AutismKB 2.0

Annotation Detail for MELK


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Basic Information Top
Gene Symbol:MELK ( HPK38,KIAA0175 )
Gene Full Name: maternal embryonic leucine zipper kinase
Band: 9p13.2
Quick LinksEntrez ID:9833; OMIM: 607025; Uniprot ID:MELK_HUMAN; ENSEMBL ID: ENSG00000165304; HGNC ID: 16870
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of MELK proteinaffects expression 20106945
C015001 arsenite arsenite results in decreased expression of MELK mRNAdecreases expression 18929588
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MELK mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MELK mRNAdecreases expression 20382639
19150397
C006780 bisphenol A bisphenol A results in increased expression of MELK mRNAincreases expression 16474171
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MELK mRNAaffects expression 17484886
D003345 Corticosterone Corticosterone results in decreased expression of MELK mRNAdecreases expression 15755911
D003520 Cyclophosphamide MELK mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D016572 Cyclosporine Cyclosporine results in decreased expression of MELK mRNAdecreases expression 20106945
D004317 Doxorubicin MELK mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D004958 Estradiol Estradiol results in increased expression of MELK mRNAincreases expression 16474171
20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MELK mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MELK mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of MELK mRNAaffects expression 17351261
D005472 Fluorouracil MELK mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D005472 Fluorouracil MELK protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
D019833 Genistein Genistein results in increased expression of MELK mRNAincreases expression 16474171
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of MELK mRNAincreases expression 20713471
D017239 Paclitaxel MELK mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of MELK mRNAincreases expression 16474171
C017947 sodium arsenite sodium arsenite inhibits the reaction [E2F1 protein binds to MELK promoter]affects binding|decreases reaction 17998272
C017947 sodium arsenite sodium arsenite promotes the reaction [E2F4 protein binds to MELK promoter]affects binding|increases reaction 17998272
C017947 sodium arsenite sodium arsenite results in decreased expression of MELK mRNAdecreases expression 17998272
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MELK mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MELK mRNAaffects cotreatment|increases expression 17942748
D014747 Vinblastine MELK protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7615322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8617505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 16.8520127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 16.8517418594
MESH:D000230 Adenocarcinoma Estradiol 16.8511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 16.8514692618
MESH:D000230 Adenocarcinoma Fluorouracil 16.8517638652
MESH:D000230 Adenocarcinoma Genistein 16.8511473722
MESH:D000236 Adenoma Benzo(a)pyrene 6.706695378
MESH:D000236 Adenoma Methylcholanthrene 6.7010545420 6695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8216712894 17306315
MESH:D000419 Albuminuria Doxorubicin 4.4621441931
MESH:D000740 Anemia Fluorouracil 8.4216511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.4211748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9919183758
MESH:D001161 Arteriosclerosis Cyclophosphamide 9.8815014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6115885639
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4011922910
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7115746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.6214601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.4815867366
MESH:D001862 Bone Resorption bisphenol A 3.7811985600
MESH:D001932 Brain Neoplasms Doxorubicin 3.7317150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.9520146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 6.9517123778
MESH:D001943 Breast Neoplasms Cyclophosphamide 6.9515136595 17388661 17020986 12006526 15093573 11325840 16978400 18234424 18323546
MESH:D001943 Breast Neoplasms Doxorubicin 6.9511325840 15668708 17426702 15136595 15567936 16096432 15994142 15939500 16264153 18695136 18382427 19526202 17983394 18628466 15634643 18234424 16322301 15993339 16935488 16826403 16115903 16595493 15692762 17369602
MESH:D001943 Breast Neoplasms Estradiol 6.9517289903 17261762 12948864 16675129 14630087 17018787 18497071 19861407
MESH:D001943 Breast Neoplasms Fluorouracil 6.9519217205 16557594 15136595 18357371 18608205 16595493 16110121
MESH:D001943 Breast Neoplasms Genistein 6.9516873071 16541309 17200150
MESH:D001943 Breast Neoplasms Methylcholanthrene 6.9517474063
MESH:D001943 Breast Neoplasms Paclitaxel 6.9511325840 16273361 18223236 15136595 18323546 16244791 16115903 18234424
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.9520435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6918705752 15700767 16011737 16227642 16050911 16097048 16192424 15673190 3786805 16124888 10355542 15721981
MESH:D002276 Carcinoid Tumor Doxorubicin 12.0816051944
MESH:D002276 Carcinoid Tumor Fluorouracil 12.0816051944
MESH:D002277 Carcinoma Fluorouracil 13.5717121937
MESH:D002277 Carcinoma Methylcholanthrene 13.5710545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 13.5716835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 19.6712619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 19.6718788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 19.6719701751
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 19.6718059187 17876044 16023760 16234567
MESH:D006528 Carcinoma, Hepatocellular Estradiol 19.6716924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 19.6716799960 16332177 17971768 17045692 18930000 17088986
MESH:D006528 Carcinoma, Hepatocellular Genistein 19.6716924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 19.6716313753
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 19.6717306315 15276417 16507464
MESH:D002278 Carcinoma in Situ bisphenol A 4.9017123778
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.8016152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 15.1116201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 15.1116201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 15.1118695887
