AutismKB 2.0

Annotation Detail for MATR3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MATR3 ( DKFZp686K0542,DKFZp686K23100,KIAA0723,MGC9105,MPD2,VCPDM )
Gene Full Name: matrin 3
Band: 5q31.2
Quick LinksEntrez ID:9782; OMIM: 164015,606070; Uniprot ID:MATR3_HUMAN; ENSEMBL ID: ENSG00000015479; HGNC ID: 6912
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1983Down syndrome
No data
No data
Desease Name
Myopathy, distal 2
Myopathy, distal
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MATR3 mRNAaffects expression 21346803
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of MATR3 mRNAdecreases expression 16514628
C109238 acyline acyline results in increased expression of MATR3 mRNAincreases expression 17510436
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MATR3 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MATR3 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MATR3 mRNAdecreases expression 20018196
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MATR3 mRNAaffects expression 17484886
D004958 Estradiol Estradiol results in increased expression of MATR3 mRNAincreases expression 16514628
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of MATR3 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MATR3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MATR3 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of MATR3 mRNAdecreases expression 17557909
D005419 Flavonoids Flavonoids results in decreased expression of MATR3 mRNAdecreases expression 18035473
C070081 fulvestrant fulvestrant results in decreased expression of MATR3 mRNAdecreases expression 16514628
C051890 irinotecan irinotecan analog results in decreased expression of MATR3 mRNAdecreases expression 18927307
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of MATR3 mRNAdecreases expression 17616710
D020849 Raloxifene Raloxifene results in decreased expression of MATR3 mRNAdecreases expression 16514628
D013629 Tamoxifen Tamoxifen affects the expression of MATR3 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MATR3 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MATR3 mRNAincreases expression 15591033
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8715322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.0120464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 7.0111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0114692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.656695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4016835633
MESH:D000419 Albuminuria Raloxifene 4.6017451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5415800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D001284 Atrophy fulvestrant 4.8611514358
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D001930 Brain Injuries Raloxifene 4.4916580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9620146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 2.9617289903 17261762 12948864 18497071 16675129 19861407 17018787 14630087
MESH:D001943 Breast Neoplasms fulvestrant 2.9618984771
MESH:D001943 Breast Neoplasms Raloxifene 2.9615775269 17595753 17242785 17893378 17261762 16837676 17952589 16912660 17440819 15758505 17049068 15572757
MESH:D001943 Breast Neoplasms Tamoxifen 2.9619289846 19115204 19059307 11161223 19410462 17893378 19288272 19189212 16273361 19200415 16873071 21152245 18425577 17261762 17049068 20135344 20390343 19155303 18984771 18815881 20859285 15668708 16202921 15565566 19103187 20544844 19066611 18351453 19142967 19084267 20005174 19221464 19244106 19011961 16818667 19189210 18855134 18629630 20065188 17440819 19487384 21138602 17242785 18821012 18997820
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9620435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7916011737 3786805 16097048 15673190 18705752 15700767 16050911 15721981 16124888 10355542 16192424 16227642
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5219066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.5716705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.5718788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.5716924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.5716924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0520419170
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.5117572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.5117572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3716120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Raloxifene 3.4515775269
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.186135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.1820889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.1818566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8817110522 16919318 15861022 16105132 17333356 17681005 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1016354765 8697196 15668235 15340226 12621046
MESH:D003072 Cognition Disorders Raloxifene 4.6315800139
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.6520423518
MESH:D003110 Colonic Neoplasms irinotecan 2.5917287894 17725105
MESH:D015179 Colorectal Neoplasms irinotecan 2.3618259882 17454858 16391804 16303861 15273666 18509181 17159606
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0318551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3819031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1617474826
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies Estradiol 15.0419279558
MESH:D003928 Diabetic Nephropathies Raloxifene 15.0417308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 15.0419279558
MESH:D049310 Distal Myopathies marker/mechanism
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.1821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.1810092053 15968718 19336974 17522070 3786805 19085960 7179309 10915739 2869522 3732212 7120509 16177239 15027814 9327722 11566570 16227642 6623471 7440962 6884620 4309450 15998439 21278145
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.1820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D004487 Edema Raloxifene 6.8715860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9316714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 15.4212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 15.4215845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 15.4219031437
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 12.5819148513
MESH:D016889 Endometrial Neoplasms Estradiol 12.5811473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.5819155303 16202921 20544844 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0210568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3520426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3516530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 18.8415959796 61145 12795759 12631006 16045604 16239168 17595544 19224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.8415345470
MESH:D005234 Fatty Liver Raloxifene 18.8417473493
