D006333 Heart Failure Selenium 6.3217162251
MESH:D006402 Hematologic Diseases Benzene 4.3716183116
MESH:D006432 Hemochromatosis Iron 4.2716574947 16640825 17236123 17255318 16604332 17053826
MESH:D006467 Hemophilia A Cyclophosphamide 4.9911918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0611000095
MESH:D006486 Hemosiderosis Iron 4.9016604332
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.2214986274
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3019900420 19110552
MESH:D006525 Hepatitis, Viral, Human Iron 5.1516640825
MESH:D006527 Hepatolenticular Degeneration Iron 4.6317182432
MESH:D006529 Hepatomegaly Iron 12.7316890145
MESH:D006529 Hepatomegaly pirinixic acid 12.7319772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.7315340226 12621046 16120746
MESH:D015658 HIV Infections Iron 3.5116597321
MESH:D006689 Hodgkin Disease Cyclophosphamide 6.7616135485 17606976
MESH:D006689 Hodgkin Disease sodium arsenite 6.7612676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7316354765 8697196 16959395 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.4616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2216899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3221332399
MESH:D006943 Hyperglycemia pirinixic acid 8.3520558911
MESH:D006943 Hyperglycemia Quercetin 8.3511834736 18262572
MESH:D006949 Hyperlipidemias Dietary Fats 3.3321332399
MESH:D006973 Hypertension Benzene 11.4217940673
MESH:D006973 Hypertension Quercetin 11.4218356687
MESH:D006973 Hypertension Raloxifene 11.4217577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.4218670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7815338365
MESH:D007006 Hypogonadism Iron 4.1916640825
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5116569931 16945680
MESH:D007037 Hypothyroidism Iron 4.7816640825
MESH:D007154 Immune System Diseases Cyclophosphamide 5.0216076520
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1812013081
MESH:D007248 Infertility, Male Cyclophosphamide 14.3816517039 7193160
MESH:D007248 Infertility, Male Ethinyl Estradiol 14.3817937319
MESH:D007248 Infertility, Male sodium arsenite 14.3815346721 12646999
MESH:D007248 Infertility, Male vinclozolin 14.3816467254
MESH:D007249 Inflammation Dietary Fats 7.3320412841
MESH:D007249 Inflammation Diethylnitrosamine 7.3318785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.3312200463 12878042
MESH:D007251 Influenza, Human Quercetin 10.0116624496
MESH:D007251 Influenza, Human Selenium 10.0116624496
MESH:D007333 Insulin Resistance Dietary Fats 6.5718457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 6.5716306350
MESH:D019189 Iron Metabolism Disorders Iron 4.7517163184
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0616580747
MESH:D007627 Keloid Quercetin 4.6517086741
MESH:D007674 Kidney Diseases Acetaminophen 9.0615629191 12587719
MESH:D007674 Kidney Diseases Quercetin 9.0616962696
MESH:D007674 Kidney Diseases sodium arsenite 9.0620008137
MESH:D007676 Kidney Failure, Chronic Selenium 3.6116518626
MESH:D007889 Leiomyoma Raloxifene 4.2116973256
MESH:D007938 Leukemia arsenic trioxide 13.7415070760
MESH:D007938 Leukemia Benzene 13.7418335105 17119257 15935818 14694614
MESH:D007938 Leukemia Cyclophosphamide 13.7410602166
MESH:D007938 Leukemia Quercetin 13.7417468513
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.3618587576 17802794 17008537 17658394 18172266 17296974
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.5217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 7.8614633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 7.8610373061
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.7819077051
MESH:D007951 Leukemia, Myeloid Benzene 8.7817506065
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9017050201 20471514 19850784 16968895 16467208
MESH:D015470 Leukemia, Myeloid, Acute Benzene 3.9019478238
MESH:D015473 Leukemia, Promyelocytic, Acute Am 80 7.5116531727 16819260
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.5111468182 17217047 16823087 12018890 16112521 15336539 9834237 16331271 17649720 17107899 17712046 16966277 12712474 19642359 16891316 11161223 15622746 19225113 19075265 16330433 15213294 19035177 17869043 15748426 12679006
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0616882451
MESH:D007970 Leukopenia Cyclophosphamide 4.6510052129 11830472
MESH:D020961 Lewy Body Disease Iron 5.1216563566
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4216417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 14.3817157831 17174718 11903743 21278145 16943688 17334410 16239168 11408273 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 14.3818296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 14.3818665156 18522880 19638242 20032147 18407596
