AutismKB 2.0

Annotation Detail for RNF40


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Basic Information Top
Gene Symbol:RNF40 ( BRE1B,DKFZp686K191,KIAA0661,MGC13051,RBP95,STARING )
Gene Full Name: ring finger protein 40
Band: 16p11.2
Quick LinksEntrez ID:9810; OMIM: 607700; Uniprot ID:BRE1B_HUMAN; ENSEMBL ID: ENSG00000103549; HGNC ID: 16867
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RNF40 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of RNF40 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RNF40 mRNAaffects expression 16483693
D005419 Flavonoids Flavonoids results in decreased expression of RNF40 mRNAdecreases expression 18035473
D012643 Selenium Selenium results in increased expression of RNF40 mRNAincreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in increased expression of RNF40 mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 2.9316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.933084413
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D019457 Chromosome Breakage Sodium Selenite 5.1715894690
MESH:D003092 Colitis Selenium 4.2017936198
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.4318551238
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.0616285004
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.6421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.6417562736 16781746 12594235 16109766 19923254 11461765 14986274 12705907 19370779 14725611 16485898 12153990 15619225 10915739 16393943 19416960 17522070 17906064 16227642 18713872 12392966 15968718 11834606 16177239 11529661 11287661 12958197 19739265 11421492 16081117 19420014 10663392 12540782 19085960 19164858 18071297 14550746 11739529 2444490 11743745 10774834
MESH:D056486 Drug-Induced Liver Injury Selenium 9.6415131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.6415131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006333 Heart Failure Selenium 3.2517162251
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D007249 Inflammation Flavonoids 2.7917296493
MESH:D007251 Influenza, Human Selenium 4.7216624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.4714714311
MESH:D007674 Kidney Diseases Acetaminophen 2.3612587719 15629191
MESH:D007676 Kidney Failure, Chronic Selenium 4.2116518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.2416705839
MESH:D008107 Liver Diseases Acetaminophen 1.6911587558 16611625 19014921 12969438 19784758 12587719 19460945 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.4114737004
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9515318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008654 Mesothelioma Selenium 2.8915107826
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.3218551238
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.7316049721 12819281
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010954 Plasmacytoma Selenium 5.4115087411
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3418760546
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7318551238
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3816049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7810091137
MESH:D014581 Urticaria Acetaminophen 3.3310982225
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34440
    • No data
    Releated disease ID Related disease Name
    PA153906318Autism Spectrum Disorder
    Releated drug ID Related drug Name
    PA451257risperidone
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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