AutismKB 2.0

Annotation Detail for ZFYVE16


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Basic Information Top
Gene Symbol:ZFYVE16 ( DKFZp686E13162,ENDOFIN,KIAA0305 )
Gene Full Name: zinc finger, FYVE domain containing 16
Band: 5q14.1
Quick LinksEntrez ID:9765; OMIM: 608880; Uniprot ID:ZFY16_HUMAN; ENSEMBL ID: ENSG00000039319; HGNC ID: 20756
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-11BMP Signalling Pathway
Pathway IDPathway Name
hsa04144Endocytosis
hsa04350TGF-beta signaling pathway
Pathway IDPathway Name
Signaling by BMP
Pathway IDPathway Name
200123BMP receptor signaling
200195TGF-beta receptor signaling
Pathway IDPathway Name
P00052TGF-beta signaling pathway
Pathway IDPathway Name
500592Signaling by BMP
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ZFYVE16 mRNAaffects expression 17562736
C058317 arsenic disulfide arsenic disulfide affects the expression of ZFYVE16 mRNAaffects expression 16529693
C006632 arsenic trioxide arsenic trioxide results in increased expression of ZFYVE16 mRNAincreases expression 18231732
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ZFYVE16 mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of ZFYVE16 mRNAdecreases expression 15336504
D003010 Clorgyline Clorgyline results in increased expression of ZFYVE16 mRNAincreases expression 19691856
C006253 pirinixic acid pirinixic acid results in increased expression of ZFYVE16 mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3419825857 11798837
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.9616206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.9619483382
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.993084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 2.9915073043 14691202 16217749 11135700 15553829
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9020889678
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6517522070 18071297 12540782 17906064 16081117 19739265 19923254 10915739 2444490 18713872 10774834 11287661 11529661 12153990 19370779 11461765 12705907 10663392 12958197 19416960 16227642 14986274 17562736 16109766 11834606 15968718 12392966 16393943 16485898 16781746 14725611 15619225 14550746 12594235 19085960 11739529 19164858 11743745 11421492 19420014 16177239
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6620426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6612903497
MESH:D005234 Fatty Liver arsenic trioxide 8.6715073043
MESH:D005234 Fatty Liver pirinixic acid 8.6720131406 19236843
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3516221962 18467677 19176532 19772884
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3412587719 15629191
MESH:D007938 Leukemia arsenic trioxide 2.9515070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic disulfide 9.6012421474
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 9.6014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1717050201 16968895 19850784 20471514 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3816891316 16331271 15213294 12018890 19075265 19035177 16823087 16112521 17649720 16330433 15622746 17869043 11468182 9834237 12679006 17712046 17107899 12712474 11161223 15336539 15748426 19642359 19225113 17217047 16966277
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6816610002 12587719 19784758 12969438 19014921 11587558 19460945 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 4.7714682389
MESH:D008113 Liver Neoplasms pirinixic acid 4.7720007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.8920377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8711798837 19825857
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2915949261 19549372 19417148 11468182 14977855
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2816882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2810525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4719769630 16624393 12452020
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6015580305
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.6019131511
MESH:D011471 Prostatic Neoplasms Clorgyline 3.6019691856
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2916646077
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.808532709
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5720435036 12845720 11780464 12973940
MESH:D014581 Urticaria Acetaminophen 3.2810982225
Pathway ID Pathway Name
KEGG:04144 Endocytosis
REACT:12034 Signaling by BMP
KEGG:04350 TGF-beta signaling pathway
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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