AutismKB 2.0

Annotation Detail for KEAP1


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Basic Information Top
Gene Symbol:KEAP1 ( INrf2,KIAA0132,KLHL19,MGC10630,MGC1114,MGC20887,MGC4407,MGC9454 )
Gene Full Name: kelch-like ECH-associated protein 1
Band: 19p13.2
Quick LinksEntrez ID:9817; OMIM: 606016; Uniprot ID:KEAP1_HUMAN; ENSEMBL ID: ENSG00000079999; HGNC ID: 23177
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04120Ubiquitin mediated proteolysis
No data
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
1848Embryoma
1904Diabetes mellitus
2066Lung cancer
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C049325 1,2-dithiol-3-thione 1,2-dithiol-3-thione inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]affects binding|decreases reaction 15302862
C477819 15-deoxyprostaglandin J2 15-deoxyprostaglandin J2 affects the metabolism of KEAP1 proteinaffects metabolic processing 18785192
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of KEAP1 mRNAaffects expression 21346803
C018855 2-tert-butylhydroquinone 2-tert-butylhydroquinone results in increased expression of KEAP1 proteinincreases expression 19033392
C018855 2-tert-butylhydroquinone 2-tert-butylhydroquinone binds to KEAP1 proteinaffects binding 19808700
C527796 3-morpholinopropyl isothiocyanate 3-morpholinopropyl isothiocyanate results in decreased expression of KEAP1 proteindecreases expression 20498004
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of KEAP1 mRNAdecreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of KEAP1 mRNAaffects expression 21346803
D000082 Acetaminophen ABCC3 protein affects the reaction [KEAP1 protein affects the glucuronidation of Acetaminophen]affects glucuronidation|affects reaction 19246624
D000082 Acetaminophen KEAP1 gene mutant form results in decreased susceptibility to Acetaminophendecreases response to substance 16293230
D000082 Acetaminophen KEAP1 protein affects the glucuronidation of Acetaminophenaffects glucuronidation 19246624
D000082 Acetaminophen KEAP1 protein affects the glutathionylation of Acetaminophenaffects glutathionylation 19246624
D000082 Acetaminophen KEAP1 protein affects the sulfation of Acetaminophenaffects sulfation 19246624
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of KEAP1 protein]decreases reaction|increases expression 19033392
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [Indomethacin inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]]affects binding|decreases reaction 11909699
D000638 Amiodarone Amiodarone results in decreased expression of KEAP1 mRNAdecreases expression 17991464
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KEAP1 mRNAaffects expression 16483693
D001151 Arsenic Arsenic binds to KEAP1 proteinaffects binding 19808700
D001151 Arsenic KEAP1 protein affects the susceptibility to Arsenicaffects response to substance 19808700
C006632 arsenic trioxide arsenic trioxide results in increased expression of KEAP1 mRNAincreases expression 19417148
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of KEAP1 mRNAdecreases expression 20498004
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of KEAP1 proteindecreases expression 20498004
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of KEAP1 mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KEAP1 mRNAdecreases expression 19150397
C034786 bis(4-hydroxycinnamoyl)methane KEAP1 protein inhibits the reaction [bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 mRNA]decreases reaction|increases expression 17535857
D019256 Cadmium Chloride Cadmium Chloride binds to KEAP1 proteinaffects binding 19808700
C012843 cinnamic aldehyde cinnamic aldehyde results in increased expression of KEAP1 proteinincreases expression 19033392
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of KEAP1 mRNAaffects cotreatment|affects expression 17602206
D003474 Curcumin KEAP1 protein inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]decreases reaction|increases expression 17535857
C014347 decitabine [decitabine affects the methylation of KEAP1 promoter] which affects the expression of KEAP1 mRNAaffects expression|affects methylation 18555005
C050229 demethoxycurcumin KEAP1 protein inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]decreases reaction|increases expression 17535857
C031710 dexamethasone 21-methanesulfonate dexamethasone 21-methanesulfonate affects the metabolism of KEAP1 proteinaffects metabolic processing 18785192
D004041 Dietary Fats Dietary Fats results in decreased expression of KEAP1 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of KEAP1 mRNAaffects cotreatment|affects expression 17602206
D004112 Dimercaprol Dimercaprol binds to KEAP1 proteinaffects binding 19808700
D004137 Dinitrochlorobenzene Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of KEAP1 protein]decreases reaction|increases expression 19033392
D004137 Dinitrochlorobenzene Dinitrochlorobenzene results in increased expression of KEAP1 proteinincreases expression 19033392
D004137 Dinitrochlorobenzene Dinitrochlorobenzene affects the metabolism of KEAP1 proteinaffects metabolic processing 18785192
D005419 Flavonoids Flavonoids results in decreased expression of KEAP1 mRNAdecreases expression 18035473
D005472 Fluorouracil KEAP1 protein affects the susceptibility to Fluorouracilaffects response to substance 18692501
C013038 hydroxyhydroquinone hydroxyhydroquinone results in increased expression of KEAP1 mRNAincreases expression 17572062
D007213 Indomethacin Acetylcysteine inhibits the reaction [Indomethacin inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]]affects binding|decreases reaction 11909699
D007213 Indomethacin Indomethacin inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]affects binding|decreases reaction 11909699
D007213 Indomethacin KEAP1 protein inhibits the reaction [Indomethacin results in increased expression of GCLC mRNA]decreases reaction|increases expression 11909699
