AutismKB 2.0

Annotation Detail for HDAC9


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Basic Information Top
Gene Symbol:HDAC9 ( DKFZp779K1053,HD7,HD7b,HD9,HDAC,HDAC7,HDAC7B,HDAC9B,HDAC9FL,HDRP,KIAA0744,MITR )
Gene Full Name: histone deacetylase 9
Band: 7p21.1
Quick LinksEntrez ID:9734; OMIM: 606543; Uniprot ID:HDAC9_HUMAN; ENSEMBL ID: ENSG00000048052; HGNC ID: 14065
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200070Signaling events mediated by HDAC Class I
200019Signaling events mediated by HDAC Class II
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Related Diseases/Disorders Top
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Desease IDDesease Name
2120Rabies
Desease Name
CANCER
non-small cell lung carcinoma
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of HDAC9 mRNAdecreases expression 19933214
D012436 S-Adenosylmethionine S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA]decreases reaction|increases expression 18098314
D003997 Dicarbethoxydihydrocollidine Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNAincreases expression 18098314
D003997 Dicarbethoxydihydrocollidine S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA]decreases reaction|increases expression 18098314
C056507 gemcitabine gemcitabine results in increased expression of HDAC9 mRNAincreases expression 17039268
D016685 Mitomycin HDAC9 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D017239 Paclitaxel HDAC9 protein results in increased susceptibility to Paclitaxelincreases response to substance 16734730
C017947 sodium arsenite sodium arsenite results in increased expression of HDAC9 mRNAincreases expression 16966095
D014284 Triiodothyronine Triiodothyronine results in increased expression of HDAC9 mRNAincreases expression 17399805
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HDAC9 mRNAdecreases expression 19933214
D019772 Topotecan HDAC9 protein affects the susceptibility to Topotecanaffects response to substance 16217747
C081489 valsartan valsartan inhibits the reaction [AGT protein results in increased expression of HDAC9 mRNA]decreases reaction|increases expression 19225232
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0415322242 14514962 11752688
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1217306315 16712894
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D001321 Autistic Disorder S-Adenosylmethionine 3.6316917939 19056591
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001859 Bone Neoplasms Paclitaxel 4.7215867366
MESH:D001943 Breast Neoplasms gemcitabine 2.0718382427 17039268
MESH:D001943 Breast Neoplasms Paclitaxel 2.0718323546 18223236 16273361 16115903 16244791 18234424 15136595 11325840
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 3.3816313753
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.3817306315 15276417 16507464
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4118572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.3618670907 16120746 18850075
MESH:D006332 Cardiomegaly valsartan 7.3619597038
MESH:D009202 Cardiomyopathies valsartan 4.5216247790
MESH:D002318 Cardiovascular Diseases valsartan 4.3911230374
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.0819524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1515668235 8697196 16354765 15340226 12621046
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.4418802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D003324 Coronary Artery Disease valsartan 3.9417719468
MESH:D003384 Coxsackievirus Infections valsartan 6.0420392896
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003921 Diabetes Mellitus, Experimental valsartan 4.7111508273
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies valsartan 4.9118630688 11427623
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004938 Esophageal Neoplasms Paclitaxel 2.9216481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6720067830
MESH:D005355 Fibrosis valsartan 9.6716893502
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8716452187
MESH:D015432 Glomerulonephritis, Membranoproliferative valsartan 5.7016928621
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4010048152 11294989
MESH:D006333 Heart Failure valsartan 4.3319027736
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 12621046 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 3.2712676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2618606429 15340226 16354765 8697196 16959395
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.7018850075 18670907
MESH:D006973 Hypertension valsartan 5.7020102058 18390891 18344623 10903974 16475468 12850387 11427623 12692753
MESH:D006974 Hypertension, Malignant valsartan 6.6311560862
MESH:D007248 Infertility, Male sodium arsenite 3.0812646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases sodium arsenite 6.8720008137
MESH:D007674 Kidney Diseases valsartan 6.8712164870 16893502 10903974
MESH:D008080 Liposarcoma Paclitaxel 4.9717353645
MESH:D008106 Liver Cirrhosis, Experimental Dicarbethoxydihydrocollidine 5.3216015684
MESH:D008106 Liver Cirrhosis, Experimental S-Adenosylmethionine 5.3215983038
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.3212878042
MESH:D008106 Liver Cirrhosis, Experimental valsartan 5.3215504291 16872305 15619341
MESH:D008113 Liver Neoplasms Mitomycin 7.8315113037
MESH:D008113 Liver Neoplasms sodium arsenite 7.8316712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1912151625
MESH:D008171 Lung Diseases sodium arsenite 3.2619095001
MESH:D008175 Lung Neoplasms sodium arsenite 2.3417077188 19931552 17306315 15276417 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3419555203 11884234
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.2114749477
MESH:D008545 Melanoma Paclitaxel 3.6512040289 12025231 16342250
MESH:D008545 Melanoma sodium arsenite 3.6516487513 19082730
MESH:D009101 Multiple Myeloma Paclitaxel 3.7814749477
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009362 Neoplasm Metastasis Paclitaxel 3.3015867366
MESH:D009369 Neoplasms sodium arsenite 2.5611559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8420056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.2312854658
MESH:D009447 Neuroblastoma Topotecan 3.9115176712
MESH:D010014 Osteolysis Paclitaxel 5.1715867366
MESH:D010051 Ovarian Neoplasms Paclitaxel 5.2511161223
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.2517306315 15276417
MESH:D010190 Pancreatic Neoplasms gemcitabine 6.1711504793 18383843 17440100 18992248 16929163
MESH:D010190 Pancreatic Neoplasms Mitomycin 6.1715113037
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms Paclitaxel 3.4816356831 17172428 17136230 16729912
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.4816039940
MESH:D011507 Proteinuria valsartan 5.0012164870 17664856 18344623
MESH:D011658 Pulmonary Fibrosis valsartan 3.8617241526
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012878 Skin Neoplasms sodium arsenite 5.7919524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7916192470
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9012854658
MESH:D013274 Stomach Neoplasms Paclitaxel 2.4418506536 18396642
MESH:D024801 Tauopathies Paclitaxel 5.0116930453
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5516712894 11723127 17306315 16452187
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9011813266
MESH:D014652 Vascular Diseases sodium arsenite 4.6217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020257 Ventricular Remodeling valsartan 5.8919027736
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
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Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA38377
    • No data
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    Releated drug ID Related drug Name
    PA449167cyclosporine
    PA451578tacrolimus
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00313 antagonist Valproic Acid Anticonvulsants;Enzyme Inhibitors;Antimanic Agents;GABA Agents
    No data
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    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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