AutismKB 2.0

Annotation Detail for CD151


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Basic Information Top
Gene Symbol:CD151 ( GP27,MER2,PETA-3,RAPH,SFA1,TSPAN24 )
Gene Full Name: CD151 molecule (Raph blood group)
Band: 11p15.5
Quick LinksEntrez ID:977; OMIM: 602243; Uniprot ID:CD151_HUMAN; ENSEMBL ID: ENSG00000177697; HGNC ID: 1630
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Cell junction organization
No data
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Pathway IDPathway Name
500126Type I hemidesmosome assembly
Related Diseases/Disorders Top
No data
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Desease Name
Nephropathy with pretibial epidermolysis bullosa and deafness
Blood group, Raph
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CD151 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CD151 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CD151 mRNAaffects expression 16483693
D001104 Arbutin Arbutin results in decreased expression of CD151 mRNAdecreases expression 17103032
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CD151 mRNAaffects cotreatment|decreases expression 20360939
D002220 Carbamazepine Carbamazepine results in decreased expression of CD151 mRNAdecreases expression 11682256
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of CD151 mRNAdecreases expression 17484886
D002330 Carmustine Carmustine results in decreased expression of CD151 mRNAdecreases expression 15980968
D002945 Cisplatin CD151 protein results in decreased susceptibility to Cisplatindecreases response to substance 16734730
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CD151 mRNAaffects cotreatment|decreases expression 20360939
D005419 Flavonoids Flavonoids results in increased expression of CD151 mRNAincreases expression 18035473
D008094 Lithium Lithium results in decreased expression of CD151 mRNAdecreases expression 11682256
D008727 Methotrexate CD151 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
C004648 testosterone enanthate testosterone enanthate affects the expression of CD151 mRNAaffects expression 17440010
D014635 Valproic Acid Valproic Acid results in decreased expression of CD151 mRNAdecreases expression 11682256
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 14.858986270
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 14.8512039119
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 14.858875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9619490988
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D058186 Acute Kidney Injury Cisplatin 3.9915814532 12690470 17670903
MESH:D000230 Adenocarcinoma Cisplatin 2.7611798837 17638652
MESH:D000236 Adenoma Diethylnitrosamine 2.876695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.9519061943 18056438 17162532 19052882 16434500 17620307
MESH:D000544 Alzheimer Disease Lithium 3.4719621015
MESH:D000550 Amblyopia Valproic Acid 5.3017688650
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.5917497229
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1017286800
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518558336 19232924 18177632 18396377 15238991 17507914 18775368 19460635 18940202 17157402 18985861 17688650 16609825 18316065 20603192
MESH:D001714 Bipolar Disorder Carbamazepine 12.2517594078 20046352
MESH:D001714 Bipolar Disorder Lithium 12.2520338123 19153942 20046352 17594078
MESH:D001714 Bipolar Disorder Valproic Acid 12.2520046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.428888407
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.9514601052
MESH:D001932 Brain Neoplasms Carmustine 4.4116187019
MESH:D001943 Breast Neoplasms Cisplatin 2.0919526202 18382427
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0917474063
MESH:D001943 Breast Neoplasms Methotrexate 2.0916978400
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8216011737 10355542 16050911 3786805 18705752 15673190 16097048 15700767 16124888 15721981 16192424 16227642
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.9216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.923084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.9218788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 8.9217982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.9218210153 20007298 17055752 16830150 18506893 18665156 19919837 16540662 20935162 10737359 17428255 19822196 17138121 18971187 20084675 11831363 18788625 16779866 3581430 21159647 19519916 16698587 16878318 16807293 19171122 18494052 20514400 19383236 19335982 19107877 19052882 18978308 16288022 17162532 10672840 20101231 18785209 20524982 19539802 19418558 17173139 20512989 3084413 16681979 17761372 16328049 19394651 20432363 19701751 20214788 17978847 18691550 18393292 19208518 16569478 20727157 16502159 16935385 18056438
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0416685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 2.836189445 17066447 18337622
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.766135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.7621159647 17174075 2727394 7505956
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7119052882
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D019465 Craniofacial Abnormalities Carbamazepine 4.129014606
MESH:D019465 Craniofacial Abnormalities Methotrexate 4.129562676 12039119
MESH:D019465 Craniofacial Abnormalities Valproic Acid 4.128888407 16575769 17688650
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0618551238
MESH:D003550 Cystic Fibrosis Methotrexate 4.2619747007
MESH:D007644 Darier Disease Lithium 5.9620338123
MESH:D003882 Dermatomyositis Methotrexate 5.1620191521
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.7919244398
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2020387270
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.4911748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.4215057820 16538175 20216337 16538176