D007460 Iodoacetamide Iodoacetamide affects the metabolism of KEAP1 proteinaffects metabolic processing 18785192
C038018 lilial lilial results in increased expression of KEAP1 proteinincreases expression 19033392
C028473 N-acetyl-4-benzoquinoneimine KEAP1 protein inhibits the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]decreases reaction|increases metabolic processing 19246624
C028473 N-acetyl-4-benzoquinoneimine N-acetyl-4-benzoquinoneimine affects the metabolism of KEAP1 proteinaffects metabolic processing 18785192
D009532 Nickel Nickel results in increased expression of KEAP1 proteinincreases expression 19033392
C029341 oxophenylarsine oxophenylarsine binds to KEAP1 proteinaffects binding 19808700
19786557
C041786 palm oil palm oil results in decreased expression of KEAP1 mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of KEAP1 mRNAaffects binding|increases activity|increases expression 19710929
C487081 PXD101 PXD101 results in decreased expression of KEAP1 mRNAdecreases expression 19606018
D011794 Quercetin Quercetin results in increased metabolism of and results in increased degradation of and results in decreased expression of KEAP1 proteindecreases expression|increases degradation|increases metabolic processing 17462537
C059514 resveratrol resveratrol inhibits the reaction [NFE2L2 protein binds to KEAP1 protein]affects binding|decreases reaction 16948474
D012402 Rotenone KEAP1 gene mutant form results in decreased susceptibility to Rotenonedecreases response to substance 19167360
D012643 Selenium Selenium results in increased expression of KEAP1 mRNAincreases expression 19244175
C017947 sodium arsenite sodium arsenite inhibits the reaction [[CUL3 protein binds to KEAP1 protein] which binds to and results in increased ubiquitination of NFE2L2 protein]affects binding|decreases reaction|increases ubiquitination 16785233
C016766 sulforafan sulforafan results in increased expression of KEAP1 proteinincreases expression 19033392
D008063 Thioctic Acid Thioctic Acid results in increased expression of KEAP1 proteinincreases expression 19033392
C066075 vanadium pentoxide vanadium pentoxide results in decreased expression of KEAP1 mRNAdecreases expression 17459161
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 3.467525203
MESH:D000138 Acidosis Ammonium Chloride 3.0618287403
MESH:D058186 Acute Kidney Injury resveratrol 3.4116538975
MESH:D055371 Acute Lung Injury Nickel 7.7216166738
MESH:D055371 Acute Lung Injury pirinixic acid 7.7218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 8.9419825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 8.9420127859 20464547
MESH:D000230 Adenocarcinoma Fluorouracil 8.9417638652
MESH:D000230 Adenocarcinoma Indomethacin 8.9416537180
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 17.803712494
MESH:D000236 Adenoma Benzo(a)pyrene 17.806695378
MESH:D000236 Adenoma Diethylnitrosamine 17.8010737359 6695378
MESH:D000236 Adenoma Indomethacin 17.8011497255
MESH:D000236 Adenoma resveratrol 17.8015688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 8.4419052882 18056438 19061943 16434500 17162532 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.4416434500
MESH:D011125 Adenomatous Polyposis Coli sulforafan 4.8317942926
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.1915276417
MESH:D018246 Adrenocortical Adenoma Arsenic 12.1017306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 12.1017306315 16712894
MESH:D019973 Alcohol-Related Disorders Curcumin 4.5717887948
MESH:D016301 Alveolar Bone Loss Indomethacin 4.8617225004
MESH:D000544 Alzheimer Disease bis(4-hydroxycinnamoyl)methane 8.4019090986
MESH:D000544 Alzheimer Disease Curcumin 8.4015590663
MESH:D000544 Alzheimer Disease Indomethacin 8.4017627676 15579461
MESH:D000544 Alzheimer Disease resveratrol 8.4016162502 16183991
MESH:D000740 Anemia Fluorouracil 3.2817963324 15504547 16511603
MESH:D000743 Anemia, Hemolytic Quercetin 3.7917084956
MESH:D000799 Angioedema Acetaminophen 3.3410982225
MESH:D001014 Aortic Aneurysm Indomethacin 4.3810231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 10.1019183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 10.1010388637
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.3718218290 20041841 18057881
MESH:D020261 Arsenic Poisoning Arsenic 2.7116835338 12569548 16251483 18414634
MESH:D001161 Arteriosclerosis Dietary Fats 3.4115238619
MESH:D018771 Arthralgia Indomethacin 4.662160914
MESH:D001169 Arthritis, Experimental resveratrol 3.1817115116
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.4616807698
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.4611248219
MESH:D001260 Ataxia Telangiectasia Quercetin 4.4815336622
MESH:D050197 Atherosclerosis Arsenic 9.3012928151 19371607
MESH:D050197 Atherosclerosis Curcumin 9.3018704882
MESH:D050197 Atherosclerosis resveratrol 9.3016873680 17967414
MESH:D001281 Atrial Fibrillation Amiodarone 3.5319698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4818445737
MESH:D001327 Autoimmune Diseases Curcumin 15.4419761891
MESH:D001327 Autoimmune Diseases Quercetin 15.4419761891
MESH:D001327 Autoimmune Diseases sulforafan 15.4419761891
MESH:D001477 Bartter Syndrome Indomethacin 4.5010684365
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.5111289319 1440618
MESH:D001778 Blood Coagulation Disorders Amiodarone 12.8219483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 12.8216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 12.8219483382
MESH:D001929 Brain Edema Indomethacin 4.5211481608
MESH:D002545 Brain Ischemia Curcumin 14.2316770732
MESH:D002545 Brain Ischemia Indomethacin 14.2312524144
MESH:D002545 Brain Ischemia resveratrol 14.2317600658
MESH:D001932 Brain Neoplasms Curcumin 3.5117596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.3020146248 17474063
MESH:D001943 Breast Neoplasms Curcumin 6.3018462866 18593918 16243823 19250217