MESH:D008103 Liver Cirrhosis Iron 14.3816640825
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.2917922224 18166357 17698563 18481824 16015684 20821823 16097048 11481614 18277467 12586293 18395095 14724832 17761835 15893842 18472332 15650968 14512876 16033810 12649538 18429990 17481882 17721639 15370692 12958196 14716496 15996030 18263696 10355542 12445418 17565644 14716833 18339082 18006644 15362042 16011737 15057751 17708605 18705752 17900296 16116963 17823541 16027843 17976157 17944888 18251166 15123356 16136751 18317297 17869086 12741479 17714472 18205269 15959796 18279442 15052691 15730626 18054572 15818738 15925388 18210741 12666154 12632512 12389079 15673190 18420326 12445421 14620537 18412020 16638106 17631135 18376398 17766677 18472094 16248980 14748882 18395914 12609069 18156304 15931870 17525996 17557913 12632514 15338365 18418968 12898905 17640975 12667390 12546737 18187930 16192424 13678700 17805973 15876570
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 6.2915086199 15383259 12918455 17719030 15366600 15763062 15479170 15081153 15864749 15492853 15339415 17666798 14709902 18364076 18567088 17036385 17348192 17201889 16270385 16627068 15798949 14726149 14659978 15369754 18237412 17432682 15067225 18095165 18371158 15099470 18210741 18239293 15842777 17203207 18637143 16009107 17640959 17198567 15733078 15161499 15942678 17724770 15138612 16570917 18672772 15793283 16544323 15571005 17196135 15744066 15298665 15723089 17881167 15577212 16042886 15504291 17534399 18629640 17465448 14643895 12925901 16603200 15591649 16169303 14568256
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.2915474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 6.2912741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.2912878042
MESH:D008107 Liver Diseases Acetaminophen 5.9612587719 12969438 19014921 16611625 11587558 19784758 19460945 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 5.9616964402 16246199 15830285 15720792 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 5.9617034775
MESH:D008108 Liver Diseases, Alcoholic Iron 4.7017207112 16737972
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8615123358
MESH:D017114 Liver Failure, Acute Acetaminophen 14.7116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 14.7114706259 16899240
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 14.7117457977
MESH:D008113 Liver Neoplasms 2-nitrofluorene 31.8015890375
MESH:D008113 Liver Neoplasms arsenic trioxide 31.8014682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 31.8019294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 31.8019996281 18754104 21047994 12771043 19256749 20101389 20434301 16942905 19833225 19499222 9163691 19073162 19850985 19254457 20583210 19427195 15885732 21278145 21167192 19426721 20492335 19638242 10737359 18644402 20405173 19690152 19255062 19812893 20118626 12112319 19551842 20137499 20501860 19294768 2862719 20452335 2422723 15175105 19090486 18977376 21071580 18978307 18648771 19642983
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 31.8015890375 3113478
MESH:D008113 Liver Neoplasms Iron 31.8020302851 16640825
MESH:D008113 Liver Neoplasms pirinixic acid 31.8016377806 20007298 15890375
MESH:D008113 Liver Neoplasms Quercetin 31.8018980244
MESH:D008113 Liver Neoplasms sodium arsenite 31.8015276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 31.8016984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 34.6720377131
MESH:D008114 Liver Neoplasms, Experimental Benzene 34.6712562636
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 34.6712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 34.6721159647 18079962 3124819 18164116 17854601 18544905 19519916 18253720 18093689 18775883 16842330 19539802 18282651 16267830 17942915 17174075 19126423 19009564 18308698 2563599 19004024 9362446
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 34.6715603536 6150874 1848544
MESH:D008114 Liver Neoplasms, Experimental Hexachlorobenzene 34.671423854
MESH:D008114 Liver Neoplasms, Experimental Quercetin 34.6719519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 34.6712151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 34.677955063
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1215213294
MESH:D008171 Lung Diseases sodium arsenite 2.9719095001
MESH:D017563 Lung Diseases, Interstitial Benzene 4.4914698565
MESH:D008175 Lung Neoplasms arsenic trioxide 14.5719825857 11798837
MESH:D008175 Lung Neoplasms Benzene 14.5712562636
MESH:D008175 Lung Neoplasms bexarotene 14.5717849452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 14.576695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 14.5711884234 16061637 19555203
MESH:D008175 Lung Neoplasms Iron 14.5716640825
