AutismKB 2.0

Annotation Detail for RUSC2


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Basic Information Top
Gene Symbol:RUSC2 ( Iporin,KIAA0375 )
Gene Full Name: RUN and SH3 domain containing 2
Band: 9p13.3
Quick LinksEntrez ID:9853; OMIM: 611053; Uniprot ID:RUSC2_HUMAN; ENSEMBL ID: ENSG00000198853; HGNC ID: 23625
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of RUSC2 mRNAincreases expression 19933214
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of RUSC2 mRNAincreases expression 16788091
D000082 Acetaminophen Acetaminophen affects the expression of RUSC2 mRNAaffects expression 17562736
C006253 pirinixic acid pirinixic acid results in increased expression of RUSC2 mRNAincreases expression 18301758
18445702
D012643 Selenium Selenium results in increased expression of RUSC2 mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RUSC2 mRNAincreases expression 19933214
D014212 Tretinoin Tretinoin results in increased expression of RUSC2 mRNAincreases expression 16788091
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2415322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.2616835633
MESH:D000505 Alopecia Tretinoin 3.8415955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.2316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4116456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.7316935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.9819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.9812125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 16.9816197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9616443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9916813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6016168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.973084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 2.971917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3516096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 7.7210977129
MESH:D002386 Cataract Tretinoin 7.7217460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9916129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D002822 Choriocarcinoma Tretinoin 5.6016461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0915340226 12621046 15668235 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 6.099407595
MESH:D003092 Colitis Selenium 10.7217936198
MESH:D003092 Colitis Tretinoin 10.7217035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5120055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.519125849 16925845 9211117 10589399 9224671 8800419 9142499 9664655 17551590 14991402
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5517562736 19420014 12958197 17906064 19085960 12540782 12705907 12392966 11834606 18713872 19923254 12153990 17522070 11739529 19370779 19739265 15968718 12594235 11421492 11743745 14986274 11287661 16393943 10663392 2444490 10774834 14725611 19164858 19416960 15619225 16177239 10915739 16081117 14550746 16109766 11529661 18071297 16485898 16227642 11461765 16781746
MESH:D056486 Drug-Induced Liver Injury Selenium 6.5515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema pirinixic acid 7.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 13.4715322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 13.4718230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.5211564622
MESH:D005124 Eye Abnormalities Tretinoin 9.5216938888 9664655
MESH:D005234 Fatty Liver pirinixic acid 3.0419236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.8420067830
MESH:D005355 Fibrosis Tretinoin 9.8417994277
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005909 Glioblastoma Tretinoin 3.1717312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6016084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9710048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.9714991402 9664655
MESH:D006333 Heart Failure pirinixic acid 7.4820558911
MESH:D006333 Heart Failure Selenium 7.4817162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly pirinixic acid 9.4816221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.4816120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4916959395 16354765 8697196 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 8.3716870215
MESH:D006930 Hyperalgesia Tretinoin 8.3716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9316778211
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812200463 12878042
MESH:D007251 Influenza, Human Selenium 4.6416624496
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007410 Intestinal Diseases Tretinoin 4.1217994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.8916580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.8915992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 2.3412587719 15629191
MESH:D007676 Kidney Failure, Chronic Selenium 4.1716518626
MESH:D007938 Leukemia Tretinoin 2.8917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9816932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1119850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3215748426 16331271 17339181 16935935 17217047 12679006 17107899 17294898 9834237 16823087 19035177 19029980 19642359 16766008 17361223 17301526 17712046 16140955 17368321 19225113 16891316 19075265 17649720 17506722 16788101
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.509224671
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5412878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5416248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6812969438 16610002 19460945 19014921 16611625 11587558 19784758 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 4.5420007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5416984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2612151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9215318939
MESH:D008527 Medulloblastoma Tretinoin 2.8717453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008591 Meningomyelocele Tretinoin 4.7816940565
MESH:D008654 Mesothelioma Selenium 2.8815107826
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2217596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009369 Neoplasms pirinixic acid 5.3117405874
MESH:D009369 Neoplasms Tretinoin 5.3116594593 16946489
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.6314600291
MESH:D009421 Nervous System Malformations Tretinoin 10.639125849
MESH:D009436 Neural Tube Defects Tretinoin 3.229142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4116936753
MESH:D010146 Pain Acetaminophen 7.3716870215
MESH:D010146 Pain Tretinoin 7.3716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5415976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010954 Plasmacytoma Selenium 5.3315087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911896295 11399792 11118676 11222880
MESH:D011507 Proteinuria Tretinoin 3.9116636307
MESH:D011625 Pterygium Tretinoin 5.1916723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4016283617 16116481
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9416192470
MESH:D012878 Skin Neoplasms Tretinoin 5.9416467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2317045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.0516051514
MESH:D014376 Tuberculosis Tretinoin 3.3816040207
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9416129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.0516752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D014820 Vitiligo Tretinoin 4.3916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
MESH:D009396 Wilms Tumor Tretinoin 4.2216287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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