MESH:D001943 Breast Neoplasms decitabine 6.3019208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 6.3020435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 6.3017474063
MESH:D001943 Breast Neoplasms Fluorouracil 6.3015136595 16110121 19217205 18608205 18357371 16595493 16557594
MESH:D001943 Breast Neoplasms Indomethacin 6.3017401462
MESH:D001943 Breast Neoplasms Nickel 6.3015986119
MESH:D001943 Breast Neoplasms Quercetin 6.3018628248
MESH:D001943 Breast Neoplasms resveratrol 6.3017534123 17651959 16393696
MESH:D001991 Bronchitis vanadium pentoxide 5.7317459161
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.8711589617
MESH:D002056 Burns Indomethacin 4.2210459503
MESH:D002100 Cachexia Indomethacin 4.5111239499 16537180 15141370 15625704
MESH:D002105 Cadmium Poisoning Quercetin 5.0416962696
MESH:D002276 Carcinoid Tumor Fluorouracil 4.1616051944
MESH:D002277 Carcinoma Curcumin 7.2518593918
MESH:D002277 Carcinoma Fluorouracil 7.2517121937
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.3017687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 23.6716705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 23.677296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 23.673084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 23.6717306315 16507464
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 23.6715073043 14691202 15553829 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 23.6710672840 16779866 20214788 20101231 16935385 16540662 16569478 21159647 17761372 16681979 16878318 19052882 19919837 19519916 19701751 18056438 18788625 16830150 16502159 3084413 18506893 20084675 20727157 18785209 16328049 18494052 19171122 19394651 17138121 18665156 17173139 18691550 16288022 17428255 19208518 18971187 17978847 16698587 17055752 20935162 20514400 19822196 18393292 20007298 19539802 20524982 18210153 19107877 19418558 20512989 19335982 17162532 11831363 19383236 20432363 16807293 10737359 3581430 18978308
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 23.6716799960 16332177 17971768 17045692 17088986 18930000
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 23.6716391822
MESH:D006528 Carcinoma, Hepatocellular Quercetin 23.6719519916 12508355
MESH:D006528 Carcinoma, Hepatocellular resveratrol 23.6719321006 16227395
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 23.6716507464 17306315 15276417
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 9.7711053908
MESH:D018827 Carcinoma, Lewis Lung resveratrol 9.7716675471
MESH:D018276 Carcinoma, Medullary Indomethacin 4.8514736730 11352223 18791128
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.7918414057
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.4717234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.3719014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 9.337296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 9.3318695887
MESH:D002292 Carcinoma, Renal Cell Indomethacin 9.3317341418
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.6812490120
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 26.8617015178
MESH:D002294 Carcinoma, Squamous Cell Arsenic 26.8615504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 26.8620419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 26.8618462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 26.8619215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 26.8616280240 16757204 17066447 18986760
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 26.8615482327 12636206
MESH:D002294 Carcinoma, Squamous Cell resveratrol 26.8616227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 26.8618572023
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.6518640142
MESH:D006332 Cardiomegaly Quercetin 3.0319794523
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7015710769 19225199
MESH:D002318 Cardiovascular Diseases Arsenic 6.4015738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases resveratrol 6.4015458977
MESH:D002340 Carotid Artery Diseases Arsenic 3.8918022660 16973168
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.5918974383
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 6.4014694615
MESH:D002386 Cataract Acetaminophen 6.4010977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 21.827505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 21.8220889678
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 21.8218226522
MESH:D002471 Cell Transformation, Neoplastic cinnamic aldehyde 21.828243401
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 21.822727394 21159647 17174075 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 21.8220056578 19524636
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.2719052882
MESH:D002764 Cholecystitis Indomethacin 4.6611181007
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 6.6019486331 9022650
MESH:D002779 Cholestasis pirinixic acid 6.6019176532
MESH:D003092 Colitis Curcumin 13.3016804969 16782535 18200517
MESH:D003092 Colitis resveratrol 13.3016474422
MESH:D003092 Colitis Selenium 13.3017936198
MESH:D003093 Colitis, Ulcerative Dinitrochlorobenzene 3.6717373747 19159591
MESH:D003103 Coloboma Curcumin 4.1018809619
MESH:D003110 Colonic Neoplasms cinnamic aldehyde 15.4617510524 16343908
MESH:D003110 Colonic Neoplasms Curcumin 15.4619359593 16340194
MESH:D003110 Colonic Neoplasms decitabine 15.4617616700
MESH:D003110 Colonic Neoplasms Fluorouracil 15.4616510598 17016597 17725105 17169374 15001691 17172411 17287894 18772588 16340194 17018589
MESH:D003110 Colonic Neoplasms Indomethacin 15.4615786552 15936596 15963497 11260862 15625704 15637740
MESH:D003110 Colonic Neoplasms Quercetin 15.4611134977 17148506 17191121 16640504 19440933 19056647 15741050
MESH:D003110 Colonic Neoplasms resveratrol 15.4616338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 7.5620501625
MESH:D015179 Colorectal Neoplasms decitabine 7.5618981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 7.5616331619 17594712 18802399 15289873 16282729 17094418 16524972 18448328 17454858 17016601 15148649 17255274 17401013 18949393 18509181 18288408 16303861 14970324 17695437 16391804 18383874 20501625