MESH:D002292 Carcinoma, Renal Cell Vinblastine 15.111485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.6020419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.606189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.6016280240 17066447 16757204 18986760
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.6018572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3216120746 18850075 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.4717007740 16364871 16952015 17308081 16242529 15476868 17382496 17351982 16651473 16455267 17974986 17519947 16278810 18627295 16612575 17329180 17928571 16109756 17924179 15505089 15792986 17131338 15811867 16731534 16269455
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9216243910 17334414
MESH:D002318 Cardiovascular Diseases Genistein 3.2416332659
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 20.4520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 20.4512371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 20.4518566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 20.4516192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 20.4520056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0816835633
MESH:D002779 Cholestasis Cyclosporine 7.5619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.5617681005 16919318 16105132 11677210 17333356 17110522 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.078697196 12621046 15340226 15668235 16354765
MESH:D003110 Colonic Neoplasms arsenite 5.8215037631
MESH:D003110 Colonic Neoplasms Fluorouracil 5.8216510598 18772588 15001691 17018589 17725105 17172411 17169374 16340194 17287894 17016597
MESH:D003110 Colonic Neoplasms Genistein 5.8217182828
MESH:D015179 Colorectal Neoplasms Doxorubicin 6.4318802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 6.4316303861 17094418 18383874 18949393 20501625 16391804 18802399 15289873 17401013 17255274 17454858 17594712 16282729 18288408 16331619 17016601 15148649 14970324 18509181 16524972 17695437 18448328
MESH:D015179 Colorectal Neoplasms Paclitaxel 6.4318802399
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 6.4315531428
MESH:D015179 Colorectal Neoplasms Vinblastine 6.4318802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003556 Cystitis Cyclophosphamide 4.9016614059 12161096 18372110 18710439 12913760 17010015 15643279 16989017 10700343 17979934 12388444 16651033 10498854 11948286 15276878 18483878 18433785 18295254 16413132 18093676
MESH:D007644 Darier Disease Fluorouracil 4.7116733453
MESH:D003704 Dementia Polychlorinated Biphenyls 4.6216140633
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.9911751995 15331540 10990075
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.1918772604
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.2616647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2617107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3319279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.0919336974 7440962 3786805 9327722 15998439 16177239 7179309 4309450 3732212 2869522 6884620 21278145 6623471 19085960 11566570 15968718 16227642 10915739 15027814 17522070 7120509 10092053
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.0917416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.0920420201
MESH:D004362 Drug Toxicity Doxorubicin 7.8918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8216714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1012538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.5016402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 12.1817359293
MESH:D016889 Endometrial Neoplasms Estradiol 12.1818566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 12.1811473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.949294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0818037988
MESH:D004802 Eosinophilia Cyclophosphamide 4.1311006010
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.2420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.2416530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 10.2416337965 16481741 15173087 16785472 17638652
MESH:D004938 Esophageal Neoplasms Paclitaxel 10.2416481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9511564622
MESH:D005234 Fatty Liver arsenite 18.1118296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 18.1117595544 16045604 16239168 15959796 19224547 12631006 61145 12795759
MESH:D005234 Fatty Liver Cyclosporine 18.1119224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.1115345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.5019069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.8510962813 14633661
MESH:D005355 Fibrosis arsenite 20.4518296743
MESH:D005355 Fibrosis Carbon Tetrachloride 20.4518705752
MESH:D005355 Fibrosis Cyclosporine 20.4512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.4520067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5916452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.138708960
MESH:D005909 Glioblastoma Doxorubicin 7.1417150277
MESH:D005909 Glioblastoma Genistein 7.1416598420
MESH:D005910 Glioma Fluorouracil 2.8316145905
MESH:D018316 Gliosarcoma Cyclophosphamide 5.4311389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.9516376943 15172196 11014644
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.7215692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.7215162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.2920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2911294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.4217888722 16495754 18674790 18006777 16144979 16879835 16330681 16244371 16244372 14766674 16707910 17875725 12587719
MESH:D006333 Heart Failure Doxorubicin 3.2917481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.8215692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3415720958
MESH:D006467 Hemophilia A Cyclophosphamide 5.2011918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.4514986274
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5119110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8116120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.9515709030
MESH:D006689 Hodgkin Disease Cyclophosphamide 16.9117606976 16135485
MESH:D006689 Hodgkin Disease Doxorubicin 16.9117606976 18501091 15147373
MESH:D006689 Hodgkin Disease sodium arsenite 16.9112676792
MESH:D006689 Hodgkin Disease Vinblastine 16.9118501091 18180244
MESH:D019584 Hot Flashes Estradiol 3.6717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.968697196 18606429 16959395 15340226 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4516899240
