AutismKB 2.0

Annotation Detail for ELMO1


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Basic Information Top
Gene Symbol:ELMO1 ( CED-12,CED12,ELMO-1,KIAA0281,MGC126406 )
Gene Full Name: engulfment and cell motility 1
Band: 7p14.2-p14.1
Quick LinksEntrez ID:9844; OMIM: 606420; Uniprot ID:ELMO1_HUMAN; ENSEMBL ID: ENSG00000155849; HGNC ID: 16286
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05131Shigellosis
hsa05100Bacterial invasion of epithelial cells
hsa04062Chemokine signaling pathway
Pathway IDPathway Name
HIV Infection
Pathway IDPathway Name
200128Neurotrophic factor-mediated Trk receptor signaling
200074Netrin-mediated signaling
200165Regulation of RAC1 activity
200192Signaling events mediated by focal adhesion kinase
Pathway IDPathway Name
P00034Integrin signalling pathway
Pathway IDPathway Name
500755Nef and signal transduction
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1860Brain tumor
1904Diabetes mellitus
2065Shigella infection
Desease Name
diabetic nephropathy
response to treatment for acute lymphoblastic leukemia
CARDIOVASCULAR
CHEMDEPENDENCY
Celiac Disease
PHARMACOGENOMIC
QT interval
IMMUNE
smoking cessation
METABOLIC
Desease Name
Diabetic nephropathy
Celiac disease
QT interval
Response to treatment for acute lymphoblastic leukemia
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ELMO1 mRNAdecreases expression 19933214
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ELMO1 proteinaffects expression 20106945
C006632 arsenic trioxide arsenic trioxide results in increased expression of ELMO1 mRNAincreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ELMO1 mRNAdecreases expression 20064835
D016572 Cyclosporine Cyclosporine results in decreased expression of ELMO1 mRNAdecreases expression 20106945
C017947 sodium arsenite sodium arsenite results in increased expression of ELMO1 mRNAincreases expression 16014739
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ELMO1 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2411752688 14514962 15322242
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5419825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5420464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.1415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.3517306315 16712894
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.9216206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.9212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8720146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8720435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.8412619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.8416217749 15073043 14691202 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.8415276417 16507464 17306315
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8220419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.8218572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.2712371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.2719524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Cyclosporine 3.1219486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2015340226 16354765 8697196 15668235 12621046
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5315322242 10048152 20055451
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3516714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6312903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver arsenic trioxide 8.7115073043
MESH:D005234 Fatty Liver Cyclosporine 8.7119224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Cyclosporine 9.7012639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.7020067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.0816452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8811294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2515340226 16120746 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 3.4012676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4916959395 15340226 18606429 8697196 16354765
MESH:D006973 Hypertension Cyclosporine 5.2410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2418670907 18850075
MESH:D007248 Infertility, Male sodium arsenite 3.1612646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Cyclosporine 6.5018776723 10903974 8314463
MESH:D007674 Kidney Diseases sodium arsenite 6.5020008137
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9712371664
MESH:D007938 Leukemia arsenic trioxide 2.9515070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1717050201 20471514 16467208 16968895 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3819225113 17107899 15622746 16112521 16966277 12018890 16331271 15336539 15748426 11468182 11161223 17217047 16330433 12712474 17869043 17712046 17649720 9834237 16823087 19642359 19035177 12679006 15213294 19075265 16891316
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 15.212125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms arsenic trioxide 15.2114682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 15.2121137059 20195826
MESH:D008113 Liver Neoplasms sodium arsenite 15.2116712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.2116984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.788603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.7820377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.7812151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D008171 Lung Diseases sodium arsenite 3.3519095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.8714755239
MESH:D008175 Lung Neoplasms arsenic trioxide 6.8719825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.8717053015 18816296 18520028 20464547 20869020 18569708 20064080 6695378 20135361
MESH:D008175 Lung Neoplasms sodium arsenite 6.8715276417 17077188 19931552 17306315 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.8711884234 19555203
MESH:D008545 Melanoma sodium arsenite 2.0616487513 19082730
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2915949261 14977855 19417148 11468182 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2816105982 16882451
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009369 Neoplasms Benzo(a)pyrene 5.4311141357
MESH:D009369 Neoplasms sodium arsenite 5.4311559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.0220056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5318481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009436 Neural Tube Defects arsenic trioxide 7.9010525206
MESH:D009436 Neural Tube Defects sodium arsenite 7.9012854658
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.1512452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.1515276417 17306315
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6015580305
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5019131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5017292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.5016039940
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2916646077
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 10.0710029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 10.0718572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 10.0716192470
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0112854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4217007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4220155912 2093021
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.8612973940 20435036 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.8617053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.8616452187 17306315 11723127 16712894
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.0311813266
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D014652 Vascular Diseases sodium arsenite 4.8217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
Pathway ID Pathway Name
KEGG:05100 Bacterial invasion of epithelial cells
KEGG:04062 Chemokine signaling pathway
REACT:6185 HIV Infection
KEGG:05131 Shigellosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27754
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA443893Diabetic Nephropathies
    PA446714Neoplasm, Residual
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA449552etoposide
    PA450428methotrexate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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