AutismKB 2.0

Annotation Detail for ACAP1


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Basic Information Top
Gene Symbol:ACAP1 ( CENTB1,KIAA0050 )
Gene Full Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
Band: 17p13.1
Quick LinksEntrez ID:9744; OMIM: 607763; Uniprot ID:ACAP1_HUMAN; ENSEMBL ID: ENSG00000072818; HGNC ID: 16467
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
No data
Pathway IDPathway Name
200060Arf6 signaling events
200046Arf6 trafficking events
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ACAP1 mRNAaffects expression 17562736
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ACAP1 mRNAdecreases expression 17484886
D003561 Cytarabine Cytarabine results in increased expression of ACAP1 mRNAincreases expression 19194470
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000799 Angioedema Acetaminophen 4.7110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.4316097048 16192424 16011737 10355542 16124888 16050911 18705752 15700767 16227642 15721981 15673190 3786805
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.003084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.0018788625
MESH:D002386 Cataract Acetaminophen 2.8110977129
MESH:D002471 Cell Transformation, Neoplastic Cytarabine 4.558243401
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0811287661 2444490 12540782 10774834 14550746 16177239 12153990 17562736 11739529 16081117 18713872 19085960 17906064 11834606 15619225 16485898 10663392 16109766 19739265 16227642 19923254 12392966 11743745 19164858 10915739 19370779 11529661 14986274 14725611 12594235 16781746 16393943 12958197 19420014 12705907 15968718 11461765 18071297 17522070 19416960 11421492
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.086884620 2869522 7179309 15968718 15027814 19085960 10915739 16177239 10092053 21278145 3732212 7440962 7120509 4309450 15998439 6623471 17522070 3786805 9327722 11566570 16227642 19336974
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.9619426721
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.6519224547 15959796 17595544 12631006 16239168 12795759 61145 16045604
MESH:D005355 Fibrosis Carbon Tetrachloride 4.1018705752
MESH:D005756 Gastritis Acetaminophen 4.5416983495
MESH:D006505 Hepatitis Carbon Tetrachloride 4.1819900420 19110552
MESH:D006689 Hodgkin Disease Cytarabine 4.8316200630
MESH:D006930 Hyperalgesia Acetaminophen 3.0616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.2716899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.7415338365
MESH:D007674 Kidney Diseases Acetaminophen 2.4212587719 15629191
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 3.0216943688 21278145 17157831 17334410 11903743 17174718 16221502 11408273 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7514716833 17557913 18054572 15123356 12666154 17805973 12445418 15730626 17481882 12632512 14748882 12586293 18166357 15673190 15925388 12632514 18481824 12741479 15057751 16248980 16015684 15338365 17823541 17708605 14724832 15362042 11481614 18412020 18705752 17761835 17869086 16192424 12649538 18376398 20821823 15931870 18006644 18339082 14620537 17631135 12609069 12898905 18420326 17714472 12389079 17922224 14716496 12546737 14512876 18210741 18395095 15996030 16136751 18251166 18277467 15818738 18472332 16638106 15370692 18187930 17944888 17766677 18472094 18395914 17698563 12958196 16033810 18418968 16097048 17900296 15650968 18205269 13678700 18279442 10355542 15893842 17721639 18263696 15959796 15052691 17565644 18429990 18317297 18156304 17976157 16116963 16027843 16011737 15876570 17640975 12445421 17525996 12667390
MESH:D008107 Liver Diseases Acetaminophen 4.1916611625 19460945 16610002 19014921 19784758 12969438 11587558 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.1915830285 16246199 17285989 16964402 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.8215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.9416871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.9416899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.3519294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.8612014681 15583823
MESH:D008546 Melanoma, Experimental Acetaminophen 4.2219513568
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2618514411
MESH:D010146 Pain Acetaminophen 2.7716870215
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cytarabine 4.6521297632
MESH:D014581 Urticaria Acetaminophen 3.5010982225
Pathway ID Pathway Name
KEGG:04144 Endocytosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26406
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    Releated drug ID Related drug Name
    PA448976choline
    PA448976choline
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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