MESH:D006973 Hypertension Cyclosporine 4.8310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8318670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7216945680 16569931
MESH:D007154 Immune System Diseases Cyclophosphamide 5.2516076520
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3812013081
MESH:D007248 Infertility, Male Cyclophosphamide 10.947193160 16517039
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.9417937319
MESH:D007248 Infertility, Male sodium arsenite 10.9412646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8112200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 7.2416393666
MESH:D007333 Insulin Resistance Estradiol 7.2416393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2516580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3615604871
MESH:D007674 Kidney Diseases Cyclosporine 14.0418776723 10903974 8314463
MESH:D007674 Kidney Diseases Doxorubicin 14.0416775033 15699352 15369732
MESH:D007674 Kidney Diseases Estradiol 14.0415618244
MESH:D007674 Kidney Diseases sodium arsenite 14.0420008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0716707910
MESH:D007680 Kidney Neoplasms Cyclosporine 11.9812371664
MESH:D007680 Kidney Neoplasms Estradiol 11.9815610895
MESH:D007680 Kidney Neoplasms Fluorouracil 11.9816985049
MESH:D007938 Leukemia Cyclophosphamide 6.5310602166
MESH:D007938 Leukemia Genistein 6.5318980019 17468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0816085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.4617008537 18587576 17658394 17296974 18172266 17802794
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.0210373061
MESH:D007970 Leukopenia Cyclophosphamide 4.8810052129 11830472
MESH:D008080 Liposarcoma Paclitaxel 4.7417353645
MESH:D008103 Liver Cirrhosis arsenite 6.6718296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.6721278145 16943688 11903743 17157831 11408273 16239168 17334410 16221502 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.6217976157 15362042 15893842 15931870 13678700 12898905 17944888 17708605 17823541 12649538 16033810 12445418 18205269 16136751 18481824 17805973 17900296 18210741 17766677 18376398 11481614 17557913 16116963 15673190 14620537 18251166 16097048 17698563 12958196 15925388 10355542 17761835 15052691 18412020 18279442 17481882 20821823 12741479 15650968 12586293 18166357 18054572 14724832 16638106 15959796 18277467 14512876 12546737 17640975 15996030 12445421 16248980 18006644 17922224 14716833 18472332 17565644 16015684 18263696 14748882 15370692 18395914 15876570 15818738 12666154 12632514 18418968 12389079 16192424 18472094 12632512 17714472 17631135 18339082 17721639 15730626 18317297 15338365 17525996 17869086 18705752 18429990 12667390 15123356 12609069 16027843 18395095 18156304 18420326 15057751 16011737 14716496 18187930
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.6216439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.6214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.6217823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.6212878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0615830285 16246199 17285989 16964402 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.6116899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 17.5618177683 2125692 15890375 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.5620195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 17.5619294768
MESH:D008113 Liver Neoplasms Fluorouracil 17.5615113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms sodium arsenite 17.5615276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.5616984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 22.678603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 22.6715583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 22.6717085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 22.671399818 598648
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 22.671423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 22.6712151625
MESH:D008171 Lung Diseases sodium arsenite 3.1119095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 12.8314755239
MESH:D008175 Lung Neoplasms arsenite 12.8316809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 12.8318816296 6695378 20464547 20135361 18569708 17053015 20064080 18520028 20869020
MESH:D008175 Lung Neoplasms Doxorubicin 12.8317418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 12.8315246190
MESH:D008175 Lung Neoplasms Methylcholanthrene 12.8316271038 17909032 9230183 16337739 7750092 6695378 20970405 11893704 15390079 20512841 1399818 10545420 21163286
MESH:D008175 Lung Neoplasms sodium arsenite 12.8316712894 17077188 17306315 15276417 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.8319555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7115086387
MESH:D008223 Lymphoma Cyclophosphamide 7.6712854902
MESH:D008223 Lymphoma Doxorubicin 7.6716098063
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.5116675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 14.2511911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 14.2517654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 14.2514749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4815621674
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 13.8712807724
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 13.8715458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.8711807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 13.8714578162 12929590
MESH:D020149 Manganese Poisoning Estradiol 4.4019453300
MESH:D008545 Melanoma Doxorubicin 7.2616827129
MESH:D008545 Melanoma Paclitaxel 7.2612040289 12025231 16342250
MESH:D008545 Melanoma sodium arsenite 7.2619082730 16487513
MESH:D008545 Melanoma Vinblastine 7.2615577323 16432458 18332650 15577320 18176117 12374674 16809738 18505091 17761969 16248763
MESH:D008546 Melanoma, Experimental Cyclophosphamide 4.7116388313
MESH:D008654 Mesothelioma Doxorubicin 3.0217638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7116801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4215792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.3016381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.3016757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.7017415656
MESH:D009101 Multiple Myeloma Paclitaxel 3.6214749477
MESH:D009203 Myocardial Infarction Doxorubicin 5.8519429709 15857846
