AutismKB 2.0

Annotation Detail for CUL7


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Basic Information Top
Gene Symbol:CUL7 ( KIAA0076,dJ20C7.5 )
Gene Full Name: cullin 7
Band: 6p21.1
Quick LinksEntrez ID:9820; OMIM: 609577; Uniprot ID:CUL7_HUMAN; ENSEMBL ID: ENSG00000044090; HGNC ID: 21024
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04120Ubiquitin mediated proteolysis
Pathway IDPathway Name
Diabetes pathways
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CUL7 mRNAaffects expression 17562736
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in decreased expression of CUL7 mRNAaffects cotreatment|decreases expression 18313992
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CUL7 mRNAdecreases expression 17557909
C006253 pirinixic acid pirinixic acid results in increased expression of CUL7 mRNAincreases expression 17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of CUL7 mRNA]increases expression|increases reaction 17950772
D012643 Selenium Selenium results in increased expression of CUL7 mRNAincreases expression 19244175
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in decreased expression of CUL7 mRNAaffects cotreatment|decreases expression 18313992
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.249612607
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8714692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002779 Cholestasis Ethinyl Estradiol 8.5217110522 17681005 11677210 16919318 17333356 16105132 15861022
MESH:D002779 Cholestasis pirinixic acid 8.5219176532
MESH:D003092 Colitis Selenium 4.2017936198
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0411461765 15619225 19416960 12594235 16781746 19739265 18071297 11421492 12705907 17522070 14725611 19164858 18713872 14986274 10663392 17906064 12392966 11834606 2444490 16081117 11743745 12958197 11739529 10915739 12153990 15968718 10774834 16177239 19923254 19420014 14550746 19085960 16485898 16109766 19370779 11287661 11529661 16227642 17562736 16393943 12540782
MESH:D056486 Drug-Induced Liver Injury Selenium 4.0415131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004362 Drug Toxicity Lamivudine 9.5615040536
MESH:D004362 Drug Toxicity Zidovudine 9.5615040536
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5712538720
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.1115345470
MESH:D005234 Fatty Liver pirinixic acid 15.1119236843 20131406
MESH:D005234 Fatty Liver Zidovudine 15.1118299183
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006333 Heart Failure pirinixic acid 7.5520558911
MESH:D006333 Heart Failure Selenium 7.5517162251
MESH:D006402 Hematologic Diseases Zidovudine 5.0612579204
MESH:D006509 Hepatitis B Lamivudine 5.4317703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.4315274664 15631357 12044531 16476009 15309715
MESH:D006529 Hepatomegaly pirinixic acid 3.4119176532 18467677 19772884 16221962
MESH:D015658 HIV Infections Lamivudine 7.5420032539 11141242 9296927 17530837
MESH:D015658 HIV Infections Zidovudine 7.5411698656 11363243 20032539 17358032 11141242
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007251 Influenza, Human Selenium 4.7216624496
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3612587719 15629191
MESH:D007676 Kidney Failure, Chronic Selenium 4.2116518626
MESH:D007680 Kidney Neoplasms Zidovudine 4.0512579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.7420370541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6911587558 12969438 19460945 19784758 19014921 16611625 12587719 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.9120007298 16377806 15890375
MESH:D008175 Lung Neoplasms Zidovudine 2.4818800350
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9515318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008654 Mesothelioma Selenium 2.8915107826
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.3617358032
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010954 Plasmacytoma Selenium 5.4115087411
MESH:D011537 Pruritus Ethinyl Estradiol 3.7716919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012206 Rhabdomyolysis Lamivudine 6.009296927
MESH:D013088 Spermatocele Ethinyl Estradiol 4.4616709447
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
OMIM:273750 THREE M SYNDROME 1 marker/mechanism
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D014625 Vaginal Neoplasms Zidovudine 5.1812579204
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8714671159 15869587
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
KEGG:04120 Ubiquitin mediated proteolysis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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