AutismKB 2.0

Annotation Detail for CD97


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Basic Information Top
Gene Symbol:CD97 ( TM7LN1 )
Gene Full Name: CD97 molecule
Band: 19p13
Quick LinksEntrez ID:976; OMIM: 601211; Uniprot ID:CD97_HUMAN; ENSEMBL ID: ENSG00000123146; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Signaling by GPCR
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CD97 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of CD97 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of CD97 mRNAaffects expression 17562736
D012436 S-Adenosylmethionine S-Adenosylmethionine results in decreased expression of CD97 mRNAdecreases expression 18098314
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CD97 proteinaffects expression 20106945
C006632 arsenic trioxide arsenic trioxide results in decreased expression of CD97 mRNAdecreases expression 19128835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CD97 mRNAdecreases expression 20064835
D004041 Dietary Fats Dietary Fats results in increased expression of CD97 mRNAincreases expression 18042831
D002117 Calcitriol Calcitriol results in increased expression of CD97 mRNAincreases expression 16002434
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CD97 mRNAincreases expression 12072388
C041786 palm oil palm oil results in increased expression of CD97 mRNAincreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of CD97 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of CD97 mRNAincreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CD97 mRNAaffects binding|decreases expression|increases activity 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.566195326
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma arsenic trioxide 7.1411798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.1420127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1414692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.753712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.756695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.5217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.5216434500
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D001161 Arteriosclerosis Dietary Fats 10.2615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.2611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001321 Autistic Disorder Acetaminophen 2.4518445737
MESH:D001321 Autistic Disorder S-Adenosylmethionine 2.4516917939 19056591
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1511289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.2716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2719483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9320146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 1.9311237771
MESH:D001943 Breast Neoplasms Dietary Fats 1.9320435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4211589617
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.5616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.563581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.563084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 11.5621507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.5616217749 11135700 15553829 15073043 14691202
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 11.561701930 6705139 20007298 20935162 17173139
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0119014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.717296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1912490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7620419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.7611237771
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.846135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.847505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.364080065
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.7319486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 13.7316105132 17681005 11677210 16919318 17110522 17333356 15861022
MESH:D002779 Cholestasis pirinixic acid 13.7319176532
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8810525206
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1218551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1815213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9018759878 11906362 2524372 8970840 12868966 11298694 8156756 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.582952479 3621924
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.3018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.306679447 8291058 16192314 9328219 18289764 9022650 11289319 7440962 6482804 1440618 9653073 18692083 18648102
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3012958197 19923254 14986274 19164858 11287661 15619225 11834606 15968718 16227642 16109766 11461765 18713872 18071297 12392966 19416960 16177239 12705907 16393943 17522070 11743745 16081117 12594235 17906064 10774834 11421492 16485898 10915739 19420014 12153990 11739529 11529661 19085960 16781746 19370779 14550746 2444490 19739265 17562736 14725611 12540782 10663392
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D050171 Dyslipidemias Dietary Fats 3.5118367378
MESH:D004421 Dystonia Phenobarbital 4.091851702
MESH:D004487 Edema pirinixic acid 2.5612083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 9.4115138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.4112538720
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.213659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.003922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.616401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.367750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.143659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.333581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.3312903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.3316530937
MESH:D005234 Fatty Liver arsenic trioxide 19.4615073043
MESH:D005234 Fatty Liver Dietary Fats 19.4619004024 18296743 17967931 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.4615345470
MESH:D005234 Fatty Liver pirinixic acid 19.4620131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.156705139
MESH:D005355 Fibrosis Dietary Fats 3.6318296743
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3616904648
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.127505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6920471113
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.616705139
MESH:D006529 Hepatomegaly Phenobarbital 8.8316109766
MESH:D006529 Hepatomegaly pirinixic acid 8.8318467677 16221962 19176532 19772884
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.7021332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0415034207
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Dietary Fats 2.4720412841
MESH:D007333 Insulin Resistance Dietary Fats 7.4211836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.4216306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.158074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.2412587719 15629191
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.5916705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.596582329
MESH:D007938 Leukemia arsenic trioxide 2.8715070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.8419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1520471514 17050201 16467208 19850784 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2617649720 17217047 19642359 16331271 19035177 9834237 16823087 16330433 17712046 15336539 16112521 12018890 11468182 15622746 17107899 15748426 15213294 12679006 19225113 12712474 16891316 17869043 16966277 11161223 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4516882451
MESH:D008103 Liver Cirrhosis Dietary Fats 6.8018296743
MESH:D008103 Liver Cirrhosis Phenobarbital 6.8021047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.249327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.9915474484
MESH:D008106 Liver Cirrhosis, Experimental S-Adenosylmethionine 2.9915983038
MESH:D008107 Liver Diseases Acetaminophen 3.9916610002 12969438 11587558 19014921 16611625 19784758 12587719 19460945
MESH:D008107 Liver Diseases Phenobarbital 3.9919363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3117185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 18.387678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 18.389163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms arsenic trioxide 18.3814682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.3820195826 21137059
MESH:D008113 Liver Neoplasms Phenobarbital 18.3819812893 19482888 15975961 8742319 19073162 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 18.3816377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 19.202876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 19.20598648 3712494 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 19.208603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 19.2020377131
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 19.201399818 2563599 18308698 17172636 6150874
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4115213294
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4914755239
MESH:D008175 Lung Neoplasms arsenic trioxide 3.4919825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4918569708 20869020 18816296 20064080 20464547 18520028 17053015 20135361 6695378
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2516381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1614977855 11468182 19417148 15949261 19549372
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1816105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5917484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.987678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0516624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.503581430
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9511141357
MESH:D009369 Neoplasms pirinixic acid 4.9517405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.426679447
MESH:D009436 Neural Tube Defects arsenic trioxide 7.4210525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009765 Obesity Dietary Fats 4.4916723640 19632207 18457598 17217161 20132043 18674790 11836018 21332399 20518802
MESH:D009765 Obesity pirinixic acid 4.4920558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.1416049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.146482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.153988306
MESH:D010018 Osteomalacia Phenobarbital 4.4817016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4319769630 16624393 12452020
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.3915580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.3916965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.597296757
MESH:D010235 Paraganglioma arsenic trioxide 4.2519927285
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.606228378
MESH:D011230 Precancerous Conditions Phenobarbital 3.692563599
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9015572423
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5719131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5717292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.5712479363 18247401 16644109 15754350 16289102
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.6312752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.433692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0516646077
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1118551238
MESH:D012640 Seizures Phenobarbital 6.113137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.946407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4019755658 10029692
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.3917007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3920155912 2093021
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.341399818 6582329 6587162 3712494 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 12.3419014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 12.341399818
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0815213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.1616049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.168074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.1612973940 20435036 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.1617053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4310091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D015430 Weight Gain Dietary Fats 3.8116723640
Pathway ID Pathway Name
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26248
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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