AutismKB 2.0

Annotation Detail for CKAP5


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Basic Information Top
Gene Symbol:CKAP5 ( CHTOG,FLJ35359,KIAA0097,MSPS,TOG,TOGp,ch-TOG )
Gene Full Name: cytoskeleton associated protein 5
Band: 11p11.2
Quick LinksEntrez ID:9793; OMIM: 611142; Uniprot ID:CKAP5_HUMAN; ENSEMBL ID: ENSG00000175216; HGNC ID: 28959
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
Pathway IDPathway Name
200166Aurora A signaling
No data
Pathway IDPathway Name
500383Loss of proteins required for interphase microtubule organization from the centrosome
500380Centrosome maturation
500381Recruitment of mitotic centrosome proteins and complexes
500384Loss of Nlp from mitotic centrosomes
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CKAP5 mRNAaffects expression 21346803
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CKAP5 mRNAdecreases expression 19150397
20382639
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of CKAP5 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of CKAP5 mRNAincreases expression 19482888
19270015
C006253 pirinixic acid pirinixic acid results in decreased expression of CKAP5 mRNAdecreases expression 17426115
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 4.076195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D018248 Adenoma, Liver Cell Phenobarbital 12.3217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 12.3216434500
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5719483382
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.1616705839
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.166705139 1701930 20935162 20007298 17173139
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.536135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.5320889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.814080065
MESH:D002779 Cholestasis pirinixic acid 3.1219176532
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.5818551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 2.0518551238 21346803
MESH:D004421 Dystonia Phenobarbital 4.471851702
MESH:D004487 Edema pirinixic acid 2.9012083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.673659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.593922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0620417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.916401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.817750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.653659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1520426865
MESH:D005234 Fatty Liver pirinixic acid 3.1920131406 19236843
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006529 Hepatomegaly Phenobarbital 10.4116109766
MESH:D006529 Hepatomegaly pirinixic acid 10.4116221962 19176532 19772884 18467677
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D007333 Insulin Resistance pirinixic acid 2.8716306350
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.3216705839
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0821047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Phenobarbital 2.2419363144
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 8.137678174
MESH:D008113 Liver Neoplasms Phenobarbital 8.1319073162 19812893 8742319 19482888 21047994 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 8.1315890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.722876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.7217172636 18308698 2563599 1399818 6150874
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.1117484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.497678174 18551238
MESH:D009369 Neoplasms pirinixic acid 2.1117405874
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.8316049721
MESH:D010018 Osteomalacia Phenobarbital 5.0017016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.6016965848
MESH:D011230 Precancerous Conditions Phenobarbital 3.992563599
MESH:D019310 Pseudolymphoma Phenobarbital 5.2212752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D012640 Seizures 2,6-dinitrotoluene 6.8018551238
MESH:D012640 Seizures Phenobarbital 6.803137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.456407741
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.361399818
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.4116049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.9510091137
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA142672107
    • No data
    Releated disease ID Related disease Name
    PA443532Bone Diseases
    PA443536Bone Diseases, Metabolic
    No data
    Drug Bank Top

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    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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