MESH:D015179 Colorectal Neoplasms Indomethacin 7.5612606626 11197048 17054584 18059344
MESH:D015179 Colorectal Neoplasms Quercetin 7.5618095365 18852136
MESH:D015179 Colorectal Neoplasms resveratrol 7.5616550006
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 3.7415095906
MESH:D016510 Corneal Neovascularization Curcumin 4.4118497527
MESH:D003327 Coronary Disease resveratrol 3.4216507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.7112609071
MESH:D018352 Coronavirus Infections Indomethacin 5.2117302372
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8610525206
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.5318551238
MESH:D003550 Cystic Fibrosis Acetylcysteine 3.9519747007
MESH:D007644 Darier Disease Fluorouracil 4.2916733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.6415213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 12.758156756 14531868 18759878 11906362 12868966 11298694 8970840 2524372
MESH:D017449 Dermatitis, Allergic Contact cinnamic aldehyde 12.7511042091
MESH:D017449 Dermatitis, Allergic Contact Dinitrochlorobenzene 12.7515491423
MESH:D017449 Dermatitis, Allergic Contact Nickel 12.7517244072 17100760 19470301
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 8.022952479 3621924
MESH:D003877 Dermatitis, Contact Nickel 8.022952479
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 7.2119496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 7.2116873680
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.1118403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1120387270
MESH:D003928 Diabetic Nephropathies Curcumin 7.8518204486
MESH:D003928 Diabetic Nephropathies resveratrol 7.8516286809
MESH:D003967 Diarrhea Indomethacin 3.347237001 7907874
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 19.1321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 19.139328219 8291058 18692083 6482804 18289764 18648102 9022650 16192314 1440618 7440962 9653073 6679447 11289319
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 19.1321346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 19.1312153990 10915739 18713872 16081117 12392966 15968718 19923254 19739265 10663392 16227642 2444490 11834606 10774834 17522070 15619225 19416960 12540782 12705907 19420014 16781746 11529661 14986274 11743745 16177239 11739529 11421492 14550746 11287661 16393943 18071297 19370779 19085960 19164858 14725611 12594235 17906064 16485898 16109766 17562736 12958197 11461765
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 19.1311287661
MESH:D056486 Drug-Induced Liver Injury Amiodarone 19.1315265979 18218290
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 19.1319107877
MESH:D056486 Drug-Induced Liver Injury Selenium 19.1315131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5919426721
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.6518446180 16133044 18043480 17190690 16326151 12774134
MESH:D004381 Duodenal Ulcer Curcumin 7.8617351913
MESH:D004381 Duodenal Ulcer Indomethacin 7.8617329845 17351913 17151854 11595431 17045617 17202747 11535926 11991626 16699067 10671773 11595415
MESH:D050171 Dyslipidemias Dietary Fats 3.0918367378
MESH:D004487 Edema bis(4-hydroxycinnamoyl)methane 17.0618449507
MESH:D004487 Edema demethoxycurcumin 17.0618449507
MESH:D004487 Edema Indomethacin 17.0610653021 7907874 8985016 16100529 7990266 8273558 19703484
MESH:D004487 Edema pirinixic acid 17.0612083418
MESH:D004487 Edema resveratrol 17.068985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.5617872969
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.6119294695
MESH:D004715 Endometriosis Indomethacin 3.7215652904
MESH:D019446 Endotoxemia Indomethacin 4.0118509659
MESH:D004751 Enteritis Indomethacin 4.2417763956 10567023 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 10.7617980183
MESH:D020345 Enterocolitis, Necrotizing resveratrol 10.7617923197
MESH:D004802 Eosinophilia Indomethacin 3.5711298111
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6116302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 15.433581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.4320426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 15.4312903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 15.4316530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 15.4315173087 17638652 16337965 16481741 16785472
MESH:D004938 Esophageal Neoplasms Indomethacin 15.4311005569
MESH:D005234 Fatty Liver Amiodarone 24.9714986274
MESH:D005234 Fatty Liver arsenic trioxide 24.9715073043
MESH:D005234 Fatty Liver Curcumin 24.9719297423
MESH:D005234 Fatty Liver Dietary Fats 24.9717967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 24.9720387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 24.9719236843 20131406
MESH:D005334 Fever Indomethacin 3.6910431976 11852909 17627676
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.516705139
MESH:D005354 Fibrosarcoma Indomethacin 4.4010962813
MESH:D005355 Fibrosis Curcumin 17.2818705752
MESH:D005355 Fibrosis Dietary Fats 17.2818296743
MESH:D005355 Fibrosis Indomethacin 17.2817994277
MESH:D005355 Fibrosis Quercetin 17.2819474275
MESH:D005499 Folliculitis Indomethacin 4.6611298111
MESH:D005534 Foot Diseases Arsenic 5.056392382
MESH:D005706 Gallbladder Neoplasms marker/mechanism 18692501
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.7916904648
MESH:D005756 Gastritis Acetaminophen 16.3416983495
MESH:D005756 Gastritis Indomethacin 16.3415046732
MESH:D005756 Gastritis Iodoacetamide 16.3415046732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.2118462866
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.1816452187
MESH:D005909 Glioblastoma Curcumin 10.1017596214
MESH:D005909 Glioblastoma Indomethacin 10.1012870263
MESH:D005909 Glioblastoma Quercetin 10.1019804834
MESH:D005910 Glioma Fluorouracil 8.7216145905
