Annotation Detail for SPCS2
Basic Information
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| Gene Symbol: | SPCS2 ( KIAA0102,MGC117366 ) |
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| Gene Full Name: | signal peptidase complex subunit 2 homolog (S. cerevisiae) |
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| Band: | 11q13.4 |
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| Quick Links | Entrez ID:9789; OMIM: NA; Uniprot ID:SPCS2_HUMAN; ENSEMBL ID: ENSG00000118363; HGNC ID: 28962 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Pathway ID | Pathway Name |
|---|
| hsa03060 | Protein export |
| Pathway ID | Pathway Name |
|---|
| Diabetes pathways |
| Integration of energy metabolism |
| Pathway ID | Pathway Name |
|---|
| P04395 | Vasopressin synthesis |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D000082 |
Acetaminophen |
Acetaminophen affects the expression of SPCS2 mRNA | affects expression | 17562736
|
| D008767 |
Methylmercury Compounds |
Methylmercury Compounds results in increased expression of SPCS2 mRNA | increases expression | 16966085
|
| D012643 |
Selenium |
[Selenium co-treated with Vitamin E] results in decreased expression of SPCS2 mRNA | affects cotreatment|decreases expression | 19244175
|
| D012643 |
Selenium |
Selenium results in decreased expression of SPCS2 mRNA | decreases expression | 19244175
|
| D014810 |
Vitamin E |
[Selenium co-treated with Vitamin E] results in decreased expression of SPCS2 mRNA | affects cotreatment|decreases expression | 19244175
|
| D014810 |
Vitamin E |
Vitamin E results in decreased expression of SPCS2 mRNA | decreases expression | 19244175
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000799 |
Angioedema |
|
Acetaminophen |
4.57 | 10982225 |
| MESH:D001321 |
Autistic Disorder |
|
Acetaminophen |
1.40 | 18445737 |
| MESH:D002252 |
Carbon Tetrachloride Poisoning |
|
Vitamin E |
4.49 | 16050911 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Acetaminophen |
1.41 | 3084413 |
| MESH:D002386 |
Cataract |
|
Acetaminophen |
2.79 | 10977129 |
| MESH:D003092 |
Colitis |
|
Selenium |
4.34 | 17936198 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
Vitamin E |
1.93 | 19769572 |
| MESH:D003704 |
Dementia |
|
Methylmercury Compounds |
5.42 | 16140633 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Acetaminophen |
4.10 | 15968718 14986274 10663392 11743745 12540782 19085960 18071297 10774834 11461765 15619225 14725611 12594235 16781746 16081117 12153990 19420014 19739265 11834606 17522070 16177239 11421492 16109766 11529661 11739529 10915739 2444490 12705907 16393943 17906064 19923254 11287661 16227642 12958197 19370779 18713872 12392966 14550746 16485898 19416960 17562736 19164858 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Selenium |
4.10 | 15131321 |
| MESH:D056487 |
Drug-Induced Liver Injury, Chronic |
|
Acetaminophen |
4.82 | 19426721 |
| MESH:C538011 |
Eales disease |
|
Vitamin E |
5.43 | 9068938 |
| MESH:D005756 |
Gastritis |
|
Acetaminophen |
4.40 | 16983495 |
| MESH:D006330 |
Heart Defects, Congenital |
|
Vitamin E |
3.17 | 16080930 |
| MESH:D006333 |
Heart Failure |
|
Selenium |
3.29 | 17162251 |
| MESH:D006548 |
Hernia, Diaphragmatic |
|
Vitamin E |
2.81 | 16863852 16490937 |
| MESH:D019584 |
Hot Flashes |
|
Vitamin E |
4.69 | 14716179 |
| MESH:D006930 |
Hyperalgesia |
|
Acetaminophen |
3.02 | 16870215 |
| MESH:D007251 |
Influenza, Human |
|
Selenium |
13.50 | 16624496 |
| MESH:D007251 |
Influenza, Human |
|
Vitamin E |
13.50 | 16624496 |
| MESH:D007674 |
Kidney Diseases |
|
Acetaminophen |
6.65 | 15629191 12587719 |
| MESH:D007674 |
Kidney Diseases |
|
Vitamin E |
6.65 | 12488133 |
| MESH:D007676 |
Kidney Failure, Chronic |
|
Selenium |
4.31 | 16518626 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Vitamin E |
1.91 | 16169303 |
| MESH:D008107 |
Liver Diseases |
|
Acetaminophen |
1.70 | 16610002 16611625 19460945 12969438 11587558 19784758 12587719 19014921 |
| MESH:D017114 |
Liver Failure, Acute |
|
Acetaminophen |
3.63 | 17185352 16871587 |
| MESH:D008171 |
Lung Diseases |
|
Vitamin E |
3.43 | 16863852 |
| MESH:D008175 |
Lung Neoplasms |
|
Vitamin E |
1.90 | 11062179 |
| MESH:D008325 |
Mammary Neoplasms, Experimental |
|
Selenium |
2.99 | 15318939 |
| MESH:D008546 |
Melanoma, Experimental |
|
Acetaminophen |
4.13 | 19513568 |
| MESH:D008569 |
Memory Disorders |
|
Methylmercury Compounds |
5.41 | 18436314 |
| MESH:D008654 |
Mesothelioma |
|
Selenium |
2.92 | 15107826 |
| MESH:D009069 |
Movement Disorders |
|
Methylmercury Compounds |
5.79 | 18436314 |
| MESH:D019636 |
Neurodegenerative Diseases |
|
Acetaminophen |
3.21 | 18514411 |
| MESH:D010146 |
Pain |
|
Acetaminophen |
2.73 | 16870215 |
| MESH:D010954 |
Plasmacytoma |
|
Selenium |
5.61 | 15087411 |
| MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
Methylmercury Compounds |
5.61 | 18436314 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Vitamin E |
3.24 | 15084515 |
| MESH:D012871 |
Skin Diseases |
|
Vitamin E |
2.52 | 18709164 |
| MESH:D020521 |
Stroke |
|
Vitamin E |
3.84 | 16517955 |
| MESH:D014581 |
Urticaria |
|
Acetaminophen |
3.44 | 10982225 |
PharmGKB Accession:PA128394559
| Releated disease ID |
Related disease Name |
| PA446155 | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
Related Diseases/Disorders