AutismKB 2.0

Annotation Detail for EIF4A3


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Basic Information Top
Gene Symbol:EIF4A3 ( DDX48,DKFZp686O16189,KIAA0111,MGC10862,NMP265,NUK34,eIF4AIII )
Gene Full Name: eukaryotic translation initiation factor 4A3
Band: 17q25.3
Quick LinksEntrez ID:9775; OMIM: 608546; Uniprot ID:IF4A3_HUMAN; ENSEMBL ID: ENSG00000141543; HGNC ID: 18683
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1841Stomach cancer
2106Pancreas cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of EIF4A3 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of EIF4A3 proteinincreases expression 19364129
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of EIF4A3 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of EIF4A3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EIF4A3 mRNAaffects cotreatment|increases expression 17942748
C017947 sodium arsenite sodium arsenite results in decreased expression of EIF4A3 mRNAdecreases expression 16014739
D013629 Tamoxifen Tamoxifen affects the expression of EIF4A3 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EIF4A3 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of EIF4A3 mRNAincreases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.0714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3115322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5019825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.5014692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.2215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.4217306315 16712894
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 10.0716206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.0712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Tamoxifen 1.9319103187 19084267 19288272 19189212 19289846 18815881 18425577 19221464 20859285 18821012 19059307 18351453 16273361 20135344 17242785 19155303 17440819 19142967 20005174 20544844 18984771 11161223 19200415 19244106 21152245 16818667 16873071 18997820 19115204 17893378 19487384 20065188 21138602 18629630 19410462 16202921 20390343 19066611 17049068 19189210 17261762 19011961 15565566 18855134 15668708
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6811589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9219066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.903084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.9015553829 16217749 11135700 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.9016507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.9016924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4212490120
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4518572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.1919524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1017110522 16105132 17333356 16919318 15861022 17681005 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2112621046 8697196 16354765 15340226 15668235
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5410525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5420055451 10048152 15322242
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4515213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7819031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8114725611 19085960 11529661 16081117 11739529 10915739 11743745 19416960 12705907 16227642 16781746 16109766 14550746 18071297 19923254 11834606 10774834 16177239 2444490 19420014 12153990 15968718 12540782 12958197 12392966 11421492 10663392 11461765 18713872 19164858 16393943 17906064 15619225 11287661 17562736 12594235 19370779 14986274 16485898 17522070 19739265
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4216714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.2412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.2419031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2419155303 16202921 17893378 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3310568697 9294722
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3712903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver arsenic trioxide 15.0815073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.0815345470
MESH:D005234 Fatty Liver Tamoxifen 15.0814986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.6419069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.6416904648
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.1416452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4711294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3112621046 15340226 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 3.4312676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5716959395 8697196 18606429 16354765 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.3117937319
MESH:D007248 Infertility, Male sodium arsenite 7.3115346721 12646999
MESH:D007249 Inflammation Tamoxifen 5.3719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3712878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007674 Kidney Diseases Acetaminophen 6.5112587719 15629191
MESH:D007674 Kidney Diseases sodium arsenite 6.5120008137
MESH:D007680 Kidney Neoplasms Tamoxifen 3.3118625569
MESH:D007938 Leukemia arsenic trioxide 2.9615070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1820471514 17050201 16968895 19850784 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4116331271 12712474 15748426 17107899 19225113 19642359 16966277 16112521 12018890 17217047 16330433 11468182 15622746 17712046 15336539 19035177 19075265 15213294 17869043 17649720 11161223 16891316 12679006 16823087 9834237
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7316882451
MESH:D008064 Lipidoses Tamoxifen 3.3715342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3612878042
MESH:D008107 Liver Diseases Acetaminophen 1.6919784758 11587558 19014921 12587719 12969438 16610002 19460945 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 11.5414682389
MESH:D008113 Liver Neoplasms sodium arsenite 11.5416712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 11.5416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.5416984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.4120377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.4112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5915213294
MESH:D008171 Lung Diseases sodium arsenite 3.3719095001
MESH:D008175 Lung Neoplasms arsenic trioxide 5.0811798837 19825857
MESH:D008175 Lung Neoplasms sodium arsenite 5.0815276417 16712894 19931552 17306315 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 5.0818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0819555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.2219428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8114580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 5.0719453300
MESH:D008545 Melanoma sodium arsenite 3.4619082730 16487513
MESH:D008545 Melanoma Tamoxifen 3.4612393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.6415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3219549372 11468182 15949261 19417148 14977855
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3016882451 16105982
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.3416624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009369 Neoplasms sodium arsenite 2.6311559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.0820056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.5219200415 19189210 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009436 Neural Tube Defects arsenic trioxide 7.9810525206
MESH:D009436 Neural Tube Defects sodium arsenite 7.9812854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.1816624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.1815276417 17306315
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6115580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010235 Paraganglioma arsenic trioxide 4.5119927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511399792 11222880 11896295 11118676
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5219131511
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.5216039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5215067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7715861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.3416646077
MESH:D012878 Skin Neoplasms sodium arsenite 6.0218572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0216192470
MESH:D013088 Spermatocele Ethinyl Estradiol 13.3616709447
MESH:D013088 Spermatocele Tamoxifen 13.3616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5019457130
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0412854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3219014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.4215213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.9512845720 20435036 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.9516712894 11723127 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.9516712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.0711813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D014652 Vascular Diseases sodium arsenite 4.8917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8715869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
Pathway ID Pathway Name
KEGG:03015 mRNA surveillance pathway
KEGG:03013 RNA transport
KEGG:03040 Spliceosome
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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