AutismKB 2.0

Annotation Detail for ARMCX2


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Basic Information Top
Gene Symbol:ARMCX2 ( ALEX2,KIAA0512,MGC13343,MGC8742 )
Gene Full Name: armadillo repeat containing, X-linked 2
Band: Xq22.1
Quick LinksEntrez ID:9823; OMIM: 300363; Uniprot ID:ARMX2_HUMAN; ENSEMBL ID: ENSG00000184867; HGNC ID: 16869
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ARMCX2 mRNAaffects expression 17562736
D002945 Cisplatin ARMCX2 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004041 Dietary Fats Dietary Fats results in increased expression of ARMCX2 mRNAincreases expression 18042831
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARMCX2 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ARMCX2 mRNAdecreases expression 17557909
C041786 palm oil palm oil results in increased expression of ARMCX2 mRNAincreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ARMCX2 mRNAaffects binding|increases activity|increases expression 19710929
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARMCX2 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2411752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D058186 Acute Kidney Injury Cisplatin 4.2415814532 17670903 12690470
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma Cisplatin 4.6517638652 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.6514692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.2616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001161 Arteriosclerosis Dietary Fats 11.1315238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 11.1311256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.7319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.3314601052
MESH:D001943 Breast Neoplasms Cisplatin 1.9118382427 19526202
MESH:D001943 Breast Neoplasms Dietary Fats 1.9120435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9120435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.173084413
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 3.1717982673
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.1112023789 16685392
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 2.8817066447 6189445 18337622
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.4211677210 17681005 15861022 17110522 16105132 17333356 16919318
MESH:D002779 Cholestasis pirinixic acid 8.4219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2016354765 15668235 8697196 15340226 12621046
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7812705907 12153990 12958197 10663392 14725611 11743745 16781746 17906064 11834606 11529661 16227642 12540782 17522070 18713872 11421492 2444490 16109766 15619225 19085960 10915739 19416960 11739529 16177239 14550746 18071297 19923254 11461765 12594235 14986274 11287661 16081117 19739265 19370779 12392966 16485898 19420014 10774834 16393943 15968718 19164858 17562736
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Cisplatin 8.8615033597 12649298 19839026 12231392
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.8611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.6518367378
MESH:D004487 Edema pirinixic acid 7.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3515322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D004938 Esophageal Neoplasms Cisplatin 2.8315173087 16481741 15464296 16785472 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Dietary Fats 14.7518296743 17967931 19551842 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.7515345470
MESH:D005234 Fatty Liver pirinixic acid 14.7519236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Dietary Fats 9.8418296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.8420067830
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.8915102660 15464296
MESH:D034381 Hearing Loss Cisplatin 4.5519898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.6515464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4610048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly pirinixic acid 9.4818467677 19772884 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.4812621046 15340226 16120746
MESH:D006689 Hodgkin Disease Cisplatin 3.8416170182 16200630
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4915340226 16354765 18606429 16959395 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.9221332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Dietary Fats 5.3420412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3412878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 7.8218457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.8216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.5815464296
MESH:D007674 Kidney Diseases Acetaminophen 6.6115629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 6.6112649298 15190930 18289764 12231392 19839026
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.2411231351
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0118296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.2015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2012878042
MESH:D008107 Liver Diseases Acetaminophen 1.6819014921 19784758 19460945 16610002 12969438 12587719 11587558 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 4.5416377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5416984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2612151625
MESH:D008175 Lung Neoplasms Cisplatin 2.5311798837 17225452 6189445
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5319555203 11884234
MESH:D008545 Melanoma Cisplatin 2.5017761969 18505091 15577323 12393984 16248763 16809738 11135225 18176117 12883367 16432458 18332650 12374674 17023156
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.1715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008654 Mesothelioma Cisplatin 3.3417638057
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009369 Neoplasms Cisplatin 5.5116773208
MESH:D009369 Neoplasms pirinixic acid 5.5117405874
MESH:D009395 Nephritis, Interstitial Cisplatin 4.9315464296
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009447 Neuroblastoma Cisplatin 3.578761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 5.098761367
MESH:D009765 Obesity Dietary Fats 4.6221332399 20132043 19632207 11836018 17217161 18674790 20518802 18457598 16723640
MESH:D009765 Obesity pirinixic acid 4.6220558911
MESH:D010051 Ovarian Neoplasms Cisplatin 2.946897625 19769630 15464296 17225452
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 3.0719003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.6415464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.7917638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911118676 11222880 11896295 11399792
MESH:D011537 Pruritus Ethinyl Estradiol 3.7116919318 15861022
MESH:D051437 Renal Insufficiency Cisplatin 4.7715464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.7614601052
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.7915464296
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3816709447
MESH:D013274 Stomach Neoplasms Cisplatin 2.3317522103 18396642 15958060
MESH:D013736 Testicular Neoplasms Cisplatin 4.9317225452 15464296
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 3.0317225452 12973940 15464296
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.4716803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D014625 Vaginal Neoplasms Cisplatin 4.9715577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D014839 Vomiting Cisplatin 5.1611897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
MESH:D015430 Weight Gain Dietary Fats 3.9916723640
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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