MESH:D005910 Glioma Indomethacin 8.7218371953 16487511
MESH:D005910 Glioma Quercetin 8.7217643826
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.8911849393
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.587505956
MESH:D006073 Gout Indomethacin 4.8511248219
MESH:D006258 Head and Neck Neoplasms Curcumin 15.6618462866 18829502
MESH:D006258 Head and Neck Neoplasms decitabine 15.6619215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 15.6615162350 15102660 18337622
MESH:D006258 Head and Neck Neoplasms Indomethacin 15.6615482327
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.3820471113
MESH:D006333 Heart Failure pirinixic acid 5.8920558911
MESH:D006333 Heart Failure Selenium 5.8917162251
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.1215633222
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.046705139
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.2115135802
MESH:D006529 Hepatomegaly Amiodarone 6.9715265979
MESH:D006529 Hepatomegaly pirinixic acid 6.9719772884 16221962 18467677 19176532
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.5517701891
MESH:D006561 Herpes Simplex resveratrol 3.6916876885
MESH:D015658 HIV Infections Nickel 3.5417263646
MESH:D006689 Hodgkin Disease sodium arsenite 2.7512676792
MESH:D006930 Hyperalgesia Acetaminophen 6.5216870215
MESH:D006930 Hyperalgesia Indomethacin 6.5212727271
MESH:D034321 Hyperamylasemia Indomethacin 5.2117883296
MESH:D006937 Hypercholesterolemia Amiodarone 18.179751232 8137927
MESH:D006937 Hypercholesterolemia Curcumin 18.1718704882
MESH:D006937 Hypercholesterolemia Dietary Fats 18.1721332399
MESH:D006937 Hypercholesterolemia resveratrol 18.1717188708
MESH:D006940 Hyperemia Indomethacin 4.5112524144
MESH:D006943 Hyperglycemia pirinixic acid 7.8120558911
MESH:D006943 Hyperglycemia Quercetin 7.8111834736 18262572
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.0217050553
MESH:D006949 Hyperlipidemias Dietary Fats 12.8621332399
MESH:D006949 Hyperlipidemias Indomethacin 12.8617546600
MESH:D006949 Hyperlipidemias resveratrol 12.8616873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.4515034207
MESH:D006973 Hypertension Arsenic 4.8716076760 9931084 11953799
MESH:D006973 Hypertension Quercetin 4.8718356687
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.8717488730
MESH:D006987 Hypesthesia Arsenic 5.0516093927
MESH:D007037 Hypothyroidism Amiodarone 4.0318020914 17991464
MESH:D007077 Ileal Diseases Indomethacin 4.5210574470 18306037
MESH:D007079 Ileitis Indomethacin 4.8510647630 10651667 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.8616133044
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.1617600658
MESH:D007248 Infertility, Male decitabine 5.7717581917
MESH:D007248 Infertility, Male sodium arsenite 5.7715346721 12646999
MESH:D007249 Inflammation Curcumin 19.9818403477 17151092 16956363
MESH:D007249 Inflammation Dietary Fats 19.9820412841
MESH:D007249 Inflammation Diethylnitrosamine 19.9818785209
MESH:D007249 Inflammation Flavonoids 19.9817296493
MESH:D007249 Inflammation Indomethacin 19.987812673 3291741 12568917
MESH:D007249 Inflammation Nickel 19.9816166738
MESH:D007249 Inflammation resveratrol 19.9816366677
MESH:D015212 Inflammatory Bowel Diseases Curcumin 2.9918596194 18200517
MESH:D007251 Influenza, Human Quercetin 15.7316624496
MESH:D007251 Influenza, Human resveratrol 15.7316624496
MESH:D007251 Influenza, Human Selenium 15.7316624496
MESH:D007333 Insulin Resistance Dietary Fats 6.1311836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 6.1316306350
MESH:D007410 Intestinal Diseases Indomethacin 3.8417994277 17329856 15610444 11713966 11855677 15831440 18236018 11686837 10210152
MESH:D007414 Intestinal Neoplasms Curcumin 3.7910783313
MESH:D019586 Intracranial Hypertension Indomethacin 4.8615241188
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.519022650 8074119
MESH:D007579 Jejunal Diseases Indomethacin 4.5216133968 10574470 18306037
MESH:D007627 Keloid Quercetin 4.4717086741
MESH:D007642 Keratosis Arsenic 4.4916930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 15.8712587719 15629191
MESH:D007674 Kidney Diseases Cadmium Chloride 15.8716962696
MESH:D007674 Kidney Diseases Indomethacin 15.8717190690
MESH:D007674 Kidney Diseases Quercetin 15.8716962696
MESH:D007674 Kidney Diseases sodium arsenite 15.8720008137
MESH:D007676 Kidney Failure, Chronic Selenium 3.4416518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 10.1016705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 10.106582329
MESH:D007680 Kidney Neoplasms Fluorouracil 10.1016985049
MESH:D007889 Leiomyoma Curcumin 4.1118555241
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.5010320625 12228301 11703811
MESH:D007938 Leukemia arsenic trioxide 12.8015070760
MESH:D007938 Leukemia Curcumin 12.8018462866
MESH:D007938 Leukemia decitabine 12.8019235587 18980019
MESH:D007938 Leukemia Quercetin 12.8017468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 8.2812560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 8.2816106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.8116972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 7.3114633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 7.3110785260 16572323 15631656
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.1119077051
MESH:D007951 Leukemia, Myeloid decitabine 8.1118454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 5.5520471514 16467208 19850784 16968895 17050201
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.5519010910 18206229 17679729 19387464 18460780 18704418
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 5.5518360721
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.9518055864
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 10.8817339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 10.8816331271 16330433 17107899 15622746 19642359 17869043 16891316 19225113 15748426 12018890 12712474 17649720 17712046 11161223 16823087 16966277 15213294 12679006 19075265 17217047 11468182 15336539 19035177 16112521 9834237
