AutismKB 2.0

Annotation Detail for ARHGEF17


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ARHGEF17 ( FLJ90019,KIAA0337,P164RHOGEF,TEM4,p164-RhoGEF )
Gene Full Name: Rho guanine nucleotide exchange factor (GEF) 17
Band: 11q13.4
Quick LinksEntrez ID:9828; OMIM: NA; Uniprot ID:ARHGH_HUMAN; ENSEMBL ID: ENSG00000110237; HGNC ID: 21726
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Signaling by Rho GTPases
Pathway IDPathway Name
200050Regulation of RhoA activity
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004317 Doxorubicin Doxorubicin results in increased expression of ARHGEF17 mRNAincreases expression 16404146
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of ARHGEF17 mRNAaffects cotreatment|decreases expression 17404688
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of ARHGEF17 mRNAaffects cotreatment|decreases expression 17404688
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Doxorubicin 4.7817418594
MESH:D000230 Adenocarcinoma Estradiol 4.7811473722
MESH:D000419 Albuminuria Doxorubicin 5.1321441931
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.5714601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 6.2017868700
MESH:D001930 Brain Injuries Progesterone 4.9115665606 15845082 15380490
MESH:D001932 Brain Neoplasms Doxorubicin 4.2617150277
MESH:D001943 Breast Neoplasms Doxorubicin 1.9718628466 16826403 16264153 16322301 18695136 17426702 15939500 15692762 16096432 17369602 11325840 16935488 16115903 17983394 18234424 15994142 19526202 18382427 16595493 15567936 15136595 15668708 15634643 15993339
MESH:D001943 Breast Neoplasms Estradiol 1.9717018787 18497071 14630087 12948864 19861407 16675129 17261762 17289903
MESH:D001943 Breast Neoplasms Progesterone 1.9715562024 17614352 16175315
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.2116111702
MESH:D002276 Carcinoid Tumor Doxorubicin 5.6816051944
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 3.2916234567 18059187 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.2916924424
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.331485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.736189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.8016455267 16612575 16242529 16364871 17924179 16651473 16952015 17131338 16278810 17308081 17974986 17329180 17928571 15476868 17007740 17519947 15792986 15811867 17382496 16269455 16109756 15505089 18627295 16731534 17351982
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0616243910 17334414
MESH:D002471 Cell Transformation, Neoplastic Estradiol 3.0618566989
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1518259882 18802399
MESH:D003928 Diabetic Nephropathies Estradiol 3.8319279558
MESH:D003929 Diabetic Neuropathies Progesterone 5.1517187935
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 2.5317416283
MESH:D004362 Drug Toxicity Doxorubicin 3.9918602426
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.3617692515
MESH:D016889 Endometrial Neoplasms Doxorubicin 8.4417359293
MESH:D016889 Endometrial Neoplasms Estradiol 8.4418566989 19148513 11473722
MESH:D004715 Endometriosis Progesterone 4.2116134523
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 6.0218037988
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 5.3319069698
MESH:D005909 Glioblastoma Doxorubicin 3.6117150277
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.8115692506
MESH:D006331 Heart Diseases Doxorubicin 3.7818006777 17888722 16495754 16244371 16244372 16144979 17875725 12587719 18674790 16879835 16330681 14766674 16707910
MESH:D006333 Heart Failure Doxorubicin 3.5917481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.3815692506
MESH:D006558 Herpes Genitalis Estradiol 5.9015709030
MESH:D006689 Hodgkin Disease Doxorubicin 3.8217606976 18501091 15147373
MESH:D019584 Hot Flashes Estradiol 4.6217088409
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 5.0515869954
MESH:D007249 Inflammation Progesterone 2.7915869954
MESH:D007333 Insulin Resistance Estradiol 3.2316627594 16393666
MESH:D007674 Kidney Diseases Doxorubicin 6.9615699352 15369732 16775033
MESH:D007674 Kidney Diseases Estradiol 6.9615618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.6416707910
MESH:D007680 Kidney Neoplasms Estradiol 3.3615610895
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 6.0216085563
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.6916439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.6914659978 14716833
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.2617085340 16842330
MESH:D008175 Lung Neoplasms Doxorubicin 2.156189445 17418594
MESH:D008223 Lymphoma Doxorubicin 3.7716098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.1817654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 5.2215621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 11.6015458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 11.6017203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 11.6017203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 5.3519453300
MESH:D008545 Melanoma Doxorubicin 2.3316827129
MESH:D008654 Mesothelioma Doxorubicin 3.2017638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.9815792986
MESH:D052016 Mucositis Doxorubicin 5.5317415656
MESH:D009203 Myocardial Infarction Doxorubicin 3.0919429709 15857846
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.6216810080
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0918259882
MESH:D009389 Neovascularization, Pathologic Estradiol 4.4717289903
MESH:D009401 Nephrosis Doxorubicin 5.4216899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.4215640375 16889571
MESH:D009421 Nervous System Malformations Estradiol 4.2311399458 16427766
MESH:D009447 Neuroblastoma Doxorubicin 3.4515555623
MESH:D012516 Osteosarcoma Doxorubicin 4.4815930896
MESH:D010051 Ovarian Neoplasms Estradiol 5.2319401270
MESH:D010051 Ovarian Neoplasms Progesterone 5.2317393432 16525653
MESH:D003557 Phyllodes Tumor Doxorubicin 6.0217983394
MESH:D010997 Pleural Neoplasms Doxorubicin 6.0217638057
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.3720887781
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.2316868541 15897917 15749863 18437689 16888761 16729912
MESH:D011471 Prostatic Neoplasms Estradiol 3.2316740699
MESH:D051437 Renal Insufficiency Doxorubicin 4.8717922066
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9718045962
MESH:D012509 Sarcoma Doxorubicin 4.4416767912 15675481 17203757 17710206 18313854 15625365
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.8316326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.5317846226
MESH:D012878 Skin Neoplasms Doxorubicin 3.1215692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 5.2216767912 15625365 17203757
MESH:D013119 Spinal Cord Injuries Progesterone 5.0215862959 16503802
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.7117909728 16010429
MESH:D013978 Tibial Fractures Estradiol 5.5519048282
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 2.8917653716
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.8717678736 16364871 17638931 17334414
Pathway ID Pathway Name
REACT:14797 Signaling by GPCR
REACT:11044 Signaling by Rho GTPases
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved