Annotation Detail for ARHGEF11
Basic Information
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| Gene Symbol: | ARHGEF11 ( DKFZp667F1223,GTRAP48,KIAA0380,PDZ-RHOGEF ) |
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| Gene Full Name: | Rho guanine nucleotide exchange factor (GEF) 11 |
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| Band: | 1q23.1 |
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| Quick Links | Entrez ID:9826; OMIM: 605708; Uniprot ID:ARHGB_HUMAN; ENSEMBL ID: ENSG00000132694; HGNC ID: 14580 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Pathway ID | Pathway Name |
|---|
| hsa04270 | Vascular smooth muscle contraction |
| Pathway ID | Pathway Name |
|---|
| Signaling by GPCR |
| Signalling by NGF |
| Axon guidance |
| Signaling by Rho GTPases |
| Pathway ID | Pathway Name |
|---|
| 200192 | Signaling events mediated by focal adhesion kinase |
| 200050 | Regulation of RhoA activity |
| Desease ID | Desease Name |
|---|
| 1904 | Diabetes mellitus |
| 2066 | Lung cancer |
| 2069 | Schizophrenia |
| Desease Name |
|---|
| CANCER |
| lung cancer |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D000643 |
Ammonium Chloride |
Ammonium Chloride affects the expression of ARHGEF11 mRNA | affects expression | 16483693
|
| D017638 |
Asbestos, Crocidolite |
Asbestos, Crocidolite affects the expression of ARHGEF11 mRNA | affects expression | 17331233
|
| C025643 |
vinclozolin |
vinclozolin results in decreased expression of ARHGEF11 mRNA | decreases expression | 18042343
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000138 |
Acidosis |
|
Ammonium Chloride |
4.30 | 18287403 |
| MESH:D001008 |
Anxiety Disorders |
|
vinclozolin |
4.00 | 19015723 |
| MESH:D003456 |
Cryptorchidism |
|
vinclozolin |
4.93 | 14966744 |
| MESH:D030342 |
Genetic Diseases, Inborn |
|
vinclozolin |
5.68 | 16973722 |
| MESH:D005832 |
Genital Diseases, Male |
|
vinclozolin |
6.17 | 16417039 |
| MESH:D007248 |
Infertility, Male |
|
vinclozolin |
3.32 | 16467254 |
| MESH:D007984 |
Leydig Cell Tumor |
|
vinclozolin |
5.47 | 16417039 |
| MESH:D055370 |
Lung Injury |
|
Asbestos, Crocidolite |
4.67 | 17365036 |
| MESH:D008654 |
Mesothelioma |
|
Asbestos, Crocidolite |
3.32 | 18303189 16966607 16166281 |
| MESH:D010995 |
Pleural Diseases |
|
Asbestos, Crocidolite |
5.55 | 10923243 |
| MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
vinclozolin |
4.64 | 18042343 19015723 18220299 |
| MESH:D011469 |
Prostatic Diseases |
|
vinclozolin |
5.68 | 18220299 |
| MESH:D011472 |
Prostatitis |
|
vinclozolin |
5.68 | 18629315 |
| MESH:D011658 |
Pulmonary Fibrosis |
|
Asbestos, Crocidolite |
3.16 | 17322281 15814490 17365031 17975199 |
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