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 10.8816087638
MESH:D015458 Leukemia, T-Cell arsenic trioxide 10.1416882451
MESH:D015458 Leukemia, T-Cell Curcumin 10.1416106398
MESH:D007964 Leukocytosis Indomethacin 4.8616537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.2117980183
MESH:D008064 Lipidoses Amiodarone 3.1517567588 15342952
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.2111479899
MESH:D008103 Liver Cirrhosis Dietary Fats 5.6718296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.6718665156 19638242 18522880 18407596 20032147
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.879327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 4.4018006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 4.4018194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.4015474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 4.4012741479
MESH:D008107 Liver Diseases Acetaminophen 8.1116610002 12969438 12587719 19784758 11587558 19460945 16611625 19014921
MESH:D008107 Liver Diseases Arsenic 8.1111134558
MESH:D008107 Liver Diseases Curcumin 8.1116956363
MESH:D008107 Liver Diseases Diethylnitrosamine 8.1117034775
MESH:D017114 Liver Failure, Acute Acetaminophen 2.8016871587 17185352
MESH:D008113 Liver Neoplasms Arsenic 29.7216368122
MESH:D008113 Liver Neoplasms arsenic trioxide 29.7214682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 29.7220195826 21137059
MESH:D008113 Liver Neoplasms Clofibric Acid 29.7217602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 29.7219690152 19996281 19294768 19850985 19499222 21167192 20101389 9163691 21278145 19427195 19426721 15885732 19254457 19090486 18648771 19255062 12112319 19551842 15175105 20583210 12771043 19073162 20137499 20492335 20452335 20501860 19812893 19256749 19638242 20118626 18977376 18754104 18644402 20434301 2862719 19833225 16942905 21047994 18978307 20405173 19642983 21071580 2422723 10737359
MESH:D008113 Liver Neoplasms Fluorouracil 29.7217045692 18383874 15113037 16603448
MESH:D008113 Liver Neoplasms pirinixic acid 29.7220007298 15890375 16377806
MESH:D008113 Liver Neoplasms Quercetin 29.7218980244
MESH:D008113 Liver Neoplasms resveratrol 29.7219321006 19812893 20405173 19073162
MESH:D008113 Liver Neoplasms sodium arsenite 29.7216712894 15276417
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 11.506587162 598648 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 11.5020377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 11.5017174075 19539802 17854601 16267830 9362446 19009564 18093689 18775883 21159647 18079962 19126423 18544905 3124819 17942915 16842330 2563599 18308698 18164116 19519916 18282651 19004024 18253720
MESH:D008114 Liver Neoplasms, Experimental Quercetin 11.5019519916
MESH:D008133 Long QT Syndrome Amiodarone 6.9211989578 15350150 17391786
MESH:D008133 Long QT Syndrome arsenic trioxide 6.9215213294
MESH:D008171 Lung Diseases Acetylcysteine 10.4912815614
MESH:D008171 Lung Diseases Amiodarone 10.4912587719
MESH:D008171 Lung Diseases sodium arsenite 10.4919095001
MESH:D017563 Lung Diseases, Interstitial Amiodarone 3.9718516814
MESH:D008175 Lung Neoplasms Arsenic 16.1617306315 17976673 19168569
MESH:D008175 Lung Neoplasms arsenic trioxide 16.1619825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 16.1617053015 18569708 20064080 18816296 20135361 20464547 20869020 18520028 6695378
MESH:D008175 Lung Neoplasms Curcumin 16.1619359593 16243823 18462866
MESH:D008175 Lung Neoplasms Diethylnitrosamine 16.1620512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Fluorouracil 16.1615246190
MESH:D008175 Lung Neoplasms Indomethacin 16.1616537180 11497255 11053908
MESH:D008175 Lung Neoplasms Quercetin 16.1616280456
MESH:D008175 Lung Neoplasms sodium arsenite 16.1616712894 15276417 17306315 17077188 19931552
MESH:D008175 Lung Neoplasms vanadium pentoxide 16.1612376484
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.2915086387
MESH:D008223 Lymphoma Curcumin 6.5718462866
MESH:D008223 Lymphoma decitabine 6.5719470736
MESH:D016393 Lymphoma, B-Cell resveratrol 3.8417088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.4714749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.2116173963
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.7515688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 5.1411606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Selenium 5.1415318939
MESH:D008545 Melanoma Curcumin 8.6318462866 17885582
MESH:D008545 Melanoma decitabine 8.6316505122 17785578
MESH:D008545 Melanoma Dinitrochlorobenzene 8.6317334785 12202904
MESH:D008545 Melanoma resveratrol 8.6317992120
MESH:D008545 Melanoma sodium arsenite 8.6319082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0819513568
MESH:D008569 Memory Disorders Curcumin 3.6817263510
MESH:D008654 Mesothelioma Selenium 2.5815107826
MESH:D008659 Metabolic Diseases resveratrol 3.9317112576
MESH:D008881 Migraine Disorders Indomethacin 3.3211903285
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 12.1916381670
MESH:D009062 Mouth Neoplasms Fluorouracil 12.1916757204 18986760
MESH:D009062 Mouth Neoplasms Indomethacin 12.1912636206
MESH:D009101 Multiple Myeloma arsenic trioxide 14.3319417148 14977855 11468182 15949261 19549372
MESH:D009101 Multiple Myeloma Curcumin 14.3319372569
MESH:D009101 Multiple Myeloma decitabine 14.3318172295
MESH:D009101 Multiple Myeloma resveratrol 14.3314749477 16490592 17935668 17049120 16267019 17164350
MESH:D009134 Muscular Atrophy, Spinal Curcumin 10.7617962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 10.7617962980
MESH:D009135 Muscular Diseases pirinixic acid 3.0216239165
MESH:D009181 Mycoses Amiodarone 4.3917974566 12754197
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.1618349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.5016105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 6.5019157545 16882708 19010910 18608210