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.3918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.3914725611 11461765 10663392 18071297 12153990 11834606 19739265 16227642 19416960 17906064 16781746 11287661 14550746 14986274 11529661 12705907 12540782 12958197 17562736 10915739 16177239 17522070 11739529 11421492 11743745 19923254 12392966 19085960 16081117 12594235 19420014 19370779 2444490 15619225 16485898 10774834 19164858 18713872 15968718 16393943 16109766
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 15.3917465707
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 15.392869522 15968718 10092053 9327722 19336974 4309450 7179309 6623471 11566570 7120509 15027814 3786805 6884620 3732212 10915739 17522070 21278145 15998439 16227642 19085960 16177239 7440962
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.3919107877
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 15.391733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Carbamazepine 8.8720216337
MESH:D004362 Drug Toxicity Cisplatin 8.8712649298 12231392 15033597 19839026
MESH:D004421 Dystonia Valproic Acid 4.081851702
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 4.7717654737
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.2916415921 16538176 20485159 19915237 18855540
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 11.3417275665
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 11.343659116 17275665
MESH:D004828 Epilepsies, Partial Carbamazepine 10.5917116037 16628512 15008574
MESH:D004828 Epilepsies, Partial Valproic Acid 10.593922381 16628512
MESH:D004827 Epilepsy Carbamazepine 7.129014606 19700373 20417680 19620853 17465707 19439326 18234410 17178248 821787 7988514
MESH:D004827 Epilepsy Valproic Acid 7.1218234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.616426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 11.857750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 11.857750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 11.0615276670 3659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 11.063659116
MESH:D004916 Erythromelalgia Carbamazepine 5.7719549232
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1816302075
MESH:D004938 Esophageal Neoplasms Cisplatin 2.7815464296 17638652 15173087 16481741 16785472
MESH:D005076 Exanthema Carbamazepine 5.5220485159
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.3461145 17595544 19224547 15959796 12631006 12795759 16045604 16239168
MESH:D005234 Fatty Liver Diethylnitrosamine 13.3421071580 20387270
MESH:D005234 Fatty Liver Valproic Acid 13.3414986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 4.9516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.178888407 18558336
MESH:D005355 Fibrosis Carbon Tetrachloride 3.5018705752
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D005909 Glioblastoma Carmustine 3.9416187019
MESH:D006086 Graft vs Host Disease Methotrexate 5.1916518429
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.7315102660 15464296
MESH:D034381 Hearing Loss Cisplatin 4.3219898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.4415464296
MESH:D006330 Heart Defects, Congenital Lithium 4.2319638421
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6319110552 19900420
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8117440010
MESH:D006689 Hodgkin Disease Cisplatin 3.6216200630 16170182
MESH:D006849 Hydrocephalus Valproic Acid 4.9217688650
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5816899240
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.7510459572
MESH:D006965 Hyperplasia Carbamazepine 5.2518773962
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1315338365
MESH:D007249 Inflammation Diethylnitrosamine 5.2318785209
MESH:D007249 Inflammation Flavonoids 5.2317296493
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.6110783313
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.2015464296
MESH:D007674 Kidney Diseases Acetaminophen 10.3212587719 15629191
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 10.3215369732
MESH:D007674 Kidney Diseases Cisplatin 10.3212231392 15190930 19839026 12649298 18289764
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.0016705839
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.8611231351
MESH:D007805 Language Development Disorders Methotrexate 5.139562676
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1517596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.0116766008
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 11.2216943688 11903743 11408273 17334410 16221502 17174718 16239168 21278145 17157831
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.2220032147 18522880 18665156 19638242 18407596
MESH:D008103 Liver Cirrhosis Methotrexate 11.2214986274
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7412445418 16192424 12632514 18376398 15650968 18187930 12649538 13678700 14620537 18251166 18472332 15338365 15057751 15818738 14716496 12632512 16248980 17631135 12666154 17761835 18481824 17714472 15370692 12958196 17565644 17708605 12898905 18412020 17869086 17805973 17481882 17766677 17823541 16097048 17698563 18418968 18210741 18395095 14748882 12609069 11481614 18420326 15893842 16011737 16136751 17525996 18705752 17976157 17944888 12667390 18395914 15959796 18166357 12586293 20821823 18429990 12546737 10355542 18006644 18263696 18277467 14716833 15673190 18156304 15730626 17721639 17557913 18279442 16116963 16027843 17922224 15123356 14724832 15362042 18317297 18205269 15931870 15052691 18472094 15996030 16015684 16033810 18054572 12445421 14512876 17640975 15925388 12741479 16638106 17900296 12389079 18339082 15876570
MESH:D008107 Liver Diseases Acetaminophen 6.5116610002 19784758 12587719 19014921 16611625 12969438 19460945 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.5115830285 16246199 17285989 15720792 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 6.5117034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.5016871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.5016899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.517678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.5119294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.5119833225 20118626 19690152 20501860 20405173 19642983 21047994 15175105 12771043 2862719 20452335 19254457 12112319 20101389 19256749 21071580 19499222 18978307 19638242 19294768 10737359 18648771 18644402 18977376 9163691 16942905 20492335 19551842 18754104 19996281 19426721 20434301 20137499 19850985 21278145 19090486 19812893 19073162 15885732 2422723 19427195 20583210 19255062 21167192