MESH:D005234 Fatty Liver Tamoxifen 18.8419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2416709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2019069698
MESH:D005355 Fibrosis Carbon Tetrachloride 8.6418705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.6420067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4511294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.5411110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6019900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9116120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.0615709030
MESH:D019584 Hot Flashes Estradiol 3.7817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0816354765 15340226 18606429 8697196 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5516899240
MESH:D006973 Hypertension Raloxifene 5.2317577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2318670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9317937319
MESH:D007248 Infertility, Male fulvestrant 6.9311514358
MESH:D007249 Inflammation Flavonoids 8.3117296493
MESH:D007249 Inflammation Tamoxifen 8.3119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.3112878042 12200463
MESH:D007333 Insulin Resistance Estradiol 2.9716627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007674 Kidney Diseases Estradiol 2.5815618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.4216705839
MESH:D007680 Kidney Neoplasms Estradiol 12.4215610895
MESH:D007680 Kidney Neoplasms Tamoxifen 12.4218625569
MESH:D007889 Leiomyoma Raloxifene 4.5016973256
MESH:D008064 Lipidoses Tamoxifen 3.1617567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8116239168 21278145 16943688 17174718 11408273 16221502 17157831 11903743 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.9416027843 12445418 15123356 15370692 15052691 12898905 18279442 12666154 17721639 18277467 10355542 18395914 16033810 17481882 17944888 18054572 18205269 14620537 16192424 15730626 12632512 15931870 18420326 14716496 12741479 14748882 13678700 18412020 18187930 17922224 12609069 15338365 12586293 17805973 16097048 18006644 15996030 12649538 17766677 15893842 15818738 18472332 11481614 17708605 17900296 16638106 15876570 15650968 12958196 17698563 14716833 16015684 12445421 12389079 17640975 17823541 15057751 16136751 18166357 12632514 18481824 18472094 12667390 18376398 15362042 15673190 17761835 14512876 17525996 17565644 18339082 15925388 20821823 16248980 18705752 17714472 18395095 17557913 18418968 17869086 18156304 12546737 17631135 18210741 18429990 18251166 14724832 16116963 15959796 16011737 18263696 18317297 17976157
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.9414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.9418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9412878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0816246199 17285989 15720792 15830285 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.6916899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.257678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.2520195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.2519294768
MESH:D008113 Liver Neoplasms Tamoxifen 14.2516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.2516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.792876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.7912014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.7912151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.3418520028 20464547 17053015 18816296 20869020 18569708 20135361 6695378 20064080
MESH:D008175 Lung Neoplasms Tamoxifen 3.3418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3411884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7819428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.9717203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.9711731420 19196723 14580682 16827153 19196722
MESH:D020149 Manganese Poisoning Estradiol 12.7519453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.7519453300
MESH:D008545 Melanoma Tamoxifen 1.8812393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2015990972
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5815863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1916381670
MESH:D052016 Mucositis irinotecan 5.0317159606
MESH:D009101 Multiple Myeloma Raloxifene 3.4416497877
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2816810080
MESH:D009232 Myxoma Raloxifene 5.5816343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.8818551238 7678174
MESH:D009362 Neoplasm Metastasis irinotecan 5.9618259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.9619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5219410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1711141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0319189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7517289903
MESH:D009421 Nervous System Malformations Estradiol 9.5016427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.5014600291
MESH:D009447 Neuroblastoma irinotecan 3.488761367
MESH:D017599 Neuroectodermal Tumors irinotecan 4.758761367
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.4316049721
MESH:D010024 Osteoporosis Raloxifene 3.3919059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.2317823083 15579764 17893378 15758505
MESH:D010051 Ovarian Neoplasms Estradiol 2.2219401270
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2111222880 11896295 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0717292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.0716740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0716220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0715067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.3315861022 16919318
MESH:D011693 Purpura Raloxifene 5.5815770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5418551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.4810029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.6616709447
MESH:D013088 Spermatocele Tamoxifen 11.6616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0619457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.552093021 20155912
MESH:D013274 Stomach Neoplasms irinotecan 2.5515723263
MESH:D020521 Stroke Raloxifene 3.8216837676
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 4.9615864552
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013978 Tibial Fractures Estradiol 13.8219048282
MESH:D013978 Tibial Fractures Raloxifene 13.8219048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.9416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.9417053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 11.9417572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.9416712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3410091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.2416837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5414671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5816343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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