MESH:D009203 Myocardial Infarction pirinixic acid 8.1719151258
MESH:D009203 Myocardial Infarction Quercetin 8.1719595682
MESH:D009203 Myocardial Infarction resveratrol 8.1717188708 16525036 16456233 16317513 17015251 17125593
MESH:D017202 Myocardial Ischemia Arsenic 8.0515371236
MESH:D017202 Myocardial Ischemia resveratrol 8.0517125593 17015251
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.1616411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 7.1619207477
MESH:D009205 Myocarditis resveratrol 4.2617322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.3618551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 20.8716624393
MESH:D009361 Neoplasm Invasiveness bis(4-hydroxycinnamoyl)methane 20.8718495463
MESH:D009361 Neoplasm Invasiveness Curcumin 20.8718495463
MESH:D009361 Neoplasm Invasiveness demethoxycurcumin 20.8718495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 11.803581430
MESH:D009362 Neoplasm Metastasis Acetylcysteine 11.8014720322
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 11.809029167 3581430
MESH:D009362 Neoplasm Metastasis Indomethacin 11.8011239499 16537180 11053908
MESH:D009369 Neoplasms Benzo(a)pyrene 16.3311141357
MESH:D009369 Neoplasms decitabine 16.3317925555 19116145 19470736
MESH:D009369 Neoplasms Fluorouracil 16.3316928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 16.3317405874
MESH:D009369 Neoplasms Quercetin 16.3315185748
MESH:D009369 Neoplasms sodium arsenite 16.3311559025
MESH:D009374 Neoplasms, Experimental Indomethacin 12.5615625704 10663608
MESH:D009374 Neoplasms, Experimental resveratrol 12.568985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 12.5620056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.0312497104
MESH:D009410 Nerve Degeneration Rotenone 3.5017356569 18619942 15790535
MESH:D009423 Nervous System Neoplasms Curcumin 5.1218462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 19.226679447
MESH:D009436 Neural Tube Defects Acetylcysteine 19.2219446573
MESH:D009436 Neural Tube Defects Arsenic 19.2216620997
MESH:D009436 Neural Tube Defects arsenic trioxide 19.2210525206
MESH:D009436 Neural Tube Defects sodium arsenite 19.2212854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 16.7718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 16.7720387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 16.7712349958
MESH:D019636 Neurodegenerative Diseases resveratrol 16.7717652729
MESH:D020078 Neurogenic Inflammation Arsenic 15.1617056641
MESH:D020078 Neurogenic Inflammation Quercetin 15.1617929310
MESH:D020078 Neurogenic Inflammation resveratrol 15.1617929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6120387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.0916436463
MESH:D009765 Obesity Curcumin 6.5519297423
MESH:D009765 Obesity Dietary Fats 6.5521332399 19632207 17217161 18457598 16723640 20132043 18674790 20518802 11836018
MESH:D009765 Obesity pirinixic acid 6.5520558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.666374098
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 12.6612819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 12.666482804 4026338
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 12.6614694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.513988306
MESH:D010003 Osteoarthritis Indomethacin 3.357009135
MESH:D010024 Osteoporosis Curcumin 3.1518719352
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 8.6819495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 8.6817513867
MESH:D010051 Ovarian Neoplasms Arsenic 16.4917306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 16.4912452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Curcumin 16.4919020741 18462866
MESH:D010051 Ovarian Neoplasms decitabine 16.4919259094 19331143
MESH:D010051 Ovarian Neoplasms Quercetin 16.4919005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 16.4915276417 17306315
MESH:D010146 Pain Acetaminophen 5.4716870215
MESH:D010146 Pain Indomethacin 5.473291741 17440234 17627676 13679232
MESH:D010149 Pain, Postoperative Indomethacin 4.1712538197 18702446
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 17.8515580305
MESH:D010190 Pancreatic Neoplasms Curcumin 17.8517440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms decitabine 17.8519294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 17.8516540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 17.8519003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Quercetin 17.8516965848
MESH:D010195 Pancreatitis Indomethacin 3.4717883296 15028970
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.007296757
MESH:D010235 Paraganglioma arsenic trioxide 3.7019927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.2116537180
MESH:D010300 Parkinson Disease Rotenone 2.7816412576 11445065 19232380 15451049 18191903 11535288 16140633 19114014 18619942
MESH:D020734 Parkinsonian Disorders Indomethacin 7.9412349958
MESH:D020734 Parkinsonian Disorders Rotenone 7.9415574749 15927086 18197244 15795934
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.2111903285
MESH:D010437 Peptic Ulcer Indomethacin 4.6511148446
MESH:D010518 Periodontitis Indomethacin 4.4117225004
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.7116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.4916905509 6392382 15371236
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.966228378
MESH:D010954 Plasmacytoma Selenium 4.3815087411
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.832563599
MESH:D011230 Precancerous Conditions Quercetin 7.8319056647
MESH:D047928 Premature Birth Indomethacin 4.6417000239
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 3.6916679765
MESH:D055728 Primary Myelofibrosis decitabine 4.2417616702
MESH:D011471 Prostatic Neoplasms Arsenic 2.3016140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.3019131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.3017292933
