AutismKB 2.0

Annotation Detail for DOCK4


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Basic Information Top
Gene Symbol:DOCK4 ( FLJ34238,KIAA0716,MGC134911,MGC134912 )
Gene Full Name: dedicator of cytokinesis 4
Band: 7q31.1
Quick LinksEntrez ID:9732; OMIM: 607679; Uniprot ID:DOCK4_HUMAN; ENSEMBL ID: ENSG00000128512; HGNC ID: 19192
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of DOCK4 proteinaffects expression 20106945
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of DOCK4 mRNAincreases expression 18687144
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DOCK4 mRNAdecreases expression 20106945
20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DOCK4 mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of DOCK4 mRNAincreases expression 15336504
D004041 Dietary Fats Dietary Fats results in increased expression of DOCK4 mRNAincreases expression 18042831
D002117 Calcitriol Calcitriol results in increased expression of DOCK4 mRNAincreases expression 16002434
D004317 Doxorubicin DOCK4 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
C011890 kojic acid kojic acid results in increased expression of DOCK4 mRNAincreases expression 16595896
C041786 palm oil palm oil results in increased expression of DOCK4 mRNAincreases expression 18042831
D010634 Phenobarbital Phenobarbital results in increased expression of DOCK4 mRNAincreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DOCK4 mRNAaffects binding|increases activity|increases expression 19710929
D018038 Sodium Selenite Sodium Selenite results in decreased expression of DOCK4 mRNAdecreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DOCK4 mRNAdecreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.576195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.5715322242 11752688 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5020127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 4.5017418594
MESH:D000236 Adenoma Benzo(a)pyrene 2.686695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.7917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.7916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.7916835633
MESH:D000419 Albuminuria Doxorubicin 4.6121441931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001161 Arteriosclerosis Dietary Fats 3.9615238619
MESH:D001321 Autistic Disorder marker/mechanism 19401682
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.9519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.9512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.8014601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.8617150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3517474063 20146248
MESH:D001943 Breast Neoplasms Calcitriol 2.3511237771
MESH:D001943 Breast Neoplasms Dietary Fats 2.3520435547
MESH:D001943 Breast Neoplasms Doxorubicin 2.3515692762 15634643 18382427 18628466 15994142 16595493 16322301 18695136 15567936 16935488 18234424 15939500 17426702 15136595 16826403 16264153 15668708 19526202 15993339 16096432 16115903 17983394 11325840 17369602
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3520435547
MESH:D002276 Carcinoid Tumor Doxorubicin 4.9116051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7221507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 4.7216023760 18059187 16234567 17876044
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.721701930 20935162 17173139 20007298 6705139
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.181485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.6820419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.6811237771
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.686189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918850075 16120746 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.5616269455 15476868 16651473 17007740 18627295 17382496 17131338 16242529 17329180 17519947 16364871 16455267 17351982 17928571 15811867 16612575 16731534 17974986 15792986 17308081 16278810 17924179 16952015 16109756 15505089
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9616243910 17334414
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.7620889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.324080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis pirinixic acid 2.8619176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8215894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.128697196 16354765 12621046 15668235 15340226
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418802399 18259882
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8216285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.3617416283
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.3615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3620420201
MESH:D004362 Drug Toxicity Doxorubicin 8.2418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.2411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4918367378
MESH:D004421 Dystonia Phenobarbital 4.061851702
MESH:D004487 Edema pirinixic acid 6.7212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0015322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.0015138306
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.4817359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.079294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.2518037988
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.183659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.973922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.596401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.327750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.103659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3920426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Dietary Fats 7.8819551842 19004024 18296743 17967931
MESH:D005234 Fatty Liver pirinixic acid 7.8820131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.6719069698
MESH:D005355 Fibrosis Dietary Fats 8.8718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8720067830
MESH:D005909 Glioblastoma Doxorubicin 3.3817150277
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.5615692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5410048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.5216244371 16495754 16144979 16244372 12587719 14766674 17888722 16879835 16330681 18006777 16707910 17875725 18674790
MESH:D006333 Heart Failure Doxorubicin 7.1617481944
