AutismKB 2.0

Annotation Detail for GAB2


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Basic Information Top
Gene Symbol:GAB2 ( KIAA0571 )
Gene Full Name: GRB2-associated binding protein 2
Band: 11q14.1
Quick LinksEntrez ID:9846; OMIM: 606203; Uniprot ID:GAB2_HUMAN; ENSEMBL ID: ENSG00000033327; HGNC ID: 14458
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05220Chronic myeloid leukemia
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
Pathway IDPathway Name
Signaling in Immune system
Pathway IDPathway Name
200032Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
200003Fc-epsilon receptor I signaling in mast cells
200128Neurotrophic factor-mediated Trk receptor signaling
200015GMCSF-mediated signaling events
200158IL2 signaling events mediated by STAT5
200082IL2-mediated signaling events
200099IL2 signaling events mediated by PI3K
200022TCR signaling in naive CD4+ T cells
Pathway IDPathway Name
P00018EGF receptor signaling pathway
P00047PDGF signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1707Multiple myeloma
1781Rheumatoid arthritis
1859Ovarian cancer
1944Breast cancer
2051Leukemia
Desease Name
NEUROLOGICAL
Alzheimer's disease (late onset)
Desease Name
Alzheimer's disease (late onset)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of GAB2 mRNAdecreases expression 19933214
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of GAB2 mRNAaffects expression 21346803
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of GAB2 mRNA]affects reaction|increases expression 18700144
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GAB2 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GAB2 mRNAdecreases expression 20064835
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of GAB2 mRNAdecreases expression 20713471
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GAB2 mRNAdecreases expression 19933214
D014212 Tretinoin FGF2 protein promotes the reaction [Tretinoin results in increased expression of GAB2 protein]increases expression|increases reaction 16009726
D014212 Tretinoin GAB2 protein promotes the reaction [FGF2 protein results in decreased susceptibility to Tretinoin]decreases response to substance|increases reaction 16009726
D014212 Tretinoin GAB2 protein results in decreased susceptibility to Tretinoindecreases response to substance 16009726
D014212 Tretinoin Tretinoin results in increased expression of GAB2 proteinincreases expression 16009726
D014635 Valproic Acid Valproic Acid results in increased expression of GAB2 mRNAincreases expression 19101580
D014810 Vitamin E Vitamin E results in increased expression of GAB2 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.1115322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.118875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 7.186695378
MESH:D000236 Adenoma Methylcholanthrene 7.1810545420 6695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7117497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.1816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D050197 Atherosclerosis Methylcholanthrene 3.5511922910
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8618316065 16609825 17507914 18940202 20603192 18177632 19232924 18775368 19460635 17688650 15238991 17157402 18985861 18396377 18558336
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.1517594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5212125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.5216206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.3715746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.378888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9720146248 17474063
MESH:D001943 Breast Neoplasms Methylcholanthrene 1.9717474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9716873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1516050911
MESH:D002277 Carcinoma Methylcholanthrene 8.8010545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.8016835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.663084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.661917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7120419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.7116051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4516120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 7.5410977129
MESH:D002386 Cataract Tretinoin 7.5417460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.326135515
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 7.3216192471
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9816354765 15340226 15668235 8697196 12621046
MESH:D002972 Cleft Palate Tretinoin 5.989407595
MESH:D003092 Colitis Tretinoin 3.9217035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.5320055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.5314991402 10589399 9664655 16925845 9211117 17551590 9142499 9125849 9224671 8800419
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.5316575769 17688650 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.5319769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2318551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.3321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.3315968718 19416960 19085960 14725611 12705907 16781746 11287661 11743745 19739265 11739529 16081117 11461765 10915739 12594235 18071297 16393943 16109766 19164858 14986274 12392966 17906064 16485898 11834606 15619225 16177239 19420014 16227642 2444490 11421492 12540782 10663392 19370779 17562736 10774834 11529661 17522070 18713872 14550746 12958197 19923254 12153990
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.3320420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.331733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:C538011 Eales disease Vitamin E 4.979068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.8515322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 12.8518230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2116569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.373659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0118234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.747562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.2611564622
MESH:D005124 Eye Abnormalities Tretinoin 9.2616938888 9664655
MESH:D005234 Fatty Liver Valproic Acid 3.4719224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.338888407 18558336
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.1810962813 14633661
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3520067830
MESH:D005355 Fibrosis Tretinoin 9.3517994277
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005909 Glioblastoma Tretinoin 3.1117312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 16.6520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 16.6510048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 16.659664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 16.6516080930
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1115340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7516490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.2414716179
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3115340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 8.0916870215
MESH:D006930 Hyperalgesia Tretinoin 8.0916870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312878042 12200463
MESH:D007251 Influenza, Human Vitamin E 4.4816624496
MESH:D007410 Intestinal Diseases Tretinoin 3.9817994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.5116580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.5115992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 6.2712587719 15629191
MESH:D007674 Kidney Diseases Vitamin E 6.2712488133
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.1216705839
MESH:D007938 Leukemia Tretinoin 2.8417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8716482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9717596541 16294345 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9716294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2617649720 16331271 19075265 17712046 17339181 17217047 16788101 16935935 9834237 15748426 19642359 12679006 17107899 17368321 16823087 16140955 19035177 17506722 17294898 16766008 19029980 17301526 16891316 19225113 17361223
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.439224671
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5618397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5616169303
MESH:D008107 Liver Diseases Acetaminophen 1.6619014921 16611625 19460945 12587719 12969438 16610002 19784758 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.697678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.6920195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.472876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 10.47598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.4712151625
MESH:D008171 Lung Diseases Vitamin E 3.2916863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0020464547 18520028 18569708 20064080 18816296 20869020 6695378 17053015 20135361
MESH:D008175 Lung Neoplasms Methylcholanthrene 5.0020512841 1399818 6695378 10545420 17909032 15390079 11893704 9230183 21163286 16271038 16337739 20970405 7750092
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0019555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 5.0011062179
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D008881 Migraine Disorders Valproic Acid 3.3118765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.7017596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.7017596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.107678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2511141357
MESH:D009369 Neoplasms Tretinoin 5.2516594593 16946489
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1814600291
MESH:D009421 Nervous System Malformations Tretinoin 10.189125849
MESH:D009436 Neural Tube Defects Tretinoin 7.669142499
MESH:D009436 Neural Tube Defects Valproic Acid 7.6616359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5916049721
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3916936753
MESH:D010146 Pain Acetaminophen 7.0716870215
MESH:D010146 Pain Tretinoin 7.0716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5115976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.2711222880 11118676 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.2720603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1517292933
MESH:D011471 Prostatic Neoplasms Vitamin E 3.1515084515
MESH:D011507 Proteinuria Tretinoin 3.7916636307
MESH:D019310 Pseudolymphoma Valproic Acid 4.8112752131 11422049
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.4916283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 11.4919155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3218551238
MESH:D012640 Seizures Valproic Acid 6.3217978042 11738929 15475178 16876388 3137016 14763951 11044598 1511512
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.8219755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.8216192470
MESH:D012878 Skin Neoplasms Tretinoin 9.8216467112
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.382093021 20155912
MESH:D013274 Stomach Neoplasms Tretinoin 2.3817261132
MESH:D020521 Stroke Vitamin E 3.6616517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1516026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1716049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1717053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5610091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8816752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D014820 Vitiligo Tretinoin 4.2516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
Pathway ID Pathway Name
KEGG:05220 Chronic myeloid leukemia
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:04380 Osteoclast differentiation
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28478
    • No data
    Releated disease ID Related disease Name
    PA443319Alzheimer Disease
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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