MESH:D011471 Prostatic Neoplasms Curcumin 2.3011398177 12497104 18156803 18226269 15129424 18769126 10851300
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.3019082440 18626508
MESH:D011471 Prostatic Neoplasms Quercetin 2.3017292933 14715546
MESH:D011471 Prostatic Neoplasms resveratrol 2.3017718901 17636462 15767336 17675339 16731767 17804756
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.3016039940
MESH:D011507 Proteinuria Arsenic 7.9621343184
MESH:D011507 Proteinuria Indomethacin 7.9611849393
MESH:D011656 Pulmonary Emphysema Curcumin 4.0919168576
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.6511597910 12490602 12832656
MESH:D012004 Rectal Neoplasms Fluorouracil 3.5916160472 18722050 18286688 15538739
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.0716325855
MESH:D015427 Reperfusion Injury pirinixic acid 5.6919058328
MESH:D015427 Reperfusion Injury resveratrol 5.6915827377 16314181 16317513 17520802 17058453
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 7.9712210543
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 7.9710666014 18379247
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.003692021
MESH:D012174 Retinitis Pigmentosa Thioctic Acid 4.3616849425
MESH:D012208 Rhabdomyosarcoma decitabine 3.9419155313
MESH:D012509 Sarcoma Curcumin 3.6918462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.4916646077
MESH:D012554 Schistosomiasis japonica Quercetin 5.0416862918
MESH:D012640 Seizures 2,4-dinitrotoluene 2.2118551238
MESH:D018805 Sepsis Curcumin 3.6718389075
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.5918724381
MESH:D012871 Skin Diseases Arsenic 2.6017938729 19834688 15952646 16353154 16702368 17453740 6392382 16759981 17548696 17050553 18709164
MESH:D012878 Skin Neoplasms Arsenic 11.5017029826 16251483 17976673 15504454 17050553 19538983
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 11.5019755658 10029692
MESH:D012878 Skin Neoplasms resveratrol 11.5015837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 11.5018572023 19524636
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4112854658
MESH:D013272 Stomach Diseases Indomethacin 3.9218545984 17207306 17638125 15038085 18209964 15472012 10192188 17160473 16113693 16184426 16280098 10486359 10215738
MESH:D013274 Stomach Neoplasms arsenic trioxide 7.4417007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 7.4420155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 7.4419037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 7.4418456281
MESH:D013274 Stomach Neoplasms Fluorouracil 7.4416424979 15786421 18396642 16951190 17522103 19015929 19084572 17172411 18567086 17498489
MESH:D013274 Stomach Neoplasms Indomethacin 7.4415609394
MESH:D013276 Stomach Ulcer Acetylcysteine 17.9217918041
MESH:D013276 Stomach Ulcer Amiodarone 17.9218087811
MESH:D013276 Stomach Ulcer bis(4-hydroxycinnamoyl)methane 17.9219188055
MESH:D013276 Stomach Ulcer Curcumin 17.9216631530 19188055
MESH:D013276 Stomach Ulcer Indomethacin 17.9210423059 15104355 18543354 16150113 17918041 11729361 17135157 17654042 17895592 16934674 10878458 15255614 17627676 18209962 18431645 17657623 10750652 12498302 17977527 14567935 16631530 15138204 1323529 16397915 16755016 18726076 11906479 11523592 11595415 18087811 11145282 16169175 12787963 18299717 16252198 12077510 18237397 12467913 11595431 18193104 18181030 12500499
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.0516321402
MESH:D013610 Tachycardia Amiodarone 3.8211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.7219225199
MESH:D013959 Thyroid Diseases Amiodarone 4.2519731979
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 18.446587162 6582329 1399818 3712494 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 18.4419014326
MESH:D013964 Thyroid Neoplasms decitabine 18.4417967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 18.447505956
MESH:D013964 Thyroid Neoplasms Indomethacin 18.4414736730 18791128 11352223
MESH:D013971 Thyrotoxicosis Amiodarone 4.3718020914 19584973
MESH:D014062 Tongue Neoplasms Fluorouracil 8.5516280240
MESH:D014062 Tongue Neoplasms resveratrol 8.5516227395
MESH:D016171 Torsades de Pointes Amiodarone 8.6111989578 17467628
MESH:D016171 Torsades de Pointes arsenic trioxide 8.6115213294
MESH:D014456 Ulcer Indomethacin 4.4010574470 17380554
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 28.7116049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 28.718074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 28.7119429237 19322015 17306315 17976673 18640142 11144890 15987713
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 28.7111780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 28.7117053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 28.7118593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 28.7117616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Quercetin 28.7116720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 28.7116452187 17306315 11723127 16712894
MESH:D014565 Urogenital Neoplasms Curcumin 4.7718462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.8210091137
MESH:D014581 Urticaria Acetaminophen 2.5210982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 13.4216803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 13.4217473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 13.4211813266
MESH:D014594 Uterine Neoplasms resveratrol 3.6717044934
MESH:D014604 Uveal Neoplasms decitabine 4.4117785578
MESH:D014652 Vascular Diseases Arsenic 10.1917056641
MESH:D014652 Vascular Diseases sodium arsenite 10.1917056641
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.8217488730
MESH:D014839 Vomiting Indomethacin 4.2411897121
MESH:D015430 Weight Gain Dietary Fats 3.3216723640
Pathway ID Pathway Name
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134887774
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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