MESH:D006333 Heart Failure pirinixic acid 7.1620558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.9515692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Phenobarbital 14.8216109766
MESH:D006529 Hepatomegaly pirinixic acid 14.8218467677 19772884 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.8212621046 16120746 15340226
MESH:D006689 Hodgkin Disease Doxorubicin 3.4518501091 17606976 15147373
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1416354765 15340226 16959395 8697196 18606429
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6521332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.6721332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218850075 18670907
MESH:D007249 Inflammation Dietary Fats 5.0020412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0012878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 12.5418457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 12.5416306350
MESH:D007333 Insulin Resistance Sodium Selenite 12.5414714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007674 Kidney Diseases Doxorubicin 3.0816775033 15369732 15699352
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.2116707910
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.2516085563
MESH:D008103 Liver Cirrhosis Dietary Fats 6.7618296743
MESH:D008103 Liver Cirrhosis Phenobarbital 6.7621047994
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.4716439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4712878042
MESH:D008107 Liver Diseases Phenobarbital 2.1819363144
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.449163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.4421137059 20195826
MESH:D008113 Liver Neoplasms Phenobarbital 14.448742319 21047994 19812893 15975961 19073162 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 14.4420007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.4416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 19.038603461
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 19.0317085340 16842330
MESH:D008114 Liver Neoplasms, Experimental kojic acid 19.0318544905
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 19.031399818 6150874 2563599 17172636 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.0312151625
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.0917365036
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.8914755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.8920869020 6695378 18816296 18520028 20064080 17053015 20464547 20135361 18569708
MESH:D008175 Lung Neoplasms Doxorubicin 4.896189445 17418594
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8919555203 11884234
MESH:D008223 Lymphoma Doxorubicin 3.5016098063
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1214737004
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.8317654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.6415621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.0615458769
MESH:D008545 Melanoma Doxorubicin 2.2916827129
MESH:D008654 Mesothelioma Asbestos, Crocidolite 6.5016166281 16966607 18303189
MESH:D008654 Mesothelioma Doxorubicin 6.5017638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.5515792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2316381670
MESH:D052016 Mucositis Doxorubicin 4.8717415656
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009203 Myocardial Infarction Doxorubicin 5.7815857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 5.7819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5617484760
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.9718259882
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9011141357
MESH:D009369 Neoplasms pirinixic acid 4.9017405874
MESH:D009401 Nephrosis Doxorubicin 4.8416899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.0515640375 16889571
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2814600291
MESH:D009447 Neuroblastoma Doxorubicin 3.2915555623
MESH:D009765 Obesity Dietary Fats 4.4719632207 16723640 18674790 18457598 20518802 17217161 11836018 21332399 20132043
MESH:D009765 Obesity pirinixic acid 4.4720558911
MESH:D010018 Osteomalacia Phenobarbital 4.4517016548
MESH:D012516 Osteosarcoma Doxorubicin 4.1615930896
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5116965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.2517983394
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.9610923243
MESH:D010997 Pleural Neoplasms Doxorubicin 5.2517638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.672563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711118676 11399792 11222880 11896295
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.8615572423
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0917292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.0916289102 18247401 16644109 15754350 12479363
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.0918437689 15749863 16729912 15897917 16868541 16888761
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.0918760546
MESH:D019310 Pseudolymphoma Phenobarbital 4.5912752131
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0515814490 17365031 17322281 17975199
MESH:D051437 Renal Insufficiency Doxorubicin 4.2917922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012509 Sarcoma Doxorubicin 4.0415625365 17203757 17710206 16767912 18313854 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.3114601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.8717846226
MESH:D012640 Seizures Phenobarbital 2.733137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.906407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.7710029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 13.7715692506
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 13.778532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.7716192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.6415625365 16767912 17203757
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.4617909728 16010429
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.461399818
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2117053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.2117653716
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.2917638931 16364871 17678736 17334414
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D015430 Weight Gain Dietary Fats 3.7916723640
Pathway ID Pathway Name
REACT:604 Hemostasis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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