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.952876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.9515583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.952563599 18775883 17854601 18544905 18308698 17942915 18282651 19009564 21159647 18093689 16842330 3124819 18164116 16267830 18253720 18079962 19126423 19539802 19519916 9362446 17174075 19004024
MESH:D017563 Lung Diseases, Interstitial Methotrexate 11.6818516814
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 11.6817228818
MESH:D008175 Lung Neoplasms Cisplatin 2.6617225452 6189445 11798837
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.6621163286 6695378 20512841 20970405
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.5716628512
MESH:D008223 Lymphoma Methotrexate 3.9717352296
MESH:D008545 Melanoma Carmustine 3.8612393984
MESH:D008545 Melanoma Cisplatin 3.8617023156 18176117 17761969 16432458 11135225 12393984 18332650 18505091 12374674 16809738 12883367 15577323 16248763
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.8215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008607 Mental Retardation Carbamazepine 3.739014606
MESH:D008654 Mesothelioma Cisplatin 3.2517638057
MESH:D008881 Migraine Disorders Valproic Acid 3.2118765137 18803445
MESH:D052016 Mucositis Methotrexate 5.3317488658
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.068888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1717596541
MESH:D009203 Myocardial Infarction Lithium 3.9316288908
MESH:D009224 Myotonia Congenita Carbamazepine 5.5220399394
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.917678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.583581430 9029167
MESH:D009369 Neoplasms Cisplatin 2.9516773208
MESH:D009395 Nephritis, Interstitial Cisplatin 4.5515464296
OMIM:609057 NEPHROPATHY WITH PRETIBIAL EPIDERMOLYSIS BULLOSA AND DEAFNESS marker/mechanism
MESH:D009421 Nervous System Malformations Carbamazepine 4.9416990009
MESH:D009436 Neural Tube Defects Valproic Acid 3.148888407 16359493
MESH:D009447 Neuroblastoma Cisplatin 3.468761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.2618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.2620387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.758761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1820387270
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.4616049721
MESH:D010018 Osteomalacia Carbamazepine 5.5217016548
MESH:D010051 Ovarian Neoplasms Cisplatin 2.8817225452 6897625 19769630 15464296
MESH:D010146 Pain Acetaminophen 7.0816870215
MESH:D010146 Pain Carbamazepine 7.0815215642
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.4819003803
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4816540662
MESH:D010267 Parapsoriasis Carbamazepine 5.7416538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.9717145499 17679678
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.3415464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.4117638057
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.582563599
MESH:D011248 Pregnancy Complications Carbamazepine 5.199014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 10.269014606
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.2620603192
MESH:D019310 Pseudolymphoma Carbamazepine 12.8112752131 9591791
MESH:D019310 Pseudolymphoma Valproic Acid 12.8112752131 11422049
MESH:D011565 Psoriasis Methotrexate 3.4417410198
MESH:D051437 Renal Insufficiency Cisplatin 10.7015464296
MESH:D051437 Renal Insufficiency Methotrexate 10.7017352296
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2119155313
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.4614601052
MESH:D012559 Schizophrenia Valproic Acid 2.0715737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 14.3718551238
MESH:D012640 Seizures Carbamazepine 14.3716180713 15946322 19414003 16876388 16938433 9046859 9844417
MESH:D012640 Seizures Lithium 14.3719660546
MESH:D012640 Seizures Valproic Acid 14.373137016 16876388 1511512 14763951 11738929 15475178 11044598 17978042
MESH:D012893 Sleep Disorders Carbamazepine 5.1719414003
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.4115464296
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8019490988
MESH:D013226 Status Epilepticus Lithium 12.8819570321 19430551 19951488
MESH:D013226 Status Epilepticus Valproic Acid 12.8812833885
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.2518855540 20485159 15057820 16415921 16538176 19915237 19694795
MESH:D013274 Stomach Neoplasms Cisplatin 2.6217522103 15958060 18396642
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6218456281
MESH:D013576 Syndactyly Methotrexate 5.079562676
MESH:D013736 Testicular Neoplasms Cisplatin 4.6615464296 17225452
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.007505956
MESH:D014178 Translocation, Genetic Valproic Acid 5.3017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.573119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2916049721
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.2917225452 12973940 15464296
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.688888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3710091137
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.2316803524
MESH:D014625 Vaginal Neoplasms Cisplatin 4.6515577323
MESH:D014839 Vomiting Cisplatin 4.7811897121
Pathway ID Pathway Name
REACT:20676 Cell junction organization
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26189
    • Releated gene ID Related gene Name
    PA26189CD151
    No data
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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