MESH:D008175 Lung Neoplasms Quercetin 14.5716280456
MESH:D008175 Lung Neoplasms sodium arsenite 14.5717077188 19931552 17306315 15276417 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 14.5711884234 19555203
MESH:D008223 Lymphoma Benzene 7.2517584886 17119257
MESH:D008223 Lymphoma Cyclophosphamide 7.2512854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.3116675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 3.9211911406
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.8411161223
MESH:D008268 Macular Degeneration Iron 3.8116640825
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.1312562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 9.0111921183
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 9.0119196722 15591091 19196723
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.0115318939
MESH:D008545 Melanoma sodium arsenite 1.9919082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 9.8219513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 9.8216388313
MESH:D008654 Mesothelioma Selenium 2.6715107826
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2415863610
MESH:D009101 Multiple Myeloma Am 80 20.4117229644
MESH:D009101 Multiple Myeloma arsenic trioxide 20.4115949261 14977855 19417148 19549372 11468182
MESH:D009101 Multiple Myeloma Benzene 20.4117119195
MESH:D009101 Multiple Myeloma IMMU-110 20.4116033844
MESH:D009101 Multiple Myeloma Raloxifene 20.4116497877
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.3617086897
MESH:D009135 Muscular Diseases pirinixic acid 3.2016239165
MESH:D009181 Mycoses Iron 5.1516640825
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3618349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 2.9616882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 5.2819151258
MESH:D009203 Myocardial Infarction Quercetin 5.2819595682
MESH:D017202 Myocardial Ischemia Iron 8.3616604332
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.3612213967
MESH:D015428 Myocardial Reperfusion Injury Iron 12.9616604332
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.9616411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 12.9619207477
MESH:D009232 Myxoma Raloxifene 5.2416343187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6716624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.449029167 3581430
MESH:D009369 Neoplasms Cyclophosphamide 14.1018854779
MESH:D009369 Neoplasms pirinixic acid 14.1017405874
MESH:D009369 Neoplasms Quercetin 14.1015185748
MESH:D009369 Neoplasms sodium arsenite 14.1011559025
MESH:D009369 Neoplasms Trichloroethylene 14.1011911487
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3720056578
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.4719196722
MESH:D009404 Nephrotic Syndrome Iron 4.2617178036
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.9214600291
MESH:D009436 Neural Tube Defects arsenic trioxide 11.0710525206
MESH:D009436 Neural Tube Defects Benzene 11.0715643154
MESH:D009436 Neural Tube Defects sodium arsenite 11.0712854658
MESH:D009447 Neuroblastoma Cyclophosphamide 3.4816115947 8761367 15176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 12.6618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 12.6620387270
MESH:D019636 Neurodegenerative Diseases Iron 12.6616604332 17296847
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.5812837982 8761367
MESH:D020078 Neurogenic Inflammation Quercetin 4.0817929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8020387270
MESH:D009503 Neutropenia Cyclophosphamide 4.048291058
MESH:D009765 Obesity Dietary Fats 4.1621332399 16723640 11836018 17217161 18674790 18457598 19632207 20132043 20518802
MESH:D009765 Obesity pirinixic acid 4.1620558911
MESH:D009784 Occupational Diseases Benzene 3.9115612468 17119257 16737584 15576619 15913788 17178637 17479406 15935809 15727169
MESH:D009845 Oligospermia Cyclophosphamide 4.4016517039
MESH:D010003 Osteoarthritis Iron 3.7816640825
MESH:D010024 Osteoporosis Iron 6.9216640825 16648989
MESH:D010024 Osteoporosis Raloxifene 6.9217882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 9.2419495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.2415579764 17893378 17823083 15758505
MESH:D010051 Ovarian Neoplasms arsenic trioxide 13.9112452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms Benzene 13.9112562636
MESH:D010051 Ovarian Neoplasms Luteolin 13.9119005980
MESH:D010051 Ovarian Neoplasms Quercetin 13.9119005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 13.9117306315 15276417
MESH:D010146 Pain Acetaminophen 6.0316870215
MESH:D010146 Pain Cyclophosphamide 6.0312161096 18093676
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 11.4215580305
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 11.4211332152