MESH:D009203 Myocardial Infarction Genistein 5.8517141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.2816810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.2817141266
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.0218259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 6.0215867366
MESH:D009369 Neoplasms Benzo(a)pyrene 11.5511141357
MESH:D009369 Neoplasms Cyclophosphamide 11.5518854779
MESH:D009369 Neoplasms Fluorouracil 11.5516928823 18239605 18600527
MESH:D009369 Neoplasms sodium arsenite 11.5511559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5820056578
MESH:D009389 Neovascularization, Pathologic arsenite 9.8715738583
MESH:D009389 Neovascularization, Pathologic Estradiol 9.8717289903
MESH:D009401 Nephrosis Doxorubicin 4.6816899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.0419348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.0416889571 15640375
MESH:D009421 Nervous System Malformations bisphenol A 22.7411399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 22.7416427766 11399458
MESH:D009421 Nervous System Malformations Genistein 22.7416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 22.7414600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.0812854658
MESH:D009447 Neuroblastoma Cyclophosphamide 7.0616115947 15176712 8761367
MESH:D009447 Neuroblastoma Doxorubicin 7.0615555623
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.808761367 12837982
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3816436463
MESH:D009503 Neutropenia Cyclophosphamide 9.478291058
MESH:D009503 Neutropenia Vinblastine 9.4717378895
MESH:D009845 Oligospermia Cyclophosphamide 4.6316517039
MESH:D010014 Osteolysis Paclitaxel 4.8915867366
MESH:D010024 Osteoporosis Genistein 3.2019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.0016169203
MESH:D012516 Osteosarcoma Doxorubicin 4.0415930896
MESH:D010049 Ovarian Diseases bisphenol A 4.9011985600
MESH:D010051 Ovarian Neoplasms Estradiol 11.1119401270
MESH:D010051 Ovarian Neoplasms Genistein 11.1119005980
MESH:D010051 Ovarian Neoplasms Paclitaxel 11.1111161223
MESH:D010051 Ovarian Neoplasms sodium arsenite 11.1117306315 15276417
MESH:D010146 Pain Cyclophosphamide 3.5512161096 18093676
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 5.5011332152
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.5016929163 19003803 16500647 15113037
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6011578682
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.3616702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0817983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.0817638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1412371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.7521297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.2210548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.2211118676 11399792 11896295 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.2820887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.2820887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.5417292933
MESH:D011471 Prostatic Neoplasms bisphenol A 3.5416740699
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 3.5417136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.5415897917 16868541 16729912 15749863 18437689 16888761
MESH:D011471 Prostatic Neoplasms Estradiol 3.5416740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.5418626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 3.5416925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Paclitaxel 3.5417172428 16356831 16729912 17136230
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 3.5415721890
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.5416039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.2315861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2016882103
MESH:D011629 Puberty, Precocious bisphenol A 4.7010548101
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.2516636934
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9315538739 18286688 16160472 18722050
MESH:D051437 Renal Insufficiency Doxorubicin 4.1317922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012509 Sarcoma Doxorubicin 3.9117203757 15675481 17710206 18313854 16767912 15625365
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.1616326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.7017846226
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.7416636934
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.2319755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 13.2315692506
MESH:D012878 Skin Neoplasms sodium arsenite 13.2319524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.2316192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4815625365 17203757 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8616709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.4316517039
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7312854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.402093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 3.4018396642 19084572 16951190 18567086 19015929 17498489 16424979 15786421 17522103 17172411
MESH:D013274 Stomach Neoplasms Paclitaxel 3.4018396642 18506536
MESH:D019966 Substance-Related Disorders bisphenol A 3.9016045194 16684133
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.9712837982
MESH:D024801 Tauopathies Paclitaxel 4.7316930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.3016010429 17909728
MESH:D013978 Tibial Fractures Estradiol 4.6019048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.9116280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.7017053015
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 11.7014692829
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 11.7017653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 11.7017306315 11723127 16452187 16712894
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.2216803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.2211813266
MESH:D014591 Uterine Diseases bisphenol A 4.9314652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2114692618
MESH:D014605 Uveitis Cyclosporine 3.901336536
MESH:D014625 Vaginal Neoplasms Vinblastine 4.9615577323
MESH:D014652 Vascular Diseases sodium arsenite 4.3417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4614671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.1317678736 16364871 17334414 17638931
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.3617120751
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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