AutismKB 2.0

Annotation Detail for ZEB2


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Basic Information Top
Gene Symbol:ZEB2 ( FLJ42816,KIAA0569,SIP-1,SIP1,SMADIP1,ZFHX1B )
Gene Full Name: zinc finger E-box binding homeobox 2
Band: 2q22.3
Quick LinksEntrez ID:9839; OMIM: 605802; Uniprot ID:ZEB2_HUMAN; ENSEMBL ID: ENSG00000169554; HGNC ID: 14881
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1832Congenital abnormality
1934Cancer
No data
No data
Desease Name
Mowat-Wilson syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of ZEB2 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ZEB2 mRNAaffects expression 17562736
D001151 Arsenic Arsenic affects the expression of ZEB2 mRNAaffects expression 18414638
D001151 Arsenic Arsenic results in decreased expression of ZEB2 mRNAdecreases expression 19654921
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of ZEB2 mRNAaffects expression 17484886
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of ZEB2 mRNAincreases expression 16934159
D004958 Estradiol Estradiol results in decreased expression of ZEB2 mRNAdecreases expression 20068009
D013755 Tetradecanoylphorbol Acetate [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ZEB2 mRNAaffects cotreatment|affects expression 16979875
D015032 Zinc [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ZEB2 mRNAaffects cotreatment|affects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000169 Acrodermatitis Zinc 5.7416889938 17202136 17190629
MESH:D000230 Adenocarcinoma Estradiol 2.1411473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D018246 Adrenocortical Adenoma Arsenic 5.5917306315
MESH:D000544 Alzheimer Disease Zinc 2.8016325427 17119284 16410023 16580781
MESH:D000755 Anemia, Sickle Cell Zinc 5.1816916123
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D020261 Arsenic Poisoning Arsenic 2.9212569548 18414634 16835338 16251483
MESH:D001249 Asthma Zinc 3.0117085522
MESH:D050197 Atherosclerosis Arsenic 3.3819371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4011289319 1440618
MESH:D001930 Brain Injuries Zinc 5.0017109824
MESH:D001943 Breast Neoplasms Estradiol 2.1218497071 12948864 17261762 16675129 19861407 17018787 17289903 14630087
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0815673190 16097048 10355542 3786805 15700767 16192424 15721981 16050911 16227642 18705752 16011737 16124888
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7117687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.223581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.223084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 9.2216507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 9.2218788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 9.2216924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D002294 Carcinoma, Squamous Cell Arsenic 8.1118922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 8.1118922899
MESH:D002294 Carcinoma, Squamous Cell Zinc 8.1116543248
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3018640142
MESH:D002318 Cardiovascular Diseases Arsenic 8.1715738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases Zinc 8.1716936243
MESH:D002340 Carotid Artery Diseases Arsenic 4.5216973168 18022660
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.197505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.1918566989
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.3219486331 9022650
MESH:D019465 Craniofacial Abnormalities Zinc 2.4419302082
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.108970840 12868966 11298694 8156756 18759878 2524372 11906362 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.753621924 2952479
MESH:D003920 Diabetes Mellitus Zinc 4.4216479319
MESH:D003928 Diabetic Nephropathies Estradiol 3.6319279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.5311289319 6679447 9022650 1440618 18692083 16192314 18289764 9328219 8291058 7440962 18648102 9653073 6482804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.5310915739 19923254 11739529 12392966 18071297 16109766 14725611 2444490 12540782 17562736 19739265 16177239 12705907 11743745 17906064 16227642 11461765 18713872 16781746 19085960 11287661 19416960 11529661 19370779 14550746 16393943 14986274 19420014 11834606 16081117 17522070 10774834 10663392 11421492 15619225 16485898 12958197 19164858 12594235 15968718 12153990
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.539327722 15998439 15968718 19336974 16177239 21278145 19085960 15027814 17522070 7179309 16227642 10915739 3786805 11566570 3732212 6623471 7120509 2869522 4309450 7440962 10092053 6884620
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 9.5317851650
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004487 Edema Tetradecanoylphorbol Acetate 3.8515177302 7812673 9599246 8113982 8273558 11698051 16716910
MESH:D016889 Endometrial Neoplasms Estradiol 3.1319148513 18566989 11473722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.853581430
MESH:D004938 Esophageal Neoplasms Zinc 4.8516543248
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.4116239168 61145 17595544 12631006 15959796 12795759 19224547 16045604
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005355 Fibrosis Carbon Tetrachloride 3.7618705752
MESH:D005534 Foot Diseases Arsenic 5.946392382
MESH:D005756 Gastritis Acetaminophen 12.4616983495
MESH:D005756 Gastritis Zinc 12.4617241300
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006130 Growth Disorders Zinc 4.1017217573
MESH:D006330 Heart Defects, Congenital marker/mechanism 17478475
MESH:D006333 Heart Failure Zinc 3.7417162251
MESH:D006335 Heart Injuries Zinc 6.1517074742
MESH:D016481 Helicobacter Infections Zinc 4.7917241300
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 10.186705139
MESH:D006505 Hepatitis Carbon Tetrachloride 10.1819900420 19110552
MESH:D006527 Hepatolenticular Degeneration Zinc 5.0017276780
