AutismKB 2.0

Annotation Detail for NOS1AP


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Basic Information Top
Gene Symbol:NOS1AP ( 6330408P19Rik,CAPON,MGC138500 )
Gene Full Name: nitric oxide synthase 1 (neuronal) adaptor protein
Band: 1q23.3
Quick LinksEntrez ID:9722; OMIM: 605551; Uniprot ID:CAPON_HUMAN; ENSEMBL ID: ENSG00000198929; HGNC ID: 16859
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-4983citrulline-nitric oxide cycle
PWY-5004superpathway of citrulline metabolism
No data
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2045Bipolar disorder
2221Behavior disease
Desease Name
CARDIOVASCULAR
Diabetes Mellitus
Electrocardiographic traits
PSYCH
QT interval
schizophrenia
METABOLIC
QT interval prolongation
sudden cardiac death
Cardiovascular Diseases
cardiac death QT interval
Diabetes Mellitus, Type 2
Desease Name
Electrocardiographic traits
QT interval
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of NOS1AP mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NOS1AP mRNAaffects expression 16483693
D007657 Ketone Bodies Ketone Bodies results in increased expression of NOS1AP mRNAincreases expression 16807920
C025299 polyphenols polyphenols results in decreased expression of NOS1AP mRNAdecreases expression 16293270
C025643 vinclozolin vinclozolin affects the expression of NOS1AP mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D001008 Anxiety Disorders vinclozolin 3.9319015723
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.1518057881 20041841 18218290
MESH:D001281 Atrial Fibrillation Amiodarone 4.1618651412 19698954
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.2719483382
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9915710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.6218974383
MESH:D003110 Colonic Neoplasms polyphenols 2.7216293270
MESH:D003456 Cryptorchidism vinclozolin 4.7814966744
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.5718218290 15265979
MESH:D056486 Drug-Induced Liver Injury polyphenols 4.5719370779
MESH:D005234 Fatty Liver Amiodarone 3.8914986274
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.9116417039
MESH:D006529 Hepatomegaly Amiodarone 4.2315265979
MESH:D006937 Hypercholesterolemia Amiodarone 4.258137927 9751232
MESH:D007037 Hypothyroidism Amiodarone 5.0017991464 18020914
MESH:D007248 Infertility, Male vinclozolin 3.2616467254
MESH:D007249 Inflammation polyphenols 3.2216366677
MESH:D007984 Leydig Cell Tumor vinclozolin 5.2716417039
MESH:D008064 Lipidoses Amiodarone 3.7615342952 17567588
MESH:D008107 Liver Diseases polyphenols 2.8516698588
MESH:D008133 Long QT Syndrome Amiodarone 3.8511989578 17391786 15350150
MESH:D008171 Lung Diseases Amiodarone 3.6012587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 5.0918516814
MESH:D009181 Mycoses Amiodarone 5.5112754197 17974566
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.4418220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.4718220299
MESH:D011472 Prostatitis vinclozolin 5.4718629315
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9612832656 12490602 11597910
OMIM:610141 QT INTERVAL, VARIATION IN marker/mechanism
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.6218724381
MESH:D013276 Stomach Ulcer Amiodarone 3.6818087811
MESH:D013610 Tachycardia Amiodarone 4.7311238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.6319225199
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.8617997062
MESH:D013959 Thyroid Diseases Amiodarone 5.3719731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.3418020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.7311989578 17467628
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA142671259
    • No data
    Releated disease ID Related disease Name
    PA443421Arrhythmias, Cardiac
    PA443459Atrial Fibrillation
    PA159018367Brugada syndrome
    PA443633Cardiomyopathy, Hypertrophic
    PA443796Coronary Artery Disease
    PA443797Coronary Disease
    PA446379Death, Sudden, Cardiac
    PA444368Heart Diseases
    PA445019Myocardial Infarction
    PA445769Sudden Infant Death
    PA445848Thromboembolism
    PA446294Torsades de Pointes
    PA446028Ventricular Fibrillation
    PA443224Abnormalities, Drug-Induced
    PA444807Long QT Syndrome
    PA447300Acquired Long QT Syndrome (aLQTS)
    PA447228congenital long QT syndrome
    PA444807Long QT Syndrome
    Releated drug ID Related drug Name
    PA164712547Beta blocking agents, selective
    PA451906warfarin
    PA451868verapamil
    PA450131isradipine
    PA10390sulfonamides, urea derivatives
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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