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.4216540662
MESH:D010190 Pancreatic Neoplasms Quercetin 11.4216965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4011578682
MESH:D010212 Papilloma Iron 4.1812065085
MESH:D010235 Paraganglioma arsenic trioxide 3.8819927285
MESH:D020447 Parasomnias Iron 5.7017352947
MESH:D010300 Parkinson Disease Iron 3.2116640825 16563566
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9312520081
MESH:D010900 Pituitary Diseases Iron 5.3616604332
MESH:D010954 Plasmacytoma Selenium 4.5715087411
MESH:D011041 Poisoning Iron 4.0116604332
MESH:D017119 Porphyria Cutanea Tarda Hexachlorobenzene 17.089918132
MESH:D017119 Porphyria Cutanea Tarda Iron 17.0816640825
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 17.0818163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.362563599
MESH:D011230 Precancerous Conditions Quercetin 8.3619056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.6321297632
MESH:D011225 Pre-Eclampsia Iron 4.1916640825
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.4511399792 11896295 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.4519015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.6218220299
MESH:D011471 Prostatic Neoplasms Am 80 1.8916289102
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8919131511
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 1.8917136230
MESH:D011471 Prostatic Neoplasms Quercetin 1.8914715546 17292933
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8915731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8916039940
MESH:D011472 Prostatitis vinclozolin 4.6218629315
MESH:D011528 Protozoan Infections Iron 5.7016640825
MESH:D011537 Pruritus Ethinyl Estradiol 3.0015861022 16919318
MESH:D011565 Psoriasis Am 80 3.9816819260
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.1616636934
MESH:D011693 Purpura Raloxifene 5.2415770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.2319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5418990726
MESH:D012148 Restless Legs Syndrome Iron 4.3216930377
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.6716646077
MESH:D012554 Schistosomiasis japonica Quercetin 5.2316862918
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.5316636934
MESH:D012878 Skin Neoplasms Iron 8.6812065085
MESH:D012878 Skin Neoplasms sodium arsenite 8.6819524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.6816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6316709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.2016517039
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5612854658
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.9512587719
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.5017007042
MESH:D013274 Stomach Neoplasms Benzene 4.5012562636
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.5018456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 4.5016033868
MESH:D020521 Stroke Raloxifene 3.5816837676
MESH:D013398 Sudden Infant Death Iron 5.1416640825
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.7512837982
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8915669648
MESH:D013953 Thymus Neoplasms Benzene 4.6410850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5912697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.4219014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.427505956
MESH:D013978 Tibial Fractures Raloxifene 4.8919048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.6515213294
MESH:D014376 Tuberculosis Iron 3.8916597321
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 14.4911780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 14.4914692829
MESH:D001749 Urinary Bladder Neoplasms Quercetin 14.4916720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 14.4917572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 14.4917306315 11723127 16712894 16452187
MESH:D014581 Urticaria Acetaminophen 2.6910982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.5011813266
MESH:D014594 Uterine Neoplasms Benzene 8.5912562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.5914692618
MESH:D014652 Vascular Diseases sodium arsenite 4.1117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2812125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.8916837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2614671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2416343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9315886252
MESH:D015430 Weight Gain Dietary Fats 3.4816723640
Pathway ID Pathway Name
KEGG:04612 Antigen processing and presentation
KEGG:05152 Tuberculosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26236
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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