MESH:D006558 Herpes Genitalis Estradiol 5.4115709030
MESH:D019584 Hot Flashes Estradiol 4.1317088409
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6817050553
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D006973 Hypertension Arsenic 2.9416076760 11953799 9931084
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D006987 Hypesthesia Arsenic 5.9416093927
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 3.208273558 15177302 7562506 11698051 7812673
MESH:D007333 Insulin Resistance Estradiol 3.1116627594 16393666
MESH:D007511 Ischemia Zinc 4.9416584753
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.409022650 8074119
MESH:D007642 Keratosis Arsenic 5.3316930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 10.8615629191 12587719
MESH:D007674 Kidney Diseases Estradiol 10.8615618244
MESH:D007674 Kidney Diseases Zinc 10.8616960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.6616518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.046582329
MESH:D007680 Kidney Neoplasms Estradiol 8.0415610895
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7017339181
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9216221502 11903743 17174718 16239168 11408273 17334410 21278145 17157831 16943688
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.5018339082 15650968 15818738 15370692 18395914 14620537 15996030 15052691 12667390 12898905 17631135 18006644 18205269 15730626 18187930 17976157 17714472 12649538 17721639 17708605 18412020 15057751 15123356 17761835 12586293 16015684 17766677 18705752 18418968 17823541 10355542 18277467 13678700 17698563 15876570 17481882 12632512 15893842 12741479 18472094 12958196 18481824 18251166 14748882 15362042 12546737 18279442 16097048 17525996 18395095 18376398 18166357 16192424 18317297 17640975 12445421 11481614 16033810 14716496 12389079 12445418 12609069 16116963 18472332 17869086 17805973 16027843 17557913 12632514 15925388 14512876 14716833 17922224 15338365 16011737 15959796 20821823 16638106 17944888 16248980 18156304 18054572 18263696 17565644 18210741 15673190 18429990 12666154 18420326 15931870 16136751 14724832 17900296
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5014716833 14659978
MESH:D008107 Liver Diseases Acetaminophen 6.8419460945 16610002 19784758 12969438 11587558 12587719 16611625 19014921
MESH:D008107 Liver Diseases Arsenic 6.8411134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.8416246199 15720792 15830285 17285989 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.1817185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.1814706259 16899240
MESH:D008113 Liver Neoplasms Arsenic 5.0116368122
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 5.0119294768
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.381399818 598648 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.3812014681 15583823
MESH:D008175 Lung Neoplasms Arsenic 2.9317306315 17976673 19168569
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 2.9311807781
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.9911408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 10.998985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 10.9912773700
MESH:D020149 Manganese Poisoning Estradiol 4.8619453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:C536990 Mowat-Wilson syndrome marker/mechanism 15006694 17103451 17478475
MESH:D009190 Myelodysplastic Syndromes marker/mechanism 18575777
MESH:D017202 Myocardial Ischemia Arsenic 4.1815371236
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4616810080
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0717289903
MESH:D009421 Nervous System Malformations Estradiol 3.9316427766 11399458
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.876679447
MESH:D009436 Neural Tube Defects Arsenic 7.8716620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.6417056641
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.656482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010051 Ovarian Neoplasms Arsenic 5.1617306315
MESH:D010051 Ovarian Neoplasms Estradiol 5.1619401270
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 3.2015976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 10.437296757
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 10.4318922899 12065085 8330346 18404319
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.4616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.3315371236 16905509 6392382
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D011225 Pre-Eclampsia Zinc 4.3617114810
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1320887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.6416140617
MESH:D011471 Prostatic Neoplasms Estradiol 2.6416740699
MESH:D011471 Prostatic Neoplasms Zinc 2.6416517595 16700911 12429649 16606632
MESH:D011507 Proteinuria Arsenic 4.2621343184
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 9.603692021
MESH:D012162 Retinal Degeneration Zinc 9.6016584753
MESH:D012871 Skin Diseases Arsenic 2.806392382 15952646 16702368 19834688 16353154 17453740 16759981 17938729 18709164 17050553 17548696
MESH:D012878 Skin Neoplasms Arsenic 6.4917029826 19538983 16251483 15504454 17050553 17976673
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 6.4912065085 8985016 8330346 18404319 11807781
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.061399818 3712494 6587162 6582329 7505956
MESH:D013978 Tibial Fractures Estradiol 5.0619048282
MESH:D014062 Tongue Neoplasms Zinc 4.6316543248
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.478074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.4715987713 17306315 19429237 19322015 11144890 18640142 17976673
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014652 Vascular Diseases Arsenic 5.0717056641
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162409612
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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